Mus musculus

33 known processes

Col1a2

collagen, type I, alpha 2

(Aliases: Cola-2,oim,AA960264,Cola2,AI325291,Col1a-2)

Col1a2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
extracellular structure organization GO:0043062 148 0.997
Human Mouse
extracellular matrix organization GO:0030198 147 0.994
Human Mouse
cellular response to amino acid stimulus GO:0071230 29 0.994
proteoglycan metabolic process GO:0006029 38 0.941
Mouse
response to amino acid GO:0043200 37 0.917
chondrocyte differentiation GO:0002062 72 0.910
Mouse
skeletal system development GO:0001501 356 0.901
Human Mouse
ossification GO:0001503 216 0.888
Mouse
protein heterotrimerization GO:0070208 8 0.873
connective tissue development GO:0061448 179 0.811
Mouse
endochondral bone morphogenesis GO:0060350 50 0.810
Mouse
bone development GO:0060348 120 0.804
Mouse
fibril organization GO:0097435 2 0.802
positive regulation of cell substrate adhesion GO:0010811 47 0.782
cartilage development involved in endochondral bone morphogenesis GO:0060351 24 0.752
Mouse
cellular response to acid chemical GO:0071229 68 0.733
replacement ossification GO:0036075 26 0.725
Mouse
bone trabecula formation GO:0060346 9 0.718
Mouse
response to organonitrogen compound GO:0010243 246 0.662
aorta morphogenesis GO:0035909 22 0.632
Mouse
extrinsic apoptotic signaling pathway GO:0097191 126 0.629
Mouse
sensory organ morphogenesis GO:0090596 242 0.625
Mouse
cellular response to growth factor stimulus GO:0071363 197 0.623
Human Mouse
extracellular fibril organization GO:0043206 2 0.621
cellular response to organonitrogen compound GO:0071417 145 0.616
protein trimerization GO:0070206 13 0.595
muscle tissue development GO:0060537 308 0.583
Mouse
collagen fibril organization GO:0030199 32 0.533
Human Mouse
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.514
Human
embryonic skeletal system development GO:0048706 120 0.514
Mouse
regulation of cell substrate adhesion GO:0010810 73 0.503
Mouse
cell matrix adhesion GO:0007160 68 0.501
Mouse
head morphogenesis GO:0060323 34 0.496
Mouse
negative regulation of tooth mineralization GO:0070171 1 0.478
regulation of apoptotic signaling pathway GO:2001233 197 0.476
Mouse
response to growth factor GO:0070848 198 0.455
Human Mouse
skeletal system morphogenesis GO:0048705 203 0.454
Mouse
cerebral cortex development GO:0021987 86 0.453
Mouse
negative regulation of apoptotic signaling pathway GO:2001234 104 0.448
Mouse
cellular response to bmp stimulus GO:0071773 14 0.441
Mouse
response to oxidative stress GO:0006979 123 0.430
trabecula formation GO:0060343 24 0.416
Mouse
lung development GO:0030324 164 0.409
anatomical structure homeostasis GO:0060249 145 0.404
Mouse
response to bmp GO:0071772 14 0.401
Mouse
negative regulation of neuron migration GO:2001223 6 0.396
Mouse
cardiac chamber morphogenesis GO:0003206 93 0.392
Mouse
cartilage development GO:0051216 140 0.391
Mouse
striated muscle tissue development GO:0014706 293 0.374
Mouse
negative regulation of cell substrate adhesion GO:0010812 16 0.361
Mouse
embryonic organ morphogenesis GO:0048562 276 0.361
Mouse
smooth muscle tissue development GO:0048745 22 0.358
Mouse
palate development GO:0060021 76 0.326
Mouse
tendon development GO:0035989 6 0.326
Mouse
aorta development GO:0035904 23 0.321
Mouse
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.314
Human
rho protein signal transduction GO:0007266 32 0.295
Human Mouse
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 16 0.291
Mouse
cartilage condensation GO:0001502 18 0.286
Mouse
aorta smooth muscle tissue morphogenesis GO:0060414 2 0.283
Mouse
limb development GO:0060173 166 0.280
Mouse
glycoprotein metabolic process GO:0009100 116 0.278
Mouse
regulation of tooth mineralization GO:0070170 2 0.276
cardiac ventricle morphogenesis GO:0003208 50 0.271
Mouse
sensory perception of sound GO:0007605 97 0.258
Mouse
regulation of chondrocyte differentiation GO:0032330 33 0.256
protein heterooligomerization GO:0051291 14 0.251
face morphogenesis GO:0060325 29 0.247
Mouse
ventricular cardiac muscle tissue morphogenesis GO:0055010 32 0.246
Mouse
regulation of removal of superoxide radicals GO:2000121 4 0.241
response to acid chemical GO:0001101 111 0.239
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.237
Mouse
bone morphogenesis GO:0060349 78 0.236
Mouse
notochord development GO:0030903 20 0.235
Mouse
regulation of biomineral tissue development GO:0070167 33 0.226
negative regulation of cell development GO:0010721 169 0.221
Mouse
peptide cross linking via chondroitin 4 sulfate glycosaminoglycan GO:0019800 8 0.211
biomineral tissue development GO:0031214 64 0.202
wound healing GO:0042060 157 0.202
cell substrate adhesion GO:0031589 130 0.201
Mouse
response to transforming growth factor beta GO:0071559 88 0.195
Human
elastic fiber assembly GO:0048251 4 0.194
endoderm formation GO:0001706 20 0.192
trabecula morphogenesis GO:0061383 40 0.191
Mouse
retinal blood vessel morphogenesis GO:0061304 3 0.190
negative regulation of gastrulation GO:2000542 3 0.189
response to inorganic substance GO:0010035 96 0.187
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 26 0.187
Mouse
blood vessel morphogenesis GO:0048514 285 0.187
Mouse
limb bud formation GO:0060174 10 0.182
Mouse
muscle tissue morphogenesis GO:0060415 53 0.179
Mouse
positive regulation of rho protein signal transduction GO:0035025 7 0.174
Mouse
ear development GO:0043583 200 0.173
Mouse
regulation of cell migration GO:0030334 219 0.172
Mouse
regulation of cell adhesion GO:0030155 154 0.170
Mouse
cardiac muscle tissue morphogenesis GO:0055008 44 0.162
Mouse
sensory perception of mechanical stimulus GO:0050954 107 0.156
Mouse
face development GO:0060324 38 0.155
Mouse
respiratory tube development GO:0030323 167 0.155
peripheral nervous system axon regeneration GO:0014012 2 0.149
artery development GO:0060840 53 0.145
Mouse
ear morphogenesis GO:0042471 118 0.145
Mouse
signal transduction in absence of ligand GO:0038034 55 0.141
Mouse
tissue homeostasis GO:0001894 115 0.141
Mouse
positive regulation of ras protein signal transduction GO:0046579 13 0.130
Mouse
cell adhesion GO:0007155 329 0.126
Mouse
multicellular organismal homeostasis GO:0048871 164 0.124
Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.123
Human
inner ear morphogenesis GO:0042472 101 0.123
Mouse
ras protein signal transduction GO:0007265 77 0.122
Human Mouse
regulation of ceramide biosynthetic process GO:2000303 1 0.121
growth plate cartilage development GO:0003417 14 0.119
negative regulation of cell adhesion GO:0007162 45 0.118
Mouse
regulation of proteolysis GO:0030162 164 0.118
negative regulation of ossification GO:0030279 49 0.115
response to organic cyclic compound GO:0014070 198 0.114
Rat
direct ossification GO:0036072 5 0.111
Mouse
cellular response to abiotic stimulus GO:0071214 56 0.110
Mouse
neuron migration GO:0001764 122 0.105
Mouse
digestive tract morphogenesis GO:0048546 147 0.104
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.104
ventricular cardiac muscle tissue development GO:0003229 38 0.103
Mouse
protein oligomerization GO:0051259 67 0.101
appendage morphogenesis GO:0035107 149 0.100
Mouse
digestive system development GO:0055123 200 0.099
Mouse
negative regulation of signal transduction in absence of ligand GO:1901099 16 0.099
Mouse
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.098
negative regulation of cell proliferation GO:0008285 296 0.095
bone trabecula morphogenesis GO:0061430 12 0.094
Mouse
embryonic skeletal system morphogenesis GO:0048704 91 0.092
Mouse
protein hydroxylation GO:0018126 4 0.092
digestive tract development GO:0048565 190 0.091
Mouse
respiratory system development GO:0060541 190 0.090
endothelial cell apoptotic process GO:0072577 9 0.087
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.084
negative regulation of blood vessel morphogenesis GO:2000181 25 0.082
otic vesicle development GO:0071599 14 0.077
Mouse
physiological cardiac muscle hypertrophy GO:0003301 3 0.076
regulation of ossification GO:0030278 112 0.074
negative regulation of macrophage chemotaxis GO:0010760 1 0.074
negative regulation of cell migration GO:0030336 59 0.073
Mouse
heart morphogenesis GO:0003007 178 0.073
Mouse
chondroitin sulfate metabolic process GO:0030204 17 0.071
cellular response to superoxide GO:0071451 14 0.071
regulation of cell motility GO:2000145 236 0.070
Mouse
nephron development GO:0072006 109 0.068
cardiac chamber development GO:0003205 108 0.067
Mouse
collagen metabolic process GO:0032963 17 0.064
multicellular organismal catabolic process GO:0044243 7 0.064
cellular response to mechanical stimulus GO:0071260 7 0.063
Mouse
regulation of endodermal cell differentiation GO:1903224 2 0.062
response to oxygen radical GO:0000305 16 0.062
regulation of transmission of nerve impulse GO:0051969 1 0.062
regulation of neuron migration GO:2001222 22 0.062
Mouse
spermatogenesis GO:0007283 284 0.062
regulation of angiogenesis GO:0045765 81 0.062
positive regulation of nervous system development GO:0051962 221 0.061
regulation of toll signaling pathway GO:0008592 1 0.060
antibacterial peptide secretion GO:0002779 1 0.059
negative regulation of cellular response to growth factor stimulus GO:0090288 46 0.058
small gtpase mediated signal transduction GO:0007264 97 0.057
Human Mouse
formation of primary germ layer GO:0001704 77 0.056
pallium development GO:0021543 120 0.055
Mouse
negative regulation of intracellular signal transduction GO:1902532 167 0.055
regulation of peptidase activity GO:0052547 96 0.055
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration GO:0014834 3 0.053
regulation of cartilage development GO:0061035 44 0.052
antimicrobial peptide secretion GO:0002776 1 0.052
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.051
Mouse
cardiac muscle tissue development GO:0048738 130 0.049
Mouse
forebrain development GO:0030900 302 0.049
Mouse
protein maturation GO:0051604 176 0.049
endoderm development GO:0007492 45 0.048
sensory perception GO:0007600 245 0.047
Mouse
glycosaminoglycan metabolic process GO:0030203 34 0.047
negative regulation of biomineral tissue development GO:0070168 11 0.046
chondroitin sulfate proteoglycan metabolic process GO:0050654 20 0.046
negative regulation of embryonic development GO:0045992 22 0.046
positive regulation of cell development GO:0010720 237 0.046
astrocyte fate commitment GO:0060018 4 0.045
acylglycerol metabolic process GO:0006639 55 0.045
chondrocyte development GO:0002063 24 0.044
Mouse
negative regulation of epithelial cell proliferation GO:0050680 64 0.044
neuromuscular process controlling balance GO:0050885 59 0.044
cardiac ventricle development GO:0003231 83 0.044
Mouse
cell growth involved in cardiac muscle cell development GO:0061049 3 0.043
positive regulation of hydrolase activity GO:0051345 148 0.043
sequestering of bmp in extracellular matrix GO:0035582 3 0.042
regulation of cellular response to oxidative stress GO:1900407 19 0.042
peptide cross linking GO:0018149 10 0.040
positive regulation of metanephric mesenchymal cell migration GO:2000591 1 0.040
limb morphogenesis GO:0035108 149 0.040
Mouse
protein processing GO:0016485 163 0.038
metal ion homeostasis GO:0055065 189 0.038
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 26 0.038
endodermal cell differentiation GO:0035987 14 0.038
response to monosaccharide GO:0034284 67 0.038
mucopolysaccharide metabolic process GO:1903510 25 0.038
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.037
renal system development GO:0072001 225 0.036
type b pancreatic cell proliferation GO:0044342 10 0.036
aminoglycan metabolic process GO:0006022 34 0.035
regulation of cell growth involved in cardiac muscle cell development GO:0061050 3 0.035
negative regulation of phospholipase activity GO:0010519 4 0.035
positive regulation of bone remodeling GO:0046852 13 0.035
response to hyperoxia GO:0055093 2 0.034
regulation of hydrolase activity GO:0051336 246 0.034
eye photoreceptor cell differentiation GO:0001754 41 0.031
regulation of cellular response to stress GO:0080135 159 0.030
neuromuscular process GO:0050905 99 0.030
negative regulation of angiogenesis GO:0016525 25 0.030
sequestering of extracellular ligand from receptor GO:0035581 6 0.030
negative regulation of endodermal cell differentiation GO:1903225 1 0.030
negative regulation of nervous system development GO:0051961 156 0.029
Mouse
removal of superoxide radicals GO:0019430 12 0.029
oxidation reduction process GO:0055114 342 0.029
regulation of schwann cell proliferation GO:0010624 2 0.029
multicellular organismal metabolic process GO:0044236 28 0.028
regulation of hormone levels GO:0010817 211 0.026
innate immune response GO:0045087 157 0.026
negative regulation of odontogenesis GO:0042483 3 0.026
organ growth GO:0035265 117 0.026
regulation of cellular ketone metabolic process GO:0010565 66 0.026
bone mineralization GO:0030282 54 0.025
urogenital system development GO:0001655 261 0.025
camera type eye development GO:0043010 266 0.025
regulation of ras protein signal transduction GO:0046578 114 0.025
Mouse
single organism cell adhesion GO:0098602 156 0.025
regulation of epithelial cell proliferation GO:0050678 141 0.025
positive regulation of cell projection organization GO:0031346 95 0.025
appendage development GO:0048736 166 0.025
Mouse
response to metal ion GO:0010038 47 0.025
collagen biosynthetic process GO:0032964 7 0.024
monocarboxylic acid metabolic process GO:0032787 191 0.024
bone resorption GO:0045453 38 0.024
positive regulation of neuron differentiation GO:0045666 141 0.024
regulation of system process GO:0044057 200 0.024
response to extracellular stimulus GO:0009991 127 0.023
negative regulation of cartilage development GO:0061037 17 0.023
peptide metabolic process GO:0006518 46 0.023
response to steroid hormone GO:0048545 56 0.023
regulation of cellular response to growth factor stimulus GO:0090287 82 0.023
regulation of body fluid levels GO:0050878 162 0.023
monosaccharide transport GO:0015749 58 0.023
response to radiation GO:0009314 165 0.023
cellular response to oxygen radical GO:0071450 14 0.023
negative regulation of immune system process GO:0002683 209 0.023
gastrulation GO:0007369 116 0.023
sulfur compound metabolic process GO:0006790 100 0.023
fat cell differentiation GO:0045444 160 0.022
positive regulation of cell growth GO:0030307 33 0.022
cardiac cell development GO:0055006 41 0.022
angiogenesis GO:0001525 201 0.022
regulation of bone mineralization GO:0030500 31 0.022
microtubule based process GO:0007017 236 0.022
regulation of cardiac muscle tissue growth GO:0055021 26 0.022
negative regulation of cell motility GO:2000146 61 0.021
Mouse
carbohydrate homeostasis GO:0033500 128 0.021
skeletal muscle organ development GO:0060538 163 0.021
regulation of neuron projection development GO:0010975 169 0.021
multicellular organismal macromolecule metabolic process GO:0044259 19 0.021
negative regulation of molecular function GO:0044092 258 0.021
positive regulation of insulin secretion GO:0032024 26 0.020
telencephalon development GO:0021537 186 0.020
Mouse
regulation of cellular component biogenesis GO:0044087 181 0.019
cell type specific apoptotic process GO:0097285 268 0.018
regionalization GO:0003002 337 0.018
odontogenesis GO:0042476 78 0.018
positive regulation of neuron projection development GO:0010976 79 0.018
insulin processing GO:0030070 2 0.018
regulation of translation GO:0006417 71 0.018
cardiac muscle cell development GO:0055013 39 0.018
neural precursor cell proliferation GO:0061351 121 0.018
organelle fission GO:0048285 170 0.017
oviduct development GO:0060066 3 0.017
pancreatic pp cell fate commitment GO:0003329 2 0.017
regulation of map kinase activity GO:0043405 120 0.017
peptidyl amino acid modification GO:0018193 336 0.017
negative regulation of hydrolase activity GO:0051346 71 0.017
epidermis development GO:0008544 187 0.017
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.017
epithelial to mesenchymal transition GO:0001837 47 0.017
response to reactive oxygen species GO:0000302 56 0.017
synaptic transmission GO:0007268 329 0.017
macromolecule catabolic process GO:0009057 281 0.016
negative regulation of lipoprotein lipase activity GO:0051005 1 0.016
antimicrobial peptide biosynthetic process GO:0002777 2 0.016
regulation of rho protein signal transduction GO:0035023 71 0.016
Mouse
positive regulation of bone resorption GO:0045780 13 0.016
cellular modified amino acid metabolic process GO:0006575 63 0.016
molting cycle GO:0042303 90 0.016
physiological muscle hypertrophy GO:0003298 3 0.015
apoptotic signaling pathway GO:0097190 306 0.015
Mouse
cellular response to cytokine stimulus GO:0071345 189 0.015
negative regulation of vasculature development GO:1901343 26 0.015
prostate gland stromal morphogenesis GO:0060741 2 0.015
response to peptide GO:1901652 136 0.015
positive regulation of cell death GO:0010942 224 0.014
positive regulation of semaphorin plexin signaling pathway GO:2001262 1 0.014
reactive oxygen species metabolic process GO:0072593 84 0.014
stem cell differentiation GO:0048863 268 0.014
regulation of sphingolipid biosynthetic process GO:0090153 1 0.014
long term synaptic potentiation GO:0060291 25 0.014
female gonad development GO:0008585 71 0.014
regulation of anatomical structure size GO:0090066 178 0.014
intestinal epithelial structure maintenance GO:0060729 4 0.014
early endosome to late endosome transport GO:0045022 2 0.014
cell recognition GO:0008037 83 0.014
positive regulation of response to wounding GO:1903036 66 0.014
response to nitric oxide GO:0071731 4 0.014
peptidyl serine modification GO:0018209 83 0.014
negative regulation of cell proliferation involved in contact inhibition GO:0060244 3 0.014
positive regulation of peptidase activity GO:0010952 49 0.014
peptide secretion GO:0002790 114 0.014
developmental maturation GO:0021700 193 0.014
development of primary female sexual characteristics GO:0046545 73 0.014
cell growth GO:0016049 130 0.014
hormone secretion GO:0046879 128 0.013
cardiac muscle cell differentiation GO:0055007 69 0.013
cardiocyte differentiation GO:0035051 87 0.013
regulation of reactive oxygen species metabolic process GO:2000377 40 0.013
cellular response to organic cyclic compound GO:0071407 87 0.013
cellular response to vitamin GO:0071295 2 0.013
covalent chromatin modification GO:0016569 163 0.013
negative regulation of protein activation cascade GO:2000258 3 0.013
positive regulation of proteolysis GO:0045862 85 0.013
antibacterial peptide biosynthetic process GO:0002780 2 0.013
superoxide metabolic process GO:0006801 27 0.013
tissue remodeling GO:0048771 102 0.012
kidney development GO:0001822 213 0.012
cellular response to fluid shear stress GO:0071498 4 0.012
response to epidermal growth factor GO:0070849 4 0.012
protein localization to nucleus GO:0034504 121 0.012
response to molecule of bacterial origin GO:0002237 143 0.012
regulation of cell size GO:0008361 72 0.012
regulation of homeostatic process GO:0032844 182 0.012
peripheral nervous system neuron axonogenesis GO:0048936 3 0.012
cellular response to oxidative stress GO:0034599 76 0.012
humoral immune response GO:0006959 57 0.012
integrin biosynthetic process GO:0045112 1 0.012
basement membrane organization GO:0071711 8 0.011
negative regulation of growth GO:0045926 99 0.011
organonitrogen compound biosynthetic process GO:1901566 192 0.011
epithelial cell proliferation GO:0050673 174 0.011
female sex differentiation GO:0046660 84 0.011
cellular ketone metabolic process GO:0042180 84 0.011
response to superoxide GO:0000303 16 0.011
integrin mediated signaling pathway GO:0007229 27 0.011
response to endoplasmic reticulum stress GO:0034976 53 0.011
regulation of response to reactive oxygen species GO:1901031 9 0.011
regulation of wnt signaling pathway GO:0030111 123 0.011
macrophage chemotaxis GO:0048246 14 0.011
negative regulation of fat cell differentiation GO:0045599 36 0.011
cardiac septum morphogenesis GO:0060411 46 0.011
regulation of gastrulation GO:0010470 16 0.011
notochord cell differentiation GO:0060034 1 0.011
negative regulation of dna replication GO:0008156 4 0.011
transforming growth factor beta2 production GO:0032906 2 0.011
bmp signaling pathway GO:0030509 93 0.011
positive regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway GO:0035793 1 0.011
phagolysosome assembly GO:0001845 3 0.011
development of primary sexual characteristics GO:0045137 143 0.011
negative regulation of protein maturation GO:1903318 79 0.011
skeletal myofibril assembly GO:0014866 4 0.010
transmembrane transport GO:0055085 412 0.010
regulation of vasculogenesis GO:2001212 9 0.010
antimicrobial peptide production GO:0002775 2 0.010
regulation of macrophage migration inhibitory factor signaling pathway GO:2000446 1 0.010
response to decreased oxygen levels GO:0036293 59 0.010
regulation of tissue remodeling GO:0034103 38 0.010
antibacterial humoral response GO:0019731 8 0.010

Col1a2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.993
Human
musculoskeletal system disease DOID:17 0 0.993
Human
myopathy DOID:423 0 0.969
muscular disease DOID:0080000 0 0.969
muscle tissue disease DOID:66 0 0.969
connective tissue disease DOID:65 0 0.931
Human
collagen disease DOID:854 0 0.721
congenital muscular dystrophy DOID:0050557 0 0.674
muscular dystrophy DOID:9884 0 0.674
ehlers danlos syndrome DOID:13359 0 0.534
osteochondrodysplasia DOID:2256 0 0.157
Human
osteogenesis imperfecta DOID:12347 0 0.157
Human
bone development disease DOID:0080006 0 0.157
Human
bone disease DOID:0080001 0 0.157
Human
heart disease DOID:114 0 0.061
cardiomyopathy DOID:0050700 0 0.061
cardiovascular system disease DOID:1287 0 0.061
glaucoma DOID:1686 0 0.036
retinal disease DOID:5679 0 0.036
retinal degeneration DOID:8466 0 0.036
sensory system disease DOID:0050155 0 0.036
eye and adnexa disease DOID:1492 0 0.036
nervous system disease DOID:863 0 0.036
eye disease DOID:5614 0 0.036
osteoporosis DOID:11476 0 0.020
Human
bone remodeling disease DOID:0080005 0 0.020
Human
bone resorption disease DOID:0080011 0 0.020
Human
intrinsic cardiomyopathy DOID:0060036 0 0.018