IMP

Process View

Homo sapiens

7 genes annotated in human

negative regulation of tumor necrosis factor mediated signaling pathway

Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of tumor necrosis factor mediated signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of tumor necrosis factor mediated signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
ZNF43	zinc finger protein 43	1.000
ZNF273	zinc finger protein 273	0.993	Human
ZNF253	zinc finger protein 253	0.967
C1QA	complement component 1, q subcomponent, A chain	0.962	Human
ZNF675	zinc finger protein 675	0.930
IRAK1	interleukin-1 receptor-associated kinase 1	0.640
TRAF6	TNF receptor-associated factor 6	0.633
ZNF430	zinc finger protein 430	0.562	Human
ZNF85	zinc finger protein 85	0.528	Human
C1QC	complement component 1, q subcomponent, C chain	0.434	Human
ZNF117	zinc finger protein 117	0.401	Human
ZNF93	zinc finger protein 93	0.393
ZNF680	zinc finger protein 680	0.361	Human
ZNF91	zinc finger protein 91	0.349
ZNF254	zinc finger protein 254	0.295	Human
A2M	alpha-2-macroglobulin	0.270
C1QB	complement component 1, q subcomponent, B chain	0.223	Human
ZNF708	zinc finger protein 708	0.141	Human
HP	haptoglobin	0.065
IRAK2	interleukin-1 receptor-associated kinase 2	0.062
AXL	AXL receptor tyrosine kinase	0.060
ALB	albumin	0.046
APOC1	apolipoprotein C-I	0.044
ZNF107	zinc finger protein 107	0.040
ZNF92	zinc finger protein 92	0.039	Human
ZNF682	zinc finger protein 682	0.031	Human
GHR	growth hormone receptor	0.012
APOA2	apolipoprotein A-II	0.010