The network for 'negative regulation of cell cycle' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of cell cycle

Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
GLC7 Glc7p 0.957
PPH3 Pph3p 0.917
RAD53 Rad53p 0.914
CDC28 Cdc28p 0.841
KEL1 Kel1p 0.820
DBF4 Dbf4p 0.722
SMC4 Smc4p 0.709
CLB3 Clb3p 0.707
RAD9 Rad9p 0.696
PPH22 Pph22p 0.696
SPT5 Spt5p 0.667
CDC20 Cdc20p 0.637
SPT16 Spt16p 0.633
SNT1 Snt1p 0.617
SIC1 Sic1p 0.589
BUB3 Bub3p 0.577
BMH1 Bmh1p 0.551
CDC34 Cdc34p 0.537
KIN1 Kin1p 0.523
RED1 Red1p 0.510
PDS1 Pds1p 0.505
CKA1 Cka1p 0.494
HHT1 Hht1p 0.485
RCO1 Rco1p 0.477
HXT4 Hxt4p 0.476
RAD54 Rad54p 0.464
PPH21 Pph21p 0.459
ZDS1 Zds1p 0.447
PSR2 Psr2p 0.421
CDC14 Cdc14p 0.407
BIM1 Bim1p 0.404
SLK19 Slk19p 0.394
HXT2 Hxt2p 0.386
PLC1 Plc1p 0.383
PSY2 Psy2p 0.362
RRM3 Rrm3p 0.362
HSL1 Hsl1p 0.362
GIC1 Gic1p 0.354
EAF1 Eaf1p 0.346
BRN1 Brn1p 0.338
TPD3 Tpd3p 0.337
FUS3 Fus3p 0.322
ECO1 Eco1p 0.321
CIN8 Cin8p 0.319
SET3 Set3p 0.317
SPA2 Spa2p 0.307
MEK1 Mek1p 0.306
GBP2 Gbp2p 0.292
SET2 Set2p 0.279
SDS22 Sds22p 0.277
KSP1 Ksp1p 0.261
BCK1 Bck1p 0.260
SKO1 Sko1p 0.258
SLG1 Slg1p 0.256
MSA1 Msa1p 0.254
HOS4 Hos4p 0.252
HXT7 Hxt7p 0.251
CTF18 Ctf18p 0.248
POL1 Pol1p 0.237
PPZ2 Ppz2p 0.220
HXT6 Hxt6p 0.220
CKS1 Cks1p 0.216
ELM1 Elm1p 0.213
RAD27 Rad27p 0.211
SIF2 Sif2p 0.210
BFA1 Bfa1p 0.210
CDC16 Cdc16p 0.205
ZDS2 Zds2p 0.204
HRR25 Hrr25p 0.200
BBC1 Bbc1p 0.200
HOS2 Hos2p 0.193
SLX5 Slx5p 0.184
CDC37 Cdc37p 0.184
ZIP1 Zip1p 0.180
YMR315W hypothetical protein 0.180
NIS1 Nis1p 0.178
DPB2 Dpb2p 0.176
CTF13 Ctf13p 0.175
WHI2 Whi2p 0.168
MTH1 Mth1p 0.166
DCC1 Dcc1p 0.164
REG1 Reg1p 0.164
SAC6 Sac6p 0.162
STE5 Ste5p 0.162
IML3 Iml3p 0.162
RTS1 Rts1p 0.162
MCM10 Mcm10p 0.160
CDC25 Cdc25p 0.158
BNI4 Bni4p 0.157
CWC2 Cwc2p 0.157
POL30 Pol30p 0.156
RPB3 Rpb3p 0.155
TID3 Tid3p 0.154
CLB4 Clb4p 0.153
RPO26 Rpo26p 0.152
MRC1 Mrc1p 0.151
CBF2 Cbf2p 0.148
EAF6 Eaf6p 0.144
GAC1 Gac1p 0.144
DMA2 Dma2p 0.143
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
mex-5 Protein MEX-5 0.487
T20F5.7 Protein T20F5.7 0.339
lag-1 Protein LAG-1 0.308
egl-18 Protein EGL-18 0.280
csn-5 Protein CSN-5 0.204
mpk-1 Protein MPK-1 0.184
D1081.8 Protein D1081.8 0.181
CELE_C24H12.5 Protein C24H12.5 0.181
sur-2 Protein SUR-2 0.178
mom-2 Protein MOM-2 0.176
hsp-16.2 Protein HSP-16.2 0.159
hsp-16.1 Protein HSP-16.1 0.153
klp-19 Protein KLP-19 0.152
dpl-1 Protein DPL-1 0.151
spd-5 Protein SPD-5 0.147
hsp-70 Protein HSP-70 0.146
asd-1 Protein ASD-1 0.143
wago-9 Protein WAGO-9 0.143
F20A1.9 Protein F20A1.9 0.137
hsp-16.41 Protein HSP-16.41 0.136
pha-4 Protein PHA-4 0.135
him-1 Protein HIM-1 0.134
oma-2 Protein OMA-2 0.125
prg-1 Protein PRG-1 0.116
ran-1 Protein RAN-1 0.109
F44E5.4 Protein F44E5.4 0.108
lin-45 Protein LIN-45 0.105
hcf-1 Protein HCF-1 0.104
R05D3.3 Protein R05D3.3 0.102
hsp-16.48 Protein HSP-16.48 0.096
mut-14 Protein MUT-14 0.095
knl-1 Protein KNL-1 0.094
lin-3 Protein LIN-3 0.094
mes-4 Protein MES-4 0.092
gla-3 Protein GLA-3 0.092
D1044.6 Protein D1044.6 0.092
met-2 Protein MET-2 0.084
fox-1 Protein FOX-1 0.084
lin-23 Protein LIN-23 0.083
cyk-7 Protein CYK-7 0.081
his-42 Protein HIS-42 0.081
dsh-2 Protein DSH-2 0.080
spdl-1 Protein SPDL-1 0.080
mat-3 Protein MAT-3 0.079
elt-6 Protein ELT-6 0.078
CELE_Y57G11C.3 Protein Y57G11C.3 0.077
ect-2 Protein ECT-2 0.077
cpg-2 Protein CPG-2 0.074
CELE_W02A11.1 Protein W02A11.1 0.074
kin-14 Protein KIN-14 0.073
daf-1 Protein DAF-1 0.072
dnj-11 Protein DNJ-11 0.071
sna-2 Protein SNA-2 0.070
F56A8.4 Protein F56A8.4 0.070
csn-3 Protein CSN-3 0.069
pmk-1 Protein PMK-1 0.069
nhr-32 Protein NHR-32 0.069
CELE_C38D4.4 Protein C38D4.4 0.068
T23B12.4 Protein T23B12.4 0.066
crt-1 Protein CRT-1 0.066
brp-1 Protein BRP-1 0.065
cep-1 Protein CEP-1 0.065
scc-1 Protein SCC-1 0.064
cyk-4 Protein CYK-4 0.064
hmg-12 Protein HMG-12 0.064
him-10 Protein HIM-10 0.064
nasp-2 Protein NASP-2 0.064
T28D9.4 Protein T28D9.4 0.064
vps-33.2 Protein VPS-33.2 0.063
eri-1 Protein ERI-1 0.063
acs-4 Protein ACS-4 0.062
F58E10.3 Protein F58E10.3 0.062
sas-5 Protein SAS-5 0.062
gmeb-1 Protein GMEB-1 0.061
lag-2 Protein LAG-2 0.060
ran-3 Protein RAN-3 0.059
plk-1 Protein PLK-1 0.058
ntl-4 Protein NTL-4 0.057
his-6 Protein HIS-6 0.057
swsn-6 Protein SWSN-6 0.057
uaf-1 Protein UAF-1 0.057
mig-5 Protein MIG-5 0.056
sas-4 Protein SAS-4 0.056
top-2 Protein TOP-2 0.056
drh-3 Protein DRH-3 0.056
hil-2 Protein HIL-2 0.055
daf-4 Protein DAF-4 0.055
set-1 Protein SET-1 0.054
csn-1 Protein CSN-1 0.054
mib-1 Protein MIB-1 0.053
F56D2.6 Protein F56D2.6 0.053
unc-62 Protein UNC-62 0.053
swsn-1 Protein SWSN-1 0.052
nfyb-1 Protein NFYB-1 0.052
emb-5 Protein EMB-5 0.052
eif-3.I Protein EIF-3.I 0.051
rla-0 Protein RLA-0 0.051
smg-9 Protein SMG-9 0.051
mrt-2 Protein MRT-2 0.051
cgh-1 Protein CGH-1 0.051
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
ccnb1 cyclin B1 0.851
sox2 SRY-box containing gene 2 0.516
ccnd1 cyclin D1 0.467
map2k4a mitogen-activated protein kinase kinase 4a 0.434
ccna2 cyclin A2 0.421
plk1 polo-like kinase 1 (Drosophila) 0.414
cxcl12a chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1) 0.342
tp53 tumor protein p53 0.328
fgf4 fibroblast growth factor 4 0.327
ccnb2 cyclin B2 0.327
lpp LIM domain containing preferred translocation partner in lipoma 0.277
id2a inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a 0.239
wnt5b wingless-type MMTV integration site family, member 5b 0.236
cdkn1c cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.214
csnk1da casein kinase 1, delta a 0.213
myf5 myogenic factor 5 0.212
wnt4a wingless-type MMTV integration site family, member 4a 0.206
wnt8b wingless-type MMTV integration site family, member 8b 0.200
g2e3 G2/M-phase specific E3 ubiquitin ligase 0.178
nusap1 nucleolar and spindle associated protein 1 0.172
mbnl2 muscleblind-like 2 (Drosophila) 0.168
kif23 kinesin family member 23 0.166
zgc:65861 zgc:65861 0.162
si:ch211-173o4.2 si:ch211-173o4.2 0.158
myod1 myogenic differentiation 1 0.154
wnt11r wingless-type MMTV integration site family, member 11, related 0.153
h1fx H1 histone family, member X 0.150
bmp2b bone morphogenetic protein 2b 0.149
ywhaqb tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b 0.147
alcama activated leukocyte cell adhesion molecule a 0.135
fabp7a fatty acid binding protein 7, brain, a 0.131
bcl2 B-cell leukemia/lymphoma 2 0.130
tgfb3 transforming growth factor, beta 3 0.130
pwp2h PWP2 periodic tryptophan protein homolog (yeast) 0.127
skp2 S-phase kinase-associated protein 2 (p45) 0.123
dlb deltaB 0.117
zff9 zinc finger protein 9 0.116
cep55l centrosomal protein 55 like 0.115
ncapg non-SMC condensin I complex, subunit G 0.111
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.109
cdh1 cadherin 1, epithelial 0.106
mcl1b myeloid cell leukemia sequence 1b 0.102
efnb2a ephrin B2a 0.098
mos v-mos Moloney murine sarcoma viral oncogene homolog 0.095
nrg1 neuregulin 1 0.094
inhbaa inhibin, beta Aa 0.093
smc4 structural maintenance of chromosomes 4 0.087
ntla no tail a 0.083
tbx2b T-box 2b 0.083
caprin1a cell cycle associated protein 1a 0.081
rtkn2 rhotekin 2 0.081
piwil2 piwi-like 2 (Drosophila) 0.080
bcl2l1 bcl2-like 1 0.080
dharma dharma 0.076
smc1al structural maintenance of chromosomes 1A, like 0.076
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.075
acvr2a activin receptor IIa 0.073
wnt2 wingless-type MMTV integration site family member 2 0.068
lef1 lymphocyte enhancer binding factor 1 0.067
sox11a SRY-box containing gene 11a 0.067
ldlrap1a low density lipoprotein receptor adaptor protein 1a 0.067
tnfsf10l tumor necrosis factor (ligand) superfamily, member 10 like 0.067
cdt1 chromatin licensing and DNA replication factor 1 0.066
anp32a acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.065
dtl denticleless homolog (Drosophila) 0.063
si:ch211-215h6.2 si:ch211-215h6.2 0.062
plcg1 phospholipase C, gamma 1 0.061
mapk3 mitogen-activated protein kinase 3 0.060
psen1 presenilin 1 0.060
btg1 B-cell translocation gene 1 0.060
id1 inhibitor of DNA binding 1 0.060
ncapd2 non-SMC condensin I complex, subunit D2 0.059
brd2a bromodomain-containing 2a 0.058
nrg2a neuregulin 2a 0.058
sass6 spindle assembly 6 homolog (C. elegans) 0.058
wnt10a wingless-type MMTV integration site family, member 10a 0.057
oep one-eyed pinhead 0.057
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.057
cxcr4b chemokine (C-X-C motif), receptor 4b 0.056
dusp1 dual specificity phosphatase 1 0.052
smc3 structural maintenance of chromosomes 3 0.050
suv39h1b suppressor of variegation 3-9 homolog 1b 0.050
ezh2 enhancer of zeste homolog 2 (Drosophila) 0.049
sema3aa semaphorin 3aa 0.049
adipor2 adiponectin receptor 2 0.048
ctgf connective tissue growth factor 0.048
hdac3 histone deacetylase 3 0.048
gro1 groucho 1 0.048
dld deltaD 0.048
erbb3a v-erb-b2 erythroblastic leukemia viral oncogene homolog 3a 0.047
myca myelocytomatosis oncogene a 0.047
sae1 SUMO1 activating enzyme subunit 1 0.047
etv1 ets variant gene 1 0.047
ddx46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.047
nasp nuclear autoantigenic sperm protein (histone-binding) 0.046
ncor1 nuclear receptor co-repressor 1 0.046
bmp4 bone morphogenetic protein 4 0.045
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.045
LOC566708 FL cytokine receptor-like 0.045
ndr2 nodal-related 2 0.043
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
p53 CG33336 gene product from transcript CG33336-RB 0.997
skpA CG16983 gene product from transcript CG16983-RD 0.995
Pp1-87B Protein phosphatase 1 at 87B 0.993
Ras85D Ras oncogene at 85D 0.993
14-3-3epsilon CG31196 gene product from transcript CG31196-RA 0.985
CSN5 COP9 complex homolog subunit 5 0.979
E2f2 E2F transcription factor 2 0.961
gro groucho 0.961
asp abnormal spindle 0.954
Snr1 Snf5-related 1 0.943
smt3 CG4494 gene product from transcript CG4494-RA 0.925
phl pole hole 0.894
Akt1 CG4006 gene product from transcript CG4006-RA 0.888
lok loki 0.886
Egfr Epidermal growth factor receptor 0.872
aop anterior open 0.855
emc extra macrochaetae 0.843
polo CG12306 gene product from transcript CG12306-RA 0.829
mus304 mutagen-sensitive 304 0.822
Cp190 Centrosomal protein 190kD 0.805
rl rolled 0.799
dap dacapo 0.798
CycB Cyclin B 0.794
mei-9 meiotic 9 0.783
Pka-C1 cAMP-dependent protein kinase 1 0.748
Vap-33-1 CG5014 gene product from transcript CG5014-RB 0.719
not non-stop 0.718
hay haywire 0.664
cdc2 CG5363 gene product from transcript CG5363-RA 0.660
wee CG4488 gene product from transcript CG4488-RA 0.657
CtBP C-terminal Binding Protein 0.621
tld tolloid 0.609
Sas-4 CG10061 gene product from transcript CG10061-RA 0.592
Cdc37 CG12019 gene product from transcript CG12019-RA 0.582
scny scrawny 0.577
Brca2 Breast cancer 2, early onset homolog 0.573
fzy fizzy 0.573
brm brahma 0.572
ci cubitus interruptus 0.570
Cul-2 Cullin-2 0.550
Doa Darkener of apricot 0.542
mus312 mutagen-sensitive 312 0.529
toc toucan 0.526
CycA Cyclin A 0.523
MED6 Mediator complex subunit 6 0.517
tefu telomere fusion 0.513
Cap-G CG34438 gene product from transcript CG34438-RF 0.508
dre4 CG1828 gene product from transcript CG1828-RB 0.494
l(2)gl lethal (2) giant larvae 0.490
Spc105R Spc105-related 0.488
DNApol-eta CG7143 gene product from transcript CG7143-RA 0.482
CycE Cyclin E 0.470
Mcm7 Minichromosome maintenance 7 0.466
Rel Relish 0.464
l(3)01239 lethal (3) 01239 0.458
CG5524 CG5524 gene product from transcript CG5524-RA 0.448
rump rumpelstiltskin 0.447
CSN3 COP9 complex homolog subunit 3 0.444
InR Insulin-like receptor 0.442
mus209 mutagen-sensitive 209 0.438
mus309 mutagen-sensitive 309 0.437
gbb glass bottom boat 0.433
pie pineapple eye 0.425
gwl greatwall 0.413
Iswi Imitation SWI 0.402
thr three rows 0.401
mus205 mutagen-sensitive 205 0.392
Chrac-14 CG13399 gene product from transcript CG13399-RA 0.386
ago archipelago 0.385
sina seven in absentia 0.376
Rpd3 CG7471 gene product from transcript CG7471-RA 0.366
Stat92E Signal-transducer and activator of transcription protein at 92E 0.363
BubR1 Bub1-related kinase 0.362
KP78b CG17216 gene product from transcript CG17216-RB 0.353
MED17 Mediator complex subunit 17 0.349
Gap1 GTPase-activating protein 1 0.349
bam bag of marbles 0.348
Jra Jun-related antigen 0.343
Csp Cysteine string protein 0.339
Fmr1 CG6203 gene product from transcript CG6203-RC 0.337
SelD Selenide,water dikinase 0.329
hbs hibris 0.327
MED15 Mediator complex subunit 15 0.324
Rsf1 Repressor splicing factor 1 0.320
cnn centrosomin 0.319
Dsor1 Downstream of raf1 0.310
Ada2b CG9638 gene product from transcript CG9638-RA 0.310
rad50 CG6339 gene product from transcript CG6339-RD 0.308
morgue modifier of rpr and grim, ubiquitously expressed 0.306
mre11 meiotic recombination 11 0.301
ptc patched 0.297
Syx1A Syntaxin 1A 0.296
Bap55 Brahma associated protein 55kD 0.293
calypso CG8445 gene product from transcript CG8445-RB 0.292
CG13350 CG13350 gene product from transcript CG13350-RA 0.287
CG9772 CG9772 gene product from transcript CG9772-RB 0.287
SF2 CG6987 gene product from transcript CG6987-RA 0.286
Mad Mothers against dpp 0.282
nbs CG6754 gene product from transcript CG6754-RC 0.282
DNApol-alpha60 DNA polymerase alpha 60kD 0.281
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
TP53 tumor protein p53 1.000
BRCA1 breast cancer 1, early onset 1.000
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.999
RB1 retinoblastoma 1 0.996
CDK4 cyclin-dependent kinase 4 0.995
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.995
SMC1A structural maintenance of chromosomes 1A 0.988
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.987
SIRT1 sirtuin 1 0.975
HDAC1 histone deacetylase 1 0.972
MCM7 minichromosome maintenance complex component 7 0.964
H2AFX H2A histone family, member X 0.957
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.954
NBN nibrin 0.951
UBE3A ubiquitin protein ligase E3A 0.948
SMAD1 SMAD family member 1 0.942
JUN jun proto-oncogene 0.938
CHEK1 CHK1 checkpoint homolog (S. pombe) 0.935
MAPK1 mitogen-activated protein kinase 1 0.928
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.923
AR androgen receptor 0.921
CCND1 cyclin D1 0.899
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 0.898
TOPBP1 topoisomerase (DNA) II binding protein 1 0.895
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.892
CBX5 chromobox homolog 5 0.883
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.879
SMC3 structural maintenance of chromosomes 3 0.877
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.872
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.871
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.859
CDK2 cyclin-dependent kinase 2 0.850
MYC v-myc myelocytomatosis viral oncogene homolog (avian) 0.831
FOXM1 forkhead box M1 0.826
CCND3 cyclin D3 0.823
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.812
PLK1 polo-like kinase 1 0.811
SMAD2 SMAD family member 2 0.795
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.795
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.794
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 0.793
PBK PDZ binding kinase 0.777
EP300 E1A binding protein p300 0.764
CREBBP CREB binding protein 0.762
BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) 0.761
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.760
CCNE1 cyclin E1 0.746
GSK3B glycogen synthase kinase 3 beta 0.740
YAP1 Yes-associated protein 1 0.738
UHRF2 ubiquitin-like with PHD and ring finger domains 2 0.732
DAXX death-domain associated protein 0.718
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.717
SMAD7 SMAD family member 7 0.713
CDK1 cyclin-dependent kinase 1 0.707
BCL2 B-cell CLL/lymphoma 2 0.702
RARA retinoic acid receptor, alpha 0.698
CDC6 cell division cycle 6 homolog (S. cerevisiae) 0.695
RFWD2 ring finger and WD repeat domain 2 0.695
FGFR2 fibroblast growth factor receptor 2 0.680
SMAD3 SMAD family member 3 0.675
MBD3 methyl-CpG binding domain protein 3 0.674
BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) 0.673
CDK8 cyclin-dependent kinase 8 0.672
ARID1A AT rich interactive domain 1A (SWI-like) 0.670
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.667
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.666
UBE2M ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) 0.656
CCNA2 cyclin A2 0.656
RBL1 retinoblastoma-like 1 (p107) 0.647
RBL2 retinoblastoma-like 2 (p130) 0.643
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 125kDa 0.640
SRF serum response factor (c-fos serum response element-binding transcription factor) 0.637
E2F1 E2F transcription factor 1 0.626
IER3 immediate early response 3 0.622
CUL2 cullin 2 0.612
PKM2 pyruvate kinase, muscle 0.612
APP amyloid beta (A4) precursor protein 0.599
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.597
STAG1 stromal antigen 1 0.592
MDC1 mediator of DNA-damage checkpoint 1 0.586
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.583
MAPK3 mitogen-activated protein kinase 3 0.582
NOTCH1 notch 1 0.581
MDM4 Mdm4 p53 binding protein homolog (mouse) 0.570
SMC4 structural maintenance of chromosomes 4 0.568
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 0.565
RAD50 RAD50 homolog (S. cerevisiae) 0.564
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.559
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.541
MSH6 mutS homolog 6 (E. coli) 0.532
UBA1 ubiquitin-like modifier activating enzyme 1 0.529
TOP2A topoisomerase (DNA) II alpha 170kDa 0.526
CSNK2B casein kinase 2, beta polypeptide 0.524
THOC4 THO complex 4 0.522
RBBP8 retinoblastoma binding protein 8 0.520
HDGF hepatoma-derived growth factor 0.515
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.513
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.512
PARP1 poly (ADP-ribose) polymerase 1 0.501
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.496
Loading network...
Mus musculus
Name Description Probability Func Analog Organism
Trp53 transformation related protein 53 1.000
Rb1 retinoblastoma 1 1.000
Mdm2 transformed mouse 3T3 cell double minute 2 0.999
Smad4 MAD homolog 4 (Drosophila) 0.995
Brca1 breast cancer 1 0.994
Apc adenomatosis polyposis coli 0.992
Pten phosphatase and tensin homolog 0.991
Shh sonic hedgehog 0.991
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.988
Ctnnb1 catenin (cadherin associated protein), beta 1 0.984
Cdkn2a cyclin-dependent kinase inhibitor 2A 0.981
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.977
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.973
Mdm4 transformed mouse 3T3 cell double minute 4 0.966
Cdkn2c cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.961
E2f1 E2F transcription factor 1 0.941
Brca2 breast cancer 2 0.935
Rbl1 retinoblastoma-like 1 (p107) 0.883
Gli3 GLI-Kruppel family member GLI3 0.878
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.874
Cdk4 cyclin-dependent kinase 4 0.862
Ptch1 patched homolog 1 0.862
Nbn nibrin 0.861
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.859
Neurod1 neurogenic differentiation 1 0.844
Fgfr2 fibroblast growth factor receptor 2 0.831
Cdk1 cyclin-dependent kinase 1 0.801
Rara retinoic acid receptor, alpha 0.792
Msh2 mutS homolog 2 (E. coli) 0.786
Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.755
Bmp4 bone morphogenetic protein 4 0.740
Gata4 GATA binding protein 4 0.739
Cdk2 cyclin-dependent kinase 2 0.737
Fzd8 frizzled homolog 8 (Drosophila) 0.726
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.703
Gli2 GLI-Kruppel family member GLI2 0.702
Smad3 MAD homolog 3 (Drosophila) 0.700
Braf Braf transforming gene 0.672
Atm ataxia telangiectasia mutated homolog (human) 0.634
Hes1 hairy and enhancer of split 1 (Drosophila) 0.626
Sirt1 sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae) 0.620
Ppp1cc protein phosphatase 1, catalytic subunit, gamma isoform 0.615
Hells helicase, lymphoid specific 0.611
En1 engrailed 1 0.601
Fgfr1 fibroblast growth factor receptor 1 0.594
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.594
Sox9 SRY-box containing gene 9 0.584
Nf1 neurofibromatosis 1 0.582
Mybl2 myeloblastosis oncogene-like 2 0.580
Rbl2 retinoblastoma-like 2 0.579
Id1 inhibitor of DNA binding 1 0.566
Smo smoothened homolog (Drosophila) 0.562
Mcm3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.551
Lin9 lin-9 homolog (C. elegans) 0.550
Lmnb1 lamin B1 0.543
Prc1 protein regulator of cytokinesis 1 0.542
Smc2 structural maintenance of chromosomes 2 0.536
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.530
Bcl2 B-cell leukemia/lymphoma 2 0.525
Tcf3 transcription factor 3 0.524
Cdc25c cell division cycle 25 homolog C (S. pombe) 0.515
Smad1 MAD homolog 1 (Drosophila) 0.512
Notch1 Notch gene homolog 1 (Drosophila) 0.496
Pthlh parathyroid hormone-like peptide 0.490
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.487
Arid1b AT rich interactive domain 1B (SWI-like) 0.485
Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha 0.470
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.465
Vhl von Hippel-Lindau tumor suppressor 0.465
Aurkb aurora kinase B 0.462
Jarid2 jumonji, AT rich interactive domain 2 0.460
Cenpk centromere protein K 0.453
C330027C09Rik RIKEN cDNA C330027C09 gene 0.452
Amhr2 anti-Mullerian hormone type 2 receptor 0.450
Ccna2 cyclin A2 0.442
Cbx1 chromobox homolog 1 (Drosophila HP1 beta) 0.422
Chek1 checkpoint kinase 1 homolog (S. pombe) 0.418
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.408
Add1 adducin 1 (alpha) 0.389
Dtl denticleless homolog (Drosophila) 0.388
Kit kit oncogene 0.381
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.381
Blm Bloom syndrome, RecQ helicase-like 0.379
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.375
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.370
Msx2 homeobox, msh-like 2 0.369
Casp1 caspase 1 0.363
Plk4 polo-like kinase 4 (Drosophila) 0.362
Fst follistatin 0.362
Kif23 kinesin family member 23 0.357
Cd80 CD80 antigen 0.354
Trp63 transformation related protein 63 0.352
Ilk integrin linked kinase 0.352
Cdk6 cyclin-dependent kinase 6 0.351
Ccnd1 cyclin D1 0.350
Meox2 mesenchyme homeobox 2 0.349
Foxa2 forkhead box A2 0.348
Cdc6 cell division cycle 6 homolog (S. cerevisiae) 0.347
Hdac1 histone deacetylase 1 0.346
Id3 inhibitor of DNA binding 3 0.343
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Top2a topoisomerase (DNA) II alpha 0.021
Cdk2 cyclin dependent kinase 2 0.015
Cdk4 cyclin-dependent kinase 4 0.014
Ptbp1 polypyrimidine tract binding protein 1 0.014
Ccne1 cyclin E1 0.010