The network for 'mitotic sister chromatid cohesion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mitotic sister chromatid cohesion

The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
ECO1 Eco1p 0.980
CTF3 Ctf3p 0.968
IML3 Iml3p 0.957
SCC2 Scc2p 0.951
PDS5 Pds5p 0.943
CTF18 Ctf18p 0.943
CTF19 Ctf19p 0.924
SMC1 Smc1p 0.898
CSM3 Csm3p 0.871
SMC3 Smc3p 0.853
MRC1 Mrc1p 0.830
RAD53 Rad53p 0.783
MCM21 Mcm21p 0.747
STU1 Stu1p 0.729
MCM22 Mcm22p 0.719
CTF4 Ctf4p 0.716
RAD24 Rad24p 0.678
RAD27 Rad27p 0.678
NSL1 Nsl1p 0.650
RFC5 Rfc5p 0.633
MCD1 Mcd1p 0.560
CHL1 Chl1p 0.544
RDH54 Rdh54p 0.519
CIK1 Cik1p 0.484
NKP2 Nkp2p 0.465
TOF1 Tof1p 0.451
CHL4 Chl4p 0.425
MCM16 Mcm16p 0.413
IRR1 Irr1p 0.408
SRS2 Srs2p 0.399
SMC4 Smc4p 0.343
CIN8 Cin8p 0.337
STU2 Stu2p 0.300
MAD1 Mad1p 0.280
OKP1 Okp1p 0.268
MTW1 Mtw1p 0.267
MIF2 Mif2p 0.258
CTF8 Ctf8p 0.242
SCC4 Scc4p 0.235
RAD5 Rad5p 0.226
SLK19 Slk19p 0.221
PSF1 Psf1p 0.210
MMS21 Mms21p 0.198
RFC2 Rfc2p 0.194
BUB3 Bub3p 0.183
WSS1 Wss1p 0.181
SGO1 Sgo1p 0.173
RMI1 Rmi1p 0.169
SMC6 Smc6p 0.152
RAD61 Rad61p 0.149
RFC3 Rfc3p 0.134
CBF2 Cbf2p 0.128
SLX5 Slx5p 0.116
NNF1 Nnf1p 0.113
POL3 Pol3p 0.111
PRI2 Pri2p 0.104
TOP3 Top3p 0.102
RAD55 Rad55p 0.099
NKP1 Nkp1p 0.099
SMC2 Smc2p 0.099
MMS1 Mms1p 0.092
KIP1 Kip1p 0.092
DSN1 Dsn1p 0.087
CSE4 Cse4p 0.086
BUB1 Bub1p 0.082
IPL1 Ipl1p 0.080
EST1 Est1p 0.080
DCC1 Dcc1p 0.077
KAR3 Kar3p 0.072
NSE4 Nse4p 0.066
SLI15 Sli15p 0.063
SPC105 Spc105p 0.062
CSM1 Csm1p 0.062
CTF13 Ctf13p 0.060
POL12 Pol12p 0.060
BRN1 Brn1p 0.055
ZPS1 Zps1p 0.051
TAF7 Taf7p 0.049
AME1 Ame1p 0.047
NUF2 Nuf2p 0.046
SRD1 Srd1p 0.045
DPB2 Dpb2p 0.042
YLR264C-A hypothetical protein 0.041
LEU2 Leu2p 0.040
CUP1-1 Cup1-1p 0.038
YLR162W hypothetical protein 0.038
SDC1 Sdc1p 0.038
YAR068W hypothetical protein 0.037
ARG8 Arg8p 0.036
YDR179W-A hypothetical protein 0.035
HST3 Hst3p 0.035
RFC4 Rfc4p 0.034
HHF2 Hhf2p 0.034
DIA2 Dia2p 0.033
YOL038C-A hypothetical protein 0.033
TFA1 Tfa1p 0.033
HO Hop 0.032
YIR035C hypothetical protein 0.032
NAR1 Nar1p 0.032
MAD2 Mad2p 0.032
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
pds5b PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.799
smc1al structural maintenance of chromosomes 1A, like 0.664
dnmt7 DNA (cytosine-5-)-methyltransferase 7 0.662
smc3 structural maintenance of chromosomes 3 0.633
smc2 structural maintenance of chromosomes 2 0.234
smc4 structural maintenance of chromosomes 4 0.143
LOC554173 abnormal spindles 0.124
rad21 RAD21 homolog (S. pombe) 0.094
pcna proliferating cell nuclear antigen 0.068
dnmt4 DNA (cytosine-5-)-methyltransferase 4 0.066
puf60a poly-U binding splicing factor a 0.055
mib mind bomb 0.042
ccnd1 cyclin D1 0.041
top2a topoisomerase (DNA) II alpha 0.036
ube2i ubiquitin-conjugating enzyme E2I 0.030
plxnb2b plexin b2b 0.029
stil TAL1 (SCL) interrupting locus 0.025
sumo2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 0.025
hcfc1b host cell factor C1b 0.023
chaf1b chromatin assembly factor 1, subunit B 0.020
cadm1a cell adhesion molecule 1a 0.019
utx ubiquitously transcribed tetratricopeptide repeat, X chromosome 0.019
creb1 cAMP responsive element binding protein 1 0.019
col10a1 collagen, type X, alpha 1 0.019
dnmt1 DNA (cytosine-5-)-methyltransferase 1 0.018
tfam transcription factor A, mitochondrial 0.017
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.015
cabin1 calcineurin binding protein 1 0.015
otpa orthopedia homolog a 0.015
pbrm1l polybromo 1, like 0.014
lamc1 laminin, gamma 1 0.014
cacnb4b calcium channel, voltage-dependent, beta 4b subunit 0.013
nrf1 nuclear respiratory factor 1 0.013
tert telomerase reverse transcriptase 0.013
sf3b1 splicing factor 3b, subunit 1 0.012
mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.012
LOC100149834 cdc2-related kinase, arginine/serine-rich-like 0.012
cct8 chaperonin containing TCP1, subunit 8 (theta) 0.012
ahctf1 AT hook containing transcription factor 1 0.012
mcm5 MCM5 minichromosome maintenance deficient 5 (S. cerevisiae) 0.011
prpf8 pre-mRNA processing factor 8 0.011
tp53 tumor protein p53 0.011
ptprb protein tyrosine phosphatase, receptor type, b 0.011
bmp7b bone morphogenetic protein 7b 0.011
hcfc1a host cell factor C1a 0.011
si:dkey-250d21.1 si:dkey-250d21.1 0.011
setdb1b SET domain, bifurcated 1b 0.010
her6 hairy-related 6 0.010
supt6h suppressor of Ty 6 homolog 0.010
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Drosophila melanogaster
Name Description Probability Func Analog Organism
dup double parked 0.115
dpa disc proliferation abnormal 0.091
Orc5 Origin recognition complex subunit 5 0.081
Uba2 Smt3 activating enzyme 2 0.074
cmet CENP-meta 0.067
rad50 CG6339 gene product from transcript CG6339-RD 0.067
Klp61F Kinesin-like protein at 61F 0.060
ida imaginal discs arrested 0.057
l(1)dd4 lethal (1) discs degenerate 4 0.053
jumu jumeau 0.046
Su(H) Suppressor of Hairless 0.042
sec15 CG7034 gene product from transcript CG7034-RA 0.037
barr barren 0.037
rod rough deal 0.035
DNApol-alpha60 DNA polymerase alpha 60kD 0.034
CycB3 Cyclin B3 0.034
pds5 CG17509 gene product from transcript CG17509-RA 0.034
stg string 0.033
mip120 Myb-interacting protein 120 0.029
Spc105R Spc105-related 0.029
pie pineapple eye 0.024
ncd non-claret disjunctional 0.024
Incenp Inner centromere protein 0.023
geminin CG3183 gene product from transcript CG3183-RA 0.022
dap dacapo 0.021
Mcm2 Minichromosome maintenance 2 0.021
MED6 Mediator complex subunit 6 0.020
dlt discs lost 0.019
CycB Cyclin B 0.018
Slbp Stem-loop binding protein 0.017
mus101 mutagen-sensitive 101 0.017
BubR1 Bub1-related kinase 0.017
CG9772 CG9772 gene product from transcript CG9772-RB 0.016
Dcr-1 Dicer-1 0.015
Mcm10 Sensitized chromosome inheritance modifier 19 0.015
Nek2 CG17256 gene product from transcript CG17256-RA 0.015
gwl greatwall 0.014
Cap-G CG34438 gene product from transcript CG34438-RF 0.013
Fcp1 CG12252 gene product from transcript CG12252-RA 0.012
hd humpty dumpty 0.012
Rca1 Regulator of cyclin A1 0.012
tefu telomere fusion 0.012
Cenp-C CG31258 gene product from transcript CG31258-RA 0.012
sw short wing 0.011
cav caravaggio 0.011
chm chameau 0.010
CG6695 CG6695 gene product from transcript CG6695-RA 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
STAG1 stromal antigen 1 0.997
RAD21 RAD21 homolog (S. pombe) 0.996
STAG2 stromal antigen 2 0.995
SMC1A structural maintenance of chromosomes 1A 0.993
WAPAL wings apart-like homolog (Drosophila) 0.987
PDS5A PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae) 0.973
SMC3 structural maintenance of chromosomes 3 0.960
RBL1 retinoblastoma-like 1 (p107) 0.944
PDS5B PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.802
E2F1 E2F transcription factor 1 0.606
CBX5 chromobox homolog 5 0.549
RB1 retinoblastoma 1 0.444
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 0.349
CHTF18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) 0.269
TROAP trophinin associated protein (tastin) 0.210
RBL2 retinoblastoma-like 2 (p130) 0.198
SSU72 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) 0.142
SMC6 structural maintenance of chromosomes 6 0.142
SUZ12 suppressor of zeste 12 homolog (Drosophila) 0.128
MBD1 methyl-CpG binding domain protein 1 0.114
ASF1B ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.114
MYBL2 v-myb myeloblastosis viral oncogene homolog (avian)-like 2 0.075
RBBP8 retinoblastoma binding protein 8 0.074
CHAF1A chromatin assembly factor 1, subunit A (p150) 0.073
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.070
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.066
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 125kDa 0.062
RBBP4 retinoblastoma binding protein 4 0.058
INCENP inner centromere protein antigens 135/155kDa 0.057
ORC1 origin recognition complex, subunit 1 0.043
CHAF1B chromatin assembly factor 1, subunit B (p60) 0.040
NSMCE1 non-SMC element 1 homolog (S. cerevisiae) 0.040
RAD54L RAD54-like (S. cerevisiae) 0.038
E2F5 E2F transcription factor 5, p130-binding 0.038
SGOL1 shugoshin-like 1 (S. pombe) 0.037
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 0.037
E2F4 E2F transcription factor 4, p107/p130-binding 0.036
CBX1 chromobox homolog 1 0.036
CDK2 cyclin-dependent kinase 2 0.035
CDT1 chromatin licensing and DNA replication factor 1 0.033
POLE polymerase (DNA directed), epsilon 0.029
MCM10 minichromosome maintenance complex component 10 0.027
BRCA2 breast cancer 2, early onset 0.027
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.027
HIST1H3B histone cluster 1, H3b 0.025
LIN54 lin-54 homolog (C. elegans) 0.024
CLSPN claspin 0.021
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 11 0.019
LIN9 lin-9 homolog (C. elegans) 0.018
LBR lamin B receptor 0.015
ATRIP ATR interacting protein 0.014
CTCF CCCTC-binding factor (zinc finger protein) 0.014
PRRC2C proline-rich coiled-coil 2C 0.014
RECQL4 RecQ protein-like 4 0.014
POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit) 0.013
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.013
EXO1 exonuclease 1 0.012
CDC25A cell division cycle 25 homolog A (S. pombe) 0.011
HAUS5 HAUS augmin-like complex, subunit 5 0.011
MCMBP minichromosome maintenance complex binding protein 0.011
ZNF638 zinc finger protein 638 0.010
SLC25A32 solute carrier family 25, member 32 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Smc1a structural maintenance of chromosomes 1A 0.998
Pten phosphatase and tensin homolog 0.924
Mecp2 methyl CpG binding protein 2 0.889
Brca1 breast cancer 1 0.872
Atrx alpha thalassemia/mental retardation syndrome X-linked homolog (human) 0.862
Pds5a PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae) 0.749
Smc3 structural maintenace of chromosomes 3 0.713
Rb1 retinoblastoma 1 0.698
Mcm3 minichromosome maintenance deficient 3 (S. cerevisiae) 0.590
Brca2 breast cancer 2 0.545
Cenpf centromere protein F 0.524
Ctnnb1 catenin (cadherin associated protein), beta 1 0.493
Zfp871 zinc finger protein 871 0.489
Pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.487
Sgol1 shugoshin-like 1 (S. pombe) 0.486
Rad51ap1 RAD51 associated protein 1 0.479
Stag2 stromal antigen 2 0.440
Atm ataxia telangiectasia mutated homolog (human) 0.402
Rbl2 retinoblastoma-like 2 0.377
E2f1 E2F transcription factor 1 0.325
Chek1 checkpoint kinase 1 homolog (S. pombe) 0.313
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.313
Mms22l MMS22-like, DNA repair protein 0.308
Trp53 transformation related protein 53 0.287
Wdhd1 WD repeat and HMG-box DNA binding protein 1 0.278
Plk1 polo-like kinase 1 (Drosophila) 0.272
Timeless timeless homolog (Drosophila) 0.266
Dlgap5 discs, large (Drosophila) homolog-associated protein 5 0.244
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.240
Dtl denticleless homolog (Drosophila) 0.239
Tpx2 TPX2, microtubule-associated protein homolog (Xenopus laevis) 0.237
Msh2 mutS homolog 2 (E. coli) 0.216
Clspn claspin homolog (Xenopus laevis) 0.204
Ccnf cyclin F 0.203
Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide 0.190
Aspm asp (abnormal spindle)-like, microcephaly associated (Drosophila) 0.185
Stag1 stromal antigen 1 0.174
Ttk Ttk protein kinase 0.170
Ndc80 NDC80 homolog, kinetochore complex component (S. cerevisiae) 0.170
Kif2c kinesin family member 2C 0.169
Kif22 kinesin family member 22 0.163
Ncaph non-SMC condensin I complex, subunit H 0.146
Aurkb aurora kinase B 0.146
Mybl2 myeloblastosis oncogene-like 2 0.139
Lig1 ligase I, DNA, ATP-dependent 0.139
Mycbp2 MYC binding protein 2 0.138
Exo1 exonuclease 1 0.132
Kif11 kinesin family member 11 0.131
Atf2 activating transcription factor 2 0.129
Cenpn centromere protein N 0.128
Cdc6 cell division cycle 6 homolog (S. cerevisiae) 0.127
Kif4 kinesin family member 4 0.123
Cdt1 chromatin licensing and DNA replication factor 1 0.110
Hmmr hyaluronan mediated motility receptor (RHAMM) 0.109
Cdc25c cell division cycle 25 homolog C (S. pombe) 0.108
Bub1 budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae) 0.104
Ercc6l excision repair cross-complementing rodent repair deficiency complementation group 6 - like 0.102
Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 0.100
Melk maternal embryonic leucine zipper kinase 0.099
Pds5b PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae) 0.098
Cdca2 cell division cycle associated 2 0.095
Mll3 myeloid/lymphoid or mixed-lineage leukemia 3 0.095
Scaf11 SR-related CTD-associated factor 11 0.091
Ncoa6 nuclear receptor coactivator 6 0.090
Kif20a kinesin family member 20A 0.090
Pole polymerase (DNA directed), epsilon 0.088
Cenpe centromere protein E 0.086
Apc adenomatosis polyposis coli 0.084
Ckap2 cytoskeleton associated protein 2 0.080
Mcm5 minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) 0.079
Eme1 essential meiotic endonuclease 1 homolog 1 (S. pombe) 0.079
Rad51 RAD51 homolog (S. cerevisiae) 0.079
Rsf1 remodeling and spacing factor 1 0.078
Mis18bp1 MIS18 binding protein 1 0.077
Ncapg non-SMC condensin I complex, subunit G 0.075
Bub1b budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae) 0.075
Dlg1 discs, large homolog 1 (Drosophila) 0.074
Mcm2 minichromosome maintenance deficient 2 mitotin (S. cerevisiae) 0.070
Mll5 myeloid/lymphoid or mixed-lineage leukemia 5 0.068
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.066
Asf1b ASF1 anti-silencing function 1 homolog B (S. cerevisiae) 0.065
Racgap1 Rac GTPase-activating protein 1 0.065
Crebbp CREB binding protein 0.065
Txndc16 thioredoxin domain containing 16 0.064
Blm Bloom syndrome, RecQ helicase-like 0.064
Usp9x ubiquitin specific peptidase 9, X chromosome 0.063
Incenp inner centromere protein 0.063
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.063
Ccna2 cyclin A2 0.061
E2f8 E2F transcription factor 8 0.058
Cnot6l CCR4-NOT transcription complex, subunit 6-like 0.057
Ube2c ubiquitin-conjugating enzyme E2C 0.057
Bod1l biorientation of chromosomes in cell division 1-like 0.055
Kif23 kinesin family member 23 0.055
Twsg1 twisted gastrulation homolog 1 (Drosophila) 0.054
Ncor1 nuclear receptor co-repressor 1 0.054
Kntc1 kinetochore associated 1 0.054
Mdm2 transformed mouse 3T3 cell double minute 2 0.051
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.049
Stil Scl/Tal1 interrupting locus 0.049
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Rattus norvegicus
Name Description Probability Func Analog Organism