IMP

Process View

Mus musculus

9 genes annotated in mouse

positive regulation of autophagy

Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of autophagy"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of autophagy" (in gray)

Name	Description	Probability	Func Analog Organism
Pten	phosphatase and tensin homolog	0.987
Mapk8ip3	mitogen-activated protein kinase 8 interacting protein 3	0.763
Tsc2	tuberous sclerosis 2	0.664	Fly
Tsc1	tuberous sclerosis 1	0.505	Fly
Rb1	retinoblastoma 1	0.338
Hif1a	hypoxia inducible factor 1, alpha subunit	0.320	Fly
Nf2	neurofibromatosis 2	0.280
Atf2	activating transcription factor 2	0.269
Mapk14	mitogen-activated protein kinase 14	0.239
Mapk8	mitogen-activated protein kinase 8	0.228	Fly
Mdm2	transformed mouse 3T3 cell double minute 2	0.207
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.201
Sesn2	sestrin 2	0.187
Cftr	cystic fibrosis transmembrane conductance regulator homolog	0.175
Foxa2	forkhead box A2	0.166	Worm
Vhl	von Hippel-Lindau tumor suppressor	0.138
Pim2	proviral integration site 2	0.133
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.128
Egln1	EGL nine homolog 1 (C. elegans)	0.125
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.119
Sqstm1	sequestosome 1	0.099	Human
Atg13	ATG13 autophagy related 13 homolog (S. cerevisiae)	0.093
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.087
Lepr	leptin receptor	0.074
Prkag1	protein kinase, AMP-activated, gamma 1 non-catalytic subunit	0.068
Socs1	suppressor of cytokine signaling 1	0.066
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.066
Gsk3b	glycogen synthase kinase 3 beta	0.051
Rint1	RAD50 interactor 1	0.048
Prkab1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	0.048
Ctnnb1	catenin (cadherin associated protein), beta 1	0.047
Apc	adenomatosis polyposis coli	0.047
Ulk1	Unc-51 like kinase 1 (C. elegans)	0.046
Cdc42	cell division cycle 42 homolog (S. cerevisiae)	0.045
Igbp1	immunoglobulin (CD79A) binding protein 1	0.045
Pim1	proviral integration site 1	0.042	Mouse
Keap1	kelch-like ECH-associated protein 1	0.041
Dmap1	DNA methyltransferase 1-associated protein 1	0.041
Mark4	MAP/microtubule affinity-regulating kinase 4	0.039
Gopc	golgi associated PDZ and coiled-coil motif containing	0.038
Pparg	peroxisome proliferator activated receptor gamma	0.038
Ikbkg	inhibitor of kappaB kinase gamma	0.037
Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	0.037
Pik3c3	phosphoinositide-3-kinase, class 3	0.035
Rora	RAR-related orphan receptor alpha	0.032
Zbtb24	zinc finger and BTB domain containing 24	0.032
Arid1b	AT rich interactive domain 1B (SWI-like)	0.030
Sav1	salvador homolog 1 (Drosophila)	0.029
Hbb-b1	hemoglobin, beta adult major chain	0.029
Epor	erythropoietin receptor	0.029
Foxa1	forkhead box A1	0.028	Worm
Rxra	retinoid X receptor alpha	0.028
Atg12	autophagy-related 12 (yeast)	0.028
Errfi1	ERBB receptor feedback inhibitor 1	0.028
Foxo1	forkhead box O1	0.026	Human
Prkce	protein kinase C, epsilon	0.024
Atxn1	ataxin 1	0.024
Ticam1	toll-like receptor adaptor molecule 1	0.023
Clock	circadian locomotor output cycles kaput	0.023
Arntl	aryl hydrocarbon receptor nuclear translocator-like	0.023
Klc1	kinesin light chain 1	0.022
Cdx2	caudal type homeobox 2	0.021
Grb2	growth factor receptor bound protein 2	0.021
Hbb-b2	hemoglobin, beta adult minor chain	0.020
Nkx2-1	NK2 homeobox 1	0.019
Xpa	xeroderma pigmentosum, complementation group A	0.019
Mapkbp1	mitogen-activated protein kinase binding protein 1	0.018
Mecp2	methyl CpG binding protein 2	0.018
Axin1	axin 1	0.018
Bsdc1	BSD domain containing 1	0.017
Mapk1	mitogen-activated protein kinase 1	0.017
P4htm	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)	0.016
Ppp3ca	protein phosphatase 3, catalytic subunit, alpha isoform	0.016
Dmtf1	cyclin D binding myb-like transcription factor 1	0.015
Chmp1b	chromatin modifying protein 1B	0.015
Pdpk1	3-phosphoinositide dependent protein kinase 1	0.015
Msh2	mutS homolog 2 (E. coli)	0.015
Htatip2	HIV-1 tat interactive protein 2, homolog (human)	0.015
Pim3	proviral integration site 3	0.014	Mouse
Mib1	mindbomb homolog 1 (Drosophila)	0.014
Rfwd2	ring finger and WD repeat domain 2	0.014
Gabarapl1	gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1	0.013
Emx1	empty spiracles homolog 1 (Drosophila)	0.013
Egln3	EGL nine homolog 3 (C. elegans)	0.012
Sox9	SRY-box containing gene 9	0.012
Nbr1	neighbor of Brca1 gene 1	0.012
E2f1	E2F transcription factor 1	0.012
Ep300	E1A binding protein p300	0.012
Rbl1	retinoblastoma-like 1 (p107)	0.011
Stat6	signal transducer and activator of transcription 6	0.011
Ep400	E1A binding protein p400	0.011
Ubc	ubiquitin C	0.011
Dnm1l	dynamin 1-like	0.011
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.011
Cdh1	cadherin 1	0.011
Rbl2	retinoblastoma-like 2	0.011
Yap1	yes-associated protein 1	0.010
Rb1cc1	RB1-inducible coiled-coil 1	0.010
Ptp4a2	protein tyrosine phosphatase 4a2	0.010
Braf	Braf transforming gene	0.010
Atp2a2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	0.010
Atg7	autophagy-related 7 (yeast)	0.010	Fly