The network for 'organic substance catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

organic substance catabolic process

The chemical reactions and pathways resulting in the breakdown of an organic substance, any molecular entity containing carbon.

Caenorhabditis elegans
Name Description Probability Func Analog Organism
rpt-2 Protein RPT-2 0.823
F56D2.6 Protein F56D2.6 0.740
sma-6 Protein SMA-6 0.721
dpy-4 Protein DPY-4 0.670
vab-3 Protein VAB-3 0.639
rpl-11.1 Protein RPL-11.1 0.636
pas-4 Protein PAS-4 0.624
ced-9 Protein CED-9 0.622
unc-52 Protein UNC-52 0.617
col-34 Protein COL-34 0.595
lin-45 Protein LIN-45 0.579
pkg-1 Protein PKG-1 0.568
rpn-7 Protein RPN-7 0.561
ape-1 Protein APE-1 0.560
prx-5 Protein PRX-5 0.542
ykt-6 Protein YKT-6 0.538
gld-1 Protein GLD-1 0.535
pbs-6 Protein PBS-6 0.533
vav-1 Protein VAV-1 0.517
K10C9.3 Protein K10C9.3 0.508
egl-30 Protein EGL-30 0.507
bre-1 Protein BRE-1 0.506
dcr-1 Protein DCR-1 0.503
rpt-3 Protein RPT-3 0.503
spd-5 Protein SPD-5 0.501
pri-2 Protein PRI-2 0.498
pmk-1 Protein PMK-1 0.496
csn-3 Protein CSN-3 0.493
unc-54 Protein UNC-54 0.484
sli-1 Protein SLI-1 0.482
cdc-37 Protein CDC-37 0.479
imb-2 Protein IMB-2 0.462
egl-18 Protein EGL-18 0.461
rnr-1 Protein RNR-1 0.458
sem-5 Protein SEM-5 0.457
app-1 Protein APP-1 0.457
rsp-8 Protein RSP-8 0.448
tba-2 Protein TBA-2 0.444
hel-1 Protein HEL-1 0.444
ZK1055.7 Protein ZK1055.7 0.443
CELE_C39E9.11 Protein C39E9.11 0.443
atg-18 Protein ATG-18 0.443
myo-3 Protein MYO-3 0.440
hgrs-1 Protein HGRS-1 0.436
egl-13 Protein EGL-13 0.434
cka-2 Protein CKA-2 0.430
etr-1 Protein ETR-1 0.428
alx-1 Protein ALX-1 0.419
pdr-1 Protein PDR-1 0.418
gpr-2 Protein GPR-2 0.417
npp-1 Protein NPP-1 0.416
rpl-11.2 Protein RPL-11.2 0.414
lev-11 Protein LEV-11 0.412
rgl-1 Protein RGL-1 0.412
rpn-12 Protein RPN-12 0.411
pat-10 Protein PAT-10 0.399
unc-6 Protein UNC-6 0.394
dpf-3 Protein DPF-3 0.391
npp-19 Protein NPP-19 0.387
upb-1 Protein UPB-1 0.384
pptr-2 Protein PPTR-2 0.383
H14E04.2 Protein H14E04.2 0.383
col-84 Protein COL-84 0.381
CELE_Y57G11C.3 Protein Y57G11C.3 0.380
CELE_C25A1.4 Protein C25A1.4 0.379
pbs-1 Protein PBS-1 0.376
F22D3.2 Protein F22D3.2 0.373
sqt-1 Protein SQT-1 0.372
hcp-1 Protein HCP-1 0.371
ubxn-4 Protein UBXN-4 0.364
T08B2.7 Protein T08B2.7 0.363
rpn-3 Protein RPN-3 0.358
K01G5.5 Protein K01G5.5 0.356
H43E16.1 Protein H43E16.1 0.353
zfp-1 Protein ZFP-1 0.350
atp-2 Protein ATP-2 0.349
dpy-31 Protein DPY-31 0.349
C42C1.4 Protein C42C1.4 0.348
vbh-1 Protein VBH-1 0.346
tat-1 Protein TAT-1 0.345
kin-3 Protein KIN-3 0.343
col-73 Protein COL-73 0.341
pgl-1 Protein PGL-1 0.339
csn-4 Protein CSN-4 0.339
mig-6 Protein MIG-6 0.338
unc-23 Protein UNC-23 0.337
pbs-5 Protein PBS-5 0.337
mei-1 Protein MEI-1 0.332
D1081.8 Protein D1081.8 0.331
dpy-13 Protein DPY-13 0.331
CELE_C10C6.6 Protein C10C6.6 0.331
zen-4 Protein ZEN-4 0.330
ifa-1 Protein IFA-1 0.330
bar-1 Protein BAR-1 0.329
ina-1 Protein INA-1 0.329
klp-15 Protein KLP-15 0.326
rpl-6 Protein RPL-6 0.324
tpxl-1 Protein TPXL-1 0.320
kin-2 Protein KIN-2 0.319
sec-24.1 Protein SEC-24.1 0.319
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Danio rerio
Name Description Probability Func Analog Organism
gro1 groucho 1 0.271
psmb1 proteasome (prosome, macropain) subunit, beta type, 1 0.256
smad2 MAD homolog 2 (Drosophila) 0.226
psmb3 proteasome (prosome, macropain) subunit, beta type, 3 0.199
nlgn4a neuroligin 4a 0.198
hspa5 heat shock protein 5 0.198
pcna proliferating cell nuclear antigen 0.192
upf1 upf1 regulator of nonsense transcripts homolog (yeast) 0.189
ncor1 nuclear receptor co-repressor 1 0.187
zgc:85866 zgc:85866 0.178
psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 0.174
sdha succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.167
mao monoamine oxidase 0.167
hk1 hexokinase 1 0.159
ccnb1 cyclin B1 0.154
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.151
aldocb aldolase C, fructose-bisphosphate, b 0.148
chd chordin 0.148
pax8 paired box gene 8 0.135
psmd6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.130
psma8 proteasome (prosome, macropain) subunit, alpha type, 8 0.126
tnni2a.4 troponin I, skeletal, fast 2a.4 0.126
psma6a proteasome (prosome, macropain) subunit, alpha type, 6a 0.120
myhz2 myosin, heavy polypeptide 2, fast muscle specific 0.118
plxnb2a plexin b2a 0.111
pgam2 phosphoglycerate mutase 2 (muscle) 0.111
psma1 proteasome (prosome, macropain) subunit, alpha type, 1 0.109
zgc:92775 zgc:92775 0.108
myhz1.2 myosin, heavy polypeptide 1.2, skeletal muscle 0.107
ctsc cathepsin C 0.107
sox9b SRY-box containing gene 9b 0.106
atp1b2a ATPase, Na+/K+ transporting, beta 2a polypeptide 0.106
tnnt3b troponin T3b, skeletal, fast 0.105
dhfr dihydrofolate reductase 0.103
yap1 Yes-associated protein 1 0.098
mdm2 transformed 3T3 cell double minute 2 homolog (mouse) 0.098
ctsba cathepsin B, a 0.098
psen1 presenilin 1 0.098
arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.096
apoa4 apolipoprotein A-IV 0.092
sass6 spindle assembly 6 homolog (C. elegans) 0.086
gpib glucose phosphate isomerase b 0.085
gapdhs glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 0.085
aurkb aurora kinase B 0.082
cyp2y3 cytochrome P450, family 2, subfamily Y, polypeptide 3 0.079
desma desmin a 0.077
psmd1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.075
cand1 cullin-associated and neddylation-dissociated 1 0.074
cdh23 cadherin-like 23 0.074
cnot8 CCR4-NOT transcription complex, subunit 8 0.074
nrg2a neuregulin 2a 0.073
tram1 translocating chain-associating membrane protein 1 0.072
mycbp2 MYC binding protein 2 0.072
psmd4b proteasome (prosome, macropain) 26S subunit, non-ATPase, 4b 0.071
suv39h1b suppressor of variegation 3-9 homolog 1b 0.070
psmc6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 0.070
snai1a snail homolog 1a (Drosophila) 0.069
rangap1 Ran GTPase activating protein 1 0.068
yrk Yes-related kinase 0.067
psmd12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 0.066
rae1 RAE1 RNA export 1 homolog (S. pombe) 0.066
s1pr2 sphingosine-1-phosphate receptor 2 0.066
crabp2a cellular retinoic acid binding protein 2, a 0.065
atp1b3b ATPase, Na+/K+ transporting, beta 3b polypeptide 0.065
chuk conserved helix-loop-helix ubiquitous kinase 0.064
zbtb4 zinc finger and BTB domain containing 4 0.064
vcp valosin containing protein 0.064
dusp1 dual specificity phosphatase 1 0.064
zgc:101661 zgc:101661 0.063
uqcrc2b ubiquinol-cytochrome c reductase core protein IIb 0.063
supt6h suppressor of Ty 6 homolog 0.062
jag1b jagged 1b 0.062
usp5 ubiquitin specific protease 5 0.061
pafah1b1b platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b 0.061
tph1b tryptophan hydroxylase 1b 0.061
hoxd4a homeo box D4a 0.060
itgb1b integrin, beta 1b 0.060
sox32 SRY-box containing gene 32 0.060
msh2 mutS homolog 2 (E. coli) 0.059
bms1l BMS1-like, ribosome assembly protein (yeast) 0.058
sema3aa semaphorin 3aa 0.058
sec61al1 Sec61 alpha like 1 0.058
prkci protein kinase C, iota 0.058
gna12 guanine nucleotide binding protein (G protein) alpha 12 0.057
bsdc1 BSD domain containing 1 0.057
psmc4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.057
psmb5 proteasome (prosome, macropain) subunit, beta type, 5 0.057
chia.2 chitinase, acidic.2 0.056
flot1 flotillin 1 0.056
psmb2 proteasome (prosome, macropain) subunit, beta type, 2 0.056
ruvbl2 RuvB-like 2 (E. coli) 0.055
si:dkey-24l11.7 si:dkey-24l11.7 0.055
mtp microsomal triglyceride transfer protein 0.054
psmc5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.054
hhip hedgehog interacting protein 0.054
ndufs4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, (NADH-coenzyme Q reductase) 0.053
myog myogenin 0.053
nadl1.2 neural adhesion molecule L1.2 0.053
ncbp2 nuclear cap binding protein subunit 2 0.052
olfm1a olfactomedin 1a 0.052
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.995
sax saxophone 0.921
Syx7 Syntaxin 7 0.845
msps mini spindles 0.813
N Notch 0.804
alpha-Adaptin CG4260 gene product from transcript CG4260-RA 0.771
EcR Ecdysone receptor 0.731
Sema-1a CG18405 gene product from transcript CG18405-RD 0.682
dco discs overgrown 0.682
slmb supernumerary limbs 0.656
rl rolled 0.652
Aos1 CG12276 gene product from transcript CG12276-RA 0.631
Lam Lamin 0.608
tefu telomere fusion 0.590
nej nejire 0.574
Hel25E Helicase at 25E 0.571
InR Insulin-like receptor 0.563
Src64B Src oncogene at 64B 0.551
CycE Cyclin E 0.551
rad50 CG6339 gene product from transcript CG6339-RD 0.521
cpa capping protein alpha 0.517
pie pineapple eye 0.505
Ras85D Ras oncogene at 85D 0.504
Top1 Topoisomerase 1 0.502
Rho1 CG8416 gene product from transcript CG8416-RB 0.498
Mi-2 CG8103 gene product from transcript CG8103-RA 0.488
Rpn11 CG18174 gene product from transcript CG18174-RA 0.481
ptc patched 0.480
Dcr-2 Dicer-2 0.478
drk downstream of receptor kinase 0.477
Rac1 CG2248 gene product from transcript CG2248-RA 0.468
ago archipelago 0.466
Lis-1 Lissencephaly-1 0.460
tsr twinstar 0.458
dos daughter of sevenless 0.454
awd abnormal wing discs 0.447
Rpt1 CG1341 gene product from transcript CG1341-RA 0.446
SNF1A SNF1A/AMP-activated protein kinase 0.438
cenG1A centaurin gamma 1A 0.438
Su(var)205 Suppressor of variegation 205 0.438
Dhc64C Dynein heavy chain 64C 0.427
Rel Relish 0.420
Mad Mothers against dpp 0.414
Mov34 CG3416 gene product from transcript CG3416-RA 0.410
Ada2b CG9638 gene product from transcript CG9638-RA 0.409
jeb jelly belly 0.407
Rheb CG1081 gene product from transcript CG1081-RA 0.399
nct nicastrin 0.395
Caki Calcium/calmodulin-dependent protein kinase 0.391
eIF-4E Eukaryotic initiation factor 4E 0.386
Hrb27C Heterogeneous nuclear ribonucleoprotein at 27C 0.386
CG8155 CG8155 gene product from transcript CG8155-RA 0.371
UbcD2 Ubiquitin conjugating enzyme 2 0.370
shg shotgun 0.368
Kr-h1 Kruppel homolog 1 0.368
Dlic Dynein light intermediate chain 0.366
CkIIalpha Casein kinase II alpha subunit 0.364
Fhos CG42610 gene product from transcript CG42610-RC 0.363
par-6 CG5884 gene product from transcript CG5884-RA 0.354
Cat Catalase 0.354
wupA wings up A 0.351
CG6617 CG6617 gene product from transcript CG6617-RA 0.351
Eno Enolase 0.348
CG9772 CG9772 gene product from transcript CG9772-RB 0.347
alpha-Cat alpha Catenin 0.346
betaTub60D beta-Tubulin at 60D 0.343
tws twins 0.339
CG7998 CG7998 gene product from transcript CG7998-RA 0.339
Tal CG2827 gene product from transcript CG2827-RA 0.338
trio CG18214 gene product from transcript CG18214-RA 0.332
Rpd3 CG7471 gene product from transcript CG7471-RA 0.332
sqh spaghetti squash 0.330
Pak PAK-kinase 0.329
Argk Arginine kinase 0.329
brp bruchpilot 0.323
Ugt35a UDP-glycosyltransferase 35a 0.315
CkIalpha Casein kinase Ialpha 0.315
G-oalpha47A G protein oalpha 47A 0.314
Cam Calmodulin 0.313
rin rasputin 0.313
Pkn Protein kinase related to protein kinase N 0.313
p53 CG33336 gene product from transcript CG33336-RB 0.308
Rpt4 CG3455 gene product from transcript CG3455-RA 0.307
BRWD3 CG31132 gene product from transcript CG31132-RA 0.306
scny scrawny 0.306
Rab1 Rab-protein 1 0.305
Tak1 TGF-beta activated kinase 1 0.303
Nedd8 CG10679 gene product from transcript CG10679-RA 0.299
unc-104 CG8566 gene product from transcript CG8566-RB 0.298
E(z) Enhancer of zeste 0.295
CkIIbeta Casein kinase II beta subunit 0.295
mask multiple ankyrin repeats single KH domain 0.293
gig gigas 0.291
Uba1 Ubiquitin activating enzyme 1 0.288
ben bendless 0.287
clt cricklet 0.287
if inflated 0.286
Rcd1 Reduction in Cnn dots 1 0.283
Eip63E Ecdysone-induced protein 63E 0.283
Yp1 Yolk protein 1 0.282
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Homo sapiens
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Acadl acyl-Coenzyme A dehydrogenase, long-chain 0.875
Decr1 2,4-dienoyl CoA reductase 1, mitochondrial 0.857
Ech1 enoyl coenzyme A hydratase 1, peroxisomal 0.838
Ldha lactate dehydrogenase A 0.786
Pkm2 pyruvate kinase, muscle 0.777
Ugt2b UDP glycosyltransferase 2 family, polypeptide B 0.706
Acadvl acyl-Coenzyme A dehydrogenase, very long chain 0.700
Gapdh glyceraldehyde-3-phosphate dehydrogenase 0.673
Rxrg retinoid X receptor gamma 0.673
Acaa2 acetyl-Coenzyme A acyltransferase 2 0.672
Aldoa aldolase A, fructose-bisphosphate 0.662
Dnaja2 DnaJ (Hsp40) homolog, subfamily A, member 2 0.646
LOC293989 cytochrome P450-like 0.641
Psma5 proteasome (prosome, macropain) subunit, alpha type 5 0.641
Stxbp1 syntaxin binding protein 1 0.632
Lamp2 lysosomal-associated membrane protein 2 0.610
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.608
Ugt1a6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.598
Psmc1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 0.561
Anxa2 annexin A2 0.549
Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 0.548
Car5a carbonic anhydrase 5a, mitochondrial 0.521
Tpi1 triosephosphate isomerase 1 0.521
Psma3 proteasome (prosome, macropain) subunit, alpha type 3 0.518
Ppp1cb protein phosphatase 1, catalytic subunit, beta isoform 0.504
Psmc2 proteasome (prosome, macropain) 26S subunit, ATPase 2 0.503
Cd8b CD8b molecule 0.503
Psmb3 proteasome (prosome, macropain) subunit, beta type 3 0.488
Eef2 eukaryotic translation elongation factor 2 0.486
Pebp1 phosphatidylethanolamine binding protein 1 0.485
Ube2g1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 0.470
Myo1b myosin Ib 0.466
Prl prolactin 0.452
Prkch protein kinase C, eta 0.450
Gja1 gap junction protein, alpha 1 0.446
Tpm3 tropomyosin 3, gamma 0.433
Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 0.417
Cpt2 carnitine palmitoyltransferase 2 0.411
Acox1 acyl-Coenzyme A oxidase 1, palmitoyl 0.411
Cap1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.398
Gna15 guanine nucleotide binding protein, alpha 15 0.398
Rgs19 regulator of G-protein signaling 19 0.394
Acta2 smooth muscle alpha-actin 0.392
Klf6 Kruppel-like factor 6 0.392
Pfn1 profilin 1 0.389
Psme2 proteasome (prosome, macropain) activator subunit 2 0.387
Shank2 SH3 and multiple ankyrin repeat domains 2 0.386
Mgst2 microsomal glutathione S-transferase 2 0.382
Ripk3 receptor-interacting serine-threonine kinase 3 0.381
Ctbs chitobiase, di-N-acetyl- 0.380
Adrbk1 adrenergic, beta, receptor kinase 1 0.379
Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 0.373
Crot carnitine O-octanoyltransferase 0.373
Ctsb cathepsin B 0.371
Acsl1 acyl-CoA synthetase long-chain family member 1 0.364
Nr0b2 nuclear receptor subfamily 0, group B, member 2 0.362
Camk4 calcium/calmodulin-dependent protein kinase IV 0.358
Tkt transketolase 0.357
Litaf lipopolysaccharide-induced TNF factor 0.354
Psma7 proteasome (prosome, macropain) subunit, alpha type 7 0.352
Igf2 insulin-like growth factor 2 0.351
Cyfip1 cytoplasmic FMR1 interacting protein 1 0.349
Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 0.348
Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 0.341
Abcc2 ATP-binding cassette, subfamily C (CFTR/MRP), member 2 0.338
Stip1 stress-induced phosphoprotein 1 0.337
Cd302 CD302 molecule 0.335
Anxa1 annexin A1 0.331
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.330
Dctn4 dynactin 4 0.330
Eif4a2 eukaryotic translation initiation factor 4A, isoform 2 0.328
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.319
Cmklr1 chemokine-like receptor 1 0.318
Csnk1d casein kinase 1, delta 0.304
Kmo kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 0.304
A1i3 alpha-1-inhibitor III 0.303
Psmb4 proteasome (prosome, macropain) subunit, beta type 4 0.302
Myo1d myosin ID 0.298
Pja2 praja 2, RING-H2 motif containing 0.297
Rab1b RAB1B, member RAS oncogene family 0.295
Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 0.292
Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 0.292
Myh1 myosin, heavy polypeptide 1, skeletal muscle, adult 0.291
Pdcd10 programmed cell death 10 0.287
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.284
Casq1 calsequestrin 1 (fast-twitch, skeletal muscle) 0.283
Il13 interleukin 13 0.282
Ube2i ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.279
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.278
Pah phenylalanine hydroxylase 0.277
Lgals3 lectin, galactoside-binding, soluble, 3 0.276
Cfl1 cofilin 1, non-muscle 0.276
Pros1 protein S (alpha) 0.275
Nnt nicotinamide nucleotide transhydrogenase 0.275
Acadm acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain 0.274
Anxa4 annexin A4 0.273
Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 0.272
Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 0.271
Csnk2b casein kinase 2, beta polypeptide 0.270
Glud1 glutamate dehydrogenase 1 0.270
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism