The network for 'cellular response to histamine' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cellular response to histamine

Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter.

Name Description Probability Func Analog Organism
RHOA ras homolog gene family, member A 0.910
GAS7 growth arrest-specific 7 0.784
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C 0.709
CKAP2L cytoskeleton associated protein 2-like 0.588
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 0.565
GRIK1 glutamate receptor, ionotropic, kainate 1 0.550
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 0.536
SLC17A6 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6 0.530
GLRA1 glycine receptor, alpha 1 0.427
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 0.421
OPRK1 opioid receptor, kappa 1 0.407
GPC5 glypican 5 0.355
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.333
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.314
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.305
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 0.288
CDH8 cadherin 8, type 2 0.276
GABRQ gamma-aminobutyric acid (GABA) receptor, theta 0.276
SV2C synaptic vesicle glycoprotein 2C 0.263
RIMS2 regulating synaptic membrane exocytosis 2 0.245
DDX25 DEAD (Asp-Glu-Ala-Asp) box polypeptide 25 0.236
GLRA3 glycine receptor, alpha 3 0.233
ELAVL2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B) 0.220
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 0.210
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A 0.207
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 0.191
NEUROD2 neurogenic differentiation 2 0.190
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 0.182
SNTG1 syntrophin, gamma 1 0.182
CCKBR cholecystokinin B receptor 0.175
KCNJ3 potassium inwardly-rectifying channel, subfamily J, member 3 0.174
ASXL2 additional sex combs like 2 (Drosophila) 0.160
KCNQ3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.156
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.152
NRXN1 neurexin 1 0.151
SLC1A6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 0.148
GABRR1 gamma-aminobutyric acid (GABA) receptor, rho 1 0.147
RIT2 Ras-like without CAAX 2 0.145
SYT13 synaptotagmin XIII 0.144
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 0.141
DCC deleted in colorectal carcinoma 0.138
NKAP NFKB activating protein 0.137
GLRA2 glycine receptor, alpha 2 0.134
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.133
DRD5 dopamine receptor D5 0.127
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.125
STIM2 stromal interaction molecule 2 0.123
ADAM18 ADAM metallopeptidase domain 18 0.118
SLITRK3 SLIT and NTRK-like family, member 3 0.117
PEX5L peroxisomal biogenesis factor 5-like 0.115
PIGR polymeric immunoglobulin receptor 0.113
STXBP5L syntaxin binding protein 5-like 0.110
ARHGAP1 Rho GTPase activating protein 1 0.109
PRKCG protein kinase C, gamma 0.103
GRM1 glutamate receptor, metabotropic 1 0.102
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.100
NPY neuropeptide Y 0.098
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 0.095
RGS7 regulator of G-protein signaling 7 0.094
UBQLN1 ubiquilin 1 0.094
PDCD7 programmed cell death 7 0.093
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.093
UBQLN4 ubiquilin 4 0.091
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.089
SCN2A sodium channel, voltage-gated, type II, alpha subunit 0.088
DAB1 disabled homolog 1 (Drosophila) 0.087
CDH18 cadherin 18, type 2 0.087
NEUROD1 neurogenic differentiation 1 0.086
RALYL RALY RNA binding protein-like 0.083
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.082
TEX15 testis expressed 15 0.082
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 0.078
MCF2 MCF.2 cell line derived transforming sequence 0.078
RIMS1 regulating synaptic membrane exocytosis 1 0.078
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.078
GRIA4 glutamate receptor, ionotrophic, AMPA 4 0.077
C6orf10 chromosome 6 open reading frame 10 0.077
GPR12 G protein-coupled receptor 12 0.076
FMNL2 formin-like 2 0.076
AKAP5 A kinase (PRKA) anchor protein 5 0.075
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 0.073
CALB1 calbindin 1, 28kDa 0.072
PROL1 proline rich, lacrimal 1 0.072
SEMG1 semenogelin I 0.072
VSTM2A V-set and transmembrane domain containing 2A 0.071
GPR22 G protein-coupled receptor 22 0.071
IFNA5 interferon, alpha 5 0.071
CDH10 cadherin 10, type 2 (T2-cadherin) 0.070
CNKSR2 connector enhancer of kinase suppressor of Ras 2 0.070
NELL1 NEL-like 1 (chicken) 0.069
GRM3 glutamate receptor, metabotropic 3 0.068
RIMBP2 RIMS binding protein 2 0.068
DAAM1 dishevelled associated activator of morphogenesis 1 0.068
GRIA3 glutamate receptor, ionotrophic, AMPA 3 0.066
SLCO1A2 solute carrier organic anion transporter family, member 1A2 0.064
GNG4 guanine nucleotide binding protein (G protein), gamma 4 0.064
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 0.063
RLF rearranged L-myc fusion 0.063
KCNA1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) 0.062
NTNG1 netrin G1 0.062
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Gabrb2 gamma-aminobutyric acid (GABA) A receptor, subunit beta 2 0.999
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 0.918
Grid1 glutamate receptor, ionotropic, delta 1 0.902
Gabra1 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 0.865
Gabra5 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5 0.742
Gabrg2 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 0.726
Nxph1 neurexophilin 1 0.484
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.449
B3galt1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.429
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 0.405
Gabra2 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2 0.396
Gad2 glutamic acid decarboxylase 2 0.336
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.248
Slc12a5 solute carrier family 12, member 5 0.243
Gria4 glutamate receptor, ionotropic, AMPA4 (alpha 4) 0.156
Slc1a2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.154
En2 engrailed 2 0.139
Cnr1 cannabinoid receptor 1 (brain) 0.124
Cdh9 cadherin 9 0.106
Trhr thyrotropin releasing hormone receptor 0.091
Rit2 Ras-like without CAAX 2 0.078
Gabrb1 gamma-aminobutyric acid (GABA) A receptor, subunit beta 1 0.076
Fgf14 fibroblast growth factor 14 0.073
Hcn1 hyperpolarization-activated, cyclic nucleotide-gated K+ 1 0.071
Grm8 glutamate receptor, metabotropic 8 0.068
Adcyap1 adenylate cyclase activating polypeptide 1 0.066
Cdh10 cadherin 10 0.063
Neurod6 neurogenic differentiation 6 0.063
Gabrg3 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3 0.061
Camk4 calcium/calmodulin-dependent protein kinase IV 0.059
Mgat4c mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative) 0.058
Odz1 odd Oz/ten-m homolog 1 (Drosophila) 0.056
Grik2 glutamate receptor, ionotropic, kainate 2 (beta 2) 0.056
Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) 0.053
Kcns2 K+ voltage-gated channel, subfamily S, 2 0.053
Gsbs G substrate 0.052
Grid2 glutamate receptor, ionotropic, delta 2 0.052
Calb1 calbindin 1 0.050
Pgr progesterone receptor 0.050
Kcnc1 potassium voltage gated channel, Shaw-related subfamily, member 1 0.048
Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) 0.046
Gdap1 ganglioside-induced differentiation-associated-protein 1 0.045
Braf Braf transforming gene 0.043
Neto1 neuropilin (NRP) and tolloid (TLL)-like 1 0.041
Gabra3 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3 0.041
En1 engrailed 1 0.041
Plcb1 phospholipase C, beta 1 0.040
Dync1i1 dynein cytoplasmic 1 intermediate chain 1 0.040
Syn2 synapsin II 0.039
Cdh8 cadherin 8 0.039
Npy2r neuropeptide Y receptor Y2 0.037
Upp2 uridine phosphorylase 2 0.037
Scn1a sodium channel, voltage-gated, type I, alpha 0.036
Thrb thyroid hormone receptor beta 0.035
Slitrk6 SLIT and NTRK-like family, member 6 0.035
Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 0.035
Nxph2 neurexophilin 2 0.035
Gad1 glutamic acid decarboxylase 1 0.034
Sva seminal vesicle antigen 0.034
Fam84a family with sequence similarity 84, member A 0.034
Mid1 midline 1 0.034
Napb N-ethylmaleimide sensitive fusion protein attachment protein beta 0.034
Kcnma1 potassium large conductance calcium-activated channel, subfamily M, alpha member 1 0.032
Hrk harakiri, BCL2 interacting protein (contains only BH3 domain) 0.031
Ncam2 neural cell adhesion molecule 2 0.031
Slc4a7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.030
Slc1a6 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 0.029
B3galt2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 0.029
Mmp16 matrix metallopeptidase 16 0.029
Folh1 folate hydrolase 0.027
Nap1l2 nucleosome assembly protein 1-like 2 0.027
Col19a1 collagen, type XIX, alpha 1 0.027
Cntn4 contactin 4 0.026
Adra2c adrenergic receptor, alpha 2c 0.025
Epha3 Eph receptor A3 0.025
Syt1 synaptotagmin I 0.025
Ceacam11 carcinoembryonic antigen-related cell adhesion molecule 11 0.025
Cer1 cerberus 1 homolog (Xenopus laevis) 0.025
Rgs7 regulator of G protein signaling 7 0.024
1810030J14Rik RIKEN cDNA 1810030J14 gene 0.024
Tbr1 T-box brain gene 1 0.024
Kcna2 potassium voltage-gated channel, shaker-related subfamily, member 2 0.024
Zic3 zinc finger protein of the cerebellum 3 0.024
Rasgrp1 RAS guanyl releasing protein 1 0.023
Htr1a 5-hydroxytryptamine (serotonin) receptor 1A 0.023
Tac2 tachykinin 2 0.023
Oprl1 opioid receptor-like 1 0.023
Npy1r neuropeptide Y receptor Y1 0.023
Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit 0.023
Dsc3 desmocollin 3 0.023
Rfpl4 ret finger protein-like 4 0.023
Gpr12 G-protein coupled receptor 12 0.023
Dmp1 dentin matrix protein 1 0.023
Tll1 tolloid-like 0.022
Ptprr protein tyrosine phosphatase, receptor type, R 0.021
Neurod1 neurogenic differentiation 1 0.021
Gjd2 gap junction protein, delta 2 0.021
Vstm2a V-set and transmembrane domain containing 2A 0.021
Slc6a15 solute carrier family 6 (neurotransmitter transporter), member 15 0.021
Kcnh1 potassium voltage-gated channel, subfamily H (eag-related), member 1 0.021
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Rattus norvegicus
Name Description Probability Func Analog Organism
Kcnc2 potassium voltage gated channel, Shaw-related subfamily, member 2 0.953
Fgf14 fibroblast growth factor 14 0.866
Kcnab1 potassium voltage-gated channel, shaker-related subfamily, beta member 1 0.752
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.636
Nxph1 neurexophilin 1 0.626
Gabra4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 0.583
Epha5 EphA5 0.563
Gabra1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.524
Gria4 glutamate receptor, ionotrophic, AMPA 4 0.469
Camk4 calcium/calmodulin-dependent protein kinase IV 0.425
Gad2 glutamate decarboxylase 2 0.417
Cnksr2 connector enhancer of kinase suppressor of Ras 2 0.395
Gabra3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 0.308
Unc13c unc-13 homolog C (C. elegans) 0.297
Drd1a dopamine receptor D1A 0.274
Hapln1 hyaluronan and proteoglycan link protein 1 0.269
Grm7 glutamate receptor, metabotropic 7 0.236
Aqp4 aquaporin 4 0.226
Kcnv1 potassium channel, subfamily V, member 1 0.209
Cntn1 contactin 1 0.207
Nrcam neuronal cell adhesion molecule 0.200
Ccbp2 chemokine binding protein 2 0.196
Csn3 casein kappa 0.161
Slc5a5 solute carrier family 5 (sodium iodide symporter), member 5 0.136
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.135
Gabrg2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 0.128
Kcnj6 potassium inwardly-rectifying channel, subfamily J, member 6 0.116
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.103
Cntn4 contactin 4 0.099
Gabrb1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.098
Cntn6 contactin 6 0.096
Cdh6 cadherin 6 0.091
Olr1469 olfactory receptor Olr1469 0.089
Kcna3 potassium voltage-gated channel, shaker-related subfamily, member 3 0.081
Chrna2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 0.081
Gabrb2 gamma-aminobutyric acid (GABA) A receptor, beta 2 0.080
Rasgrp1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 0.077
Neurod1 neurogenic differentiation 1 0.076
Opcml opioid binding protein/cell adhesion molecule-like 0.073
Elavl4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D) 0.073
Lrrc7 leucine rich repeat containing 7 0.072
Rgs8 regulator of G-protein signaling 8 0.071
Syt7 synaptotagmin VII 0.070
Folh1 folate hydrolase 1 0.069
Cacnb4 calcium channel, voltage-dependent, beta 4 subunit 0.068
Syt9 synaptotagmin IX 0.067
Adcyap1r1 adenylate cyclase activating polypeptide 1 receptor 1 0.067
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.067
Dgkb diacylglycerol kinase, beta 0.066
Cnr1 cannabinoid receptor 1 (brain) 0.065
Gria2 glutamate receptor, ionotropic, AMPA 2 0.064
Ceacam3 carcinoembryonic antigen-related cell adhesion molecule 3 0.064
Gcm1 glial cells missing homolog 1 (Drosophila) 0.063
Rin1 Ras and Rab interactor 1 0.063
Kcnt1 potassium channel, subfamily T, member 1 0.062
Drd2 dopamine receptor D2 0.062
Vom2r31 vomeronasal 2 receptor, 31 0.060
Kcnj3 potassium inwardly-rectifying channel, subfamily J, member 3 0.060
Kcnh7 potassium voltage-gated channel, subfamily H (eag-related), member 7 0.060
Avp arginine vasopressin 0.052
Grm1 glutamate receptor, metabotropic 1 0.052
Cx3cr1 chemokine (C-X3-C motif) receptor 1 0.050
Kcna1 potassium voltage-gated channel, shaker-related subfamily, member 1 0.050
Kalrn kalirin, RhoGEF kinase 0.050
Synpr synaptoporin 0.050
Psg29 pregnancy-specific glycoprotein 29 0.049
Htr2a 5-hydroxytryptamine (serotonin) receptor 2A 0.048
Cml3 camello-like 3 0.047
Nefl neurofilament, light polypeptide 0.047
Gabra2 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2 0.047
Kcnj9 potassium inwardly-rectifying channel, subfamily J, member 9 0.046
Slco1a5 solute carrier organic anion transporter family, member 1a5 0.046
Syt4 synaptotagmin IV 0.046
Gja6 gap junction protein, alpha 6 0.046
Cntn3 contactin 3 (plasmacytoma associated) 0.045
Mog myelin oligodendrocyte glycoprotein 0.045
Oprl1 opiate receptor-like 1 0.043
Sstr2 somatostatin receptor 2 0.042
Foxg1 forkhead box G1 0.042
Prph2 peripherin 2 0.042
Gng7 guanine nucleotide binding protein (G protein), gamma 7 0.041
Hpcal4 hippocalcin-like 4 0.041
Necab1 N-terminal EF-hand calcium binding protein 1 0.040
Rit2 Ras-like without CAAX 2 0.040
Grm4 glutamate receptor, metabotropic 4 0.040
Gabrg3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.040
Camk1g calcium/calmodulin-dependent protein kinase IG 0.039
Sh3gl2 SH3-domain GRB2-like 2 0.039
Pmch pro-melanin-concentrating hormone 0.038
Hrh2 histamine receptor H 2 0.037
Hpca hippocalcin 0.037
Gipr gastric inhibitory polypeptide receptor 0.036
Prkcg protein kinase C, gamma 0.036
Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 0.036
Snap91 synaptosomal-associated protein 91 0.035
Kcnb2 potassium voltage gated channel, Shab-related subfamily, member 2 0.035
Hoxa1 homeo box A1 0.035
Omg oligodendrocyte-myelin glycoprotein 0.034
Nrsn1 neurensin 1 0.034
Htr5a 5-hydroxytryptamine (serotonin) receptor 5A 0.034
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism