The network for 'late endosome to vacuole transport' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

late endosome to vacuole transport

The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
VPS4 Vps4p 0.920
BRO1 Bro1p 0.846
IST1 Ist1p 0.789
VPS21 Vps21p 0.774
SNF7 Snf7p 0.763
DID2 Did2p 0.647
PEP5 Pep5p 0.520
VTA1 Vta1p 0.510
VPS24 Vps24p 0.478
VAM6 Vam6p 0.461
PEP3 Pep3p 0.427
SRN2 Srn2p 0.393
COG8 Cog8p 0.338
VPS17 Vps17p 0.325
VPS8 Vps8p 0.309
YKL023W hypothetical protein 0.308
VPS16 Vps16p 0.295
VPS33 Vps33p 0.276
OSH6 Osh6p 0.231
YPT52 Ypt52p 0.206
MYO5 Myo5p 0.187
VPS3 Vps3p 0.185
LSB1 Lsb1p 0.183
ATG14 Atg14p 0.170
PEP1 Pep1p 0.170
VPS38 Vps38p 0.165
VPS60 Vps60p 0.163
VAM7 Vam7p 0.162
VPS28 Vps28p 0.161
MVP1 Mvp1p 0.157
BBC1 Bbc1p 0.156
PIN3 Pin3p 0.117
HSE1 Hse1p 0.110
HSV2 Hsv2p 0.109
YPT1 Ypt1p 0.106
VTI1 Vti1p 0.105
VPS30 Vps30p 0.092
GDI1 Gdi1p 0.089
RAV1 Rav1p 0.088
OSH7 Osh7p 0.084
YPT10 Ypt10p 0.079
YTA6 Yta6p 0.076
MRS6 Mrs6p 0.064
APM2 Apm2p 0.061
CHS5 Chs5p 0.061
INP53 Inp53p 0.059
VPS5 Vps5p 0.059
APL5 Apl5p 0.059
YMR1 Ymr1p 0.058
YER128W hypothetical protein 0.058
YPR091C hypothetical protein 0.057
PEP8 Pep8p 0.056
HUR1 Hur1p 0.053
HAL5 Hal5p 0.053
VPS36 Vps36p 0.053
AZF1 Azf1p 0.051
MTC4 Mtc4p 0.050
PAR32 Par32p 0.048
MON1 Mon1p 0.048
APL4 Apl4p 0.047
GYL1 Gyl1p 0.046
SEC26 Sec26p 0.046
VPS41 Vps41p 0.044
CRZ1 Crz1p 0.044
VPS34 Vps34p 0.044
MON2 Mon2p 0.043
TGL4 Tgl4p 0.043
CSR2 Csr2p 0.042
YMR087W hypothetical protein 0.042
SRD1 Srd1p 0.041
EAP1 Eap1p 0.041
YOL038C-A hypothetical protein 0.040
ART5 Art5p 0.040
ABP1 Abp1p 0.040
YMR086W hypothetical protein 0.039
RHO1 Rho1p 0.038
YOL087C hypothetical protein 0.038
MDH2 Mdh2p 0.038
YLR422W hypothetical protein 0.038
SYN8 Syn8p 0.037
ALY1 Aly1p 0.037
LEU2 Leu2p 0.037
RVS167 Rvs167p 0.036
HSP30 Hsp30p 0.036
COT1 Cot1p 0.036
ARP10 Arp10p 0.036
YLR264C-A hypothetical protein 0.036
YLR162W hypothetical protein 0.035
NRG1 Nrg1p 0.035
SAP30 Sap30p 0.035
STB3 Stb3p 0.034
ARG8 Arg8p 0.034
YJL218W hypothetical protein 0.034
MF(ALPHA)2 Mf(alpha)2p 0.034
FAA2 Faa2p 0.034
YSC84 Ysc84p 0.034
YIR014W hypothetical protein 0.034
OPT2 Opt2p 0.034
NYV1 Nyv1p 0.033
MF(ALPHA)1 Mf(alpha)1p 0.033
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
MON1B MON1 homolog B (yeast) 0.935
CHMP1A chromatin modifying protein 1A 0.680
PDCD6IP programmed cell death 6 interacting protein 0.672
CALCOCO2 calcium binding and coiled-coil domain 2 0.539
ARCN1 archain 1 0.499
COPA coatomer protein complex, subunit alpha 0.492
FBXL15 F-box and leucine-rich repeat protein 15 0.452
COPB1 coatomer protein complex, subunit beta 1 0.428
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.326
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.316
ANKRD13A ankyrin repeat domain 13A 0.314
CHMP4B chromatin modifying protein 4B 0.313
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) 0.279
OCRL oculocerebrorenal syndrome of Lowe 0.273
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.263
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.235
SMAD4 SMAD family member 4 0.224
EEA1 early endosome antigen 1 0.210
ARRB2 arrestin, beta 2 0.195
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.190
EPS15 epidermal growth factor receptor pathway substrate 15 0.179
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.163
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) 0.132
ZFYVE9 zinc finger, FYVE domain containing 9 0.105
DEDD death effector domain containing 0.097
SMAD1 SMAD family member 1 0.087
COPG coatomer protein complex, subunit gamma 0.081
LRRK2 leucine-rich repeat kinase 2 0.077
CARD11 caspase recruitment domain family, member 11 0.076
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.072
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) 0.065
CXXC5 CXXC finger protein 5 0.065
SOX7 SRY (sex determining region Y)-box 7 0.062
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.060
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 0.060
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.056
PDCD6 programmed cell death 6 0.055
SPG20 spastic paraplegia 20 (Troyer syndrome) 0.052
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.052
WWP1 WW domain containing E3 ubiquitin protein ligase 1 0.052
TDP2 tyrosyl-DNA phosphodiesterase 2 0.051
TRIM37 tripartite motif containing 37 0.050
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae) 0.046
RNF11 ring finger protein 11 0.045
SCNN1B sodium channel, nonvoltage-gated 1, beta 0.044
ING2 inhibitor of growth family, member 2 0.043
SMAD7 SMAD family member 7 0.043
RNF168 ring finger protein 168 0.043
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 0.040
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 0.040
STAMBP STAM binding protein 0.038
C1orf93 chromosome 1 open reading frame 93 0.037
TRAF4 TNF receptor-associated factor 4 0.037
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 0.036
SH3GL2 SH3-domain GRB2-like 2 0.036
WASL Wiskott-Aldrich syndrome-like 0.036
SH3KBP1 SH3-domain kinase binding protein 1 0.035
WNK1 WNK lysine deficient protein kinase 1 0.034
ZFAND5 zinc finger, AN1-type domain 5 0.032
KLF5 Kruppel-like factor 5 (intestinal) 0.031
LNX1 ligand of numb-protein X 1 0.031
SDCBP2 syndecan binding protein (syntenin) 2 0.030
ERBB2IP erbb2 interacting protein 0.030
R3HCC1 R3H domain and coiled-coil containing 1 0.029
ADAM15 ADAM metallopeptidase domain 15 0.029
SNX9 sorting nexin 9 0.028
UBQLN2 ubiquilin 2 0.028
PTK2 PTK2 protein tyrosine kinase 2 0.028
CCDC127 coiled-coil domain containing 127 0.027
SGK3 serum/glucocorticoid regulated kinase family, member 3 0.027
SKI v-ski sarcoma viral oncogene homolog (avian) 0.027
SBF1 SET binding factor 1 0.027
GGA3 golgi-associated, gamma adaptin ear containing, ARF binding protein 3 0.027
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.026
SMAD5 SMAD family member 5 0.026
CBLC Cas-Br-M (murine) ecotropic retroviral transforming sequence c 0.026
KRT15 keratin 15 0.025
GOLGA5 golgin A5 0.023
DNM1 dynamin 1 0.023
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 0.022
UVRAG UV radiation resistance associated gene 0.022
ZFYVE20 zinc finger, FYVE domain containing 20 0.022
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 0.022
NBR1 neighbor of BRCA1 gene 1 0.022
TM9SF4 transmembrane 9 superfamily protein member 4 0.022
PIK3C3 phosphoinositide-3-kinase, class 3 0.022
VPS24 vacuolar protein sorting 24 homolog (S. cerevisiae) 0.021
PTEN phosphatase and tensin homolog 0.021
TSG101 tumor susceptibility gene 101 0.020
SNF8 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) 0.020
MKL2 MKL/myocardin-like 2 0.020
SCNN1A sodium channel, nonvoltage-gated 1 alpha 0.019
VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae) 0.019
BCAR1 breast cancer anti-estrogen resistance 1 0.019
BECN1 beclin 1, autophagy related 0.019
DDX24 DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 0.019
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.019
POLH polymerase (DNA directed), eta 0.019
MTMR4 myotubularin related protein 4 0.018
PLEKHO1 pleckstrin homology domain containing, family O member 1 0.018
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism