The network for 'histone exchange' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

histone exchange

The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
ARP4 Arp4p 0.995
SWC4 Swc4p 0.990
SWR1 Swr1p 0.980
BDF1 Bdf1p 0.964
SWC3 Swc3p 0.962
EPL1 Epl1p 0.907
SWC5 Swc5p 0.773
VPS71 Vps71p 0.763
YAF9 Yaf9p 0.609
VPS72 Vps72p 0.565
ISW1 Isw1p 0.511
TRA1 Tra1p 0.251
ARP6 Arp6p 0.248
RVB2 Rvb2p 0.234
RSC8 Rsc8p 0.224
MOT1 Mot1p 0.153
ADA2 Ada2p 0.152
RSC4 Rsc4p 0.147
IES1 Ies1p 0.146
SWC7 Swc7p 0.144
TAF6 Taf6p 0.135
RSC2 Rsc2p 0.135
NGG1 Ngg1p 0.128
RCO1 Rco1p 0.119
SPT8 Spt8p 0.096
YTA7 Yta7p 0.077
RLF2 Rlf2p 0.076
SWI1 Swi1p 0.074
NHP10 Nhp10p 0.069
SET3 Set3p 0.067
SPT7 Spt7p 0.063
STH1 Sth1p 0.061
NTO1 Nto1p 0.061
SPT15 Spt15p 0.053
CHD1 Chd1p 0.051
GCN5 Gcn5p 0.050
HHT1 Hht1p 0.050
HDA2 Hda2p 0.047
ARP7 Arp7p 0.044
HTZ1 Htz1p 0.041
EAF1 Eaf1p 0.037
LEO1 Leo1p 0.035
RSC9 Rsc9p 0.033
RVB1 Rvb1p 0.032
RSC3 Rsc3p 0.029
RSC6 Rsc6p 0.029
HIR2 Hir2p 0.027
RSC30 Rsc30p 0.025
UME1 Ume1p 0.025
SUM1 Sum1p 0.025
IOC2 Ioc2p 0.024
UBP8 Ubp8p 0.024
NPL6 Npl6p 0.023
IOC3 Ioc3p 0.023
ARP8 Arp8p 0.022
CAC2 Cac2p 0.021
SPT20 Spt20p 0.021
EAF6 Eaf6p 0.020
INO80 Ino80p 0.020
SRD1 Srd1p 0.020
PRS2 Prs2p 0.020
ARP9 Arp9p 0.019
SUS1 Sus1p 0.019
SNF11 Snf11p 0.018
SPT10 Spt10p 0.018
YLR264C-A hypothetical protein 0.017
YOL038C-A hypothetical protein 0.017
LEU2 Leu2p 0.017
SET1 Set1p 0.017
RSC58 Rsc58p 0.016
HHT2 Hht2p 0.016
YLR162W hypothetical protein 0.016
CKB1 Ckb1p 0.016
SAS4 Sas4p 0.016
HXT3 Hxt3p 0.016
IES6 Ies6p 0.016
CRP1 Crp1p 0.016
SCT1 Sct1p 0.015
MER1 Mer1p 0.015
SET2 Set2p 0.015
HO Hop 0.015
YIR035C hypothetical protein 0.014
TAF12 Taf12p 0.014
SPL2 Spl2p 0.014
RTF1 Rtf1p 0.014
ATP6 Atp6p 0.014
YLR042C hypothetical protein 0.014
ARP10 Arp10p 0.014
OPT2 Opt2p 0.013
CHA1 Cha1p 0.013
YAR068W hypothetical protein 0.013
YPR157W hypothetical protein 0.013
ARG8 Arg8p 0.013
GBP2 Gbp2p 0.013
REV1 Rev1p 0.013
ZPS1 Zps1p 0.013
RIF1 Rif1p 0.013
YIL151C hypothetical protein 0.013
SCY1 Scy1p 0.013
NUP170 Nup170p 0.013
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
His2Av Histone H2A variant 0.720
rept reptin 0.337
Bap55 Brahma associated protein 55kD 0.331
SelD Selenide,water dikinase 0.282
CG1240 CG1240 gene product from transcript CG1240-RA 0.235
CG3363 CG3363 gene product from transcript CG3363-RB 0.159
D1 D1 chromosomal protein 0.146
Snr1 Snf5-related 1 0.145
CSN6 COP9 complex homolog subunit 6 0.139
Su(var)205 Suppressor of variegation 205 0.075
Hrb98DE Heterogeneous nuclear ribonucleoprotein at 98DE 0.073
Chd1 Chromodomain-helicase-DNA-binding protein 1 0.070
CG6693 CG6693 gene product from transcript CG6693-RA 0.064
MRG15 CG6363 gene product from transcript CG6363-RA 0.057
msl-3 male-specific lethal 3 0.051
Sce Sex combs extra 0.047
Caf1 Chromatin assembly factor 1 subunit 0.040
nopo no poles 0.038
His3.3B Histone H3.3B 0.038
CG9018 CG9018 gene product from transcript CG9018-RA 0.038
thoc5 CG2980 gene product from transcript CG2980-RA 0.038
cav caravaggio 0.037
Prp8 pre-mRNA processing factor 8 0.036
Tango6 Transport and Golgi organization 6 0.033
Kmn1 kinetochore Mis12-Ndc80 network component 1 0.033
Mi-2 CG8103 gene product from transcript CG8103-RA 0.031
CG10267 CG10267 gene product from transcript CG10267-RB 0.030
Cdc37 CG12019 gene product from transcript CG12019-RA 0.029
Apc10 Anaphase promoting complex subunit 10 0.028
asf1 anti-silencing factor 1 0.028
CG15443 CG15443 gene product from transcript CG15443-RA 0.026
CG14213 CG14213 gene product from transcript CG14213-RB 0.026
ash1 absent, small, or homeotic discs 1 0.026
Su(var)3-7 Suppressor of variegation 3-7 0.025
SMC2 CG10212 gene product from transcript CG10212-RA 0.024
pr-set7 CG3307 gene product from transcript CG3307-RC 0.024
Aos1 CG12276 gene product from transcript CG12276-RA 0.024
Pp4-19C Protein phosphatase 19C 0.023
Uch-L3 Ubiquitin C-terminal hydrolase 0.022
CG5933 CG5933 gene product from transcript CG5933-RA 0.021
Rbp1 RNA-binding protein 1 0.021
CG1218 CG1218 gene product from transcript CG1218-RA 0.020
CTCF CG8591 gene product from transcript CG8591-RA 0.020
Spt5 CG7626 gene product from transcript CG7626-RA 0.019
snama something that sticks like glue 0.019
Hpr1 CG2031 gene product from transcript CG2031-RA 0.019
DMAP1 CG11132 gene product from transcript CG11132-RA 0.019
Nuf2 CG8902 gene product from transcript CG8902-RA 0.018
Grip75 CG6176 gene product from transcript CG6176-RA 0.018
Dcp1 Decapping protein 1 0.018
SuUR Suppressor of Under-Replication 0.018
CG16734 CG16734 gene product from transcript CG16734-RD 0.017
CG12470 CG12470 gene product from transcript CG12470-RA 0.017
Coprox Coproporphyrinogen oxidase 0.017
CG4400 CG4400 gene product from transcript CG4400-RA 0.016
CG12343 CG12343 gene product from transcript CG12343-RA 0.016
hang hangover 0.016
Hdac3 Histone deacetylase 3 0.015
Ravus CG15889 gene product from transcript CG15889-RA 0.015
CG7045 CG7045 gene product from transcript CG7045-RA 0.015
mfr misfire 0.015
dom domino 0.015
MED31 Mediator complex subunit 31 0.015
snf sans fille 0.015
YL-1 CG4621 gene product from transcript CG4621-RA 0.015
morgue modifier of rpr and grim, ubiquitously expressed 0.015
Su(var)2-HP2 CG12864 gene product from transcript CG12864-RB 0.014
Lim3 CG10699 gene product from transcript CG10699-RB 0.014
kto kohtalo 0.014
CG13245 CG13245 gene product from transcript CG13245-RA 0.014
CG2608 CG2608 gene product from transcript CG2608-RA 0.014
CG10326 CG10326 gene product from transcript CG10326-RA 0.014
CG6066 CG6066 gene product from transcript CG6066-RA 0.013
dj don juan 0.013
CG18004 CG18004 gene product from transcript CG18004-RB 0.013
WRNexo WRN exonuclease 0.013
srpk79D serine-arginine protein kinase at 79D 0.013
endoB endophilin B 0.013
Dpy-30L1 Dpy-30-like 1 0.013
CG9601 CG9601 gene product from transcript CG9601-RA 0.013
jigr1 jing interacting gene regulatory 1 0.013
Paf-AHalpha Platelet-activating factor acetylhydrolase alpha 0.013
CG12259 CG12259 gene product from transcript CG12259-RA 0.013
MED1 Mediator complex subunit 1 0.013
Atac1 ATAC component 1 0.012
msl-2 male-specific lethal 2 0.012
klhl10 CG12423 gene product from transcript CG12423-RB 0.012
HP4 Heterochromatin protein 4 0.012
TH1 CG9984 gene product from transcript CG9984-RA 0.012
CG7593 CG7593 gene product from transcript CG7593-RA 0.012
Hira CG12153 gene product from transcript CG12153-RA 0.012
E(bx) Enhancer of bithorax 0.012
CG32418 CG32418 gene product from transcript CG32418-RA 0.012
FLASH FLASH ortholog 0.012
Hcf Host cell factor 0.011
HBS1 CG1898 gene product from transcript CG1898-RA 0.011
CG17261 CG17261 gene product from transcript CG17261-RA 0.011
snRNP-U1-70K small ribonucleoprotein particle U1 subunit 70K 0.011
Cyt-c-d Cytochrome c distal 0.011
RfC3 Replication factor C subunit 3 0.011
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Homo sapiens
Name Description Probability Func Analog Organism
RUVBL1 RuvB-like 1 (E. coli) 1.000
YY1 YY1 transcription factor 0.999
ACTL6A actin-like 6A 0.999
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.985
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.903
DPCD deleted in primary ciliary dyskinesia homolog (mouse) 0.866
C20orf20 chromosome 20 open reading frame 20 0.839
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.806
MRFAP1 Morf4 family associated protein 1 0.712
INO80E INO80 complex subunit E 0.625
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.585
INO80 INO80 homolog (S. cerevisiae) 0.557
ACTR5 ARP5 actin-related protein 5 homolog (yeast) 0.510
TRRAP transformation/transcription domain-associated protein 0.462
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.405
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.392
MORF4L2 mortality factor 4 like 2 0.389
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.249
CHAF1B chromatin assembly factor 1, subunit B (p60) 0.247
CDAN1 congenital dyserythropoietic anemia, type I 0.245
TLK1 tousled-like kinase 1 0.242
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.231
SET SET nuclear oncogene 0.203
CHRAC1 chromatin accessibility complex 1 0.174
HDAC2 histone deacetylase 2 0.142
MRFAP1L1 Morf4 family associated protein 1-like 1 0.140
CENPA centromere protein A 0.140
HMGB2 high mobility group box 2 0.138
NUP153 nucleoporin 153kDa 0.126
RPA1 replication protein A1, 70kDa 0.123
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.107
ACTR8 ARP8 actin-related protein 8 homolog (yeast) 0.106
TTI1 Tel2 interacting protein 1 homolog (S. pombe) 0.106
KAT2A K(lysine) acetyltransferase 2A 0.100
POLE polymerase (DNA directed), epsilon 0.099
EP400 E1A binding protein p400 0.092
CBX5 chromobox homolog 5 0.090
PIH1D1 PIH1 domain containing 1 0.089
MSH6 mutS homolog 6 (E. coli) 0.078
NFRKB nuclear factor related to kappaB binding protein 0.077
INO80D INO80 complex subunit D 0.057
DMC1 DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) 0.056
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.055
PTMA prothymosin, alpha 0.054
ASF1B ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.053
MORF4L1 mortality factor 4 like 1 0.053
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.053
INO80C INO80 complex subunit C 0.053
TOP2B topoisomerase (DNA) II beta 180kDa 0.052
KAT5 K(lysine) acetyltransferase 5 0.049
BCLAF1 BCL2-associated transcription factor 1 0.048
POLE4 polymerase (DNA-directed), epsilon 4 (p12 subunit) 0.047
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.044
ATXN7 ataxin 7 0.043
HMGB1 high mobility group box 1 0.042
DEK DEK oncogene 0.042
DMAP1 DNA methyltransferase 1 associated protein 1 0.041
H2AFV H2A histone family, member V 0.040
USP1 ubiquitin specific peptidase 1 0.039
RAD21 RAD21 homolog (S. pombe) 0.037
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.037
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.036
SLBP stem-loop binding protein 0.035
SUZ12 suppressor of zeste 12 homolog (Drosophila) 0.035
CREB1 cAMP responsive element binding protein 1 0.034
INO80B INO80 complex subunit B 0.034
RSF1 remodeling and spacing factor 1 0.033
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 0.032
RUVBL2 RuvB-like 2 (E. coli) 0.032
H2AFZ H2A histone family, member Z 0.031
FBL fibrillarin 0.030
DUT deoxyuridine triphosphatase 0.030
YAF2 YY1 associated factor 2 0.029
RRM1 ribonucleotide reductase M1 0.029
PRMT1 protein arginine methyltransferase 1 0.028
PPIH peptidylprolyl isomerase H (cyclophilin H) 0.028
HMGN2 high mobility group nucleosomal binding domain 2 0.028
MAX MYC associated factor X 0.027
FOXM1 forkhead box M1 0.027
FBXW7 F-box and WD repeat domain containing 7 0.025
MCRS1 microspherule protein 1 0.025
ACTR6 ARP6 actin-related protein 6 homolog (yeast) 0.025
PRRC2C proline-rich coiled-coil 2C 0.024
TLK2 tousled-like kinase 2 0.023
ZNF267 zinc finger protein 267 0.023
TOP1 topoisomerase (DNA) I 0.022
SUMO4 SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae) 0.022
NASP nuclear autoantigenic sperm protein (histone-binding) 0.022
PSIP1 PC4 and SFRS1 interacting protein 1 0.022
CBX1 chromobox homolog 1 0.021
UBN1 ubinuclein 1 0.021
FDFT1 farnesyl-diphosphate farnesyltransferase 1 0.021
BIN1 bridging integrator 1 0.021
KPNA6 karyopherin alpha 6 (importin alpha 7) 0.021
PRPS1 phosphoribosyl pyrophosphate synthetase 1 0.020
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia) 0.020
RBBP4 retinoblastoma binding protein 4 0.020
NRIP1 nuclear receptor interacting protein 1 0.020
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.020
SRP9 signal recognition particle 9kDa 0.019
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Mus musculus
Name Description Probability Func Analog Organism
Dmap1 DNA methyltransferase 1-associated protein 1 0.289
H3f3a H3 histone, family 3A 0.192
Esr1 estrogen receptor 1 (alpha) 0.064
Ep400 E1A binding protein p400 0.048
Kiss1 KiSS-1 metastasis-suppressor 0.047
Hmgb1 high mobility group box 1 0.039
Hist1h1c histone cluster 1, H1c 0.038
Pou5f1 POU domain, class 5, transcription factor 1 0.038
Kat5 K(lysine) acetyltransferase 5 0.038
Bglap bone gamma carboxyglutamate protein 0.034
Amhr2 anti-Mullerian hormone type 2 receptor 0.022
Cga glycoprotein hormones, alpha subunit 0.019
Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 0.018
Hist1h2br histone cluster 1 H2br 0.017
Pax8 paired box gene 8 0.013
Duox2 dual oxidase 2 0.012
Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.011
Hist1h2bp histone cluster 1, H2bp 0.011
Cdk1 cyclin-dependent kinase 1 0.011
H2afz H2A histone family, member Z 0.011
Baz1a bromodomain adjacent to zinc finger domain 1A 0.010
Max Max protein 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism