Mus musculus

130 known processes

Prkci

protein kinase C, iota

(Aliases: mKIAA4165,AI427505,aPKClambda,Prkcl,2310021H13Rik,KIAA4165,PKClambda,Pkci,Pkcl)

Prkci biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of phosphorylation GO:0042326 166 0.656
Mouse
muscle cell differentiation GO:0042692 261 0.465
Mouse
negative regulation of protein phosphorylation GO:0001933 126 0.362
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.352
protein localization to organelle GO:0033365 185 0.331
carbohydrate metabolic process GO:0005975 230 0.315
Mouse
multicellular organism growth GO:0035264 161 0.306
regulation of transferase activity GO:0051338 263 0.303
release of cytochrome c from mitochondria GO:0001836 23 0.301
Mouse
negative regulation of molecular function GO:0044092 258 0.296
Mouse
cellular component assembly involved in morphogenesis GO:0010927 139 0.273
peptidyl amino acid modification GO:0018193 336 0.271
Mouse Worm
negative regulation of phosphate metabolic process GO:0045936 184 0.268
Mouse
digestive tract development GO:0048565 190 0.263
Zebrafish
ras protein signal transduction GO:0007265 77 0.257
regulation of cellular amino acid metabolic process GO:0006521 5 0.248
regulation of organelle organization GO:0033043 289 0.232
Mouse
organelle fission GO:0048285 170 0.231
regulation of protein targeting GO:1903533 61 0.227
Mouse
cellular response to peptide GO:1901653 92 0.224
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.220
myotube differentiation GO:0014902 105 0.216
positive regulation of nervous system development GO:0051962 221 0.204
Human
apoptotic signaling pathway GO:0097190 306 0.201
Mouse
negative regulation of protein metabolic process GO:0051248 282 0.199
Mouse
regulation of kinase activity GO:0043549 249 0.197
amine metabolic process GO:0009308 45 0.192
axonogenesis GO:0007409 274 0.191
muscle cell development GO:0055001 133 0.185
protein localization to endosome GO:0036010 2 0.184
organic cyclic compound catabolic process GO:1901361 295 0.183
Yeast Mouse
regulation of neuron differentiation GO:0045664 281 0.182
Human Mouse
spermatogenesis GO:0007283 284 0.182
cation transport GO:0006812 399 0.177
Mouse
glucose metabolic process GO:0006006 92 0.172
Mouse
membrane organization GO:0061024 245 0.172
positive regulation of protein modification process GO:0031401 299 0.167
Mouse
positive regulation of cellular amine metabolic process GO:0033240 5 0.166
g protein coupled receptor signaling pathway GO:0007186 243 0.165
macromolecule catabolic process GO:0009057 281 0.164
Yeast Mouse
establishment of protein localization to organelle GO:0072594 118 0.162
positive regulation of cell development GO:0010720 237 0.162
Human
ribonucleotide metabolic process GO:0009259 291 0.161
Mouse
urogenital system development GO:0001655 261 0.157
cell substrate adhesion GO:0031589 130 0.156
gland development GO:0048732 330 0.155
cellular ketone metabolic process GO:0042180 84 0.154
locomotory behavior GO:0007626 195 0.151
intracellular protein transport GO:0006886 204 0.150
Mouse
digestive tract morphogenesis GO:0048546 147 0.150
Zebrafish
cellular amino acid metabolic process GO:0006520 103 0.149
purine nucleotide metabolic process GO:0006163 302 0.146
Mouse
cellular amine metabolic process GO:0044106 44 0.144
glucose homeostasis GO:0042593 128 0.144
Mouse
cell adhesion GO:0007155 329 0.140
Mouse
mitotic cell cycle process GO:1903047 159 0.140
Zebrafish
cell cell adhesion GO:0098609 41 0.140
endocytosis GO:0006897 168 0.139
Worm
regulation of cellular response to stress GO:0080135 159 0.138
carbohydrate homeostasis GO:0033500 128 0.137
Mouse
regulation of vesicle mediated transport GO:0060627 139 0.137
Mouse
skeletal muscle organ development GO:0060538 163 0.135
cellular homeostasis GO:0019725 240 0.130
regulation of protein localization GO:0032880 231 0.127
forebrain development GO:0030900 302 0.126
regulation of angiogenesis GO:0045765 81 0.125
regulation of cell migration GO:0030334 219 0.122
negative regulation of phosphorus metabolic process GO:0010563 184 0.122
Mouse
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.122
Mouse
negative regulation of cellular component organization GO:0051129 194 0.122
Mouse
protein modification by small protein conjugation GO:0032446 187 0.121
Mouse
regulation of bmp signaling pathway GO:0030510 60 0.121
mitochondrion organization GO:0007005 134 0.118
Mouse
cell junction organization GO:0034330 77 0.118
Human Zebrafish
regulation of cell adhesion GO:0030155 154 0.117
Mouse
neuron apoptotic process GO:0051402 142 0.117
Human
digestive system development GO:0055123 200 0.116
Zebrafish
morphogenesis of a polarized epithelium GO:0001738 37 0.114
Zebrafish
placenta development GO:0001890 140 0.113
Mouse
regulation of cell activation GO:0050865 289 0.112
Mouse
negative regulation of intracellular signal transduction GO:1902532 167 0.112
hexose metabolic process GO:0019318 98 0.112
Mouse
morphogenesis of a branching structure GO:0001763 203 0.111
bmp signaling pathway GO:0030509 93 0.111
negative regulation of neuron apoptotic process GO:0043524 92 0.110
Human
cellular response to dna damage stimulus GO:0006974 207 0.109
plasma membrane organization GO:0007009 90 0.107
immune effector process GO:0002252 321 0.107
Mouse
positive regulation of protein kinase activity GO:0045860 144 0.106
skin development GO:0043588 220 0.106
Mouse
protein ubiquitination GO:0016567 171 0.105
Mouse
blood coagulation GO:0007596 76 0.105
Mouse
positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 11 0.105
regulation of neuron apoptotic process GO:0043523 122 0.104
Human
regulation of protein kinase activity GO:0045859 232 0.103
transmembrane transport GO:0055085 412 0.102
Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.102
regulation of cytoskeleton organization GO:0051493 122 0.102
Mouse
regulation of homeostatic process GO:0032844 182 0.099
negative regulation of cellular amine metabolic process GO:0033239 1 0.099
cellular amino acid biosynthetic process GO:0008652 22 0.099
regulation of establishment of protein localization GO:0070201 181 0.098
morphogenesis of a branching epithelium GO:0061138 193 0.098
regulation of cell size GO:0008361 72 0.097
cell type specific apoptotic process GO:0097285 268 0.097
Human
negative regulation of kinase activity GO:0033673 81 0.095
lipid modification GO:0030258 65 0.095
cell growth GO:0016049 130 0.094
Mouse
protein import into nucleus GO:0006606 95 0.094
regulation of defense response GO:0031347 233 0.094
striated muscle tissue development GO:0014706 293 0.094
establishment or maintenance of cell polarity GO:0007163 86 0.094
negative regulation of cell proliferation GO:0008285 296 0.093
negative regulation of immune system process GO:0002683 209 0.093
developmental cell growth GO:0048588 84 0.093
Mouse
response to peptide hormone GO:0043434 127 0.092
purine ribonucleotide metabolic process GO:0009150 290 0.092
Mouse
ribonucleoside triphosphate catabolic process GO:0009203 199 0.091
Mouse
activation of cysteine type endopeptidase activity involved in apoptotic process by cytochrome c GO:0008635 4 0.091
formation of radial glial scaffolds GO:0021943 4 0.091
regulation of nucleotide metabolic process GO:0006140 169 0.090
Mouse
positive regulation of cell motility GO:2000147 116 0.089
positive regulation of protein phosphorylation GO:0001934 242 0.088
Mouse
negative regulation of transferase activity GO:0051348 85 0.088
actin cytoskeleton reorganization GO:0031532 21 0.088
regulation of secretion by cell GO:1903530 249 0.088
Mouse
regulation of cell projection organization GO:0031344 206 0.087
Human Mouse
neural precursor cell proliferation GO:0061351 121 0.087
Zebrafish
male gamete generation GO:0048232 285 0.085
histone modification GO:0016570 159 0.085
maintenance of location GO:0051235 89 0.084
apoptotic process involved in mammary gland involution GO:0060057 4 0.084
stress activated mapk cascade GO:0051403 80 0.084
ribose phosphate metabolic process GO:0019693 291 0.084
Mouse
regulation of hormone secretion GO:0046883 88 0.083
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.082
lipid localization GO:0010876 126 0.082
organelle localization GO:0051640 179 0.082
Zebrafish
regulation of cell motility GO:2000145 236 0.081
protein modification by small protein conjugation or removal GO:0070647 207 0.081
Mouse
myosin filament assembly GO:0031034 2 0.081
mitotic cell cycle GO:0000278 195 0.081
Zebrafish
cytoplasmic transport GO:0016482 234 0.080
muscle system process GO:0003012 141 0.080
neuron death GO:0070997 154 0.080
Human
regulation of proteolysis GO:0030162 164 0.080
Mouse
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.079
single organism nuclear import GO:1902593 95 0.079
protein maturation GO:0051604 176 0.079
Mouse
positive regulation of cell migration GO:0030335 109 0.078
cell division GO:0051301 120 0.078
Worm
cellular macromolecule catabolic process GO:0044265 206 0.077
Yeast Mouse
microglia differentiation GO:0014004 2 0.077
nuclear division GO:0000280 158 0.077
anatomical structure homeostasis GO:0060249 145 0.077
cellular nitrogen compound catabolic process GO:0044270 280 0.077
Yeast Mouse
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.077
response to oxygen levels GO:0070482 62 0.075
muscle tissue development GO:0060537 308 0.075
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.075
gtp metabolic process GO:0046039 144 0.074
Mouse
positive regulation of bmp signaling pathway GO:0030513 23 0.074
regulation of hydrolase activity GO:0051336 246 0.073
Mouse
regulation of intracellular protein transport GO:0033157 82 0.073
Mouse
glial cell apoptotic process GO:0034349 3 0.072
Human
cellular metal ion homeostasis GO:0006875 151 0.071
response to growth factor GO:0070848 198 0.071
Mouse
peptidyl serine phosphorylation GO:0018105 74 0.071
Mouse Worm
regulation of cell cycle GO:0051726 281 0.071
spermatid differentiation GO:0048515 115 0.070
response to vitamin d GO:0033280 3 0.068
regulation of carbohydrate metabolic process GO:0006109 75 0.068
nitrogen compound transport GO:0071705 271 0.068
positive regulation of organelle organization GO:0010638 128 0.068
Mouse
negative regulation of insulin receptor signaling pathway GO:0046627 14 0.068
Mouse
substrate adhesion dependent cell spreading GO:0034446 30 0.068
connective tissue development GO:0061448 179 0.068
regulation of cellular amine metabolic process GO:0033238 20 0.068
organic hydroxy compound biosynthetic process GO:1901617 77 0.067
ion transmembrane transport GO:0034220 361 0.067
peptide transport GO:0015833 133 0.067
blood circulation GO:0008015 195 0.067
positive regulation of creb transcription factor activity GO:0032793 4 0.066
negative regulation of cell cycle GO:0045786 123 0.066
positive regulation of secretion GO:0051047 130 0.066
Mouse
regulation of myotube differentiation GO:0010830 62 0.066
glycerolipid metabolic process GO:0046486 122 0.065
striated muscle cell development GO:0055002 125 0.065
monosaccharide metabolic process GO:0005996 106 0.065
Mouse
regulation of endocytosis GO:0030100 69 0.065
regulation of microtubule based process GO:0032886 52 0.065
regulation of membrane potential GO:0042391 192 0.064
positive regulation of kinase activity GO:0033674 155 0.064
regulation of transmembrane transport GO:0034762 128 0.064
monocarboxylic acid metabolic process GO:0032787 191 0.063
organelle assembly GO:0070925 177 0.063
Yeast
post embryonic organ development GO:0048569 17 0.062
Worm
ameboidal type cell migration GO:0001667 128 0.061
Zebrafish
nuclear transport GO:0051169 139 0.061
development of primary sexual characteristics GO:0045137 143 0.061
Worm
spermatid development GO:0007286 108 0.061
cellular response to oxidative stress GO:0034599 76 0.061
blood vessel morphogenesis GO:0048514 285 0.061
small gtpase mediated signal transduction GO:0007264 97 0.061
negative regulation of endopeptidase activity GO:0010951 44 0.061
Mouse
protein import GO:0017038 101 0.060
glycosyl compound catabolic process GO:1901658 206 0.059
Mouse
chromatin modification GO:0016568 187 0.059
hormone metabolic process GO:0042445 86 0.059
chemotaxis GO:0006935 247 0.058
somite development GO:0061053 81 0.058
regulation of protein serine threonine kinase activity GO:0071900 157 0.058
positive regulation of map kinase activity GO:0043406 84 0.058
cellular response to external stimulus GO:0071496 88 0.058
cell cell junction organization GO:0045216 72 0.058
Human Zebrafish
lipid biosynthetic process GO:0008610 179 0.058
syncytium formation by plasma membrane fusion GO:0000768 42 0.057
regulation of mapk cascade GO:0043408 248 0.057
epithelium migration GO:0090132 63 0.057
retinal blood vessel morphogenesis GO:0061304 3 0.056
organic anion transport GO:0015711 137 0.056
nucleobase containing small molecule metabolic process GO:0055086 352 0.056
Mouse
nucleotide metabolic process GO:0009117 332 0.056
Mouse
activation of cysteine type endopeptidase activity GO:0097202 27 0.056
regulation of hormone levels GO:0010817 211 0.056
response to organonitrogen compound GO:0010243 246 0.055
axon guidance GO:0007411 141 0.055
response to peptide GO:1901652 136 0.054
regulation of wnt signaling pathway GO:0030111 123 0.054
defense response to other organism GO:0098542 197 0.054
Mouse
regulation of purine nucleotide metabolic process GO:1900542 169 0.053
Mouse
mesonephric tubule development GO:0072164 94 0.053
positive regulation of transcription from rna polymerase ii promoter involved in smooth muscle cell differentiation GO:2000721 2 0.053
negative regulation of lymphocyte apoptotic process GO:0070229 24 0.053
wound healing GO:0042060 157 0.052
Mouse
inflammatory response GO:0006954 244 0.052
Mouse
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.052
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 34 0.052
intrinsic apoptotic signaling pathway GO:0097193 132 0.052
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.052
multicellular organismal homeostasis GO:0048871 164 0.051
telencephalon development GO:0021537 186 0.051
single organism cell adhesion GO:0098602 156 0.051
Mouse
regulation of mitotic cell cycle GO:0007346 126 0.051
mitotic nuclear division GO:0007067 48 0.051
response to hypoxia GO:0001666 58 0.051
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.051
Mouse
protein processing GO:0016485 163 0.050
Mouse
cellular carbohydrate metabolic process GO:0044262 119 0.050
Mouse
positive regulation of peptidase activity GO:0010952 49 0.050
homeostasis of number of cells GO:0048872 210 0.049
regulation of cell cycle process GO:0010564 160 0.049
dendrite development GO:0016358 115 0.049
protein localization to nucleus GO:0034504 121 0.049
somitogenesis GO:0001756 69 0.049
meiotic cell cycle GO:0051321 122 0.048
hindbrain development GO:0030902 128 0.048
Zebrafish
regulation of cellular component biogenesis GO:0044087 181 0.048
Mouse
positive regulation of phagocytosis engulfment GO:0060100 3 0.048
skeletal system development GO:0001501 356 0.048
leukocyte proliferation GO:0070661 172 0.047
Mouse
lipid homeostasis GO:0055088 63 0.047
regulation of striated muscle cell differentiation GO:0051153 81 0.047
stress activated protein kinase signaling cascade GO:0031098 81 0.047
regulation of myeloid cell differentiation GO:0045637 96 0.047
purine ribonucleoside catabolic process GO:0046130 205 0.047
Mouse
cellular ion homeostasis GO:0006873 165 0.046
positive regulation of hydrolase activity GO:0051345 148 0.046
Mouse
cognition GO:0050890 149 0.046
germ cell development GO:0007281 185 0.046
Mouse
lactation GO:0007595 25 0.046
fat cell differentiation GO:0045444 160 0.046
regulation of inflammatory response GO:0050727 147 0.045
hormone secretion GO:0046879 128 0.045
epithelial tube morphogenesis GO:0060562 303 0.045
Zebrafish
nucleocytoplasmic transport GO:0006913 139 0.045
cation homeostasis GO:0055080 212 0.045
cellular process regulating host cell cycle in response to virus GO:0060154 3 0.045
nucleoside phosphate metabolic process GO:0006753 338 0.045
Mouse
negative regulation of cellular protein metabolic process GO:0032269 247 0.045
Mouse
regulation of transporter activity GO:0032409 57 0.045
small molecule biosynthetic process GO:0044283 132 0.044
nucleoside triphosphate metabolic process GO:0009141 230 0.044
Mouse
apical junction assembly GO:0043297 15 0.044
extracellular structure organization GO:0043062 148 0.044
regulation of cytoplasmic transport GO:1903649 112 0.044
regulation of response to wounding GO:1903034 189 0.044
Mouse
negative regulation of inflammatory response GO:0050728 61 0.043
myeloid cell differentiation GO:0030099 233 0.043
regulation of cell growth GO:0001558 91 0.043
guanosine containing compound catabolic process GO:1901069 144 0.043
Mouse
dendritic spine maintenance GO:0097062 4 0.043
regulation of fatty acid metabolic process GO:0019217 28 0.043
positive regulation of smooth muscle cell migration GO:0014911 4 0.043
lipid storage GO:0019915 36 0.043
response to radiation GO:0009314 165 0.043
regulation of ion transmembrane transport GO:0034765 119 0.042
negative regulation of protein modification process GO:0031400 163 0.042
Mouse
positive regulation of cellular component biogenesis GO:0044089 94 0.042
mesenchymal cell differentiation GO:0048762 107 0.042
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.042
Mouse
regulation of intracellular transport GO:0032386 159 0.042
Mouse
dna repair GO:0006281 107 0.042
positive regulation of growth GO:0045927 104 0.042
regulation of vasculature development GO:1901342 88 0.042
peptide hormone secretion GO:0030072 109 0.042
regulation of stem cell differentiation GO:2000736 50 0.041
regulation of protein import into nucleus GO:0042306 52 0.041
metencephalon development GO:0022037 89 0.041
mesoderm development GO:0007498 100 0.041
Zebrafish
regulation of ion transport GO:0043269 215 0.041
Mouse
cerebellum development GO:0021549 77 0.041
response to insulin GO:0032868 100 0.041
maintenance of epithelial cell apical basal polarity GO:0045199 2 0.041
Zebrafish
regulation of cysteine type endopeptidase activity GO:2000116 65 0.040
Mouse
t cell activation GO:0042110 289 0.040
Mouse
regulation of cell substrate adhesion GO:0010810 73 0.040
aromatic compound catabolic process GO:0019439 286 0.040
Yeast Mouse
glycerolipid biosynthetic process GO:0045017 50 0.040
inorganic ion transmembrane transport GO:0098660 234 0.040
regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061418 2 0.040
defense response to protozoan GO:0042832 25 0.040
regulation of glucose metabolic process GO:0010906 60 0.040
purine nucleotide catabolic process GO:0006195 211 0.040
Mouse
neural tube formation GO:0001841 108 0.040
Zebrafish
cell junction assembly GO:0034329 52 0.040
stem cell development GO:0048864 219 0.040
cytokine production GO:0001816 319 0.039
Mouse
heterocycle catabolic process GO:0046700 280 0.039
Yeast Mouse
respiratory system development GO:0060541 190 0.039
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.039
positive regulation of endocytosis GO:0045807 42 0.039
cellular response to organonitrogen compound GO:0071417 145 0.039
sphingolipid metabolic process GO:0006665 45 0.039
regulation of nucleotide catabolic process GO:0030811 122 0.039
Mouse
regulation of extent of cell growth GO:0061387 52 0.038
integrin mediated signaling pathway GO:0007229 27 0.038
organonitrogen compound catabolic process GO:1901565 264 0.038
Mouse
endomembrane system organization GO:0010256 147 0.038
actin cytoskeleton organization GO:0030036 220 0.038
positive regulation of mammary gland involution GO:1903521 4 0.038
cellular response to extracellular stimulus GO:0031668 81 0.038
adult behavior GO:0030534 135 0.038
positive regulation of glial cell proliferation GO:0060252 4 0.038
Human
divalent inorganic cation homeostasis GO:0072507 138 0.038
negative regulation of organelle organization GO:0010639 90 0.038
Mouse
epithelial cell migration GO:0010631 63 0.038
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001269 3 0.038
regulation of peptide transport GO:0090087 91 0.038
glycosyl compound metabolic process GO:1901657 246 0.038
Mouse
branching morphogenesis of an epithelial tube GO:0048754 159 0.038
positive regulation of endopeptidase activity GO:0010950 43 0.038
regionalization GO:0003002 337 0.038
trunk neural crest cell migration GO:0036484 4 0.037
regulation of protein processing GO:0070613 96 0.037
Mouse
pronephric nephron development GO:0039019 1 0.037
oxidation reduction process GO:0055114 342 0.037
Mouse
regulation of protein localization to nucleus GO:1900180 60 0.037
regulation of map kinase activity GO:0043405 120 0.037
cellular response to nutrient levels GO:0031669 64 0.037
nuclear import GO:0051170 95 0.036
guanosine containing compound metabolic process GO:1901068 144 0.036
Mouse
protein targeting GO:0006605 143 0.036
Mouse
ribonucleotide catabolic process GO:0009261 208 0.036
Mouse
negative regulation of transcription from rna polymerase ii promoter in response to stress GO:0097201 1 0.036
negative regulation of catenin import into nucleus GO:0035414 2 0.036
wnt signaling pathway GO:0016055 188 0.036
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.036
positive regulation of neuron death GO:1901216 28 0.036
positive regulation of cell growth GO:0030307 33 0.036
cellular calcium ion homeostasis GO:0006874 119 0.036
striated muscle myosin thick filament assembly GO:0071688 1 0.036
regulation of peptidase activity GO:0052547 96 0.035
Mouse
kidney development GO:0001822 213 0.035
regulation of cellular response to hypoxia GO:1900037 2 0.035
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 2 0.035
cilium morphogenesis GO:0060271 102 0.035
regulation of protein stability GO:0031647 52 0.035
nucleotide catabolic process GO:0009166 217 0.035
Mouse
p38mapk cascade GO:0038066 4 0.035
rhythmic process GO:0048511 174 0.034
regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001267 4 0.034
gliogenesis GO:0042063 141 0.034
Human Mouse
response to corticosterone GO:0051412 1 0.034
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.034
Human Mouse
negative regulation of neuron death GO:1901215 98 0.034
Human
response to monosaccharide GO:0034284 67 0.034
adult locomotory behavior GO:0008344 91 0.033
asymmetric stem cell division GO:0098722 3 0.033
cellular lipid metabolic process GO:0044255 323 0.033
organophosphate catabolic process GO:0046434 232 0.033
Mouse
learning or memory GO:0007611 148 0.033
microtubule based process GO:0007017 236 0.033
Zebrafish Mouse
regulation of protein transport GO:0051223 163 0.033
Mouse
nephron epithelium development GO:0072009 92 0.033
regulation of peptide secretion GO:0002791 77 0.033
organonitrogen compound biosynthetic process GO:1901566 192 0.033
angiogenesis GO:0001525 201 0.033
osteoclast differentiation GO:0030316 62 0.033
stem cell proliferation GO:0072089 117 0.033
Zebrafish
embryonic placenta development GO:0001892 98 0.033
Mouse
metanephric mesangial cell differentiation GO:0072209 1 0.032
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.032
Mouse
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.032
ribonucleoside triphosphate metabolic process GO:0009199 220 0.032
Mouse
purine containing compound metabolic process GO:0072521 311 0.032
Mouse
organophosphate biosynthetic process GO:0090407 122 0.032
regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 14 0.032
positive regulation of mapk cascade GO:0043410 170 0.032
covalent chromatin modification GO:0016569 163 0.032
purine ribonucleotide catabolic process GO:0009154 208 0.032
Mouse
regulation of neuron death GO:1901214 134 0.032
Human
neural tube development GO:0021915 160 0.032
Zebrafish
regulation of innate immune response GO:0045088 91 0.031
actin filament bundle assembly GO:0051017 40 0.031
cell matrix adhesion GO:0007160 68 0.031
regulation of cellular component size GO:0032535 121 0.031
Mouse
neuronal action potential GO:0019228 54 0.031
platelet derived growth factor receptor alpha signaling pathway GO:0035790 3 0.031
lipoprotein transport GO:0042953 7 0.031
lipid transport GO:0006869 98 0.031
retina morphogenesis in camera type eye GO:0060042 45 0.031
Zebrafish
neuron migration GO:0001764 122 0.031
carbon catabolite activation of transcription GO:0045991 4 0.031
apoptotic mitochondrial changes GO:0008637 48 0.031
Mouse
positive regulation of endothelial cell chemotaxis GO:2001028 1 0.030
mapk cascade GO:0000165 281 0.030
developmental growth involved in morphogenesis GO:0060560 138 0.030
Mouse
endothelial cell migration GO:0043542 44 0.030
phenol containing compound metabolic process GO:0018958 60 0.030
carbon catabolite regulation of transcription GO:0045990 4 0.030
rho protein signal transduction GO:0007266 32 0.030
response to iron ion GO:0010039 4 0.030
regulation of mitochondrial membrane permeability GO:0046902 17 0.030
segmentation GO:0035282 93 0.030
second messenger mediated signaling GO:0019932 73 0.030
maintenance of apical basal cell polarity GO:0035090 3 0.030
Zebrafish
cytosolic calcium ion transport GO:0060401 48 0.030
camera type eye development GO:0043010 266 0.030
Zebrafish
regulation of ion transmembrane transporter activity GO:0032412 54 0.029
fatty acid metabolic process GO:0006631 121 0.029
protein acylation GO:0043543 64 0.029
sodium ion transmembrane transport GO:0035725 49 0.029
response to decreased oxygen levels GO:0036293 59 0.029
positive regulation of cell cycle GO:0045787 92 0.029
response to amino acid GO:0043200 37 0.029
canonical wnt signaling pathway GO:0060070 130 0.029
embryonic epithelial tube formation GO:0001838 130 0.029
Zebrafish
regulation of mammary gland involution GO:1903519 4 0.029
regulation of anatomical structure size GO:0090066 178 0.029
Mouse
outflow tract morphogenesis GO:0003151 53 0.029
negative regulation of peptidase activity GO:0010466 46 0.029
Mouse
regulation of lymphocyte proliferation GO:0050670 117 0.029
Mouse
mesenchyme development GO:0060485 152 0.029
leukocyte apoptotic process GO:0071887 71 0.028
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.028
Mouse
metal ion homeostasis GO:0055065 189 0.028
cellular response to amino acid stimulus GO:0071230 29 0.028
glial cell differentiation GO:0010001 131 0.028
Mouse
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.028
Mouse
myeloid cell homeostasis GO:0002262 114 0.028
purine nucleoside triphosphate metabolic process GO:0009144 226 0.028
Mouse
positive regulation of apoptotic signaling pathway GO:2001235 95 0.028
Mouse
membrane fusion GO:0061025 38 0.027
Mouse
positive regulation of neuron projection development GO:0010976 79 0.027
Human
carbohydrate derivative biosynthetic process GO:1901137 183 0.027
metanephric glomerular endothelium development GO:0072264 1 0.027
microtubule based movement GO:0007018 84 0.027
positive regulation of mitotic cell cycle embryonic GO:0045977 2 0.027
compound eye development GO:0048749 1 0.027
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.027
tight junction assembly GO:0070830 9 0.027
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.027
carbohydrate biosynthetic process GO:0016051 74 0.027

Prkci disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
kidney cancer DOID:263 0 0.385
urinary system cancer DOID:3996 0 0.385
renal carcinoma DOID:4451 0 0.385
cancer DOID:162 0 0.385
disease of cellular proliferation DOID:14566 0 0.385
organ system cancer DOID:0050686 0 0.385
nephritis DOID:10952 0 0.061
glomerulonephritis DOID:2921 0 0.061
focal segmental glomerulosclerosis DOID:1312 0 0.061
kidney disease DOID:557 0 0.061
disease of anatomical entity DOID:7 0 0.061
urinary system disease DOID:18 0 0.061
glomerulosclerosis DOID:0050851 0 0.061
nervous system disease DOID:863 0 0.034
sensory system disease DOID:0050155 0 0.033
diabetes mellitus DOID:9351 0 0.027
type 2 diabetes mellitus DOID:9352 0 0.027
disease of metabolism DOID:0014667 0 0.027
carbohydrate metabolism disease DOID:0050013 0 0.027
glucose metabolism disease DOID:4194 0 0.027
acquired metabolic disease DOID:0060158 0 0.027