IMP

Process View

Mus musculus

10 genes annotated in mouse

Multi-species View

positive regulation of macrophage activation

GO:0043032

Any process that stimulates, induces or increases the rate of macrophage activation.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of macrophage activation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of macrophage activation" (in gray)

Name	Description	Probability	Func Analog Organism
Csf2rb2	colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)	0.999	Mouse
Csf2rb	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.989	Mouse
Stat6	signal transducer and activator of transcription 6	0.975
Il1rl1	interleukin 1 receptor-like 1	0.913
Stat3	signal transducer and activator of transcription 3	0.828
Fas	Fas (TNF receptor superfamily member 6)	0.760
Ifng	interferon gamma	0.669
Il6	interleukin 6	0.583
Il2	interleukin 2	0.532
Hspa9	heat shock protein 9	0.477
Selp	selectin, platelet	0.465
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.421
Il1r1	interleukin 1 receptor, type I	0.326	Mouse
Il13	interleukin 13	0.313
Osmr	oncostatin M receptor	0.266
Il4ra	interleukin 4 receptor, alpha	0.265
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.264
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.230
Il1b	interleukin 1 beta	0.222
Il1rn	interleukin 1 receptor antagonist	0.212
Serpina3n	serine (or cysteine) peptidase inhibitor, clade A, member 3N	0.188
Lrg1	leucine-rich alpha-2-glycoprotein 1	0.185
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.148
Slfn4	schlafen 4	0.129
Il33	interleukin 33	0.122
Myd88	myeloid differentiation primary response gene 88	0.114
Il18rap	interleukin 18 receptor accessory protein	0.112	Mouse
Mmp8	matrix metallopeptidase 8	0.110
Il1r2	interleukin 1 receptor, type II	0.104	Mouse
Hp	haptoglobin	0.098
Ccl2	chemokine (C-C motif) ligand 2	0.096
Adam8	a disintegrin and metallopeptidase domain 8	0.095
Lcn2	lipocalin 2	0.093
Klrk1	killer cell lectin-like receptor subfamily K, member 1	0.091
Nlrp3	NLR family, pyrin domain containing 3	0.090
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.089
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.088
Plaur	plasminogen activator, urokinase receptor	0.085
Il17ra	interleukin 17 receptor A	0.080
Hsp90b1	heat shock protein 90, beta (Grp94), member 1	0.078
C5ar1	complement component 5a receptor 1	0.077
Lox	lysyl oxidase	0.076
1100001G20Rik	RIKEN cDNA 1100001G20 gene	0.075
Chi3l3	chitinase 3-like 3	0.061
Litaf	LPS-induced TN factor	0.058
F10	coagulation factor X	0.056
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.054
Cd14	CD14 antigen	0.053
Clec4d	C-type lectin domain family 4, member d	0.052
Ccr1	chemokine (C-C motif) receptor 1	0.052
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.052
Runx1	runt related transcription factor 1	0.051
Tnf	tumor necrosis factor	0.047
Cp	ceruloplasmin	0.047
Saa3	serum amyloid A 3	0.047
C1ra	complement component 1, r subcomponent A	0.046
Cxcl2	chemokine (C-X-C motif) ligand 2	0.046
Slpi	secretory leukocyte peptidase inhibitor	0.045
Tlr4	toll-like receptor 4	0.044
Il1rap	interleukin 1 receptor accessory protein	0.044	Mouse
Cxcl1	chemokine (C-X-C motif) ligand 1	0.044
Cd80	CD80 antigen	0.043
Ccr2	chemokine (C-C motif) receptor 2	0.043
Col1a1	collagen, type I, alpha 1	0.042
Bcl3	B-cell leukemia/lymphoma 3	0.042
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.042
Tmem176a	transmembrane protein 176A	0.041
Slc10a6	solute carrier family 10 (sodium/bile acid cotransporter family), member 6	0.039
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.038
Steap4	STEAP family member 4	0.036
Rel	reticuloendotheliosis oncogene	0.036
S100a8	S100 calcium binding protein A8 (calgranulin A)	0.035
S100a9	S100 calcium binding protein A9 (calgranulin B)	0.034
Clec4e	C-type lectin domain family 4, member e	0.033
Mmp3	matrix metallopeptidase 3	0.033
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.032
Cxcr2	chemokine (C-X-C motif) receptor 2	0.031
Hdc	histidine decarboxylase	0.031
Mdm2	transformed mouse 3T3 cell double minute 2	0.031
Il13ra2	interleukin 13 receptor, alpha 2	0.030
Trp63	transformation related protein 63	0.030
Cxcl5	chemokine (C-X-C motif) ligand 5	0.029
Il6st	interleukin 6 signal transducer	0.028
Ghr	growth hormone receptor	0.025
Il13ra1	interleukin 13 receptor, alpha 1	0.025
Rag1	recombination activating gene 1	0.024
Il4	interleukin 4	0.024	Mouse
Ccl17	chemokine (C-C motif) ligand 17	0.023
Cd40lg	CD40 ligand	0.023
Lif	leukemia inhibitory factor	0.021
Itk	IL2-inducible T-cell kinase	0.021
Soat2	sterol O-acyltransferase 2	0.019
Clca1	chloride channel calcium activated 1	0.018
Fgd3	FYVE, RhoGEF and PH domain containing 3	0.018
Tollip	toll interacting protein	0.018
Dnaja3	DnaJ (Hsp40) homolog, subfamily A, member 3	0.018
Inpp5d	inositol polyphosphate-5-phosphatase D	0.017
Ccl7	chemokine (C-C motif) ligand 7	0.017
Serpine1	serine (or cysteine) peptidase inhibitor, clade E, member 1	0.017
Arid5a	AT rich interactive domain 5A (MRF1-like)	0.016
Foxp3	forkhead box P3	0.016
Lyz2	lysozyme 2	0.015
Cpa3	carboxypeptidase A3, mast cell	0.015
Tnfsf8	tumor necrosis factor (ligand) superfamily, member 8	0.015
St3gal1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	0.015
Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	0.014
Traf1	TNF receptor-associated factor 1	0.014
Il17a	interleukin 17A	0.014
Chordc1	cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1	0.014
Cd28	CD28 antigen	0.014
Thbs2	thrombospondin 2	0.014
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.014
Card11	caspase recruitment domain family, member 11	0.014
Il2ra	interleukin 2 receptor, alpha chain	0.014
C4b	complement component 4B (Childo blood group)	0.014
Rhoj	ras homolog gene family, member J	0.014
F7	coagulation factor VII	0.013
Icos	inducible T-cell co-stimulator	0.013
Mefv	Mediterranean fever	0.013
Mmp19	matrix metallopeptidase 19	0.013
Gdf5	growth differentiation factor 5	0.013
Sfrp1	secreted frizzled-related protein 1	0.013
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.012
Nfatc2ip	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein	0.012
Hamp2	hepcidin antimicrobial peptide 2	0.012
Cfh	complement component factor h	0.012
Cd300lf	CD300 antigen like family member F	0.012
Ch25h	cholesterol 25-hydroxylase	0.012
Tgm2	transglutaminase 2, C polypeptide	0.012
Mvp	major vault protein	0.012
Sbno2	strawberry notch homolog 2 (Drosophila)	0.012
Il18r1	interleukin 18 receptor 1	0.011	Mouse
Lrpprc	leucine-rich PPR-motif containing	0.011
Plek	pleckstrin	0.011
Spp1	secreted phosphoprotein 1	0.011
Dab2	disabled homolog 2 (Drosophila)	0.011
Timp1	tissue inhibitor of metalloproteinase 1	0.011
Tnc	tenascin C	0.011
Gcnt2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme	0.011
Lap3	leucine aminopeptidase 3	0.011
LOC677008	natural killer cell receptor 2B4-like	0.011
Pigr	polymeric immunoglobulin receptor	0.011
Gpr97	G protein-coupled receptor 97	0.011
Rgs16	regulator of G-protein signaling 16	0.011
Fcgr2b	Fc receptor, IgG, low affinity IIb	0.010
Vhl	von Hippel-Lindau tumor suppressor	0.010
Hmox1	heme oxygenase (decycling) 1	0.010
Has2	hyaluronan synthase 2	0.010
Serpina3m	serine (or cysteine) peptidase inhibitor, clade A, member 3M	0.010