The network for 'endosome transport via multivesicular body sorting pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endosome transport via multivesicular body sorting pathway

The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
DID2 Did2p 0.823
VPS4 Vps4p 0.751
VPS21 Vps21p 0.600
YPT52 Ypt52p 0.455
MRS6 Mrs6p 0.428
SNF7 Snf7p 0.405
VPS60 Vps60p 0.394
PEP1 Pep1p 0.386
IST1 Ist1p 0.332
VPS24 Vps24p 0.315
GDI1 Gdi1p 0.261
YIP4 Yip4p 0.181
DID4 Did4p 0.177
YPT10 Ypt10p 0.160
VTA1 Vta1p 0.154
SRN2 Srn2p 0.152
VPS55 Vps55p 0.125
VPS68 Vps68p 0.110
CRZ1 Crz1p 0.106
YPT1 Ypt1p 0.100
YMR086W hypothetical protein 0.077
PEP8 Pep8p 0.077
NYV1 Nyv1p 0.072
VTI1 Vti1p 0.071
VPS28 Vps28p 0.069
YIP5 Yip5p 0.059
YOR111W hypothetical protein 0.059
BRO1 Bro1p 0.058
COG8 Cog8p 0.054
YPT6 Ypt6p 0.054
CSR2 Csr2p 0.051
SEC26 Sec26p 0.051
VPS17 Vps17p 0.051
VPS36 Vps36p 0.051
VPS3 Vps3p 0.049
RET3 Ret3p 0.045
APS1 Aps1p 0.044
ALY1 Aly1p 0.042
HAL5 Hal5p 0.039
RIM13 Rim13p 0.039
YER128W hypothetical protein 0.038
APM2 Apm2p 0.037
PKH2 Pkh2p 0.036
YKL023W hypothetical protein 0.035
SYN8 Syn8p 0.034
YMR258C hypothetical protein 0.033
TVP18 Tvp18p 0.033
HUR1 Hur1p 0.032
VPS27 Vps27p 0.031
END3 End3p 0.031
AZF1 Azf1p 0.031
PEP3 Pep3p 0.030
SNF8 Snf8p 0.029
SRD1 Srd1p 0.029
AOS1 Aos1p 0.028
LEU2 Leu2p 0.028
ALY2 Aly2p 0.028
YLR162W hypothetical protein 0.027
COP1 Cop1p 0.027
YOL038C-A hypothetical protein 0.027
YLR264C-A hypothetical protein 0.027
TOK1 Tok1p 0.027
CAD1 Cad1p 0.026
RAV2 Rav2p 0.025
SAP30 Sap30p 0.025
PAM1 Pam1p 0.024
MER1 Mer1p 0.024
YPL150W hypothetical protein 0.024
MDH2 Mdh2p 0.024
MVP1 Mvp1p 0.024
ARP10 Arp10p 0.024
PAR32 Par32p 0.024
SSP1 Ssp1p 0.023
YPR091C hypothetical protein 0.023
PGM3 Pgm3p 0.023
YJL055W hypothetical protein 0.023
DAP1 Dap1p 0.023
PCL9 Pcl9p 0.023
RIM20 Rim20p 0.023
CUP1-1 Cup1-1p 0.022
EMP47 Emp47p 0.022
ARG8 Arg8p 0.022
YLR042C hypothetical protein 0.022
YAR068W hypothetical protein 0.022
HDA2 Hda2p 0.021
HPF1 Hpf1p 0.021
ADE16 Ade16p 0.021
YIR035C hypothetical protein 0.021
YMR087W hypothetical protein 0.021
YTA6 Yta6p 0.021
TGL1 Tgl1p 0.021
CAM1 Cam1p 0.021
ATP6 Atp6p 0.021
PTI1 Pti1p 0.021
OPT2 Opt2p 0.021
EAR1 Ear1p 0.021
PUF2 Puf2p 0.021
URA3 Ura3p 0.020
ZPS1 Zps1p 0.020
EIS1 Eis1p 0.020
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Rab7 Rab-protein 7 0.994
Vps25 Vacuolar protein sorting 25 0.991
lsn larsen 0.975
vps24 Charged multivesicular body protein 3 0.906
Rab5 Rab-protein 5 0.849
Hrs Hepatocyte growth factor regulated tyrosine kinase substrate 0.798
vps2 CG14542 gene product from transcript CG14542-RA 0.590
Vps36 Vacuolar protein sorting 36 0.564
TSG101 tumor suppressor protein 101 0.324
Vps20 Vacuolar protein sorting 20 0.307
RhoL rho-like 0.297
CG10103 CG10103 gene product from transcript CG10103-RA 0.242
CHMP2B Charged multivesicular body protein 2b 0.190
Sop2 Suppressor of profilin 2 0.174
Vps28 Vacuolar protein sorting 28 0.167
Pi3K59F Phosphotidylinositol 3 kinase 59F 0.159
slik Sterile20-like kinase 0.142
Vps4 Vacuolar protein sorting 4 0.080
PHGPx CG12013 gene product from transcript CG12013-RC 0.067
Xbp1 X box binding protein-1 0.058
betaCop beta-coatomer protein 0.058
Chmp1 CG4108 gene product from transcript CG4108-RA 0.043
shrb shrub 0.043
Syx7 Syntaxin 7 0.042
rhea CG6831 gene product from transcript CG6831-RA 0.037
CG1572 CG1572 gene product from transcript CG1572-RA 0.030
Xrp1 CG17836 gene product from transcript CG17836-RB 0.030
CG10277 CG10277 gene product from transcript CG10277-RB 0.028
CG6259 CG6259 gene product from transcript CG6259-RA 0.023
Stam Signal transducing adaptor molecule 0.021
lqf liquid facets 0.021
Rheb CG1081 gene product from transcript CG1081-RA 0.020
CG4699 CG4699 gene product from transcript CG4699-RJ 0.020
atl atlastin 0.019
Dlic Dynein light intermediate chain 0.018
fab1 CG6355 gene product from transcript CG6355-RA 0.017
CG11009 CG11009 gene product from transcript CG11009-RB 0.017
CG8839 CG8839 gene product from transcript CG8839-RA 0.015
alphaCop alpha-coatomer protein 0.014
CG13117 CG13117 gene product from transcript CG13117-RA 0.014
eIF-1A Eukaryotic initiation factor 1A 0.013
Atg8a Autophagy-specific gene 8a 0.013
Psn Presenilin 0.012
Rab2 Rab-protein 2 0.012
Prp38 pre-mRNA processing factor 38 0.011
Rab14 Rab-protein 14 0.011
CycG Cyclin G 0.011
skd skuld 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
PDCD6IP programmed cell death 6 interacting protein 0.996
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.979
RNF11 ring finger protein 11 0.955
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 0.940
TSG101 tumor susceptibility gene 101 0.927
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2 0.917
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.837
ARCN1 archain 1 0.832
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.729
CALCOCO2 calcium binding and coiled-coil domain 2 0.673
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.645
CHMP4B chromatin modifying protein 4B 0.610
SYNRG synergin, gamma 0.554
SNF8 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) 0.553
STAMBP STAM binding protein 0.518
SMAD1 SMAD family member 1 0.515
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.479
SMAD4 SMAD family member 4 0.477
CHMP1A chromatin modifying protein 1A 0.466
ZFYVE9 zinc finger, FYVE domain containing 9 0.457
SH3GL2 SH3-domain GRB2-like 2 0.378
SMAD5 SMAD family member 5 0.355
SH3KBP1 SH3-domain kinase binding protein 1 0.345
FBXL15 F-box and leucine-rich repeat protein 15 0.294
SORT1 sortilin 1 0.292
COPB1 coatomer protein complex, subunit beta 1 0.291
ANKRD13A ankyrin repeat domain 13A 0.277
CD2AP CD2-associated protein 0.263
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.263
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.259
RABEP1 rabaptin, RAB GTPase binding effector protein 1 0.255
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.253
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 0.237
PDCD6 programmed cell death 6 0.230
RHOA ras homolog gene family, member A 0.184
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.153
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 0.143
NBR1 neighbor of BRCA1 gene 1 0.134
EEA1 early endosome antigen 1 0.131
SNX9 sorting nexin 9 0.131
LRRK2 leucine-rich repeat kinase 2 0.127
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.113
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.113
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 0.112
IGF2R insulin-like growth factor 2 receptor 0.111
SCNN1B sodium channel, nonvoltage-gated 1, beta 0.107
SPG20 spastic paraplegia 20 (Troyer syndrome) 0.093
SMAD7 SMAD family member 7 0.092
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) 0.088
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.084
C1orf93 chromosome 1 open reading frame 93 0.080
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.078
RAB6A RAB6A, member RAS oncogene family 0.077
DNM2 dynamin 2 0.076
CXXC5 CXXC finger protein 5 0.074
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.070
PTPN23 protein tyrosine phosphatase, non-receptor type 23 0.068
ELL elongation factor RNA polymerase II 0.067
DAZAP2 DAZ associated protein 2 0.058
ING2 inhibitor of growth family, member 2 0.057
EPS15 epidermal growth factor receptor pathway substrate 15 0.056
RAB22A RAB22A, member RAS oncogene family 0.055
OCRL oculocerebrorenal syndrome of Lowe 0.050
SGK3 serum/glucocorticoid regulated kinase family, member 3 0.048
TOM1L1 target of myb1 (chicken)-like 1 0.045
APIP APAF1 interacting protein 0.044
RAB5A RAB5A, member RAS oncogene family 0.044
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 0.042
PLEKHO1 pleckstrin homology domain containing, family O member 1 0.041
CARD11 caspase recruitment domain family, member 11 0.041
POU5F1 POU class 5 homeobox 1 0.038
TRAF4 TNF receptor-associated factor 4 0.038
VPS24 vacuolar protein sorting 24 homolog (S. cerevisiae) 0.037
CHMP6 chromatin modifying protein 6 0.037
MED15 mediator complex subunit 15 0.036
SCNN1A sodium channel, nonvoltage-gated 1 alpha 0.035
DTX1 deltex homolog 1 (Drosophila) 0.034
COPA coatomer protein complex, subunit alpha 0.033
ZRANB1 zinc finger, RAN-binding domain containing 1 0.033
SMAD6 SMAD family member 6 0.031
GOLGA5 golgin A5 0.031
NDFIP2 Nedd4 family interacting protein 2 0.031
ADRBK1 adrenergic, beta, receptor kinase 1 0.031
KRT15 keratin 15 0.030
KLF5 Kruppel-like factor 5 (intestinal) 0.029
UBQLN2 ubiquilin 2 0.029
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.029
YAP1 Yes-associated protein 1 0.029
EIF1B eukaryotic translation initiation factor 1B 0.028
CCDC127 coiled-coil domain containing 127 0.028
EXOC7 exocyst complex component 7 0.027
WNK1 WNK lysine deficient protein kinase 1 0.027
ZFAND5 zinc finger, AN1-type domain 5 0.027
CLTC clathrin, heavy chain (Hc) 0.026
ARRDC3 arrestin domain containing 3 0.026
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.026
SBF1 SET binding factor 1 0.025
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 0.025
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.025
CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c 0.025
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism