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Mus musculus

28 genes annotated in mouse

programmed necrotic cell death

A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "programmed necrotic cell death"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "programmed necrotic cell death" (in gray)

Name	Description	Probability	Func Analog Organism
Tnf	tumor necrosis factor	1.000
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.994
Ikbkg	inhibitor of kappaB kinase gamma	0.993
Traf2	TNF receptor-associated factor 2	0.991
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.986	Mouse
Casp8	caspase 8	0.973
Igh	immunoglobulin heavy chain complex	0.964
Trp53	transformation related protein 53	0.954
Pten	phosphatase and tensin homolog	0.932
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.919
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.914
Lta	lymphotoxin A	0.826	Mouse
Ikbkb	inhibitor of kappaB kinase beta	0.806
Myd88	myeloid differentiation primary response gene 88	0.728
Itch	itchy, E3 ubiquitin protein ligase	0.726
Fas	Fas (TNF receptor superfamily member 6)	0.710
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.691
Cd19	CD19 antigen	0.687
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.678
Bax	BCL2-associated X protein	0.642
Tlr4	toll-like receptor 4	0.627
Rnf31	ring finger protein 31	0.613
Sharpin	SHANK-associated RH domain interacting protein	0.610	Mouse
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.600
Cd40	CD40 antigen	0.595
Ltb	lymphotoxin B	0.580
Sfn	stratifin	0.493
Trp63	transformation related protein 63	0.488	Mouse
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.480
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.468
Ifng	interferon gamma	0.465
Birc3	baculoviral IAP repeat-containing 3	0.457
Fadd	Fas (TNFRSF6)-associated via death domain	0.357
Bcl3	B-cell leukemia/lymphoma 3	0.351
Bak1	BCL2-antagonist/killer 1	0.334	Mouse
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.317
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.306
Il7	interleukin 7	0.255
Stat3	signal transducer and activator of transcription 3	0.246
Stat2	signal transducer and activator of transcription 2	0.240
Atf2	activating transcription factor 2	0.234
Nlrp3	NLR family, pyrin domain containing 3	0.227
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.203
Irf1	interferon regulatory factor 1	0.194	Mouse
Il10	interleukin 10	0.178
Socs1	suppressor of cytokine signaling 1	0.159
Mdm4	transformed mouse 3T3 cell double minute 4	0.159
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.148
Stat6	signal transducer and activator of transcription 6	0.142
Map3k1	mitogen-activated protein kinase kinase kinase 1	0.137
Irf8	interferon regulatory factor 8	0.128	Mouse
Lyst	lysosomal trafficking regulator	0.124
Foxp3	forkhead box P3	0.123
Cxcl13	chemokine (C-X-C motif) ligand 13	0.122
Mapk8	mitogen-activated protein kinase 8	0.119
Ripk3	receptor-interacting serine-threonine kinase 3	0.117
Hccs	holocytochrome c synthetase	0.115
Mapk8ip3	mitogen-activated protein kinase 8 interacting protein 3	0.108
Mavs	mitochondrial antiviral signaling protein	0.107
Chuk	conserved helix-loop-helix ubiquitous kinase	0.106
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.106
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.100
Map3k8	mitogen-activated protein kinase kinase kinase 8	0.099
Pmaip1	phorbol-12-myristate-13-acetate-induced protein 1	0.093
Gbp2	guanylate binding protein 2	0.093
Gbp3	guanylate binding protein 3	0.093
Il1r1	interleukin 1 receptor, type I	0.079
Ticam1	toll-like receptor adaptor molecule 1	0.078
Tcf3	transcription factor 3	0.076
Ncoa3	nuclear receptor coactivator 3	0.071
Ikzf1	IKAROS family zinc finger 1	0.071
1810019J16Rik	RIKEN cDNA 1810019J16 gene	0.070
Il6st	interleukin 6 signal transducer	0.064
Icos	inducible T-cell co-stimulator	0.061
Pycard	PYD and CARD domain containing	0.061
Cyld	cylindromatosis (turban tumor syndrome)	0.061
Card11	caspase recruitment domain family, member 11	0.057
Casp7	caspase 7	0.056	Mouse
Stim2	stromal interaction molecule 2	0.056
Bcl2	B-cell leukemia/lymphoma 2	0.055	Mouse
Trim21	tripartite motif-containing 21	0.054
Aicda	activation-induced cytidine deaminase	0.054
Irf4	interferon regulatory factor 4	0.053	Mouse
Cxcr5	chemokine (C-X-C motif) receptor 5	0.050
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.050
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.050
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.050
Pml	promyelocytic leukemia	0.048
Pou2af1	POU domain, class 2, associating factor 1	0.048
Casp3	caspase 3	0.046	Mouse
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.046
Traf6	TNF receptor-associated factor 6	0.046	Mouse
Batf	basic leucine zipper transcription factor, ATF-like	0.045
Trp73	transformation related protein 73	0.044	Mouse
Ltbr	lymphotoxin B receptor	0.043
Eya2	eyes absent 2 homolog (Drosophila)	0.043
Mlkl	mixed lineage kinase domain-like	0.042
Bid	BH3 interacting domain death agonist	0.041
Tgfb1	transforming growth factor, beta 1	0.041
Bcl6	B-cell leukemia/lymphoma 6	0.040
Rbck1	RanBP-type and C3HC4-type zinc finger containing 1	0.039
Pdcd1	programmed cell death 1	0.038
Ikzf3	IKAROS family zinc finger 3	0.037
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.037
Stat1	signal transducer and activator of transcription 1	0.036
Mapk14	mitogen-activated protein kinase 14	0.036	Mouse
Prf1	perforin 1 (pore forming protein)	0.036
Lrrk2	leucine-rich repeat kinase 2	0.035
Lyz2	lysozyme 2	0.035
Aim1	absent in melanoma 1	0.034
Uba7	ubiquitin-like modifier activating enzyme 7	0.034
Tcrd	T-cell receptor delta chain	0.034
Hif1a	hypoxia inducible factor 1, alpha subunit	0.034
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.034
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.032
Diablo	diablo homolog (Drosophila)	0.031
Il2rb	interleukin 2 receptor, beta chain	0.031
Il18	interleukin 18	0.031
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.030
Ppp3r1	protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)	0.030
Ppp3cb	protein phosphatase 3, catalytic subunit, beta isoform	0.029
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.029
Prmt1	protein arginine N-methyltransferase 1	0.029
Vdr	vitamin D receptor	0.029
Gbp7	guanylate binding protein 7	0.029
Ahr	aryl-hydrocarbon receptor	0.029
Cd44	CD44 antigen	0.028
Tlr2	toll-like receptor 2	0.028
Xiap	X-linked inhibitor of apoptosis	0.028	Mouse
Aim2	absent in melanoma 2	0.028
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.027	Mouse
Traf3ip2	TRAF3 interacting protein 2	0.027
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.026
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.025	Mouse
Mvp	major vault protein	0.025
Ifnar1	interferon (alpha and beta) receptor 1	0.025
Mknk2	MAP kinase-interacting serine/threonine kinase 2	0.025
Id2	inhibitor of DNA binding 2	0.024
Gzmb	granzyme B	0.024	Rat
Jak3	Janus kinase 3	0.024
Mapk9	mitogen-activated protein kinase 9	0.024	Mouse
Nmi	N-myc (and STAT) interactor	0.023
Mapkapk2	MAP kinase-activated protein kinase 2	0.023
Tcrb	T-cell receptor beta chain	0.022
Ccl1	chemokine (C-C motif) ligand 1	0.022
Irf6	interferon regulatory factor 6	0.022	Mouse
Il1b	interleukin 1 beta	0.022
Vhl	von Hippel-Lindau tumor suppressor	0.022
Rbl1	retinoblastoma-like 1 (p107)	0.022
Trafd1	TRAF type zinc finger domain containing 1	0.022
Kitl	kit ligand	0.021
Rsad2	radical S-adenosyl methionine domain containing 2	0.021
Wwox	WW domain-containing oxidoreductase	0.020
Fasl	Fas ligand (TNF superfamily, member 6)	0.020	Human Mouse
Ly96	lymphocyte antigen 96	0.020
Igtp	interferon gamma induced GTPase	0.020
Dok1	docking protein 1	0.020
Tapbpl	TAP binding protein-like	0.019
Atrx	alpha thalassemia/mental retardation syndrome X-linked homolog (human)	0.019
AW112010	expressed sequence AW112010	0.019
Tor3a	torsin family 3, member A	0.019
Gbp1	guanylate binding protein 1	0.019
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.019
Usp9x	ubiquitin specific peptidase 9, X chromosome	0.019
Kit	kit oncogene	0.019
Vegfb	vascular endothelial growth factor B	0.019
Il27ra	interleukin 27 receptor, alpha	0.018
Lag3	lymphocyte-activation gene 3	0.018
St14	suppression of tumorigenicity 14 (colon carcinoma)	0.018
Batf2	basic leucine zipper transcription factor, ATF-like 2	0.018
Cdh1	cadherin 1	0.018
Naip2	NLR family, apoptosis inhibitory protein 2	0.017
Irgm2	immunity-related GTPase family M member 2	0.017
Flii	flightless I homolog (Drosophila)	0.017
Tnfrsf13b	tumor necrosis factor receptor superfamily, member 13b	0.017
Il18r1	interleukin 18 receptor 1	0.017
Il6	interleukin 6	0.017
Sh3bp2	SH3-domain binding protein 2	0.017
Mx2	myxovirus (influenza virus) resistance 2	0.017
Il4ra	interleukin 4 receptor, alpha	0.017
Lif	leukemia inhibitory factor	0.017
Tnfsf9	tumor necrosis factor (ligand) superfamily, member 9	0.016
Cdcp1	CUB domain containing protein 1	0.016
Siae	sialic acid acetylesterase	0.016
Il15	interleukin 15	0.016
Mapk12	mitogen-activated protein kinase 12	0.016	Mouse
Il2rg	interleukin 2 receptor, gamma chain	0.016
Parp1	poly (ADP-ribose) polymerase family, member 1	0.016
BC006779	cDNA sequence BC006779	0.016
Oasl1	2'-5' oligoadenylate synthetase-like 1	0.016
Bbc3	BCL2 binding component 3	0.016
Ifnar2	interferon (alpha and beta) receptor 2	0.015
Huwe1	HECT, UBA and WWE domain containing 1	0.015
Socs3	suppressor of cytokine signaling 3	0.015
Skil	SKI-like	0.015
Trim30d	tripartite motif-containing 30D	0.015
Lgals9	lectin, galactose binding, soluble 9	0.015
Tox	thymocyte selection-associated high mobility group box	0.015
Rel	reticuloendotheliosis oncogene	0.014
Ccrl2	chemokine (C-C motif) receptor-like 2	0.014
Irgm1	immunity-related GTPase family M member 1	0.014
Ptgs2	prostaglandin-endoperoxide synthase 2	0.014
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.014
Gbp6	guanylate binding protein 6	0.014
Fam83h	family with sequence similarity 83, member H	0.013
Mx1	myxovirus (influenza virus) resistance 1	0.013
Tmem173	transmembrane protein 173	0.013
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.013	Mouse
Stat5a	signal transducer and activator of transcription 5A	0.013
Apobec1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	0.013
2010106G01Rik	RIKEN cDNA 2010106G01 gene	0.013
Usp25	ubiquitin specific peptidase 25	0.013
Ccl2	chemokine (C-C motif) ligand 2	0.013
2310061I04Rik	RIKEN cDNA 2310061I04 gene	0.013
Bcl2l1	BCL2-like 1	0.013	Mouse
Il22	interleukin 22	0.013
Oas2	2'-5' oligoadenylate synthetase 2	0.013
Il2ra	interleukin 2 receptor, alpha chain	0.013
Gsta4	glutathione S-transferase, alpha 4	0.013
Zbp1	Z-DNA binding protein 1	0.013
Gsdmd	gasdermin D	0.013
Plscr1	phospholipid scramblase 1	0.013
Nr1h2	nuclear receptor subfamily 1, group H, member 2	0.012
Wrn	Werner syndrome homolog (human)	0.012
Cd28	CD28 antigen	0.012
Ikbke	inhibitor of kappaB kinase epsilon	0.012
Mov10	Moloney leukemia virus 10	0.012
Ube2l6	ubiquitin-conjugating enzyme E2L 6	0.012
Myc	myelocytomatosis oncogene	0.012
C1qbp	complement component 1, q subcomponent binding protein	0.012
Plac8	placenta-specific 8	0.012
Ubd	ubiquitin D	0.012
Ticam2	toll-like receptor adaptor molecule 2	0.012
Etv6	ets variant gene 6 (TEL oncogene)	0.012
Gch1	GTP cyclohydrolase 1	0.012
Stk4	serine/threonine kinase 4	0.011
Pik3c2a	phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide	0.011
Irf7	interferon regulatory factor 7	0.011	Mouse
Parp14	poly (ADP-ribose) polymerase family, member 14	0.011
Tnfsf10	tumor necrosis factor (ligand) superfamily, member 10	0.011	Mouse
Atp11c	ATPase, class VI, type 11C	0.011
Mfn2	mitofusin 2	0.011
Tmco4	transmembrane and coiled-coil domains 4	0.011
Pdcd1lg2	programmed cell death 1 ligand 2	0.011
Irak3	interleukin-1 receptor-associated kinase 3	0.011
Il4	interleukin 4	0.011
Klc1	kinesin light chain 1	0.011
Sptlc2	serine palmitoyltransferase, long chain base subunit 2	0.011
Cflar	CASP8 and FADD-like apoptosis regulator	0.011
Obfc2b	oligonucleotide/oligosaccharide-binding fold containing 2B	0.011
Cxcl9	chemokine (C-X-C motif) ligand 9	0.011
Ifngr1	interferon gamma receptor 1	0.011
Myh9	myosin, heavy polypeptide 9, non-muscle	0.011
Cxcl10	chemokine (C-X-C motif) ligand 10	0.011
Il2	interleukin 2	0.011
Zbtb7b	zinc finger and BTB domain containing 7B	0.010
Aldh2	aldehyde dehydrogenase 2, mitochondrial	0.010
Prkcd	protein kinase C, delta	0.010
Met	met proto-oncogene	0.010
Cd40lg	CD40 ligand	0.010	Mouse
Mib1	mindbomb homolog 1 (Drosophila)	0.010
Hr	hairless	0.010
Ate1	arginyltransferase 1	0.010
Adam8	a disintegrin and metallopeptidase domain 8	0.010
Samhd1	SAM domain and HD domain, 1	0.010
Cmpk2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	0.010
Gbp5	guanylate binding protein 5	0.010