The network for 'postreplication repair' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

postreplication repair

The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RAD5 Rad5p 0.951
REV1 Rev1p 0.859
REV7 Rev7p 0.857
POL2 Pol2p 0.776
POL3 Pol3p 0.526
UBC13 Ubc13p 0.490
POL30 Pol30p 0.458
MSH6 Msh6p 0.437
REV3 Rev3p 0.404
RAD9 Rad9p 0.385
HTB2 Htb2p 0.372
PIF1 Pif1p 0.267
SMC6 Smc6p 0.240
MSH3 Msh3p 0.235
RAD18 Rad18p 0.223
PMS1 Pms1p 0.217
SHU1 Shu1p 0.193
RAD1 Rad1p 0.162
DPB2 Dpb2p 0.157
POL32 Pol32p 0.152
RAD17 Rad17p 0.140
POL12 Pol12p 0.135
RAD24 Rad24p 0.133
HTA1 Hta1p 0.111
CDC9 Cdc9p 0.108
HTB1 Htb1p 0.096
RAD30 Rad30p 0.094
SIZ1 Siz1p 0.091
MMS21 Mms21p 0.089
RNH203 Rnh203p 0.088
NSE4 Nse4p 0.085
MGS1 Mgs1p 0.083
HHF2 Hhf2p 0.082
DUN1 Dun1p 0.077
MEX67 Mex67p 0.072
UBA1 Uba1p 0.071
CSM2 Csm2p 0.064
RFC2 Rfc2p 0.057
DPB3 Dpb3p 0.057
XRS2 Xrs2p 0.048
HHT2 Hht2p 0.048
TAF4 Taf4p 0.047
PAN2 Pan2p 0.047
ORC6 Orc6p 0.045
DDC1 Ddc1p 0.045
RFA3 Rfa3p 0.043
RAD55 Rad55p 0.043
SDC1 Sdc1p 0.041
SRD1 Srd1p 0.040
TIF4632 Tif4632p 0.040
NRD1 Nrd1p 0.040
RAD27 Rad27p 0.040
HOR2 Hor2p 0.040
URA3 Ura3p 0.040
YLR264C-A hypothetical protein 0.039
IBD2 Ibd2p 0.038
YHR127W hypothetical protein 0.038
PBP1 Pbp1p 0.036
RAD54 Rad54p 0.036
YOL038C-A hypothetical protein 0.035
DLS1 Dls1p 0.035
PRS2 Prs2p 0.035
MER1 Mer1p 0.035
SEM1 Sem1p 0.035
MGT1 Mgt1p 0.034
APN1 Apn1p 0.034
SMC5 Smc5p 0.034
CRP1 Crp1p 0.033
RAD59 Rad59p 0.033
SLN1 Sln1p 0.033
LEU2 Leu2p 0.033
TFG2 Tfg2p 0.032
YAR068W hypothetical protein 0.032
RTT107 Rtt107p 0.032
YLR162W hypothetical protein 0.032
SWC7 Swc7p 0.032
NTG2 Ntg2p 0.031
HDA2 Hda2p 0.031
HXT3 Hxt3p 0.031
RDH54 Rdh54p 0.030
EXO1 Exo1p 0.030
PRE2 Pre2p 0.029
APN2 Apn2p 0.029
HO Hop 0.029
HLR1 Hlr1p 0.028
WSS1 Wss1p 0.028
YIR035C hypothetical protein 0.028
SHU2 Shu2p 0.028
RPB11 Rpb11p 0.027
YLR042C hypothetical protein 0.027
ARO9 Aro9p 0.027
ARP10 Arp10p 0.026
EST2 Est2p 0.026
ATP6 Atp6p 0.026
YBR013C hypothetical protein 0.026
SPT5 Spt5p 0.025
SKG6 Skg6p 0.025
RAD10 Rad10p 0.025
CUP1-1 Cup1-1p 0.025
RPB3 Rpb3p 0.025
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
mus205 mutagen-sensitive 205 0.744
rad50 CG6339 gene product from transcript CG6339-RD 0.666
mus210 mutagen-sensitive 210 0.551
mus101 mutagen-sensitive 101 0.508
hay haywire 0.484
RecQ5 homolog of RecQ 0.415
CG5524 CG5524 gene product from transcript CG5524-RA 0.414
mus308 mutagen-sensitive 308 0.398
lok loki 0.309
Brca2 Breast cancer 2, early onset homolog 0.214
mus201 mutagen-sensitive 201 0.198
mei-9 meiotic 9 0.180
DNApol-eta CG7143 gene product from transcript CG7143-RA 0.178
nbs CG6754 gene product from transcript CG6754-RC 0.156
nopo no poles 0.102
okr okra 0.091
Irbp Inverted repeat-binding protein 0.088
Smc5 CG32438 gene product from transcript CG32438-RE 0.072
mre11 meiotic recombination 11 0.071
Mcm3 Minichromosome maintenance 3 0.068
cnk connector enhancer of ksr 0.065
mus309 mutagen-sensitive 309 0.064
pie pineapple eye 0.061
mus304 mutagen-sensitive 304 0.059
sno strawberry notch 0.047
Rev1 CG12189 gene product from transcript CG12189-RA 0.045
barr barren 0.042
fzy fizzy 0.039
Chrac-14 CG13399 gene product from transcript CG13399-RA 0.036
wds will die slowly 0.036
dmt dalmatian 0.034
mei-41 meiotic 41 0.032
RecQ4 CG7487 gene product from transcript CG7487-RA 0.032
mus301 mutagen-sensitive 301 0.031
RnrL Ribonucleoside diphosphate reductase large subunit 0.029
Ercc1 CG10215 gene product from transcript CG10215-RA 0.029
tefu telomere fusion 0.029
mus312 mutagen-sensitive 312 0.026
Mcm7 Minichromosome maintenance 7 0.025
stnA stoned A 0.024
stwl stonewall 0.023
CG7376 CG7376 gene product from transcript CG7376-RA 0.022
CDC45L CG3658 gene product from transcript CG3658-RA 0.021
spn-A spindle A 0.021
dpa disc proliferation abnormal 0.021
CG5174 CG5174 gene product from transcript CG5174-RM 0.021
dre4 CG1828 gene product from transcript CG1828-RB 0.020
Lig4 Ligase4 0.019
CG5931 CG5931 gene product from transcript CG5931-RA 0.019
Ace Acetylcholine esterase 0.018
nod no distributive disjunction 0.017
Su(z)2 Suppressor of zeste 2 0.017
egh egghead 0.017
lt light 0.017
CG3975 CG3975 gene product from transcript CG3975-RA 0.016
phr photorepair 0.016
Klp61F Kinesin-like protein at 61F 0.016
Df31 Decondensation factor 31 0.016
CG4680 CG4680 gene product from transcript CG4680-RA 0.015
ari-1 ariadne 0.015
Orc5 Origin recognition complex subunit 5 0.015
cav caravaggio 0.015
l(1)G0222 lethal (1) G0222 0.014
fdl fused lobes 0.014
Orc2 Origin recognition complex subunit 2 0.014
Nipped-A CG33554 gene product from transcript CG33554-RE 0.013
CG14814 CG14814 gene product from transcript CG14814-RA 0.013
Smg6 CG6369 gene product from transcript CG6369-RA 0.013
Cks30A Cyclin-dependent kinase subunit 30A 0.013
Spc105R Spc105-related 0.013
CG13350 CG13350 gene product from transcript CG13350-RA 0.012
Pcaf CG4107 gene product from transcript CG4107-RA 0.012
RpA-70 Replication Protein A 70 0.012
Dp1 Dodeca-satellite-binding protein 1 0.012
alph alphabet 0.012
CG11414 CG11414 gene product from transcript CG11414-RA 0.012
Mnn1 Menin 1 0.012
spn-B spindle B 0.011
CG9776 CG9776 gene product from transcript CG9776-RA 0.011
eIF-1A Eukaryotic initiation factor 1A 0.011
Fkbp13 CG9847 gene product from transcript CG9847-RC 0.011
mu2 mutator 2 0.011
CG9576 CG9576 gene product from transcript CG9576-RA 0.011
capt capulet 0.011
eIF3-S8 CG4954 gene product from transcript CG4954-RA 0.011
cmet CENP-meta 0.011
ogre optic ganglion reduced 0.010
pav pavarotti 0.010
ncd non-claret disjunctional 0.010
SMC2 CG10212 gene product from transcript CG10212-RA 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
HIST1H2BD histone cluster 1, H2bd 1.000
HIST1H2BF histone cluster 1, H2bf 1.000
HIST1H2BE histone cluster 1, H2be 1.000
RAD18 RAD18 homolog (S. cerevisiae) 0.998
HIST1H1C histone cluster 1, H1c 0.998
PCNA proliferating cell nuclear antigen 0.997
HIST1H2BH histone cluster 1, H2bh 0.997
HIST1H2AC histone cluster 1, H2ac 0.997
HIST1H2BG histone cluster 1, H2bg 0.996
HIST1H2BI histone cluster 1, H2bi 0.994
HIST1H3D histone cluster 1, H3d 0.989
HIST1H2BK histone cluster 1, H2bk 0.987
HIST1H2BC histone cluster 1, H2bc 0.979
HIST2H2AA4 histone cluster 2, H2aa4 0.969
POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit) 0.959
POLH polymerase (DNA directed), eta 0.951
HIST1H2AE histone cluster 1, H2ae 0.880
HIST2H2BE histone cluster 2, H2be 0.795
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.739
HIST1H2AJ histone cluster 1, H2aj 0.674
MSH6 mutS homolog 6 (E. coli) 0.527
FANCD2 Fanconi anemia, complementation group D2 0.411
REV1 REV1 homolog (S. cerevisiae) 0.306
HIST1H2AI histone cluster 1, H2ai 0.305
HIST1H3H histone cluster 1, H3h 0.287
POLI polymerase (DNA directed) iota 0.215
HIST1H4H histone cluster 1, H4h 0.156
PABPC1 poly(A) binding protein, cytoplasmic 1 0.156
DZIP3 DAZ interacting protein 3, zinc finger 0.154
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.150
PAN3 PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) 0.129
RPA3 replication protein A3, 14kDa 0.127
WRN Werner syndrome, RecQ helicase-like 0.122
HIST1H2AG histone cluster 1, H2ag 0.120
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 125kDa 0.112
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.111
POLE2 polymerase (DNA directed), epsilon 2 (p59 subunit) 0.089
ING2 inhibitor of growth family, member 2 0.086
HIST1H2AM histone cluster 1, H2am 0.079
H2AFX H2A histone family, member X 0.076
RBBP8 retinoblastoma binding protein 8 0.073
ERCC6 excision repair cross-complementing rodent repair deficiency, complementation group 6 0.063
PAN2 PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) 0.061
REV3L REV3-like, catalytic subunit of DNA polymerase zeta (yeast) 0.059
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 0.059
RNF11 ring finger protein 11 0.051
POLK polymerase (DNA directed) kappa 0.049
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 0.048
HIST1H3G histone cluster 1, H3g 0.047
GINS2 GINS complex subunit 2 (Psf2 homolog) 0.044
HIST1H2BJ histone cluster 1, H2bj 0.044
HIST1H2BB histone cluster 1, H2bb 0.042
CHRAC1 chromatin accessibility complex 1 0.041
RAD51AP1 RAD51 associated protein 1 0.037
MSH3 mutS homolog 3 (E. coli) 0.036
ATXN3 ataxin 3 0.032
HIST1H2BM histone cluster 1, H2bm 0.032
TNRC6B trinucleotide repeat containing 6B 0.031
TNRC6A trinucleotide repeat containing 6A 0.031
HIST1H2BO histone cluster 1, H2bo 0.029
HIST1H2AB histone cluster 1, H2ab 0.029
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.029
EXO1 exonuclease 1 0.028
GINS1 GINS complex subunit 1 (Psf1 homolog) 0.028
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 0.027
MLH1 mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) 0.026
UBE2N ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) 0.026
CDK5RAP3 CDK5 regulatory subunit associated protein 3 0.026
SHPRH SNF2 histone linker PHD RING helicase 0.021
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 0.021
HIST1H4D histone cluster 1, H4d 0.021
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.020
ZNRF1 zinc and ring finger 1 0.019
ANKRD32 ankyrin repeat domain 32 0.019
CLSPN claspin 0.019
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae) 0.018
HIST1H2AL histone cluster 1, H2al 0.018
HIST1H4E histone cluster 1, H4e 0.017
RAD50 RAD50 homolog (S. cerevisiae) 0.016
MARCH5 membrane-associated ring finger (C3HC4) 5 0.015
HIST2H2AA3 histone cluster 2, H2aa3 0.015
HIST1H1E histone cluster 1, H1e 0.015
CALCOCO2 calcium binding and coiled-coil domain 2 0.015
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.015
RNF168 ring finger protein 168 0.014
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.014
PAIP2 poly(A) binding protein interacting protein 2 0.014
TIMELESS timeless homolog (Drosophila) 0.014
WWOX WW domain containing oxidoreductase 0.013
POLE4 polymerase (DNA-directed), epsilon 4 (p12 subunit) 0.012
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.012
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.012
CBWD2 COBW domain containing 2 0.012
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.012
HIST2H4B histone cluster 2, H4b 0.012
XAB2 XPA binding protein 2 0.012
HIST1H3A histone cluster 1, H3a 0.011
HIST1H1D histone cluster 1, H1d 0.011
PFN1 profilin 1 0.011
PCGF6 polycomb group ring finger 6 0.011
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Mus musculus
Name Description Probability Func Analog Organism
Rev1 REV1 homolog (S. cerevisiae) 0.835
Nbn nibrin 0.524
Brca2 breast cancer 2 0.501
Polh polymerase (DNA directed), eta (RAD 30 related) 0.111
Stk11 serine/threonine kinase 11 0.094
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.091
Hprt hypoxanthine guanine phosphoribosyl transferase 0.075
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.072
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.064
Trp53 transformation related protein 53 0.058
Timeless timeless homolog (Drosophila) 0.046
Rb1 retinoblastoma 1 0.041
Atr ataxia telangiectasia and Rad3 related 0.035
Ube2d3 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 0.032
Mdm2 transformed mouse 3T3 cell double minute 2 0.032
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.028
Brca1 breast cancer 1 0.028
Polk polymerase (DNA directed), kappa 0.027
Atm ataxia telangiectasia mutated homolog (human) 0.027
Apc adenomatosis polyposis coli 0.025
Nsfl1c NSFL1 (p97) cofactor (p47) 0.023
Chek1 checkpoint kinase 1 homolog (S. pombe) 0.023
Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 0.021
Prkdc protein kinase, DNA activated, catalytic polypeptide 0.020
Ube2n ubiquitin-conjugating enzyme E2N 0.020
Poli polymerase (DNA directed), iota 0.018
E2f1 E2F transcription factor 1 0.018
Cdc7 cell division cycle 7 (S. cerevisiae) 0.012
Wdhd1 WD repeat and HMG-box DNA binding protein 1 0.012
Pask PAS domain containing serine/threonine kinase 0.012
Clk4 CDC like kinase 4 0.012
Ppp1ca protein phosphatase 1, catalytic subunit, alpha isoform 0.011
Ttk Ttk protein kinase 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism