Mus musculus

260 known processes

Pitx2

paired-like homeodomain transcription factor 2

(Aliases: Munc30,Otlx2,Pitx2cbeta,Ptx2,Rieg,Brx1b,Pitx2c,Brx1a,Pitx2b,9430085M16Rik,Brx1,Pitx2a)

Pitx2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regionalization GO:0003002 337 1.000
embryonic skeletal system development GO:0048706 120 1.000
Zebrafish
embryonic organ morphogenesis GO:0048562 276 1.000
limb morphogenesis GO:0035108 149 1.000
carbon catabolite repression of transcription from rna polymerase ii promoter GO:0000437 1 1.000
determination of heart left right asymmetry GO:0061371 48 1.000
appendage morphogenesis GO:0035107 149 1.000
pyramidal neuron migration GO:0021852 1 1.000
lateral motor column neuron migration GO:0097477 3 1.000
heart morphogenesis GO:0003007 178 1.000
determination of left right symmetry GO:0007368 80 1.000
heart formation GO:0060914 16 1.000
visceral motor neuron differentiation GO:0021524 3 1.000
peripheral nervous system neuron axonogenesis GO:0048936 3 1.000
cell proliferation in hindbrain GO:0021534 10 1.000
positive regulation of secondary heart field cardioblast proliferation GO:0072513 4 1.000
sinoatrial node cell differentiation GO:0060921 3 1.000
cardiac cell fate determination GO:0060913 2 1.000
epithelial tube morphogenesis GO:0060562 303 1.000
cardiac chamber morphogenesis GO:0003206 93 1.000
cardiac atrium morphogenesis GO:0003209 23 1.000
forebrain neuron fate commitment GO:0021877 13 1.000
neural tube closure GO:0001843 90 1.000
embryonic appendage morphogenesis GO:0035113 126 1.000
commitment of neuronal cell to specific neuron type in forebrain GO:0021902 7 1.000
motor neuron migration GO:0097475 4 1.000
spinal cord motor neuron migration GO:0097476 4 1.000
embryonic eye morphogenesis GO:0048048 29 1.000
Zebrafish
neural tube development GO:0021915 160 1.000
cardiac muscle tissue morphogenesis GO:0055008 44 1.000
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 2 1.000
endodermal cell fate commitment GO:0001711 12 1.000
stem cell development GO:0048864 219 1.000
embryonic heart tube development GO:0035050 65 1.000
Zebrafish
telencephalon development GO:0021537 186 1.000
embryonic skeletal system morphogenesis GO:0048704 91 1.000
Zebrafish
endodermal cell fate specification GO:0001714 4 1.000
limb development GO:0060173 166 1.000
nephric duct elongation GO:0035849 1 1.000
mesenchyme development GO:0060485 152 1.000
nodal signaling pathway involved in determination of left right asymmetry GO:0038107 2 1.000
cardioblast migration to the midline involved in heart field formation GO:0060975 1 1.000
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 1.000
negative regulation of cardiac chamber morphogenesis GO:1901220 2 1.000
embryonic heart tube morphogenesis GO:0003143 51 1.000
cardiac septum morphogenesis GO:0060411 46 1.000
muscle tissue development GO:0060537 308 1.000
appendage development GO:0048736 166 1.000
embryonic viscerocranium morphogenesis GO:0048703 8 1.000
Zebrafish
gastrulation GO:0007369 116 1.000
positive regulation of auditory receptor cell differentiation GO:0045609 1 1.000
embryonic heart tube left right pattern formation GO:0060971 5 1.000
Zebrafish
cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 3 1.000
auditory receptor cell fate determination GO:0042668 3 1.000
cardiac atrium development GO:0003230 24 1.000
somitogenesis GO:0001756 69 1.000
primary neural tube formation GO:0014020 95 1.000
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000802 1 1.000
cardiac ventricle development GO:0003231 83 1.000
endocardial cushion morphogenesis GO:0003203 18 1.000
somite rostral caudal axis specification GO:0032525 13 1.000
left right pattern formation GO:0060972 23 1.000
regulation of apoptotic process involved in outflow tract morphogenesis GO:1902256 2 1.000
skeletal muscle cell differentiation GO:0035914 66 1.000
trophectodermal cell differentiation GO:0001829 21 1.000
cell fate specification GO:0001708 72 1.000
positive regulation of transcription by glucose GO:0046016 3 1.000
atrial septum development GO:0003283 12 1.000
nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry GO:1900164 2 1.000
mesenchymal cell differentiation GO:0048762 107 1.000
respiratory system development GO:0060541 190 1.000
cardiac chamber development GO:0003205 108 1.000
muscle tissue morphogenesis GO:0060415 53 1.000
regulation of heart morphogenesis GO:2000826 22 1.000
embryonic heart tube anterior posterior pattern specification GO:0035054 3 1.000
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process GO:2000763 1 1.000
neuron projection guidance GO:0097485 141 1.000
Worm
metanephric nephron morphogenesis GO:0072273 19 1.000
cerebral cortex neuron differentiation GO:0021895 19 1.000
cardiac septum development GO:0003279 59 1.000
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 4 1.000
outflow tract septum morphogenesis GO:0003148 11 1.000
spinal cord development GO:0021510 81 1.000
horizontal cell localization GO:0035852 1 1.000
striated muscle tissue development GO:0014706 293 1.000
renal system development GO:0072001 225 1.000
clara cell differentiation GO:0060486 4 1.000
midbrain hindbrain boundary morphogenesis GO:0021555 4 1.000
metanephros morphogenesis GO:0003338 24 1.000
pituitary gland development GO:0021983 38 1.000
heart field specification GO:0003128 6 1.000
notochord formation GO:0014028 5 1.000
telencephalon regionalization GO:0021978 14 1.000
positive regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901228 4 1.000
specification of organ identity GO:0010092 30 1.000
diencephalon development GO:0021536 63 1.000
cell migration involved in gastrulation GO:0042074 13 1.000
atrioventricular bundle cell differentiation GO:0003167 1 1.000
hindlimb morphogenesis GO:0035137 42 1.000
regulation of cardioblast proliferation GO:0003264 9 1.000
cardioblast migration GO:0003260 1 1.000
regulation of cardiac chamber formation GO:1901210 1 1.000
cardiac muscle cell differentiation GO:0055007 69 1.000
regulation of organ morphogenesis GO:2000027 144 1.000
ventricular septum morphogenesis GO:0060412 27 1.000
stem cell differentiation GO:0048863 268 1.000
cardiac ventricle morphogenesis GO:0003208 50 1.000
morphogenesis of a branching structure GO:0001763 203 1.000
left lung morphogenesis GO:0060460 3 1.000
cardiac muscle tissue development GO:0048738 130 1.000
granulocyte colony stimulating factor production GO:0071611 1 1.000
regulation of organ formation GO:0003156 34 1.000
forebrain neuron differentiation GO:0021879 52 1.000
oviduct epithelium development GO:0035846 1 1.000
positive regulation of transcription from rna polymerase ii promoter by glucose GO:0000432 3 1.000
regulation of cell proliferation involved in heart morphogenesis GO:2000136 15 1.000
sensory organ morphogenesis GO:0090596 242 1.000
Human Zebrafish Mouse
neuron fate specification GO:0048665 30 1.000
positive regulation of ureteric bud formation GO:0072107 3 1.000
cardiac muscle cell myoblast differentiation GO:0060379 8 1.000
skeletal system morphogenesis GO:0048705 203 1.000
Zebrafish
regulation of ureteric bud formation GO:0072106 3 1.000
formation of primary germ layer GO:0001704 77 1.000
negative regulation of mesodermal cell fate specification GO:0042662 3 1.000
segmentation GO:0035282 93 1.000
embryonic epithelial tube formation GO:0001838 130 1.000
positive regulation of nephron tubule epithelial cell differentiation GO:2000768 1 1.000
positive regulation of macrophage colony stimulating factor production GO:1901258 1 1.000
atrioventricular valve morphogenesis GO:0003181 13 1.000
cell differentiation involved in embryonic placenta development GO:0060706 26 1.000
mitral valve morphogenesis GO:0003183 4 1.000
cardioblast proliferation GO:0003263 8 1.000
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 1.000
regulation of nephron tubule epithelial cell differentiation GO:0072182 9 1.000
positive regulation of inner ear receptor cell differentiation GO:2000982 1 1.000
sinoatrial node development GO:0003163 4 1.000
organ growth GO:0035265 117 1.000
hindbrain development GO:0030902 128 1.000
nephron tubule morphogenesis GO:0072078 68 1.000
neural crest cell development GO:0014032 48 1.000
secondary heart field specification GO:0003139 6 0.999
cardiac conduction system development GO:0003161 12 0.999
gland development GO:0048732 330 0.999
neural tube formation GO:0001841 108 0.999
forebrain generation of neurons GO:0021872 63 0.999
cerebellar granule cell precursor proliferation GO:0021930 10 0.999
digestive system development GO:0055123 200 0.999
positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 18 0.999
atrial septum morphogenesis GO:0060413 11 0.999
cardiocyte differentiation GO:0035051 87 0.999
digestive tract development GO:0048565 190 0.999
outflow tract morphogenesis GO:0003151 53 0.999
olfactory lobe development GO:0021988 32 0.999
regulation of skeletal muscle fiber differentiation GO:1902809 3 0.999
positive regulation of heart growth GO:0060421 18 0.999
ventral spinal cord interneuron specification GO:0021521 11 0.999
regulation of cardiac chamber morphogenesis GO:1901219 2 0.999
forebrain regionalization GO:0021871 25 0.999
regulation of tongue muscle cell differentiation GO:2001035 2 0.999
cell differentiation in spinal cord GO:0021515 53 0.999
endocrine system development GO:0035270 98 0.999
embryonic retina morphogenesis in camera type eye GO:0060059 7 0.999
ear morphogenesis GO:0042471 118 0.999
skeletal system development GO:0001501 356 0.999
cell proliferation involved in heart morphogenesis GO:0061323 15 0.999
urogenital system development GO:0001655 261 0.999
regulation of canonical wnt signaling pathway GO:0060828 82 0.999
his purkinje system cell differentiation GO:0060932 2 0.999
striated muscle cell proliferation GO:0014855 39 0.999
cell fate commitment GO:0045165 210 0.999
Mouse
mesodermal to mesenchymal transition involved in gastrulation GO:0060809 1 0.999
positive regulation of mesenchymal cell proliferation involved in ureter development GO:2000729 3 0.999
response to fibroblast growth factor GO:0071774 47 0.999
neural crest cell migration GO:0001755 32 0.999
anterior commissure morphogenesis GO:0021960 6 0.999
ventral spinal cord interneuron differentiation GO:0021514 16 0.999
mesenchymal cell development GO:0014031 93 0.999
morphogenesis of embryonic epithelium GO:0016331 159 0.999
Zebrafish
endoderm formation GO:0001706 20 0.999
regulation of cardiac muscle tissue development GO:0055024 31 0.999
cochlea morphogenesis GO:0090103 22 0.999
bmp signaling pathway GO:0030509 93 0.999
neural tube patterning GO:0021532 43 0.999
positive regulation of mesenchymal cell proliferation GO:0002053 33 0.999
regulation of cardiac muscle tissue growth GO:0055021 26 0.999
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.999
spinal cord motor neuron cell fate specification GO:0021520 13 0.999
tricuspid valve development GO:0003175 3 0.999
medial motor column neuron differentiation GO:0021526 2 0.999
central nervous system neuron differentiation GO:0021953 162 0.999
epithelial cell differentiation involved in kidney development GO:0035850 23 0.999
renal vesicle development GO:0072087 17 0.999
ventral spinal cord interneuron fate commitment GO:0060579 14 0.999
negative regulation of heart looping GO:1901208 1 0.999
positive regulation of cardiac muscle cell proliferation GO:0060045 15 0.999
atrial cardiac muscle cell differentiation GO:0055011 2 0.999
blastocyst formation GO:0001825 33 0.999
ventral spinal cord development GO:0021517 48 0.999
lung induction GO:0060492 3 0.999
pulmonary valve development GO:0003177 5 0.999
head morphogenesis GO:0060323 34 0.999
Zebrafish
axial mesodermal cell fate commitment GO:0048322 1 0.999
forebrain morphogenesis GO:0048853 17 0.999
regulation of branching involved in ureteric bud morphogenesis GO:0090189 22 0.999
cardiac chamber formation GO:0003207 10 0.999
trabecular meshwork development GO:0002930 2 0.999
branching morphogenesis of an epithelial tube GO:0048754 159 0.999
vagus nerve development GO:0021564 3 0.999
endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003199 4 0.999
embryonic heart tube formation GO:0003144 1 0.999
cerebellar purkinje cell granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation GO:0021937 6 0.998
cardiac right atrium morphogenesis GO:0003213 3 0.998
regulation of vascular wound healing GO:0061043 2 0.998
regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003256 6 0.998
forebrain development GO:0030900 302 0.998
positive regulation of cardioblast differentiation GO:0051891 3 0.998
endocardial cushion formation GO:0003272 13 0.998
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.998
renal tubule development GO:0061326 87 0.998
neural plate morphogenesis GO:0001839 9 0.998
negative regulation of canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060829 1 0.998
olfactory bulb development GO:0021772 30 0.998
positive regulation of epithelial cell differentiation involved in kidney development GO:2000698 2 0.998
gonad morphogenesis GO:0035262 1 0.998
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000800 1 0.998
hypophysis morphogenesis GO:0048850 3 0.998
cerebral cortex development GO:0021987 86 0.998
cardiac ventricle formation GO:0003211 8 0.998
renal vesicle morphogenesis GO:0072077 15 0.998
ventricular cardiac muscle tissue morphogenesis GO:0055010 32 0.998
positive regulation of transcription via serum response element binding GO:0010735 1 0.998
tongue morphogenesis GO:0043587 8 0.998
aorta morphogenesis GO:0035909 22 0.998
specification of organ position GO:0010159 3 0.998
ventricular septum development GO:0003281 42 0.998
cell proliferation in forebrain GO:0021846 30 0.998
wnt signaling pathway GO:0016055 188 0.998
regulation of cerebellar granule cell precursor proliferation GO:0021936 12 0.998
glomerular mesangial cell development GO:0072144 3 0.998
primitive streak formation GO:0090009 10 0.998
apoptotic process involved in outflow tract morphogenesis GO:0003275 2 0.998
heart valve morphogenesis GO:0003179 21 0.997
lung development GO:0030324 164 0.997
bundle of his development GO:0003166 4 0.997
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.997
regulation of myoblast proliferation GO:2000291 8 0.997
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.997
negative regulation of apoptotic process involved in outflow tract morphogenesis GO:1902257 2 0.997
paraxial mesodermal cell differentiation GO:0048342 2 0.997
cerebral cortex radially oriented cell migration GO:0021799 31 0.997
spinal cord association neuron differentiation GO:0021527 14 0.997
somite development GO:0061053 81 0.997
odontogenesis of dentin containing tooth GO:0042475 66 0.997
Rat
cardiac right ventricle formation GO:0003219 3 0.997
embryonic placenta development GO:0001892 98 0.997
spinal cord dorsal ventral patterning GO:0021513 23 0.997
primary prostatic bud elongation GO:0060516 2 0.997
negative regulation of wnt signaling pathway involved in heart development GO:0003308 4 0.997
mesoderm development GO:0007498 100 0.997
Zebrafish
ventricular cardiac myofibril assembly GO:0055005 3 0.997
regulation of macrophage colony stimulating factor production GO:1901256 1 0.997
cardiac neural crest cell development involved in heart development GO:0061308 7 0.997
regulation of cardioblast differentiation GO:0051890 3 0.997
digestive tract morphogenesis GO:0048546 147 0.997
positive regulation of tongue muscle cell differentiation GO:2001037 2 0.997
atrial septum primum morphogenesis GO:0003289 3 0.997
tube closure GO:0060606 91 0.997
skeletal muscle organ development GO:0060538 163 0.996
regulation of striated muscle cell differentiation GO:0051153 81 0.996
cardiac left ventricle formation GO:0003218 1 0.996
morphogenesis of a branching epithelium GO:0061138 193 0.996
mesenchymal cell proliferation involved in ureter development GO:0072198 4 0.996
mesenchyme morphogenesis GO:0072132 32 0.996
ureteric bud morphogenesis GO:0060675 62 0.996
heart valve development GO:0003170 23 0.996
uterine epithelium development GO:0035847 1 0.996
mitral valve development GO:0003174 4 0.996
forelimb morphogenesis GO:0035136 40 0.996
endoderm development GO:0007492 45 0.996
Zebrafish
determination of digestive tract left right asymmetry GO:0071907 1 0.996
Zebrafish
canonical wnt signaling pathway GO:0060070 130 0.996
negative regulation of wnt signaling pathway GO:0030178 73 0.996
s shaped body morphogenesis GO:0072050 6 0.996
tendon formation GO:0035992 4 0.996
tendon cell differentiation GO:0035990 4 0.996
wnt signaling pathway involved in kidney development GO:0061289 2 0.995
metanephric capsule specification GO:0072267 1 0.995
anterior head development GO:0097065 2 0.995
myotube cell development GO:0014904 60 0.995
mesoderm morphogenesis GO:0048332 64 0.995
regulation of neural retina development GO:0061074 3 0.995
prostate gland stromal morphogenesis GO:0060741 2 0.995
developmental growth involved in morphogenesis GO:0060560 138 0.995
camera type eye development GO:0043010 266 0.995
embryonic camera type eye development GO:0031076 36 0.995
axon guidance GO:0007411 141 0.995
Worm
embryonic limb morphogenesis GO:0030326 126 0.995
regulation of endodermal cell differentiation GO:1903224 2 0.995
regulation of heart looping GO:1901207 1 0.995
regulation of transcription involved in primary germ layer cell fate commitment GO:0060796 2 0.995
bone morphogenesis GO:0060349 78 0.995
negative regulation of transcription from rna polymerase ii promoter by glucose GO:0000433 1 0.995
positive regulation of cardiac muscle tissue growth GO:0055023 15 0.995
pancreatic a cell fate commitment GO:0003326 2 0.995
face morphogenesis GO:0060325 29 0.995
Zebrafish
somite specification GO:0001757 4 0.995
cardiac muscle cell development GO:0055013 39 0.995
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development GO:0060528 4 0.995
cell proliferation in external granule layer GO:0021924 10 0.995
mammary placode formation GO:0060596 4 0.994
regulation of muscle tissue development GO:1901861 97 0.994
cerebellar purkinje cell layer development GO:0021680 26 0.994
positive regulation of stem cell proliferation GO:2000648 59 0.994
regulation of myotube differentiation GO:0010830 62 0.994
floor plate morphogenesis GO:0033505 3 0.994
regulation of bmp signaling pathway GO:0030510 60 0.994
pancreatic pp cell fate commitment GO:0003329 2 0.994
spinal cord motor neuron differentiation GO:0021522 35 0.994
ectoderm formation GO:0001705 3 0.994
epithelial tube formation GO:0072175 130 0.994
metanephric s shaped body morphogenesis GO:0072284 2 0.994
regulation of epithelial cell differentiation involved in kidney development GO:2000696 10 0.994
regulation of cell migration involved in sprouting angiogenesis GO:0090049 4 0.994
positive regulation of anterior head development GO:2000744 2 0.994
closure of optic fissure GO:0061386 2 0.994
Zebrafish
spinal cord patterning GO:0021511 25 0.994
positive regulation of cardiac muscle tissue development GO:0055025 19 0.993
stem cell maintenance GO:0019827 130 0.993
neuron migration GO:0001764 122 0.993
planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 2 0.993
metanephric nephron tubule formation GO:0072289 4 0.993
inner ear receptor cell differentiation GO:0060113 61 0.993
cellular response to fibroblast growth factor stimulus GO:0044344 47 0.993
lens morphogenesis in camera type eye GO:0002089 24 0.993
Mouse
axis elongation involved in somitogenesis GO:0090245 4 0.993
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.993
regulation of skeletal muscle fiber development GO:0048742 36 0.993
endocardial cushion development GO:0003197 26 0.993
regulation of transcription from rna polymerase ii promoter involved in ventral spinal cord interneuron specification GO:0021913 4 0.993
determination of left right asymmetry in nervous system GO:0035545 1 0.993
zygotic determination of anterior posterior axis embryo GO:0007354 3 0.992
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.992
prostate gland morphogenesis GO:0060512 32 0.992
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.992
regulation of stem cell proliferation GO:0072091 78 0.992
regulation of secondary heart field cardioblast proliferation GO:0003266 9 0.992
regulation of myoblast differentiation GO:0045661 29 0.992
paraxial mesodermal cell fate commitment GO:0048343 2 0.992
regulation of neuron differentiation GO:0045664 281 0.992
hypothalamus development GO:0021854 16 0.992
carbon catabolite repression of transcription GO:0045013 1 0.992
ear development GO:0043583 200 0.992
endocardial cell differentiation GO:0060956 4 0.991
cell fate determination GO:0001709 32 0.991
glomerular mesangial cell differentiation GO:0072008 3 0.991
regulation of somitogenesis GO:0014807 6 0.991
gabaergic neuron differentiation GO:0097154 11 0.991
Worm
positive regulation of skeletal muscle fiber differentiation GO:1902811 2 0.991
positive regulation of skeletal muscle tissue regeneration GO:0043415 4 0.991
ventricular cardiac muscle tissue development GO:0003229 38 0.991
nephron morphogenesis GO:0072028 69 0.990
kidney development GO:0001822 213 0.990
mesodermal cell migration GO:0008078 4 0.990
negative regulation of canonical wnt signaling pathway GO:0090090 51 0.990
regulation of mesodermal cell fate specification GO:0042661 5 0.990
renal capsule specification GO:0072130 1 0.989
retinal ganglion cell axon guidance GO:0031290 18 0.989
pulmonary valve formation GO:0003193 1 0.989
regulation of anterior head development GO:2000742 2 0.989
macrophage colony stimulating factor production GO:0036301 1 0.989
regulation of cilium assembly GO:1902017 7 0.989
comma shaped body morphogenesis GO:0072049 5 0.989
hemangioblast cell differentiation GO:0060217 1 0.988
metencephalon development GO:0022037 89 0.988
negative regulation of cardiac chamber formation GO:1901211 1 0.988
regulation of canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060827 1 0.988
nephron tubule epithelial cell differentiation GO:0072160 11 0.988
myotube differentiation GO:0014902 105 0.988
axonogenesis GO:0007409 274 0.988
Worm
pancreas development GO:0031016 57 0.988
mesonephric tubule morphogenesis GO:0072171 63 0.988
pulmonary valve morphogenesis GO:0003184 5 0.988
left right axis specification GO:0070986 13 0.988
lung epithelial cell differentiation GO:0060487 29 0.988
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.988
coronary vasculature development GO:0060976 12 0.987
neural crest cell differentiation GO:0014033 54 0.987
striated muscle cell development GO:0055002 125 0.987
sinoatrial node cell development GO:0060931 3 0.987
gastrulation with mouth forming second GO:0001702 29 0.987
cardiac right ventricle morphogenesis GO:0003215 13 0.987
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.987
middle ear morphogenesis GO:0042474 23 0.987
mesonephric tubule development GO:0072164 94 0.987
regulation of endodermal cell fate specification GO:0042663 2 0.987
cerebral cortex gabaergic interneuron differentiation GO:0021892 9 0.987
tube formation GO:0035148 140 0.986
gonad development GO:0008406 141 0.986
Rat
renal vesicle induction GO:0072034 3 0.986
embryonic digit morphogenesis GO:0042733 56 0.986
locus ceruleus development GO:0021703 1 0.986
mesodermal cell fate specification GO:0007501 11 0.986
metanephric renal vesicle morphogenesis GO:0072283 12 0.986
positive regulation of cerebellar granule cell precursor proliferation GO:0021940 10 0.986
lung cell differentiation GO:0060479 30 0.986
cerebellar cortex formation GO:0021697 22 0.985
intracellular receptor signaling pathway GO:0030522 74 0.985
Zebrafish
morphogenesis of a polarized epithelium GO:0001738 37 0.985
cerebral cortex cell migration GO:0021795 44 0.985
somatic motor neuron differentiation GO:0021523 6 0.985
mesoderm formation GO:0001707 62 0.984
negative regulation of embryonic development GO:0045992 22 0.984
semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:0071527 1 0.984
positive regulation of striated muscle tissue development GO:0045844 31 0.984
cerebral cortex tangential migration GO:0021800 7 0.984
maintenance of apical basal cell polarity GO:0035090 3 0.984
carbon catabolite activation of transcription GO:0045991 4 0.984
pharynx development GO:0060465 1 0.983
heart valve formation GO:0003188 10 0.983
auditory receptor cell fate specification GO:0042667 1 0.983
nephron epithelium morphogenesis GO:0072088 68 0.982
tongue muscle cell differentiation GO:0035981 2 0.982
diencephalon morphogenesis GO:0048852 6 0.982
positive regulation of growth GO:0045927 104 0.982
left lung development GO:0060459 4 0.982
regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901213 9 0.982
positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 3 0.982
deltoid tuberosity development GO:0035993 3 0.981
coronary vasculature morphogenesis GO:0060977 9 0.981
cellular response to growth factor stimulus GO:0071363 197 0.981
branch elongation involved in ureteric bud branching GO:0060681 3 0.981
septum primum development GO:0003284 4 0.981
megakaryocyte differentiation GO:0030219 26 0.981
muscle cell differentiation GO:0042692 261 0.981
regulation of embryonic development GO:0045995 71 0.980
mesodermal cell fate commitment GO:0001710 17 0.980
embryonic forelimb morphogenesis GO:0035115 32 0.980
aortic valve development GO:0003176 5 0.980
pericardium development GO:0060039 16 0.980
branching involved in mammary gland duct morphogenesis GO:0060444 27 0.980
positive regulation of skeletal muscle cell differentiation GO:2001016 4 0.980
midbrain hindbrain boundary maturation GO:0021732 1 0.979
nephric duct formation GO:0072179 4 0.979
cardiac pacemaker cell development GO:0060926 5 0.979
canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060823 1 0.979
cardiac endothelial cell differentiation GO:0003348 4 0.978
ventral midline development GO:0007418 4 0.977
paramesonephric duct development GO:0061205 3 0.977
regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation GO:2000702 1 0.977
carbon catabolite regulation of transcription from rna polymerase ii promoter GO:0000429 4 0.977
cell migration to the midline involved in heart development GO:0003318 1 0.976
respiratory tube development GO:0030323 167 0.976
astrocyte fate commitment GO:0060018 4 0.976
muscle cell development GO:0055001 133 0.975
placenta development GO:0001890 140 0.975
enamel mineralization GO:0070166 7 0.975
epithelial mesenchymal signaling involved in prostate gland development GO:0060738 2 0.975
cardiac cell fate commitment GO:0060911 10 0.974
negative regulation of neuron projection development GO:0010977 50 0.974
neuron fate determination GO:0048664 9 0.974
heart growth GO:0060419 45 0.974
his purkinje system development GO:0003164 4 0.973
cell differentiation in hindbrain GO:0021533 24 0.973
negative regulation of neuron differentiation GO:0045665 101 0.973
bone development GO:0060348 120 0.972
carbon catabolite regulation of transcription GO:0045990 4 0.972
lung morphogenesis GO:0060425 50 0.972
glial cell derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation GO:2000701 1 0.972
kidney epithelium development GO:0072073 121 0.972
epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 10 0.972
regulation of wnt signaling pathway GO:0030111 123 0.971
skeletal muscle fiber development GO:0048741 58 0.971
atrial ventricular junction remodeling GO:0003294 2 0.971
negative regulation of gastrulation GO:2000542 3 0.971
globus pallidus development GO:0021759 2 0.971
noradrenergic neuron differentiation GO:0003357 6 0.971
cerebral cortex gabaergic interneuron migration GO:0021853 6 0.971
negative regulation of transcription by glucose GO:0045014 1 0.970
venous blood vessel morphogenesis GO:0048845 7 0.970
brain morphogenesis GO:0048854 32 0.970
ameboidal type cell migration GO:0001667 128 0.970
regulation of cardiac muscle cell proliferation GO:0060043 23 0.970
mesodermal cell differentiation GO:0048333 22 0.969
aortic valve morphogenesis GO:0003180 4 0.969
forebrain anterior posterior pattern specification GO:0021797 5 0.969
endodermal cell fate determination GO:0007493 2 0.969
tongue development GO:0043586 18 0.968
semicircular canal morphogenesis GO:0048752 7 0.968
myoblast proliferation GO:0051450 11 0.967
epithelial cell maturation involved in prostate gland development GO:0060743 4 0.966
cell differentiation involved in kidney development GO:0061005 33 0.966
body morphogenesis GO:0010171 45 0.966
Zebrafish
cerebellar purkinje cell differentiation GO:0021702 13 0.966
eye photoreceptor cell development GO:0042462 31 0.966
liver development GO:0001889 66 0.965
transcriptional activation by promoter enhancer looping GO:0071733 2 0.965

Pitx2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.996
musculoskeletal system disease DOID:17 0 0.996
cardiovascular system disease DOID:1287 0 0.969