IMP
Process View
negative regulation of insulin secretion
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of insulin secretion"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| MPDZ | multiple PDZ domain protein | 0.785 | ||
| INSR | insulin receptor | 0.620 | ||
| KCNE1 | potassium voltage-gated channel, Isk-related family, member 1 | 0.437 | ||
| LIN7B | lin-7 homolog B (C. elegans) | 0.391 | ||
| GRB10 | growth factor receptor-bound protein 10 | 0.330 | ||
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.205 | ||
| VAC14 | Vac14 homolog (S. cerevisiae) | 0.199 | ||
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.162 | ||
| GABBR1 | gamma-aminobutyric acid (GABA) B receptor, 1 | 0.160 | ||
| HDAC2 | histone deacetylase 2 | 0.119 | ||
| ZNF746 | zinc finger protein 746 | 0.098 | ||
| IRS1 | insulin receptor substrate 1 | 0.082 | ||
| IGF1R | insulin-like growth factor 1 receptor | 0.081 | ||
| SLC6A3 | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | 0.055 | ||
| BMPR1B | bone morphogenetic protein receptor, type IB | 0.050 | ||
| ADORA2A | adenosine A2a receptor | 0.049 | ||
| MED15 | mediator complex subunit 15 | 0.043 | ||
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.037 | ||
| IRS2 | insulin receptor substrate 2 | 0.033 | Human | |
| KCNJ5 | potassium inwardly-rectifying channel, subfamily J, member 5 | 0.030 | Human | |
| SLC9A3R1 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 | 0.029 | ||
| WFIKKN2 | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 | 0.024 | ||
| ABCC8 | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 | 0.023 | Rat | |
| KCNJ11 | potassium inwardly-rectifying channel, subfamily J, member 11 | 0.021 | ||
| CHRNA4 | cholinergic receptor, nicotinic, alpha 4 | 0.021 | ||
| MTNR1A | melatonin receptor 1A | 0.020 | ||
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.017 | ||
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.016 | ||
| GAB1 | GRB2-associated binding protein 1 | 0.015 | ||
| GPR6 | G protein-coupled receptor 6 | 0.015 | ||
| KCNJ3 | potassium inwardly-rectifying channel, subfamily J, member 3 | 0.015 | Human | |
| ARRDC3 | arrestin domain containing 3 | 0.015 | ||
| STAT5B | signal transducer and activator of transcription 5B | 0.014 | ||
| RASGRF1 | Ras protein-specific guanine nucleotide-releasing factor 1 | 0.013 | ||
| NOG | noggin | 0.013 | ||
| COL4A3 | collagen, type IV, alpha 3 (Goodpasture antigen) | 0.012 | ||
| KCNJ16 | potassium inwardly-rectifying channel, subfamily J, member 16 | 0.012 | Human | |
| GJD2 | gap junction protein, delta 2, 36kDa | 0.012 | ||
| PYY | peptide YY | 0.012 | ||
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | 0.011 | ||
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 0.011 | ||
| NXPH3 | neurexophilin 3 | 0.011 | ||
| GPR50 | G protein-coupled receptor 50 | 0.011 | ||
| GLP1R | glucagon-like peptide 1 receptor | 0.010 |