IMP
Process View
The network for 'mature dendritic cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
mature dendritic cell differentiation
The process in which antigen-activated dendritic cells acquire the specialized features of a mature dendritic cell. Mature dendritic cells upregulate the surface expression of MHC molecules, chemokine receptors and adhesion molecules, and increase the number of dendrites (cytoplasmic protrusions) in preparation for migration to lymphoid organs where they present antigen to T cells.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| CAV2 | caveolin 2 | 0.829 | |
| MPO | myeloperoxidase | 0.603 | |
| INADL | InaD-like (Drosophila) | 0.499 | |
| CCR7 | chemokine (C-C motif) receptor 7 | 0.450 | |
| CTSG | cathepsin G | 0.352 | |
| MS4A1 | membrane-spanning 4-domains, subfamily A, member 1 | 0.316 | |
| MS4A3 | membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) | 0.287 | |
| CLC | Charcot-Leyden crystal protein | 0.174 | |
| CCL19 | chemokine (C-C motif) ligand 19 | 0.172 | |
| RNASE3 | ribonuclease, RNase A family, 3 | 0.143 | |
| CAMP | cathelicidin antimicrobial peptide | 0.137 | |
| CLEC4G | C-type lectin domain family 4, member G | 0.115 | |
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | 0.105 | |
| GPR183 | G protein-coupled receptor 183 | 0.091 | |
| IL21R | interleukin 21 receptor | 0.087 | |
| CCL22 | chemokine (C-C motif) ligand 22 | 0.086 | |
| ELANE | elastase, neutrophil expressed | 0.081 | |
| LTF | lactotransferrin | 0.078 | |
| BPI | bactericidal/permeability-increasing protein | 0.077 | |
| P2RY10 | purinergic receptor P2Y, G-protein coupled, 10 | 0.075 | |
| IL16 | interleukin 16 (lymphocyte chemoattractant factor) | 0.067 | |
| DEFA4 | defensin, alpha 4, corticostatin | 0.067 | |
| CCL21 | chemokine (C-C motif) ligand 21 | 0.060 | |
| AZU1 | azurocidin 1 | 0.060 | |
| STAT4 | signal transducer and activator of transcription 4 | 0.056 | |
| HBD | hemoglobin, delta | 0.056 | |
| FAIM3 | Fas apoptotic inhibitory molecule 3 | 0.053 | |
| PGLYRP1 | peptidoglycan recognition protein 1 | 0.049 | |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.048 | |
| CXCR5 | chemokine (C-X-C motif) receptor 5 | 0.044 | |
| IRF8 | interferon regulatory factor 8 | 0.039 | |
| SLAMF1 | signaling lymphocytic activation molecule family member 1 | 0.038 | |
| PROCR | protein C receptor, endothelial | 0.037 | |
| IL7R | interleukin 7 receptor | 0.036 | |
| GPR171 | G protein-coupled receptor 171 | 0.035 | |
| CYTIP | cytohesin 1 interacting protein | 0.035 | |
| GPR18 | G protein-coupled receptor 18 | 0.033 | |
| IRF4 | interferon regulatory factor 4 | 0.031 | |
| CCR5 | chemokine (C-C motif) receptor 5 | 0.031 | |
| ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | 0.031 | |
| RASGRP1 | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | 0.031 | |
| RETN | resistin | 0.030 | |
| CCR6 | chemokine (C-C motif) receptor 6 | 0.030 | |
| CFP | complement factor properdin | 0.028 | |
| HDC | histidine decarboxylase | 0.028 | |
| CD27 | CD27 molecule | 0.026 | |
| EBI3 | Epstein-Barr virus induced 3 | 0.026 | |
| CD83 | CD83 molecule | 0.026 | |
| IL2RA | interleukin 2 receptor, alpha | 0.025 | |
| FCER2 | Fc fragment of IgE, low affinity II, receptor for (CD23) | 0.025 | |
| KLRB1 | killer cell lectin-like receptor subfamily B, member 1 | 0.024 | |
| SIGLEC5 | sialic acid binding Ig-like lectin 5 | 0.024 | |
| PRTN3 | proteinase 3 | 0.024 | |
| LAMP3 | lysosomal-associated membrane protein 3 | 0.023 | |
| LYL1 | lymphoblastic leukemia derived sequence 1 | 0.023 | |
| CIITA | class II, major histocompatibility complex, transactivator | 0.023 | |
| MMP8 | matrix metallopeptidase 8 (neutrophil collagenase) | 0.023 | |
| TNFSF8 | tumor necrosis factor (ligand) superfamily, member 8 | 0.023 | |
| TCL1A | T-cell leukemia/lymphoma 1A | 0.023 | |
| CXCR3 | chemokine (C-X-C motif) receptor 3 | 0.022 | |
| IL10 | interleukin 10 | 0.022 | |
| CD79A | CD79a molecule, immunoglobulin-associated alpha | 0.021 | |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 0.021 | |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.021 | |
| IL2RB | interleukin 2 receptor, beta | 0.021 | |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.021 | |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.021 | |
| HBB | hemoglobin, beta | 0.021 | |
| PF4 | platelet factor 4 | 0.021 | |
| CD96 | CD96 molecule | 0.020 | |
| LY9 | lymphocyte antigen 9 | 0.020 | |
| CST7 | cystatin F (leukocystatin) | 0.019 | |
| HP | haptoglobin | 0.019 | |
| TNFRSF17 | tumor necrosis factor receptor superfamily, member 17 | 0.019 | |
| ADD2 | adducin 2 (beta) | 0.019 | |
| FLT3 | fms-related tyrosine kinase 3 | 0.019 | |
| IGJ | immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides | 0.018 | |
| ORM2 | orosomucoid 2 | 0.018 | |
| PVRIG | poliovirus receptor related immunoglobulin domain containing | 0.018 | |
| ICOS | inducible T-cell co-stimulator | 0.018 | |
| VPREB1 | pre-B lymphocyte 1 | 0.018 | |
| SLAMF7 | SLAM family member 7 | 0.018 | |
| SELL | selectin L | 0.017 | |
| S100A12 | S100 calcium binding protein A12 | 0.017 | |
| AIM2 | absent in melanoma 2 | 0.017 | |
| IL18R1 | interleukin 18 receptor 1 | 0.017 | |
| LTC4S | leukotriene C4 synthase | 0.017 | |
| CCR2 | chemokine (C-C motif) receptor 2 | 0.016 | |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | 0.016 | |
| ITGB7 | integrin, beta 7 | 0.016 | |
| IL18RAP | interleukin 18 receptor accessory protein | 0.016 | |
| HPD | 4-hydroxyphenylpyruvate dioxygenase | 0.016 | |
| TRAT1 | T cell receptor associated transmembrane adaptor 1 | 0.016 | |
| CD1C | CD1c molecule | 0.016 | |
| BTLA | B and T lymphocyte associated | 0.016 | |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.015 | |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.015 | |
| CLEC10A | C-type lectin domain family 10, member A | 0.015 | |
| P2RY2 | purinergic receptor P2Y, G-protein coupled, 2 | 0.015 | |
| LTB | lymphotoxin beta (TNF superfamily, member 3) | 0.014 |
Loading network...
Mus musculus
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Ccl3 | chemokine (C-C motif) ligand 3 | 0.997 | |
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.995 | |
| Ccr1 | chemokine (C-C motif) receptor 1 | 0.991 | |
| Ifng | interferon gamma | 0.984 | |
| Ccl4 | chemokine (C-C motif) ligand 4 | 0.952 | |
| Ccr2 | chemokine (C-C motif) receptor 2 | 0.872 | |
| Ccl7 | chemokine (C-C motif) ligand 7 | 0.855 | |
| C3ar1 | complement component 3a receptor 1 | 0.854 | |
| Ccl8 | chemokine (C-C motif) ligand 8 | 0.849 | |
| Tnfrsf4 | tumor necrosis factor receptor superfamily, member 4 | 0.842 | |
| Itgax | integrin alpha X | 0.835 | |
| Ccl12 | chemokine (C-C motif) ligand 12 | 0.828 | |
| Cd7 | CD7 antigen | 0.818 | |
| Il1b | interleukin 1 beta | 0.808 | |
| Ctsw | cathepsin W | 0.784 | |
| Klrk1 | killer cell lectin-like receptor subfamily K, member 1 | 0.749 | |
| Batf | basic leucine zipper transcription factor, ATF-like | 0.745 | |
| Gzmb | granzyme B | 0.653 | |
| Folr2 | folate receptor 2 (fetal) | 0.622 | |
| Mmp12 | matrix metallopeptidase 12 | 0.621 | |
| Xcr1 | chemokine (C motif) receptor 1 | 0.609 | |
| Ccl22 | chemokine (C-C motif) ligand 22 | 0.595 | |
| Ubd | ubiquitin D | 0.583 | |
| Sh2d2a | SH2 domain protein 2A | 0.569 | |
| Slamf8 | SLAM family member 8 | 0.558 | |
| Klrg1 | killer cell lectin-like receptor subfamily G, member 1 | 0.538 | |
| Fcer1g | Fc receptor, IgE, high affinity I, gamma polypeptide | 0.532 | |
| Tlr2 | toll-like receptor 2 | 0.516 | |
| Il18rap | interleukin 18 receptor accessory protein | 0.511 | |
| Cd6 | CD6 antigen | 0.496 | |
| Ccr5 | chemokine (C-C motif) receptor 5 | 0.492 | |
| Cxcl13 | chemokine (C-X-C motif) ligand 13 | 0.468 | |
| Gpr132 | G protein-coupled receptor 132 | 0.465 | |
| Fcgr1 | Fc receptor, IgG, high affinity I | 0.451 | |
| Irg1 | immunoresponsive gene 1 | 0.448 | |
| Xcl1 | chemokine (C motif) ligand 1 | 0.393 | |
| H2-Eb1 | histocompatibility 2, class II antigen E beta | 0.373 | |
| Selp | selectin, platelet | 0.368 | |
| Tbxas1 | thromboxane A synthase 1, platelet | 0.363 | |
| Clec4d | C-type lectin domain family 4, member d | 0.355 | |
| Ltb | lymphotoxin B | 0.352 | |
| Tnfsf14 | tumor necrosis factor (ligand) superfamily, member 14 | 0.351 | |
| Il1rn | interleukin 1 receptor antagonist | 0.328 | |
| Cd3e | CD3 antigen, epsilon polypeptide | 0.324 | |
| Cxcl9 | chemokine (C-X-C motif) ligand 9 | 0.323 | |
| Flt3 | FMS-like tyrosine kinase 3 | 0.322 | |
| Gzma | granzyme A | 0.315 | |
| Lta | lymphotoxin A | 0.302 | |
| Cd180 | CD180 antigen | 0.300 | |
| Klrd1 | killer cell lectin-like receptor, subfamily D, member 1 | 0.299 | |
| Cxcr3 | chemokine (C-X-C motif) receptor 3 | 0.289 | |
| Icos | inducible T-cell co-stimulator | 0.274 | |
| Bdkrb1 | bradykinin receptor, beta 1 | 0.259 | |
| Ccr7 | chemokine (C-C motif) receptor 7 | 0.258 | |
| Gzmk | granzyme K | 0.252 | |
| Cd4 | CD4 antigen | 0.249 | |
| Ctla4 | cytotoxic T-lymphocyte-associated protein 4 | 0.242 | |
| Cd8a | CD8 antigen, alpha chain | 0.230 | |
| Pdcd1lg2 | programmed cell death 1 ligand 2 | 0.229 | |
| Socs1 | suppressor of cytokine signaling 1 | 0.221 | |
| Fasl | Fas ligand (TNF superfamily, member 6) | 0.217 | |
| Ch25h | cholesterol 25-hydroxylase | 0.214 | |
| Muc13 | mucin 13, epithelial transmembrane | 0.213 | |
| Tnfrsf9 | tumor necrosis factor receptor superfamily, member 9 | 0.210 | |
| Elane | elastase, neutrophil expressed | 0.210 | |
| Oxt | oxytocin | 0.208 | |
| Ccl9 | chemokine (C-C motif) ligand 9 | 0.208 | |
| Mpo | myeloperoxidase | 0.207 | |
| Csf3r | colony stimulating factor 3 receptor (granulocyte) | 0.206 | |
| Prdm1 | PR domain containing 1, with ZNF domain | 0.202 | |
| Klrb1b | killer cell lectin-like receptor subfamily B member 1B | 0.200 | |
| Cxcl2 | chemokine (C-X-C motif) ligand 2 | 0.199 | |
| Cxcl1 | chemokine (C-X-C motif) ligand 1 | 0.198 | |
| Il2rb | interleukin 2 receptor, beta chain | 0.191 | |
| Art2a-ps | ADP-ribosyltransferase 2a, pseudogene | 0.191 | |
| Ccr8 | chemokine (C-C motif) receptor 8 | 0.190 | |
| Cma1 | chymase 1, mast cell | 0.190 | |
| Mmp3 | matrix metallopeptidase 3 | 0.187 | |
| Aire | autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) | 0.184 | |
| Il2ra | interleukin 2 receptor, alpha chain | 0.184 | |
| Ly6d | lymphocyte antigen 6 complex, locus D | 0.182 | |
| Siglec1 | sialic acid binding Ig-like lectin 1, sialoadhesin | 0.182 | |
| Cd40 | CD40 antigen | 0.179 | |
| Tnf | tumor necrosis factor | 0.176 | |
| Klrc1 | killer cell lectin-like receptor subfamily C, member 1 | 0.176 | |
| Gfpt2 | glutamine fructose-6-phosphate transaminase 2 | 0.173 | |
| Cx3cr1 | chemokine (C-X3-C) receptor 1 | 0.172 | |
| Ptgir | prostaglandin I receptor (IP) | 0.172 | |
| AF251705 | cDNA sequence AF251705 | 0.171 | |
| Il1a | interleukin 1 alpha | 0.170 | |
| Cd96 | CD96 antigen | 0.170 | |
| Ciita | class II transactivator | 0.168 | |
| Blk | B lymphoid kinase | 0.164 | |
| Prss2 | protease, serine, 2 | 0.157 | |
| Ncr1 | natural cytotoxicity triggering receptor 1 | 0.155 | |
| Ccl6 | chemokine (C-C motif) ligand 6 | 0.152 | |
| Fcer2a | Fc receptor, IgE, low affinity II, alpha polypeptide | 0.152 | |
| Cd209a | CD209a antigen | 0.151 | |
| Ccl20 | chemokine (C-C motif) ligand 20 | 0.148 | |
| H2-Oa | histocompatibility 2, O region alpha locus | 0.146 |