The network for 'negative regulation of chromatin silencing' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of chromatin silencing

Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RXT2 Rxt2p 0.854
PHO23 Pho23p 0.736
CTI6 Cti6p 0.724
SIN3 Sin3p 0.706
UME1 Ume1p 0.704
HOS4 Hos4p 0.376
SAP30 Sap30p 0.360
NTO1 Nto1p 0.351
RNR2 Rnr2p 0.304
HHT1 Hht1p 0.265
HHO1 Hho1p 0.253
SNT1 Snt1p 0.245
SDS3 Sds3p 0.222
RAP1 Rap1p 0.158
NDD1 Ndd1p 0.146
EAF3 Eaf3p 0.143
RPD3 Rpd3p 0.143
HOS3 Hos3p 0.125
MIG2 Mig2p 0.123
SRP54 Srp54p 0.118
HDA2 Hda2p 0.118
SIR2 Sir2p 0.117
MCM3 Mcm3p 0.115
MOB1 Mob1p 0.111
IRC8 Irc8p 0.109
RCO1 Rco1p 0.108
SUM1 Sum1p 0.102
ASH1 Ash1p 0.100
FKH2 Fkh2p 0.091
CDC6 Cdc6p 0.088
SWI1 Swi1p 0.085
SET3 Set3p 0.083
OPI1 Opi1p 0.080
UME6 Ume6p 0.079
ROX1 Rox1p 0.078
CAF40 Caf40p 0.077
KIC1 Kic1p 0.077
RIM101 Rim101p 0.076
HXT3 Hxt3p 0.076
HOS2 Hos2p 0.069
YKR075C hypothetical protein 0.068
IXR1 Ixr1p 0.067
HST3 Hst3p 0.066
GLN3 Gln3p 0.066
DEF1 Def1p 0.064
RXT3 Rxt3p 0.061
GBP2 Gbp2p 0.061
HST1 Hst1p 0.060
YLR455W hypothetical protein 0.057
CYC8 Cyc8p 0.056
CSR2 Csr2p 0.055
MIG3 Mig3p 0.054
MRS6 Mrs6p 0.054
BUD4 Bud4p 0.053
VHS1 Vhs1p 0.052
CKA1 Cka1p 0.051
SGF73 Sgf73p 0.051
AFT1 Aft1p 0.050
AGP2 Agp2p 0.050
NRG1 Nrg1p 0.048
POP2 Pop2p 0.048
SPT8 Spt8p 0.047
CCT2 Cct2p 0.046
HHF2 Hhf2p 0.046
SNF5 Snf5p 0.045
ARP8 Arp8p 0.042
SWI6 Swi6p 0.042
HAL5 Hal5p 0.041
SIR4 Sir4p 0.041
STE4 Ste4p 0.039
TBS1 Tbs1p 0.039
SPT10 Spt10p 0.039
PRR2 Prr2p 0.038
PHM8 Phm8p 0.037
VAC17 Vac17p 0.037
TRA1 Tra1p 0.037
HO Hop 0.035
DED1 Ded1p 0.035
MTR10 Mtr10p 0.035
SWI5 Swi5p 0.034
CTK1 Ctk1p 0.034
AVT6 Avt6p 0.034
YPL014W hypothetical protein 0.034
RSC4 Rsc4p 0.034
CHD1 Chd1p 0.033
HFI1 Hfi1p 0.033
GCR2 Gcr2p 0.033
SFL1 Sfl1p 0.033
PMD1 Pmd1p 0.032
YLR278C hypothetical protein 0.032
HHT2 Hht2p 0.032
MSN4 Msn4p 0.032
YML082W hypothetical protein 0.032
PSR1 Psr1p 0.032
DOT6 Dot6p 0.031
CAT8 Cat8p 0.031
YOR390W hypothetical protein 0.030
GDH3 Gdh3p 0.029
UBP8 Ubp8p 0.029
CTK3 Ctk3p 0.029
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Chd1 Chromodomain-helicase-DNA-binding protein 1 0.457
Su(var)3-3 Suppressor of variegation 3-3 0.321
noi noisette 0.298
CTCF CG8591 gene product from transcript CG8591-RA 0.155
Hcf Host cell factor 0.133
msl-2 male-specific lethal 2 0.127
mod(mdg4) modifier of mdg4 0.122
lid little imaginal discs 0.116
msl-3 male-specific lethal 3 0.113
Su(var)3-7 Suppressor of variegation 3-7 0.099
Dp1 Dodeca-satellite-binding protein 1 0.098
mof males absent on the first 0.096
egg eggless 0.082
Sir2 CG5216 gene product from transcript CG5216-RA 0.080
ash1 absent, small, or homeotic discs 1 0.079
Scm Sex comb on midleg 0.072
cg combgap 0.058
brm brahma 0.057
Su(z)2 Suppressor of zeste 2 0.056
msl-1 male-specific lethal 1 0.051
dome domeless 0.049
Pc Polycomb 0.048
Pcaf CG4107 gene product from transcript CG4107-RA 0.042
Rga Regena 0.038
Pk61C Protein kinase 61C 0.030
mle maleless 0.029
JIL-1 CG6297 gene product from transcript CG6297-RA 0.027
tna tonalli 0.027
Sxl Sex lethal 0.024
trx trithorax 0.024
Snr1 Snf5-related 1 0.023
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.022
bin3 bicoid-interacting protein 3 0.022
Rsf1 Repressor splicing factor 1 0.019
MRG15 CG6363 gene product from transcript CG6363-RA 0.019
sina seven in absentia 0.019
lok loki 0.017
mip130 Myb-interacting protein 130 0.017
CG4119 CG4119 gene product from transcript CG4119-RA 0.016
polybromo CG11375 gene product from transcript CG11375-RA 0.016
pzg putzig 0.016
D1 D1 chromosomal protein 0.015
bon bonus 0.015
Slbp Stem-loop binding protein 0.015
snf sans fille 0.015
dalao CG7055 gene product from transcript CG7055-RA 0.014
CG8436 CG8436 gene product from transcript CG8436-RA 0.014
E(var)3-9 Enhancer of variegation 3-9 0.014
Hr39 Hormone receptor-like in 39 0.014
CG5591 CG5591 gene product from transcript CG5591-RA 0.013
Hdac3 Histone deacetylase 3 0.013
CG1622 CG1622 gene product from transcript CG1622-RA 0.012
rin rasputin 0.012
sxc super sex combs 0.012
z zeste 0.012
ast asteroid 0.011
wapl wings apart-like 0.011
Mcm3 Minichromosome maintenance 3 0.011
simj simjang 0.011
CG11504 CG11504 gene product from transcript CG11504-RB 0.010
wech CG42396 gene product from transcript CG42396-RC 0.010
CG10153 CG10153 gene product from transcript CG10153-RA 0.010
esc extra sexcombs 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 1.000
PBRM1 polybromo 1 0.998
HDAC1 histone deacetylase 1 0.997
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.993
ARID1A AT rich interactive domain 1A (SWI-like) 0.991
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.986
NCOR1 nuclear receptor corepressor 1 0.981
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.977
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0.972
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.959
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 0.945
DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 0.872
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.861
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.859
EP300 E1A binding protein p300 0.828
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.750
BCOR BCL6 corepressor 0.746
CREBBP CREB binding protein 0.692
NR2E3 nuclear receptor subfamily 2, group E, member 3 0.621
SP1 Sp1 transcription factor 0.612
NCOR2 nuclear receptor corepressor 2 0.600
RBBP4 retinoblastoma binding protein 4 0.472
BCL6 B-cell CLL/lymphoma 6 0.469
SAP30 Sin3A-associated protein, 30kDa 0.466
HCFC1 host cell factor C1 (VP16-accessory protein) 0.458
RBBP7 retinoblastoma binding protein 7 0.451
SKI v-ski sarcoma viral oncogene homolog (avian) 0.429
SMAD3 SMAD family member 3 0.357
RB1 retinoblastoma 1 0.303
CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae) 0.273
CHD4 chromodomain helicase DNA binding protein 4 0.240
MCM7 minichromosome maintenance complex component 7 0.201
ARID1B AT rich interactive domain 1B (SWI1-like) 0.172
MAPK14 mitogen-activated protein kinase 14 0.153
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.133
MSL2 male-specific lethal 2 homolog (Drosophila) 0.118
HDAC2 histone deacetylase 2 0.118
SETD2 SET domain containing 2 0.113
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.098
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.092
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.091
RCOR1 REST corepressor 1 0.087
LIG1 ligase I, DNA, ATP-dependent 0.085
NCOA3 nuclear receptor coactivator 3 0.084
PHF12 PHD finger protein 12 0.080
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.077
TRIM33 tripartite motif containing 33 0.076
NONO non-POU domain containing, octamer-binding 0.074
CHD7 chromodomain helicase DNA binding protein 7 0.073
SMAD1 SMAD family member 1 0.071
BRD1 bromodomain containing 1 0.069
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.069
SPEN spen homolog, transcriptional regulator (Drosophila) 0.069
MED13L mediator complex subunit 13-like 0.068
HDAC3 histone deacetylase 3 0.068
ING2 inhibitor of growth family, member 2 0.066
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.065
ESR1 estrogen receptor 1 0.064
HDAC4 histone deacetylase 4 0.059
MECP2 methyl CpG binding protein 2 (Rett syndrome) 0.053
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.052
CARM1 coactivator-associated arginine methyltransferase 1 0.051
SAP30L SAP30-like 0.050
MLL myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.049
ADRBK1 adrenergic, beta, receptor kinase 1 0.048
BRWD1 bromodomain and WD repeat domain containing 1 0.047
WHSC1 Wolf-Hirschhorn syndrome candidate 1 0.046
ZNF512B zinc finger protein 512B 0.046
TRAF4 TNF receptor-associated factor 4 0.042
CDK9 cyclin-dependent kinase 9 0.040
RBL1 retinoblastoma-like 1 (p107) 0.039
PRC1 protein regulator of cytokinesis 1 0.039
PPARA peroxisome proliferator-activated receptor alpha 0.038
RNF19A ring finger protein 19A 0.038
NQO1 NAD(P)H dehydrogenase, quinone 1 0.038
MAPK3 mitogen-activated protein kinase 3 0.038
NCOA1 nuclear receptor coactivator 1 0.036
SFPQ splicing factor proline/glutamine-rich 0.035
HIPK2 homeodomain interacting protein kinase 2 0.033
SMAD7 SMAD family member 7 0.033
THAP11 THAP domain containing 11 0.031
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 0.031
SKIL SKI-like oncogene 0.031
MASTL microtubule associated serine/threonine kinase-like 0.030
RSBN1 round spermatid basic protein 1 0.030
HDAC6 histone deacetylase 6 0.029
SIRT1 sirtuin 1 0.029
KIAA1267 KIAA1267 0.028
MYST3 MYST histone acetyltransferase (monocytic leukemia) 3 0.028
ZMYM2 zinc finger, MYM-type 2 0.028
SETD7 SET domain containing (lysine methyltransferase) 7 0.027
PABPN1 poly(A) binding protein, nuclear 1 0.027
CEP350 centrosomal protein 350kDa 0.026
TRRAP transformation/transcription domain-associated protein 0.026
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.025
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 0.024
YY1 YY1 transcription factor 0.024
MYST1 MYST histone acetyltransferase 1 0.023
PRRC2C proline-rich coiled-coil 2C 0.023
PLEKHO1 pleckstrin homology domain containing, family O member 1 0.023
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Mus musculus
Name Description Probability Func Analog Organism
Arid1a AT rich interactive domain 1A (SWI-like) 0.996
Hdac1 histone deacetylase 1 0.870
Suds3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.816
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.798
Ncor1 nuclear receptor co-repressor 1 0.721
Hdac2 histone deacetylase 2 0.550
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.509
Mcm3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.502
Pum2 pumilio 2 (Drosophila) 0.481
Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.350
Arid2 AT rich interactive domain 2 (ARID, RFX-like) 0.235
Ep300 E1A binding protein p300 0.209
Sp1 trans-acting transcription factor 1 0.209
Mcm4 minichromosome maintenance deficient 4 homolog (S. cerevisiae) 0.189
Kdm5b lysine (K)-specific demethylase 5B 0.188
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.170
Hist1h2bc histone cluster 1, H2bc 0.162
Dnmt1 DNA methyltransferase (cytosine-5) 1 0.160
Mcm6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae) 0.155
Ctcf CCCTC-binding factor 0.151
Bod1l biorientation of chromosomes in cell division 1-like 0.135
Mcm7 minichromosome maintenance deficient 7 (S. cerevisiae) 0.128
Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.126
Tcf3 transcription factor 3 0.116
Cdt1 chromatin licensing and DNA replication factor 1 0.115
Nipbl Nipped-B homolog (Drosophila) 0.110
Sap25 sin3 associated polypeptide 0.108
Trp53 transformation related protein 53 0.103
Smad4 MAD homolog 4 (Drosophila) 0.099
Mll5 myeloid/lymphoid or mixed-lineage leukemia 5 0.095
Cdk2 cyclin-dependent kinase 2 0.093
Pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.087
Timeless timeless homolog (Drosophila) 0.084
Rnf220 ring finger protein 220 0.081
Racgap1 Rac GTPase-activating protein 1 0.080
Arhgdia Rho GDP dissociation inhibitor (GDI) alpha 0.071
Zfp292 zinc finger protein 292 0.068
Crebbp CREB binding protein 0.067
Lig1 ligase I, DNA, ATP-dependent 0.066
Yy1 YY1 transcription factor 0.062
Asxl1 additional sex combs like 1 (Drosophila) 0.062
Foxp1 forkhead box P1 0.061
Rrm2 ribonucleotide reductase M2 0.061
Ccna2 cyclin A2 0.061
Pbrm1 polybromo 1 0.058
Cnot6 CCR4-NOT transcription complex, subunit 6 0.054
Angel2 angel homolog 2 (Drosophila) 0.053
Rfc5 replication factor C (activator 1) 5 0.051
Nono non-POU-domain-containing, octamer binding protein 0.047
Rnf38 ring finger protein 38 0.047
Ncapg2 non-SMC condensin II complex, subunit G2 0.046
Prkd3 protein kinase D3 0.045
Nanog Nanog homeobox 0.043
Tk1 thymidine kinase 1 0.043
Rad54l RAD54 like (S. cerevisiae) 0.042
Mll1 myeloid/lymphoid or mixed-lineage leukemia 1 0.041
Rcor1 REST corepressor 1 0.041
Rrm1 ribonucleotide reductase M1 0.041
Rcc1 regulator of chromosome condensation 1 0.041
8430410K20Rik RIKEN cDNA 8430410K20 gene 0.038
Tet1 tet oncogene 1 0.038
Jarid2 jumonji, AT rich interactive domain 2 0.038
Zmym5 zinc finger, MYM-type 5 0.038
Pias1 protein inhibitor of activated STAT 1 0.037
Tcfcp2l1 transcription factor CP2-like 1 0.037
Hcfc1 host cell factor C1 0.035
Zmym4 zinc finger, MYM-type 4 0.035
Ncoa6 nuclear receptor coactivator 6 0.034
Rara retinoic acid receptor, alpha 0.034
Ccne1 cyclin E1 0.034
Pole polymerase (DNA directed), epsilon 0.034
Pou2f1 POU domain, class 2, transcription factor 1 0.034
Rpa2 replication protein A2 0.033
Fam76b family with sequence similarity 76, member B 0.032
Pum1 pumilio 1 (Drosophila) 0.032
Pou5f1 POU domain, class 5, transcription factor 1 0.031
Kdm1a lysine (K)-specific demethylase 1A 0.031
Smad1 MAD homolog 1 (Drosophila) 0.031
Gnb2 guanine nucleotide binding protein (G protein), beta 2 0.030
Gtf3c2 general transcription factor IIIC, polypeptide 2, beta 0.030
Atm ataxia telangiectasia mutated homolog (human) 0.030
Ss18 synovial sarcoma translocation, Chromosome 18 0.030
Nfatc3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.029
Sox2 SRY-box containing gene 2 0.029
Rad50 RAD50 homolog (S. cerevisiae) 0.029
Mecp2 methyl CpG binding protein 2 0.029
Chd4 chromodomain helicase DNA binding protein 4 0.028
Pld3 phospholipase D family, member 3 0.028
Msl1 male-specific lethal 1 homolog (Drosophila) 0.028
Fzr1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.027
Numa1 nuclear mitotic apparatus protein 1 0.027
Ylpm1 YLP motif containing 1 0.027
Ncapd3 non-SMC condensin II complex, subunit D3 0.027
Tmem115 transmembrane protein 115 0.027
Arid1b AT rich interactive domain 1B (SWI-like) 0.026
Tex264 testis expressed gene 264 0.026
Tmem131 transmembrane protein 131 0.026
Etv6 ets variant gene 6 (TEL oncogene) 0.025
Brd4 bromodomain containing 4 0.025
Mta2 metastasis-associated gene family, member 2 0.025
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Rattus norvegicus
Name Description Probability Func Analog Organism