The network for 'chromatin silencing at rdna' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

chromatin silencing at rdna

Repression of transcription of ribosomal DNA by altering the structure of chromatin.

Saccharomyces cerevisiae
Name Description Probability Func Analog Organism
RXT2 Rxt2p 0.526
CTI6 Cti6p 0.522
TOF2 Tof2p 0.387
RPD3 Rpd3p 0.323
SIN3 Sin3p 0.307
HOS4 Hos4p 0.297
RIF1 Rif1p 0.277
UME6 Ume6p 0.261
PHO23 Pho23p 0.236
UME1 Ume1p 0.233
RCO1 Rco1p 0.226
NET1 Net1p 0.218
SAP30 Sap30p 0.189
SET1 Set1p 0.159
SGF29 Sgf29p 0.109
RXT3 Rxt3p 0.108
IES3 Ies3p 0.108
ASF1 Asf1p 0.103
FOB1 Fob1p 0.097
SET2 Set2p 0.092
NTO1 Nto1p 0.092
SNT1 Snt1p 0.092
SIR2 Sir2p 0.089
ZDS1 Zds1p 0.084
SDS3 Sds3p 0.084
SAS3 Sas3p 0.082
SUM1 Sum1p 0.077
HOS2 Hos2p 0.072
CKA2 Cka2p 0.067
HIT1 Hit1p 0.063
CHD1 Chd1p 0.063
SIF2 Sif2p 0.056
WWM1 Wwm1p 0.053
FUN30 Fun30p 0.051
CSM1 Csm1p 0.050
RLF2 Rlf2p 0.048
SET3 Set3p 0.048
LTE1 Lte1p 0.047
HHT1 Hht1p 0.047
TRA1 Tra1p 0.046
SPT21 Spt21p 0.044
ASH1 Ash1p 0.044
TOP1 Top1p 0.043
HHT2 Hht2p 0.042
YPL014W hypothetical protein 0.041
BDF1 Bdf1p 0.041
MMS1 Mms1p 0.040
NGG1 Ngg1p 0.039
HDA2 Hda2p 0.037
IXR1 Ixr1p 0.037
INM1 Inm1p 0.037
NMT1 Nmt1p 0.037
THP1 Thp1p 0.037
IOC2 Ioc2p 0.036
ARP4 Arp4p 0.036
RFM1 Rfm1p 0.036
MDH1 Mdh1p 0.036
COX13 Cox13p 0.034
SAE2 Sae2p 0.033
OPI1 Opi1p 0.032
SIW14 Siw14p 0.032
MED7 Med7p 0.031
PRS2 Prs2p 0.031
SRD1 Srd1p 0.031
SUB1 Sub1p 0.031
HIR2 Hir2p 0.030
ADA2 Ada2p 0.030
YLR264C-A hypothetical protein 0.030
NUR1 Nur1p 0.029
STB3 Stb3p 0.029
GIC1 Gic1p 0.029
YLR162W hypothetical protein 0.029
MER1 Mer1p 0.029
TSC3 Tsc3p 0.029
RTT106 Rtt106p 0.028
HST3 Hst3p 0.028
YNR014W hypothetical protein 0.028
YOL038C-A hypothetical protein 0.028
IFH1 Ifh1p 0.027
POL2 Pol2p 0.027
LEO1 Leo1p 0.027
LEU2 Leu2p 0.027
MHT1 Mht1p 0.026
PSR2 Psr2p 0.026
SPL2 Spl2p 0.026
ARP10 Arp10p 0.026
GLK1 Glk1p 0.026
ICS2 Ics2p 0.025
LGE1 Lge1p 0.025
SPT2 Spt2p 0.025
YPR157W hypothetical protein 0.024
HDA1 Hda1p 0.024
FAA1 Faa1p 0.024
UTP25 Utp25p 0.024
GCR2 Gcr2p 0.024
DCS2 Dcs2p 0.024
VPS71 Vps71p 0.024
ZPS1 Zps1p 0.024
SDC1 Sdc1p 0.024
MPT5 Mpt5p 0.023
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
HDAC1 histone deacetylase 1 0.999
EP300 E1A binding protein p300 0.990
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.941
HDAC2 histone deacetylase 2 0.932
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 0.906
KDM1A lysine (K)-specific demethylase 1A 0.890
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.828
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.743
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.742
SIRT1 sirtuin 1 0.687
RBBP4 retinoblastoma binding protein 4 0.629
DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 0.628
BCOR BCL6 corepressor 0.606
SAP30 Sin3A-associated protein, 30kDa 0.306
NCOR1 nuclear receptor corepressor 1 0.271
EED embryonic ectoderm development 0.260
RBBP7 retinoblastoma binding protein 7 0.236
CREBBP CREB binding protein 0.230
SMAD3 SMAD family member 3 0.179
NCL nucleolin 0.176
CHD4 chromodomain helicase DNA binding protein 4 0.162
KAT5 K(lysine) acetyltransferase 5 0.150
BCL6 B-cell CLL/lymphoma 6 0.147
PHF19 PHD finger protein 19 0.126
SFPQ splicing factor proline/glutamine-rich 0.123
CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae) 0.123
HCFC1 host cell factor C1 (VP16-accessory protein) 0.117
SMAD7 SMAD family member 7 0.113
SMN1 survival of motor neuron 1, telomeric 0.101
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.098
NR2E3 nuclear receptor subfamily 2, group E, member 3 0.097
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.092
NCOR2 nuclear receptor corepressor 2 0.088
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 0.082
UHRF1 ubiquitin-like with PHD and ring finger domains 1 0.079
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.076
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.071
SUZ12 suppressor of zeste 12 homolog (Drosophila) 0.040
SKI v-ski sarcoma viral oncogene homolog (avian) 0.040
SP1 Sp1 transcription factor 0.035
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.033
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.032
NBN nibrin 0.031
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.030
ARID1A AT rich interactive domain 1A (SWI-like) 0.026
WRN Werner syndrome, RecQ helicase-like 0.020
SETD7 SET domain containing (lysine methyltransferase) 7 0.020
ING2 inhibitor of growth family, member 2 0.019
HDAC4 histone deacetylase 4 0.019
KLHDC4 kelch domain containing 4 0.019
FUS fused in sarcoma 0.019
KAT2B K(lysine) acetyltransferase 2B 0.019
C20orf20 chromosome 20 open reading frame 20 0.016
PLEKHO1 pleckstrin homology domain containing, family O member 1 0.016
FOXO1 forkhead box O1 0.015
MYBBP1A MYB binding protein (P160) 1a 0.015
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.015
CHD8 chromodomain helicase DNA binding protein 8 0.014
RSF1 remodeling and spacing factor 1 0.014
MBD1 methyl-CpG binding domain protein 1 0.013
SMAD1 SMAD family member 1 0.013
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.013
FBXL15 F-box and leucine-rich repeat protein 15 0.013
AR androgen receptor 0.013
MTA1 metastasis associated 1 0.012
FOXO3 forkhead box O3 0.012
TRAF4 TNF receptor-associated factor 4 0.011
ZNF512B zinc finger protein 512B 0.011
ZMYM2 zinc finger, MYM-type 2 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Hdac1 histone deacetylase 1 0.970
Arid1a AT rich interactive domain 1A (SWI-like) 0.741
Suds3 suppressor of defective silencing 3 homolog (S. cerevisiae) 0.703
Dkc1 dyskeratosis congenita 1, dyskerin homolog (human) 0.508
Sin3a transcriptional regulator, SIN3A (yeast) 0.487
Kdm5b lysine (K)-specific demethylase 5B 0.448
Baz1b bromodomain adjacent to zinc finger domain, 1B 0.438
Ep400 E1A binding protein p400 0.324
Trp53 transformation related protein 53 0.286
Dmap1 DNA methyltransferase 1-associated protein 1 0.263
Baz1a bromodomain adjacent to zinc finger domain 1A 0.239
Hdac2 histone deacetylase 2 0.205
Ncor1 nuclear receptor co-repressor 1 0.189
Ctcf CCCTC-binding factor 0.143
Qrich1 glutamine-rich 1 0.135
Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.131
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.126
Sp1 trans-acting transcription factor 1 0.119
Chd4 chromodomain helicase DNA binding protein 4 0.109
Mta2 metastasis-associated gene family, member 2 0.106
Lepr leptin receptor 0.100
Rnf2 ring finger protein 2 0.092
Rnf220 ring finger protein 220 0.085
Ep300 E1A binding protein p300 0.081
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.079
Arid1b AT rich interactive domain 1B (SWI-like) 0.079
Cry1 cryptochrome 1 (photolyase-like) 0.075
Hcfc1 host cell factor C1 0.071
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.069
Sox2 SRY-box containing gene 2 0.068
Nanog Nanog homeobox 0.068
Zfp292 zinc finger protein 292 0.066
Crebbp CREB binding protein 0.058
Suz12 suppressor of zeste 12 homolog (Drosophila) 0.053
Kdm1a lysine (K)-specific demethylase 1A 0.051
Rbbp4 retinoblastoma binding protein 4 0.047
Per2 period homolog 2 (Drosophila) 0.045
Sfpq splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) 0.043
Yy1 YY1 transcription factor 0.043
Srsf10 serine/arginine-rich splicing factor 10 0.043
Brd4 bromodomain containing 4 0.042
Ezh2 enhancer of zeste homolog 2 (Drosophila) 0.042
Acin1 apoptotic chromatin condensation inducer 1 0.041
Creb1 cAMP responsive element binding protein 1 0.039
Hnrnpm heterogeneous nuclear ribonucleoprotein M 0.038
Fzr1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.038
Pum1 pumilio 1 (Drosophila) 0.037
Rock1 Rho-associated coiled-coil containing protein kinase 1 0.037
Usp7 ubiquitin specific peptidase 7 0.037
Ubn1 ubinuclein 1 0.036
Max Max protein 0.032
Asxl1 additional sex combs like 1 (Drosophila) 0.030
Rspry1 ring finger and SPRY domain containing 1 0.030
Hdac3 histone deacetylase 3 0.029
Fam193a family with sequence similarity 193, member A 0.029
Epc2 enhancer of polycomb homolog 2 (Drosophila) 0.028
Mga MAX gene associated 0.027
Pparg peroxisome proliferator activated receptor gamma 0.026
Kdm6a 4lysine (K)-specific demethylase 6A 0.026
Smc6 structural maintenance of chromosomes 6 0.025
Abl1 c-abl oncogene 1, non-receptor tyrosine kinase 0.025
Rasl11a RAS-like, family 11, member A 0.025
Rif1 Rap1 interacting factor 1 homolog (yeast) 0.025
Irs2 insulin receptor substrate 2 0.024
Hmgb1 high mobility group box 1 0.023
Sart3 squamous cell carcinoma antigen recognized by T-cells 3 0.023
Tcfcp2l1 transcription factor CP2-like 1 0.023
Pou2f1 POU domain, class 2, transcription factor 1 0.022
E2f1 E2F transcription factor 1 0.022
L3mbtl2 l(3)mbt-like 2 (Drosophila) 0.022
Foxp1 forkhead box P1 0.022
Krit1 KRIT1, ankyrin repeat containing 0.022
Ghr growth hormone receptor 0.022
Foxo3 forkhead box O3 0.021
Cnot4 CCR4-NOT transcription complex, subunit 4 0.021
Ranbp2 RAN binding protein 2 0.021
Tubgcp2 tubulin, gamma complex associated protein 2 0.021
Safb scaffold attachment factor B 0.021
Rc3h2 ring finger and CCCH-type zinc finger domains 2 0.021
Ldb1 LIM domain binding 1 0.021
Daxx Fas death domain-associated protein 0.021
Srsf4 serine/arginine-rich splicing factor 4 0.020
Trrap transformation/transcription domain-associated protein 0.020
Baz2a bromodomain adjacent to zinc finger domain, 2A 0.020
Srrm1 serine/arginine repetitive matrix 1 0.020
Nfatc3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.020
Terf1 telomeric repeat binding factor 1 0.020
Npc1 Niemann Pick type C1 0.020
Scaf4 SR-related CTD-associated factor 4 0.019
Polr1a polymerase (RNA) I polypeptide A 0.019
Tcf3 transcription factor 3 0.019
Pcgf1 polycomb group ring finger 1 0.019
Thoc2 THO complex 2 0.019
Topors topoisomerase I binding, arginine/serine-rich 0.019
Mecp2 methyl CpG binding protein 2 0.019
Cry2 cryptochrome 2 (photolyase-like) 0.019
Setdb1 SET domain, bifurcated 1 0.019
Rest RE1-silencing transcription factor 0.018
Hnrnpu heterogeneous nuclear ribonucleoprotein U 0.018
Sap25 sin3 associated polypeptide 0.018
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Rattus norvegicus
Name Description Probability Func Analog Organism