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Rattus norvegicus

10 genes annotated in rat

negative adaptation of signaling pathway

The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.

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Known genes in the process in rat Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative adaptation of signaling pathway"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative adaptation of signaling pathway" (in gray)

Name	Description	Probability	Func Analog Organism
Kcnb2	potassium voltage gated channel, Shab-related subfamily, member 2	0.153
Adora2a	adenosine A2a receptor	0.142
Rftn2	raftlin family member 2	0.115
Slc14a2	solute carrier family 14 (urea transporter), member 2	0.115
Znf483	zinc finger protein 483	0.100
Prph2	peripherin 2	0.094
Pde1b	phosphodiesterase 1B, calmodulin-dependent	0.086
Pomc	proopiomelanocortin	0.076
Trhr	thyrotropin releasing hormone receptor	0.068
Dlg4	discs, large homolog 4 (Drosophila)	0.050
Zfp382	zinc finger protein 382	0.049
Kcnh5	potassium voltage-gated channel, subfamily H (eag-related), member 5	0.049
Hoxa1	homeo box A1	0.045
Fbxo10	F-box protein 10	0.043
Cx3cr1	chemokine (C-X3-C motif) receptor 1	0.042
Scn4a	sodium channel, voltage-gated, type IV, alpha subunit	0.041
Sebox	SEBOX homeobox	0.040
Uncx	UNC homeobox	0.040
Chrna2	cholinergic receptor, nicotinic, alpha 2 (neuronal)	0.038
Mag	myelin-associated glycoprotein	0.038
Apba2	amyloid beta (A4) precursor protein-binding, family A, member 2	0.038
Hoxc4	homeo box C4	0.038
Acrv1	acrosomal vesicle protein 1	0.037
Entpd1	ectonucleoside triphosphate diphosphohydrolase 1	0.037
Pou3f2	POU class 3 homeobox 2	0.037
Itpkb	inositol 1,4,5-trisphosphate 3-kinase B	0.035
St18	suppression of tumorigenicity 18	0.034
Kcnn3	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	0.032
Rgs9	regulator of G-protein signaling 9	0.030
Nmbr	neuromedin B receptor	0.030
Grp	gastrin releasing peptide	0.029
Csf1	colony stimulating factor 1 (macrophage)	0.029
Itgam	integrin, alpha M	0.029
Impg2	interphotoreceptor matrix proteoglycan 2	0.028
Chrna7	cholinergic receptor, nicotinic, alpha 7	0.027
Grk1	G protein-coupled receptor kinase 1	0.027	Rat
Git1	G protein-coupled receptor kinase interacting ArfGAP 1	0.027
Gabra4	gamma-aminobutyric acid (GABA) A receptor, alpha 4	0.027
Hcrtr1	hypocretin (orexin) receptor 1	0.026
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.025
Pitx3	paired-like homeodomain 3	0.024
RGD1308049	similar to RIKEN cDNA 2410004C24	0.024
Syt6	synaptotagmin VI	0.024
LOC286987	hemiferrin, transferrin-like protein	0.024
N5	DNA binding protein N5	0.024
Lims1	LIM and senescent cell antigen-like domains 1	0.024
Gad2	glutamate decarboxylase 2	0.024
Dspp	dentin sialophosphoprotein	0.024
Scn3a	sodium channel, voltage-gated, type III, alpha	0.023
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.023
Mamdc4	MAM domain containing 4	0.022
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.022
Syt8	synaptotagmin VIII	0.022
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.022
Fgf14	fibroblast growth factor 14	0.022
Il9r	interleukin 9 receptor	0.021
Dnm3	dynamin 3	0.021
Coro1a	coronin, actin binding protein 1A	0.021
Ctsj	cathepsin J	0.020
Pfkfb2	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	0.020
Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	0.020
Kcnc2	potassium voltage gated channel, Shaw-related subfamily, member 2	0.020
Chrnb3	cholinergic receptor, nicotinic, beta 3	0.020
Syn3	synapsin III	0.020
Syt5	synaptotagmin V	0.020
St8sia4	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	0.020
Kcnab2	potassium voltage-gated channel, shaker-related subfamily, beta member 2	0.020
Htr6	5-hydroxytryptamine (serotonin) receptor 6	0.019
Kcnj6	potassium inwardly-rectifying channel, subfamily J, member 6	0.019
Syngap1	synaptic Ras GTPase activating protein 1 homolog (rat)	0.019
Gria1	glutamate receptor, ionotropic, AMPA 1	0.019
Lnpep	leucyl/cystinyl aminopeptidase	0.018
Olr1654	olfactory receptor 1654	0.018
Pla2g2c	phospholipase A2, group IIC	0.018
Fgf7	fibroblast growth factor 7	0.018
RGD1309414	similar to KIAA0913 protein	0.018
Cacna1a	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.018
Grik1	glutamate receptor, ionotropic, kainate 1	0.017
Svs4	seminal vesicle secretory protein 4	0.017
Sncb	synuclein, beta	0.017
Accn3	amiloride-sensitive cation channel 3	0.017
Epha8	Eph receptor A8	0.017
Gabrg3	gamma-aminobutyric acid (GABA) A receptor, gamma 3	0.017
Kcna3	potassium voltage-gated channel, shaker-related subfamily, member 3	0.017
Ptms	parathymosin	0.017
Gucy2f	guanylate cyclase 2F	0.016
RGD1565057	similar to hypothetical protein FLJ32871	0.016
Gja6	gap junction protein, alpha 6	0.016
LOC687035	similar to Tripartite motif protein 56	0.016
Avp	arginine vasopressin	0.016
Slc1a1	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	0.016
Gabra3	gamma-aminobutyric acid (GABA) A receptor, alpha 3	0.016
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.016
Dgkz	diacylglycerol kinase zeta	0.016
Hcrt	hypocretin	0.016
Fzr1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.015
Camk2n2	calcium/calmodulin-dependent protein kinase II inhibitor 2	0.015
Adora1	adenosine A1 receptor	0.015
Amph	amphiphysin	0.015
Gabrg1	gamma-aminobutyric acid (GABA) A receptor, gamma 1	0.015
Prx	periaxin	0.015
Foxj1	forkhead box J1	0.015
Adam10	ADAM metallopeptidase domain 10	0.015
Tnfsf4	tumor necrosis factor (ligand) superfamily, member 4	0.015
Ampd1	adenosine monophosphate deaminase 1 (isoform M)	0.015
Hist1h2aa	histone cluster 1, H2aa	0.015
Slc12a5	solute carrier family 12 (potassium-chloride transporter), member 5	0.015
Mutyh	mutY homolog (E. coli)	0.014
Cga	glycoprotein hormones, alpha polypeptide	0.014
Slc30a1	solute carrier family 30 (zinc transporter), member 1	0.014
Sema3a	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	0.014
Bsn	bassoon	0.014
Cxcr5	chemokine (C-X-C motif) receptor 5	0.014
LOC100361261	rCG23560-like	0.014
Sox17	SRY (sex determining region Y)-box 17	0.014
Kcnh7	potassium voltage-gated channel, subfamily H (eag-related), member 7	0.014
Dcc	deleted in colorectal carcinoma	0.014
Cntn5	contactin 5	0.014
Kcnq3	potassium voltage-gated channel, KQT-like subfamily, member 3	0.014
B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.014
Vipr2	vasoactive intestinal peptide receptor 2	0.013	Rat
Oprm1	opioid receptor, mu 1	0.013
Tbxa2r	thromboxane A2 receptor	0.013
Slc6a11	solute carrier family 6 (neurotransmitter transporter, GABA), member 11	0.013
Pfkfb3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	0.013
Utrn	utrophin	0.013
RGD1304737	similar to KIAA1086 protein	0.013
Drd3	dopamine receptor D3	0.013
Ucn	urocortin	0.013
Cntn3	contactin 3 (plasmacytoma associated)	0.013
Cdh22	cadherin 22	0.013
Cel	carboxyl ester lipase	0.013
Kcnk3	potassium channel, subfamily K, member 3	0.013
Csk	c-src tyrosine kinase	0.013
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1	0.013
Faslg	Fas ligand (TNF superfamily, member 6)	0.012
Lep	leptin	0.012
Celsr3	cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)	0.012
Gnrh1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	0.012
Sirpa	signal-regulatory protein alpha	0.012
Adam3a	ADAM metallopeptidase domain 3A (cyritestin 1)	0.012
Sstr3	somatostatin receptor 3	0.012
Mpp2	membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)	0.012
Fam126b	family with sequence similarity 126, member B	0.012
Cd80	Cd80 molecule	0.012
Th	tyrosine hydroxylase	0.012
Kcnq2	potassium voltage-gated channel, KQT-like subfamily, member 2	0.012
Oprd1	opioid receptor, delta 1	0.012
Apoa4	apolipoprotein A-IV	0.012
Mstn	myostatin	0.012
Hrh3	histamine receptor H3	0.012
Hand1	heart and neural crest derivatives expressed 1	0.012
Slc18a3	solute carrier family 18 (vesicular acetylcholine), member 3	0.012
Scn10a	sodium channel, voltage-gated, type X, alpha subunit	0.012
Odf4	outer dense fiber of sperm tails 4	0.012
Cfp	complement factor properdin	0.011
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.011
Vegp2	von Ebners gland protein 2	0.011
Hpcal4	hippocalcin-like 4	0.011
Pnma1	paraneoplastic antigen MA1	0.011
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.011
Gad1	glutamate decarboxylase 1	0.011
Ppyr1	pancreatic polypeptide receptor 1	0.011
Cmtm2a	CKLF-like MARVEL transmembrane domain containing 2A	0.011
Prrx1	paired related homeobox 1	0.011
Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	0.011
Cacna1h	calcium channel, voltage-dependent, T type, alpha 1H subunit	0.011
Grm6	glutamate receptor, metabotropic 6	0.011	Rat
Iapp	islet amyloid polypeptide	0.011
Lipe	lipase, hormone sensitive	0.011
Ucn2	urocortin 2	0.010
Foxa3	forkhead box A3	0.010
Gipr	gastric inhibitory polypeptide receptor	0.010
Trhr2	thyrotropin releasing hormone receptor 2	0.010
Dnmt1	DNA (cytosine-5-)-methyltransferase 1	0.010
Syt2	synaptotagmin II	0.010
Defa	defensin, alpha 5, Paneth cell-specific	0.010
RGD1307722	similar to hypothetical protein MGC20700	0.010