IMP
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hypoxia inducible factor 1alpha signaling pathway
A series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia.
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In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "hypoxia inducible factor 1alpha signaling pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| VHL | von Hippel-Lindau tumor suppressor | 0.183 | ||
| COMMD6 | COMM domain containing 6 | 0.136 | ||
| EGLN1 | egl nine homolog 1 (C. elegans) | 0.117 | ||
| SOCS1 | suppressor of cytokine signaling 1 | 0.101 | ||
| HTT | huntingtin | 0.092 | ||
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.085 | ||
| CUL2 | cullin 2 | 0.076 | ||
| SGK3 | serum/glucocorticoid regulated kinase family, member 3 | 0.074 | ||
| EGLN3 | egl nine homolog 3 (C. elegans) | 0.062 | ||
| ZYG11B | zyg-11 homolog B (C. elegans) | 0.047 | ||
| EPAS1 | endothelial PAS domain protein 1 | 0.033 | ||
| KAT2B | K(lysine) acetyltransferase 2B | 0.025 | ||
| COMMD7 | COMM domain containing 7 | 0.025 | ||
| NCOA6 | nuclear receptor coactivator 6 | 0.023 | ||
| HIPK2 | homeodomain interacting protein kinase 2 | 0.018 | ||
| EP300 | E1A binding protein p300 | 0.017 | ||
| COMMD10 | COMM domain containing 10 | 0.015 | ||
| SP1 | Sp1 transcription factor | 0.013 | ||
| TCEB2 | transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) | 0.013 | ||
| ISOC2 | isochorismatase domain containing 2 | 0.012 | ||
| POLI | polymerase (DNA directed) iota | 0.011 |