Mus musculus

172 known processes

Fas

Fas (TNF receptor superfamily member 6)

(Aliases: AI196731,CD95,lpr,APT1,TNFR6,APO1,Tnfrsf6)

Fas biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
defense response to other organism GO:0098542 197 1.000
Mouse
regulation of cell activation GO:0050865 289 1.000
lymphocyte homeostasis GO:0002260 64 0.999
t cell differentiation in thymus GO:0033077 77 0.999
extrinsic apoptotic signaling pathway GO:0097191 126 0.998
t cell differentiation GO:0030217 174 0.998
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.998
regulation of inflammatory response GO:0050727 147 0.998
Mouse
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.998
Mouse
positive regulation of cell activation GO:0050867 158 0.997
positive regulation of adaptive immune response GO:0002821 61 0.997
apoptotic signaling pathway GO:0097190 306 0.996
antibacterial peptide production GO:0002778 2 0.996
lymphocyte differentiation GO:0030098 242 0.996
negative regulation of inflammatory response to antigenic stimulus GO:0002862 10 0.996
t cell activation GO:0042110 289 0.994
necroptotic signaling pathway GO:0097527 3 0.993
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.991
regulation of leukocyte differentiation GO:1902105 159 0.991
b cell activation GO:0042113 161 0.987
positive regulation of lymphocyte proliferation GO:0050671 70 0.986
regulation of lymphocyte proliferation GO:0050670 117 0.985
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.984
positive regulation of t cell proliferation GO:0042102 52 0.984
regulation of t cell activation GO:0050863 170 0.984
t helper cell differentiation GO:0042093 28 0.983
regulation of establishment of protein localization GO:0070201 181 0.982
positive regulation of defense response GO:0031349 124 0.982
Mouse
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 6 0.981
immune effector process GO:0002252 321 0.981
regulation of leukocyte mediated immunity GO:0002703 104 0.980
regulation of response to wounding GO:1903034 189 0.979
Mouse
regulation of endopeptidase activity GO:0052548 89 0.978
Rat
alpha beta t cell differentiation GO:0046632 69 0.977
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.976
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 0.975
regulation of leukocyte proliferation GO:0070663 121 0.974
positive regulation of apoptotic process GO:0043065 217 0.973
positive regulation of cytokine production GO:0001819 174 0.973
regulation of cellular ketone metabolic process GO:0010565 66 0.972
cellular response to interleukin 18 GO:0071351 3 0.972
immunoglobulin secretion GO:0048305 17 0.969
intrinsic apoptotic signaling pathway GO:0097193 132 0.965
Mouse
positive regulation of leukocyte differentiation GO:1902107 86 0.964
positive regulation of isotype switching to igg isotypes GO:0048304 7 0.963
regulation of cytokine biosynthetic process GO:0042035 59 0.963
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.961
adaptive immune response GO:0002250 155 0.959
activation of cysteine type endopeptidase activity GO:0097202 27 0.958
humoral immune response GO:0006959 57 0.954
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.954
interleukin 18 mediated signaling pathway GO:0035655 2 0.954
positive regulation of t cell activation GO:0050870 101 0.952
regulation of protein localization GO:0032880 231 0.950
negative regulation of apoptotic signaling pathway GO:2001234 104 0.950
regulation of inflammatory response to antigenic stimulus GO:0002861 21 0.949
negative regulation of cell activation GO:0050866 111 0.949
positive regulation of gamma delta t cell differentiation GO:0045588 6 0.949
positive regulation of glial cell proliferation GO:0060252 4 0.946
glial cell apoptotic process GO:0034349 3 0.945
i kappab kinase nf kappab signaling GO:0007249 85 0.944
regulation of lymphocyte differentiation GO:0045619 107 0.936
neutrophil apoptotic process GO:0001781 3 0.936
signal transduction in absence of ligand GO:0038034 55 0.935
immune response activating signal transduction GO:0002757 116 0.932
type i interferon signaling pathway GO:0060337 10 0.931
immunoglobulin mediated immune response GO:0016064 69 0.930
positive regulation of antibacterial peptide biosynthetic process GO:0006963 1 0.929
regulation of cytokine production involved in immune response GO:0002718 26 0.929
leukocyte migration GO:0050900 124 0.929
positive regulation of neuron apoptotic process GO:0043525 25 0.927
myeloid leukocyte activation GO:0002274 83 0.923
regulation of b cell mediated immunity GO:0002712 37 0.922
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.917
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.915
cytokine mediated signaling pathway GO:0019221 115 0.914
Mouse Rat
positive regulation of cytokine biosynthetic process GO:0042108 40 0.912
t cell proliferation GO:0042098 120 0.911
regulation of alpha beta t cell activation GO:0046634 53 0.908
response to organic cyclic compound GO:0014070 198 0.908
positive regulation of cell death GO:0010942 224 0.907
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.907
t cell receptor signaling pathway GO:0050852 46 0.905
positive regulation of lymphocyte activation GO:0051251 140 0.905
positive regulation of cellular amine metabolic process GO:0033240 5 0.904
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.902
regulation of intracellular transport GO:0032386 159 0.900
negative regulation of cellular protein metabolic process GO:0032269 247 0.899
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.898
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.898
neuron apoptotic process GO:0051402 142 0.895
tyrosine phosphorylation of stat1 protein GO:0042508 3 0.895
regulation of alpha beta t cell differentiation GO:0046637 35 0.894
coagulation GO:0050817 78 0.893
response to corticosteroid GO:0031960 20 0.890
positive regulation of mapk cascade GO:0043410 170 0.888
negative regulation of t cell apoptotic process GO:0070233 18 0.883
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.882
negative regulation of protein metabolic process GO:0051248 282 0.881
cd4 positive or cd8 positive alpha beta t cell lineage commitment GO:0043369 8 0.880
positive regulation of tyrosine phosphorylation of stat1 protein GO:0042511 1 0.879
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.876
regulation of immunoglobulin production GO:0002637 42 0.876
regulation of t helper 1 cell differentiation GO:0045625 7 0.875
activation induced cell death of t cells GO:0006924 10 0.875
response to molecule of bacterial origin GO:0002237 143 0.875
Rat
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.874
response to interleukin 1 GO:0070555 11 0.872
Rat
negative regulation of lymphocyte apoptotic process GO:0070229 24 0.871
lymphocyte activation involved in immune response GO:0002285 93 0.871
regulation of type 2 immune response GO:0002828 18 0.869
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.868
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.868
positive regulation of endopeptidase activity GO:0010950 43 0.865
Rat
chemokine biosynthetic process GO:0042033 8 0.864
peptidyl tyrosine phosphorylation GO:0018108 143 0.862
cellular amine metabolic process GO:0044106 44 0.861
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.861
cellular response to cytokine stimulus GO:0071345 189 0.856
Mouse Rat
positive regulation of alpha beta t cell activation GO:0046635 39 0.855
regulation of cd4 positive alpha beta t cell differentiation GO:0043370 21 0.853
lymphocyte apoptotic process GO:0070227 54 0.852
regulation of interleukin 6 production GO:0032675 55 0.852
cellular amino acid metabolic process GO:0006520 103 0.851
response to hypoxia GO:0001666 58 0.849
Rat
t helper 2 cell differentiation GO:0045064 12 0.849
production of molecular mediator of immune response GO:0002440 103 0.847
regulation of lymphocyte activation GO:0051249 240 0.844
immunoglobulin production GO:0002377 73 0.842
regulation of t cell proliferation GO:0042129 92 0.840
regulation of interleukin 2 production GO:0032663 28 0.839
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.835
Rat
positive regulation of intracellular transport GO:0032388 70 0.835
negative regulation of molecular function GO:0044092 258 0.831
negative regulation of protein phosphorylation GO:0001933 126 0.830
defense response to bacterium GO:0042742 119 0.828
Mouse
negative regulation of interferon gamma mediated signaling pathway GO:0060336 1 0.826
granulocyte chemotaxis GO:0071621 39 0.826
cytokine production GO:0001816 319 0.823
cd4 positive alpha beta t cell activation GO:0035710 45 0.822
pattern recognition receptor signaling pathway GO:0002221 47 0.822
positive regulation of programmed cell death GO:0043068 218 0.821
regulation of defense response GO:0031347 233 0.820
Mouse
cell type specific apoptotic process GO:0097285 268 0.813
regulation of b cell activation GO:0050864 81 0.808
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.806
cytoplasmic transport GO:0016482 234 0.801
jak stat cascade involved in growth hormone signaling pathway GO:0060397 4 0.791
t cell activation involved in immune response GO:0002286 43 0.791
regulation of tolerance induction dependent upon immune response GO:0002652 1 0.790
defense response to protozoan GO:0042832 25 0.788
defense response to virus GO:0051607 68 0.788
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.784
leukocyte differentiation GO:0002521 342 0.783
positive t cell selection GO:0043368 23 0.783
interleukin 10 secretion GO:0072608 4 0.781
antigen receptor mediated signaling pathway GO:0050851 64 0.780
negative regulation of synapse assembly GO:0051964 3 0.776
antibacterial peptide biosynthetic process GO:0002780 2 0.770
regulation of cd8 positive alpha beta cytotoxic t cell extravasation GO:2000452 2 0.768
positive regulation of leukocyte proliferation GO:0070665 73 0.767
release of cytochrome c from mitochondria GO:0001836 23 0.765
regulation of membrane potential GO:0042391 192 0.764
leukocyte homeostasis GO:0001776 79 0.764
chronic inflammatory response GO:0002544 9 0.763
positive regulation of macrophage activation GO:0043032 10 0.760
blood coagulation GO:0007596 76 0.758
regulation of b cell differentiation GO:0045577 23 0.756
interleukin 11 mediated signaling pathway GO:0038154 2 0.756
cellular response to external stimulus GO:0071496 88 0.755
Human
regulation of toll like receptor 2 signaling pathway GO:0034135 3 0.750
regulation of insulin receptor signaling pathway GO:0046626 21 0.735
chemokine metabolic process GO:0050755 10 0.734
negative regulation of t helper 1 cell differentiation GO:0045626 3 0.733
dna metabolic process GO:0006259 303 0.732
cellular response to interleukin 15 GO:0071350 2 0.730
negative regulation of b cell proliferation GO:0030889 13 0.724
leukocyte activation involved in immune response GO:0002366 126 0.721
interleukin 5 secretion GO:0072603 2 0.720
positive regulation of interleukin 12 production GO:0032735 21 0.719
tumor necrosis factor mediated signaling pathway GO:0033209 13 0.717
Mouse Rat
protein maturation GO:0051604 176 0.714
regulation of cysteine type endopeptidase activity GO:2000116 65 0.714
Rat
regulation of peptidase activity GO:0052547 96 0.712
Rat
negative regulation of phosphorylation GO:0042326 166 0.712
regulation of natural killer cell proliferation GO:0032817 2 0.712
programmed necrotic cell death GO:0097300 28 0.710
regulation of neuron apoptotic process GO:0043523 122 0.708
regulation of secretion by cell GO:1903530 249 0.708
regulation of t cell differentiation GO:0045580 83 0.703
positive regulation of protein secretion GO:0050714 52 0.702
negative regulation of inflammatory response GO:0050728 61 0.701
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.699
regulation of cellular amine metabolic process GO:0033238 20 0.695
t cell differentiation involved in immune response GO:0002292 30 0.692
response to lipopolysaccharide GO:0032496 128 0.692
Rat
response to endoplasmic reticulum stress GO:0034976 53 0.692
positive regulation of b cell mediated immunity GO:0002714 26 0.685
response to interleukin 15 GO:0070672 3 0.683
regulation of antibacterial peptide biosynthetic process GO:0002808 1 0.682
negative regulation of cell proliferation GO:0008285 296 0.680
positive regulation of antimicrobial peptide production GO:0002225 1 0.677
isotype switching to igg isotypes GO:0048291 10 0.672
cell cell adhesion GO:0098609 41 0.672
negative regulation of lymphocyte proliferation GO:0050672 45 0.670
erk1 and erk2 cascade GO:0070371 77 0.668
regulation of tumor necrosis factor biosynthetic process GO:0042534 10 0.665
positive regulation of cytokine secretion GO:0050715 41 0.662
cell activation involved in immune response GO:0002263 126 0.661
regulation of neuron death GO:1901214 134 0.661
positive regulation of chronic inflammatory response GO:0002678 4 0.657
lymphocyte proliferation GO:0046651 164 0.655
regulation of interleukin 10 secretion GO:2001179 4 0.655
regulation of innate immune response GO:0045088 91 0.654
neuron death GO:0070997 154 0.652
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.650
b cell mediated immunity GO:0019724 71 0.645
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 2 0.645
t cell homeostasis GO:0043029 35 0.641
cytokine biosynthetic process GO:0042089 68 0.637
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.636
Rat
isotype switching to ige isotypes GO:0048289 7 0.631
zymogen activation GO:0031638 41 0.628
divalent inorganic cation homeostasis GO:0072507 138 0.628
insulin receptor signaling pathway GO:0008286 49 0.626
regulation of platelet activation GO:0010543 17 0.622
cellular response to abiotic stimulus GO:0071214 56 0.622
Human Rat
interleukin 27 mediated signaling pathway GO:0070106 1 0.619
regulation of myotube differentiation GO:0010830 62 0.617
cytokine secretion GO:0050663 72 0.614
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.611
regulation of protein transport GO:0051223 163 0.610
positive regulation of apoptotic signaling pathway GO:2001235 95 0.606
regulation of cellular amino acid metabolic process GO:0006521 5 0.605
dna recombination GO:0006310 92 0.602
detection of molecule of bacterial origin GO:0032490 2 0.602
regulation of cd4 positive alpha beta t cell activation GO:2000514 24 0.601
cellular extravasation GO:0045123 17 0.601
positive regulation of response to wounding GO:1903036 66 0.599
Mouse
regulation of defense response to bacterium GO:1900424 3 0.599
t helper 1 cell differentiation GO:0045063 13 0.597
response to organonitrogen compound GO:0010243 246 0.596
Rat
interleukin 2 mediated signaling pathway GO:0038110 2 0.592
negative regulation of protein modification process GO:0031400 163 0.591
myeloid leukocyte migration GO:0097529 57 0.579
regulation of cytokine production GO:0001817 266 0.577
positive regulation of inflammatory response GO:0050729 47 0.575
Mouse
positive regulation of neuron death GO:1901216 28 0.574
negative regulation of leukocyte proliferation GO:0070664 46 0.567
cellular response to oxidative stress GO:0034599 76 0.566
Rat
positive regulation of t cell differentiation GO:0045582 52 0.566
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.559
positive regulation of protein modification process GO:0031401 299 0.558
regulation of myeloid cell differentiation GO:0045637 96 0.545
immune response regulating signaling pathway GO:0002764 125 0.544
circadian rhythm GO:0007623 114 0.543
homeostasis of number of cells GO:0048872 210 0.539
regulation of protein homooligomerization GO:0032462 3 0.539
nitric oxide mediated signal transduction GO:0007263 4 0.536
negative regulation of phosphorus metabolic process GO:0010563 184 0.529
tyrosine phosphorylation of stat protein GO:0007260 23 0.529
negative regulation of phosphate metabolic process GO:0045936 184 0.528
cation transport GO:0006812 399 0.528
spleen development GO:0048536 39 0.526
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 36 0.525
regulation of secretion GO:0051046 274 0.521
regulation of protein targeting GO:1903533 61 0.518
negative regulation of adaptive immune response GO:0002820 25 0.517
response to dexamethasone GO:0071548 8 0.517
myeloid dendritic cell activation GO:0001773 25 0.516
cd4 positive alpha beta t cell lineage commitment GO:0043373 6 0.515
positive regulation of t cell mediated cytotoxicity GO:0001916 15 0.514
regulation of kinase activity GO:0043549 249 0.513
inflammatory response to antigenic stimulus GO:0002437 30 0.509
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 40 0.507
toll like receptor 4 signaling pathway GO:0034142 9 0.506
endothelial cell apoptotic process GO:0072577 9 0.505
regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 22 0.505
cellular response to type i interferon GO:0071357 10 0.505
cation homeostasis GO:0055080 212 0.505
negative regulation of cd4 positive alpha beta t cell activation GO:2000515 10 0.505
t cell extravasation GO:0072683 4 0.499
positive regulation of activated t cell proliferation GO:0042104 8 0.499
positive regulation of translational initiation GO:0045948 4 0.498
regulation of leukocyte apoptotic process GO:2000106 56 0.494
regulation of tyrosine phosphorylation of stat1 protein GO:0042510 2 0.494
negative regulation of homeostatic process GO:0032845 71 0.492
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.490
regulation of interleukin 6 biosynthetic process GO:0045408 11 0.490
t helper cell lineage commitment GO:0002295 6 0.487
positive regulation of immune effector process GO:0002699 107 0.484
establishment of protein localization to organelle GO:0072594 118 0.482
nuclear transport GO:0051169 139 0.478
myeloid leukocyte differentiation GO:0002573 119 0.476
regulation of homotypic cell cell adhesion GO:0034110 13 0.472
positive regulation of secretion GO:0051047 130 0.470
cellular divalent inorganic cation homeostasis GO:0072503 127 0.468
positive regulation of interleukin 1 secretion GO:0050716 14 0.464
t helper 2 cell cytokine production GO:0035745 4 0.464
positive regulation of interferon alpha production GO:0032727 4 0.461
alpha beta t cell activation GO:0046631 91 0.459
regulation of activated t cell proliferation GO:0046006 16 0.459
amine metabolic process GO:0009308 45 0.459
regulation of apoptotic signaling pathway GO:2001233 197 0.459
peptidyl serine modification GO:0018209 83 0.455
response to amino acid GO:0043200 37 0.451
Rat
regulation of t cell apoptotic process GO:0070232 28 0.448
hemostasis GO:0007599 78 0.446
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.444
regulation of antimicrobial humoral response GO:0002759 3 0.440
positive regulation of protein transport GO:0051222 93 0.439
negative regulation of t cell activation GO:0050868 65 0.437
negative regulation of b cell mediated immunity GO:0002713 7 0.435
regulation of t helper 2 cell cytokine production GO:2000551 3 0.435
regulation of interleukin 13 secretion GO:2000665 2 0.431
regulation of alpha beta t cell proliferation GO:0046640 18 0.430
cell adhesion GO:0007155 329 0.430
peptidyl serine phosphorylation GO:0018105 74 0.420
positive regulation of map kinase activity GO:0043406 84 0.419
cytosolic calcium ion homeostasis GO:0051480 70 0.417
nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070431 6 0.415
gamma delta t cell differentiation GO:0042492 11 0.415
regulation of myeloid leukocyte differentiation GO:0002761 58 0.413
thymic t cell selection GO:0045061 22 0.413
lymph node development GO:0048535 18 0.411
follicular dendritic cell differentiation GO:0002268 2 0.410
inclusion body assembly GO:0070841 3 0.409
protein processing GO:0016485 163 0.408
regulation of interleukin 12 biosynthetic process GO:0045075 8 0.406
inflammatory response GO:0006954 244 0.404
Mouse
positive regulation of interleukin 2 production GO:0032743 19 0.399
negative regulation of reactive oxygen species biosynthetic process GO:1903427 0 0.397
negative regulation of immune system process GO:0002683 209 0.396
positive regulation of leukocyte mediated immunity GO:0002705 70 0.395
gamma delta t cell activation GO:0046629 13 0.393
regulation of dendritic cell apoptotic process GO:2000668 3 0.392
regulation of t helper cell differentiation GO:0045622 14 0.390
b cell proliferation GO:0042100 53 0.390
dendritic spine maintenance GO:0097062 4 0.390
regulation of macrophage differentiation GO:0045649 9 0.389
second messenger mediated signaling GO:0019932 73 0.388
innate immune response GO:0045087 157 0.384
lymphocyte migration GO:0072676 26 0.384
cell substrate adhesion GO:0031589 130 0.380
positive regulation of regulatory t cell differentiation GO:0045591 4 0.379
thymocyte apoptotic process GO:0070242 19 0.379
interleukin 6 mediated signaling pathway GO:0070102 6 0.377
cellular response to peptide GO:1901653 92 0.376
cellular response to growth factor stimulus GO:0071363 197 0.375
regulation of thymocyte apoptotic process GO:0070243 14 0.373
t cell apoptotic process GO:0070231 39 0.372
negative regulation of t helper 1 type immune response GO:0002826 5 0.372
positive regulation of dephosphorylation GO:0035306 6 0.372
cellular response to molecule of bacterial origin GO:0071219 83 0.370
regulation of interferon gamma production GO:0032649 57 0.369
interferon beta biosynthetic process GO:0045350 4 0.365
carbohydrate metabolic process GO:0005975 230 0.365
positive regulation of protein homooligomerization GO:0032464 3 0.363
negative regulation of thymocyte apoptotic process GO:0070244 8 0.361
positive regulation of cd4 positive alpha beta t cell activation GO:2000516 16 0.356
negative regulation of chronic inflammatory response GO:0002677 3 0.353
monocyte extravasation GO:0035696 2 0.353
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.353
positive regulation of interleukin 18 production GO:0032741 2 0.351
antimicrobial peptide biosynthetic process GO:0002777 2 0.350
t cell lineage commitment GO:0002360 13 0.347
negative thymic t cell selection GO:0045060 12 0.347
positive regulation of protein phosphorylation GO:0001934 242 0.347
necroptotic process GO:0070266 21 0.347
positive regulation of macrophage differentiation GO:0045651 5 0.346
t cell selection GO:0045058 34 0.345
response to purine containing compound GO:0014074 28 0.345
activation of janus kinase activity GO:0042976 2 0.344
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.343
t helper 1 cell lineage commitment GO:0002296 2 0.340
negative regulation of cytokine production GO:0001818 84 0.339
regulation of hydrolase activity GO:0051336 246 0.339
Rat
regulation of t helper 2 cell differentiation GO:0045628 8 0.338
positive regulation of inflammatory response to antigenic stimulus GO:0002863 11 0.337
b cell receptor signaling pathway GO:0050853 20 0.335
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.335
negative t cell selection GO:0043383 13 0.331
regulation of isotype switching GO:0045191 22 0.331
mast cell proliferation GO:0070662 4 0.330
oogenesis GO:0048477 56 0.328
interferon gamma mediated signaling pathway GO:0060333 5 0.328
myeloid leukocyte cytokine production GO:0061082 12 0.328
positive regulation of protein kinase activity GO:0045860 144 0.327
epidermal growth factor receptor signaling pathway GO:0007173 28 0.327
response to steroid hormone GO:0048545 56 0.327
cellular response to dexamethasone stimulus GO:0071549 8 0.326
regulation of b cell proliferation GO:0030888 39 0.326
regulation of chronic inflammatory response to antigenic stimulus GO:0002874 3 0.325
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.325
myd88 dependent toll like receptor signaling pathway GO:0002755 7 0.323
regulation of acute inflammatory response GO:0002673 27 0.322
icosanoid transport GO:0071715 14 0.321
regulation of interleukin 5 secretion GO:2000662 2 0.319
negative regulation of t helper 2 cell differentiation GO:0045629 4 0.318
cellular response to biotic stimulus GO:0071216 92 0.317
positive regulation of type 2 immune response GO:0002830 9 0.317
stress activated mapk cascade GO:0051403 80 0.316
myotube differentiation GO:0014902 105 0.316
regulation of dendritic cell chemotaxis GO:2000508 1 0.315
regulation of adaptive immune response GO:0002819 90 0.314
cd4 positive cd25 positive alpha beta regulatory t cell differentiation GO:0002361 4 0.314
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.311
positive regulation of defense response to bacterium GO:1900426 1 0.311
regulation of endocytosis GO:0030100 69 0.309
regulation of b cell apoptotic process GO:0002902 13 0.307
interferon gamma production GO:0032609 67 0.306
nuclear import GO:0051170 95 0.304
regulation of homeostatic process GO:0032844 182 0.303
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.301
positive regulation of activation of membrane attack complex GO:0001970 2 0.300
regulation of protein secretion GO:0050708 82 0.299
protein autophosphorylation GO:0046777 61 0.297
positive regulation of interferon gamma production GO:0032729 39 0.296
regulation of protein kinase activity GO:0045859 232 0.296
regulation of growth of symbiont in host GO:0044126 19 0.292
positive regulation of hydrolase activity GO:0051345 148 0.292
Rat
carbohydrate derivative biosynthetic process GO:1901137 183 0.291
cellular response to hormone stimulus GO:0032870 150 0.289
Rat
ossification GO:0001503 216 0.285
response to interleukin 18 GO:0070673 4 0.285
single organism nuclear import GO:1902593 95 0.284
positive regulation of interleukin 6 production GO:0032755 37 0.283
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.280
Rat
energy reserve metabolic process GO:0006112 39 0.280
alpha beta t cell proliferation GO:0046633 21 0.280
myeloid cell differentiation GO:0030099 233 0.276
regulation of lymphocyte apoptotic process GO:0070228 41 0.274
regulation of binding GO:0051098 111 0.271
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.267
regulation of interleukin 1 production GO:0032652 26 0.267
apoptotic process involved in embryonic digit morphogenesis GO:1902263 3 0.266
regulation of interleukin 10 production GO:0032653 21 0.266
t cell migration GO:0072678 19 0.265
activation of mapk activity GO:0000187 59 0.263
somatic cell dna recombination GO:0016444 51 0.263
modulation by virus of host morphology or physiology GO:0019048 3 0.262
protein import into nucleus GO:0006606 95 0.262
regulation of hemostasis GO:1900046 28 0.261
positive regulation of mast cell degranulation GO:0043306 10 0.259
positive regulation of t cell mediated immunity GO:0002711 24 0.258
regulation of epidermal growth factor receptor signaling pathway GO:0042058 13 0.257
fatty acid transport GO:0015908 28 0.256
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.255
regulation of t cell extravasation GO:2000407 3 0.253
cholesterol esterification GO:0034435 3 0.252
negative regulation of response to wounding GO:1903035 77 0.250
negative regulation of intracellular signal transduction GO:1902532 167 0.249
cell fate commitment GO:0045165 210 0.249
positive regulation of t helper 2 cell differentiation GO:0045630 4 0.246
granulocyte activation GO:0036230 10 0.245
alpha beta t cell activation involved in immune response GO:0002287 31 0.245
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.245
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 15 0.244
positive regulation of isotype switching to ige isotypes GO:0048295 4 0.242
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 27 0.240
cellular response to organonitrogen compound GO:0071417 145 0.240
Rat
negative regulation of alpha beta t cell activation GO:0046636 18 0.240
regulation of blood coagulation GO:0030193 28 0.239
mammary gland lobule development GO:0061377 22 0.238
natural killer cell proliferation GO:0001787 3 0.238
response to oxygen levels GO:0070482 62 0.238
Human Rat
rhythmic process GO:0048511 174 0.237
ras protein signal transduction GO:0007265 77 0.234
regulation of interleukin 8 production GO:0032677 3 0.233
immune complex clearance GO:0002434 2 0.231
protein targeting GO:0006605 143 0.229
cellular response to granulocyte macrophage colony stimulating factor stimulus GO:0097011 3 0.228
positive regulation of podosome assembly GO:0071803 3 0.227
negative regulation of lymphocyte activation GO:0051250 91 0.225
apoptotic mitochondrial changes GO:0008637 48 0.225
leukocyte mediated immunity GO:0002443 174 0.225
positive regulation of intracellular protein transport GO:0090316 42 0.224
positive regulation of nf kappab transcription factor activity GO:0051092 30 0.222
extracellular structure organization GO:0043062 148 0.222
regulation of map kinase activity GO:0043405 120 0.221

Fas disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.996
Human
disease of anatomical entity DOID:7 0 0.996
Human
primary immunodeficiency disease DOID:612 0 0.750
blood protein disease DOID:620 0 0.750
agammaglobulinemia DOID:2583 0 0.750
common variable immunodeficiency DOID:12177 0 0.750
b cell deficiency DOID:2115 0 0.750
hematopoietic system disease DOID:74 0 0.750
hypersensitivity reaction disease DOID:0060056 0 0.628
Human
retinal disease DOID:5679 0 0.271
retinal degeneration DOID:8466 0 0.271
sensory system disease DOID:0050155 0 0.271
eye and adnexa disease DOID:1492 0 0.271
nervous system disease DOID:863 0 0.271
eye disease DOID:5614 0 0.271
hemolytic anemia DOID:583 0 0.233
hemolytic uremic syndrome DOID:12554 0 0.233
normocytic anemia DOID:720 0 0.233
anemia DOID:2355 0 0.233