Homo sapiens

41 known processes

TOP1

topoisomerase (DNA) I

(Aliases: TOPI)

TOP1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
post embryonic development GO:0009791 2 0.992
Worm Fly
cellular response to dna damage stimulus GO:0006974 379 0.964
posttranscriptional regulation of gene expression GO:0010608 213 0.954
oogenesis GO:0048477 2 0.939
Worm Fly
chromatin assembly or disassembly GO:0006333 78 0.926
Yeast
rna stabilization GO:0043489 18 0.866
rna processing GO:0006396 255 0.864
dna conformation change GO:0071103 113 0.851
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.831
female gamete generation GO:0007292 2 0.783
Worm Fly
cell development GO:0048468 328 0.747
Worm Fly
multicellular organismal aging GO:0010259 3 0.739
Worm
nucleic acid transport GO:0050657 39 0.720
positive regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902177 4 0.694
positive regulation of chromatin assembly or disassembly GO:0045799 2 0.692
regulation of cell cycle process GO:0010564 266 0.692
mitotic cell cycle phase transition GO:0044772 162 0.671
rna splicing GO:0008380 131 0.669
regulation of cell cycle GO:0051726 393 0.658
stem cell differentiation GO:0048863 93 0.648
negative regulation of cell cycle phase transition GO:1901988 89 0.615
response to abiotic stimulus GO:0009628 336 0.570
positive regulation of cell death GO:0010942 263 0.550
determination of adult lifespan GO:0008340 2 0.532
Worm
regulation of cell differentiation GO:0045595 393 0.524
regulation of cellular response to oxidative stress GO:1900407 26 0.520
cell cycle phase transition GO:0044770 173 0.507
negative regulation of transport GO:0051051 176 0.497
regulation of cellular component biogenesis GO:0044087 281 0.490
rna splicing via transesterification reactions GO:0000375 90 0.481
regulation of cell cycle phase transition GO:1901987 126 0.480
regulation of dna metabolic process GO:0051052 153 0.474
Yeast
negative regulation of protein metabolic process GO:0051248 391 0.472
negative regulation of cell cycle process GO:0010948 121 0.457
rna interference GO:0016246 4 0.434
spermatid differentiation GO:0048515 4 0.433
regulation of response to dna damage stimulus GO:2001020 94 0.425
dna packaging GO:0006323 77 0.411
Yeast Fly
mrna processing GO:0006397 133 0.396
positive regulation of apoptotic process GO:0043065 246 0.395
positive regulation of organelle organization GO:0010638 195 0.394
ectodermal placode development GO:0071696 1 0.386
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 28 0.381
interspecies interaction between organisms GO:0044419 156 0.356
spermatid development GO:0007286 4 0.354
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.352
negative regulation of cellular protein metabolic process GO:0032269 353 0.348
alternative mrna splicing via spliceosome GO:0000380 27 0.345
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.332
positive regulation of cellular component organization GO:0051130 376 0.325
viral life cycle GO:0019058 132 0.316
negative regulation of translation GO:0017148 37 0.310
mrna stabilization GO:0048255 18 0.306
regulation of cellular response to stress GO:0080135 244 0.295
chromatin organization GO:0006325 351 0.295
regulation of rna stability GO:0043487 23 0.285
oocyte differentiation GO:0009994 2 0.283
cell cycle checkpoint GO:0000075 117 0.280
cellular response to dsrna GO:0071359 19 0.277
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 10 0.265
regulation of alternative mrna splicing via spliceosome GO:0000381 22 0.263
ossification GO:0001503 121 0.259
system process GO:0003008 349 0.257
regulation of cell development GO:0060284 161 0.252
intrinsic apoptotic signaling pathway GO:0097193 127 0.248
dna damage checkpoint GO:0000077 68 0.239
response to oxygen containing compound GO:1901700 369 0.231
positive regulation of cell cycle GO:0045787 140 0.227
negative regulation of cell cycle GO:0045786 193 0.226
behavior GO:0007610 112 0.225
organ morphogenesis GO:0009887 147 0.223
mrna metabolic process GO:0016071 175 0.218
positive regulation of programmed cell death GO:0043068 249 0.217
regulation of mitotic cell cycle phase transition GO:1901990 118 0.215
regulation of nuclear division GO:0051783 65 0.210
apoptotic signaling pathway GO:0097190 268 0.199
striated muscle cell differentiation GO:0051146 43 0.191
positive regulation of cellular component biogenesis GO:0044089 158 0.180
regulation of mrna metabolic process GO:1903311 53 0.180
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.177
segmentation GO:0035282 4 0.171
negative regulation of gene silencing by rna GO:0060967 3 0.170
muscle system process GO:0003012 81 0.169
regulation of translation GO:0006417 89 0.165
macromolecule methylation GO:0043414 97 0.164
cellular amine metabolic process GO:0044106 41 0.163
negative regulation of developmental process GO:0051093 247 0.163
regulation of meiosis GO:0040020 3 0.160
generation of neurons GO:0048699 152 0.155
chromatin remodeling GO:0006338 55 0.149
chordate embryonic development GO:0043009 34 0.149
growth GO:0040007 202 0.149
embryo development GO:0009790 123 0.148
Mouse Worm Fly
cytoplasmic transport GO:0016482 379 0.144
ncrna processing GO:0034470 83 0.143
g2 dna damage checkpoint GO:0031572 26 0.142
ribonucleoprotein complex biogenesis GO:0022613 116 0.137
ribonucleoprotein complex subunit organization GO:0071826 81 0.135
positive regulation of response to oxidative stress GO:1902884 7 0.134
signal transduction by phosphorylation GO:0023014 297 0.133
regulation of chromosome organization GO:0033044 103 0.133
response to dsrna GO:0043331 25 0.133
protein import GO:0017038 130 0.132
dna integrity checkpoint GO:0031570 71 0.129
regulation of kinase activity GO:0043549 314 0.125
mitotic cell cycle checkpoint GO:0007093 68 0.124
negative regulation of cell death GO:0060548 345 0.123
positive regulation of chromatin modification GO:1903310 30 0.118
tube morphogenesis GO:0035239 95 0.117
dna templated transcription termination GO:0006353 3 0.117
muscle cell development GO:0055001 29 0.115
negative regulation of response to oxidative stress GO:1902883 18 0.114
negative regulation of oxidative stress induced cell death GO:1903202 17 0.114
positive regulation of immune response GO:0050778 159 0.113
chromosome segregation GO:0007059 114 0.112
Yeast Worm Fly
neuron differentiation GO:0030182 138 0.111
negative regulation of cellular response to oxidative stress GO:1900408 18 0.110
response to other organism GO:0051707 261 0.109
regulation of chromatin modification GO:1903308 51 0.108
heterochromatin assembly GO:0031507 6 0.107
epithelial tube morphogenesis GO:0060562 38 0.107
cardiac muscle contraction GO:0060048 34 0.107
cellular component morphogenesis GO:0032989 314 0.107
meiotic nuclear division GO:0007126 10 0.104
Worm
positive regulation of transport GO:0051050 336 0.104
vasculature development GO:0001944 181 0.103
regulation of proteolysis GO:0030162 293 0.102
positive regulation of dna metabolic process GO:0051054 73 0.102
intracellular receptor signaling pathway GO:0030522 104 0.102
regulation of single stranded viral rna replication via double stranded dna intermediate GO:0045091 8 0.101
negative regulation of cellular component organization GO:0051129 235 0.100
regulation of oxidative stress induced cell death GO:1903201 24 0.099
mitotic cell cycle process GO:1903047 286 0.099
Yeast
oocyte development GO:0048599 1 0.096
single organism reproductive process GO:0044702 98 0.096
Worm Fly
regulation of establishment of protein localization GO:0070201 242 0.096
regulation of chromatin organization GO:1902275 56 0.095
cellular response to oxygen containing compound GO:1901701 276 0.095
regulation of protein complex assembly GO:0043254 147 0.094
regulation of mitotic spindle organization GO:0060236 6 0.093
response to endoplasmic reticulum stress GO:0034976 49 0.093
regulation of response to external stimulus GO:0032101 222 0.093
striated muscle contraction GO:0006941 52 0.092
positive regulation of response to dna damage stimulus GO:2001022 43 0.091
organelle fission GO:0048285 149 0.088
Yeast Worm
circulatory system development GO:0072359 262 0.088
neurogenesis GO:0022008 169 0.087
regulation of stem cell differentiation GO:2000736 56 0.086
regulation of response to wounding GO:1903034 101 0.086
mrna splicing via spliceosome GO:0000398 89 0.086
positive regulation of immune system process GO:0002684 283 0.085
nervous system development GO:0007399 293 0.083
cell death in response to oxidative stress GO:0036473 29 0.079
negative regulation of phosphorus metabolic process GO:0010563 267 0.078
nitrogen compound transport GO:0071705 191 0.077
cardiovascular system development GO:0072358 262 0.077
protein catabolic process GO:0030163 325 0.076
positive regulation of cell cycle process GO:0090068 106 0.076
somitogenesis GO:0001756 2 0.076
ribonucleoprotein complex assembly GO:0022618 78 0.075
ncrna metabolic process GO:0034660 108 0.074
muscle structure development GO:0061061 98 0.074
positive regulation of proteolysis GO:0045862 142 0.073
chromatin assembly GO:0031497 61 0.072
positive regulation of chromosome organization GO:2001252 41 0.070
purine ribonucleoside metabolic process GO:0046128 437 0.069
blood vessel morphogenesis GO:0048514 162 0.068
protein maturation GO:0051604 233 0.067
modification of morphology or physiology of other organism GO:0035821 43 0.066
negative regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway GO:1903377 5 0.066
regulation of multi organism process GO:0043900 157 0.066
myosin filament assembly GO:0031034 2 0.066
regulation of response to oxidative stress GO:1902882 26 0.066
hematopoietic stem cell differentiation GO:0060218 4 0.065
response to nitrogen compound GO:1901698 184 0.064
mitotic nuclear division GO:0007067 119 0.064
Yeast
protein localization to nucleus GO:0034504 136 0.063
protein localization to organelle GO:0033365 280 0.062
nuclear pore organization GO:0006999 10 0.060
reproductive process GO:0022414 106 0.060
Worm Fly
negative regulation of rna splicing GO:0033119 15 0.059
cellular macromolecule catabolic process GO:0044265 380 0.059
blood vessel development GO:0001568 172 0.059
regulation of cellular amine metabolic process GO:0033238 11 0.058
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.057
blastoderm segmentation GO:0007350 2 0.057
regeneration GO:0031099 4 0.057
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.056
neuron projection development GO:0031175 106 0.056
regulation of axon regeneration GO:0048679 1 0.054
protein deacylation GO:0035601 39 0.053
mating GO:0007618 1 0.053
regulation of organelle assembly GO:1902115 40 0.052
positive regulation of multi organism process GO:0043902 56 0.052
regulation of mitotic cell cycle GO:0007346 189 0.051
positive regulation of oxidative stress induced cell death GO:1903209 5 0.051
dna recombination GO:0006310 77 0.051
Yeast
positive regulation of phosphorylation GO:0042327 394 0.051
protein stabilization GO:0050821 64 0.050
viral process GO:0016032 146 0.050
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.050
regulation of translational initiation GO:0006446 24 0.049
regulation of cytoskeleton organization GO:0051493 177 0.049
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.048
sister chromatid segregation GO:0000819 54 0.048
Yeast
chromosome condensation GO:0030261 15 0.047
Yeast Fly
centrosome cycle GO:0007098 32 0.047
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.047
regulation of viral genome replication GO:0045069 48 0.046
positive regulation of signal transduction by p53 class mediator GO:1901798 10 0.046
regulation of rna splicing GO:0043484 62 0.046
visual perception GO:0007601 27 0.045
zymogen activation GO:0031638 70 0.045
covalent chromatin modification GO:0016569 254 0.045
transmembrane transport GO:0055085 399 0.045
regulation of translational initiation in response to stress GO:0043558 1 0.044
negative regulation of mitotic cell cycle GO:0045930 102 0.044
translation GO:0006412 132 0.044
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.044
regulation of cell division GO:0051302 116 0.043
nuclear division GO:0000280 128 0.043
Yeast Worm
regulation of oocyte development GO:0060281 1 0.043
negative regulation of posttranscriptional gene silencing GO:0060149 3 0.043
circadian rhythm GO:0007623 21 0.043
meiosis i GO:0007127 4 0.042
cellular response to vitamin d GO:0071305 5 0.042
anatomical structure formation involved in morphogenesis GO:0048646 284 0.042
neurological system process GO:0050877 163 0.042
amine metabolic process GO:0009308 44 0.042
regulation of nucleocytoplasmic transport GO:0046822 98 0.041
androgen receptor signaling pathway GO:0030521 34 0.041
cell projection morphogenesis GO:0048858 129 0.041
androgen biosynthetic process GO:0006702 3 0.040
reproductive structure development GO:0048608 55 0.040
Worm
positive regulation of transferase activity GO:0051347 227 0.040
cellular macromolecular complex assembly GO:0034622 324 0.039
regulation of protein localization to nucleus GO:1900180 85 0.039
regulation of mrna splicing via spliceosome GO:0048024 32 0.039
central nervous system development GO:0007417 123 0.039
nucleoside catabolic process GO:0009164 408 0.038
histone h4 k20 methylation GO:0034770 1 0.038
angiogenesis GO:0001525 147 0.038
sensory perception of light stimulus GO:0050953 35 0.037
negative regulation of apoptotic signaling pathway GO:2001234 97 0.037
secretion by cell GO:0032940 226 0.037
histone deacetylation GO:0016575 32 0.037
multi organism cellular process GO:0044764 156 0.037
immune response GO:0006955 307 0.037
posttranscriptional gene silencing GO:0016441 25 0.036
heart morphogenesis GO:0003007 48 0.036
membrane organization GO:0061024 292 0.036
regulation of mrna stability GO:0043488 23 0.035
embryo development ending in birth or egg hatching GO:0009792 34 0.035
Worm
positive regulation of hydrolase activity GO:0051345 331 0.034
regulation of protein kinase activity GO:0045859 289 0.034
regulation of chromatin assembly GO:0010847 2 0.034
regulation of leukocyte activation GO:0002694 115 0.034
response to cytokine GO:0034097 232 0.033
regulation of immune response GO:0050776 201 0.033
response to oxidative stress GO:0006979 121 0.033
regulation of growth rate GO:0040009 1 0.033
pattern specification process GO:0007389 43 0.033
chemical homeostasis GO:0048878 306 0.032
methylation GO:0032259 106 0.032
cellular process involved in reproduction in multicellular organism GO:0022412 15 0.032
Worm Fly
detection of stimulus GO:0051606 85 0.032
cellular component assembly involved in morphogenesis GO:0010927 73 0.032
regulation of mrna processing GO:0050684 48 0.032
regulation of chromatin assembly or disassembly GO:0001672 6 0.031
mitotic cell cycle GO:0000278 326 0.031
Yeast
heterochromatin organization GO:0070828 6 0.031
cellular component disassembly GO:0022411 92 0.031
striated muscle myosin thick filament assembly GO:0071688 2 0.031
anterior posterior axis specification embryo GO:0008595 2 0.031
regulation of neuron projection regeneration GO:0070570 1 0.031
muscle organ development GO:0007517 56 0.030
protein localization to chromosome GO:0034502 30 0.030
immune effector process GO:0002252 159 0.030
regulation of secretion by cell GO:1903530 177 0.030
nucleosome organization GO:0034728 66 0.030
myosin filament organization GO:0031033 2 0.030
dna templated transcription initiation GO:0006352 35 0.029
vitamin d receptor signaling pathway GO:0070561 4 0.029
developmental cell growth GO:0048588 18 0.029
response to decreased oxygen levels GO:0036293 96 0.029
mitotic spindle elongation GO:0000022 4 0.029
negative regulation of multicellular organismal process GO:0051241 317 0.029
cellular response to heat GO:0034605 14 0.028
regulation of protein stability GO:0031647 87 0.028
protein processing GO:0016485 226 0.028
dna geometric change GO:0032392 32 0.028
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.028
reproduction GO:0000003 63 0.028
Worm Fly
regulation of protein localization GO:0032880 296 0.028
b cell activation GO:0042113 33 0.028
organelle assembly GO:0070925 176 0.028
neural crest cell development GO:0014032 3 0.028
positive regulation of apoptotic signaling pathway GO:2001235 70 0.028
response to lipid GO:0033993 206 0.027
base excision repair GO:0006284 21 0.027
epithelium development GO:0060429 227 0.027
regulation of nervous system development GO:0051960 88 0.027
rna transport GO:0050658 39 0.027
lymphocyte activation GO:0046649 133 0.027
protein deacetylation GO:0006476 38 0.027
muscle cell differentiation GO:0042692 63 0.027
regulation of erk1 and erk2 cascade GO:0070372 99 0.026
negative regulation of organelle organization GO:0010639 126 0.026
embryonic placenta development GO:0001892 1 0.026
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.026
dna damage response detection of dna damage GO:0042769 3 0.026
lipid biosynthetic process GO:0008610 177 0.025
response to organic cyclic compound GO:0014070 204 0.025
regulation of mitosis GO:0007088 63 0.025
nuclear import GO:0051170 106 0.025
negative regulation of cellular catabolic process GO:0031330 83 0.025
dna repair GO:0006281 198 0.025
branch elongation of an epithelium GO:0060602 3 0.025
regulation of intracellular protein transport GO:0033157 123 0.025
locomotory behavior GO:0007626 1 0.025
regulation of histone modification GO:0031056 47 0.025
cellular response to organic cyclic compound GO:0071407 127 0.024
anterior posterior axis specification GO:0009948 2 0.024
regulation of lymphocyte activation GO:0051249 103 0.024
regulation of gene expression epigenetic GO:0040029 73 0.024
Yeast
cellular response to oxygen levels GO:0071453 55 0.024
dna dependent dna replication GO:0006261 44 0.024
Yeast
skeletal system development GO:0001501 79 0.024
rrna metabolic process GO:0016072 40 0.024
signal transduction by p53 class mediator GO:0072331 72 0.024
neuromuscular junction development GO:0007528 3 0.024
negative regulation of viral transcription GO:0032897 23 0.024
cell morphogenesis GO:0000902 296 0.024
actin cytoskeleton organization GO:0030036 207 0.024
mitotic dna integrity checkpoint GO:0044774 30 0.024
positive regulation of mapk cascade GO:0043410 190 0.024
immune response activating signal transduction GO:0002757 90 0.024
axis elongation GO:0003401 4 0.023
positive regulation of immune effector process GO:0002699 40 0.023
organophosphate catabolic process GO:0046434 430 0.023
negative regulation of protein processing GO:0010955 142 0.023
morphogenesis of a branching epithelium GO:0061138 20 0.023
endomembrane system organization GO:0010256 196 0.023
mitotic dna damage checkpoint GO:0044773 28 0.023
regulation of cell migration GO:0030334 289 0.023
neuron intrinsic apoptotic signaling pathway in response to oxidative stress GO:0036480 7 0.023
actin filament based process GO:0030029 224 0.023
regulation of secretion GO:0051046 194 0.022
positive regulation of protein transport GO:0051222 135 0.022
microtubule cytoskeleton organization GO:0000226 176 0.022
hematopoietic progenitor cell differentiation GO:0002244 38 0.022
heart development GO:0007507 95 0.022
histone exchange GO:0043486 3 0.022
transcription from rna polymerase i promoter GO:0006360 11 0.022
innate immune response GO:0045087 178 0.022
nucleoside triphosphate metabolic process GO:0009141 422 0.022
determination of bilateral symmetry GO:0009855 15 0.022
regulation of neurogenesis GO:0050767 82 0.022
positive regulation of kinase activity GO:0033674 204 0.022
negative regulation of programmed cell death GO:0043069 321 0.022
response to temperature stimulus GO:0009266 22 0.022
positive regulation of cell division GO:0051781 59 0.021
regulation of striated muscle tissue development GO:0016202 26 0.021
cell type specific apoptotic process GO:0097285 125 0.021
multi multicellular organism process GO:0044706 18 0.021
spliceosomal complex assembly GO:0000245 17 0.021
regulation of transcription by chromatin organization GO:0034401 1 0.021
positive regulation of protein phosphorylation GO:0001934 313 0.021
positive regulation of peptidase activity GO:0010952 88 0.021
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.020
hippocampus development GO:0021766 1 0.020
response to heat GO:0009408 21 0.020
regulation of neuron apoptotic process GO:0043523 35 0.020
morphogenesis of an epithelium GO:0002009 60 0.020
neuromuscular synaptic transmission GO:0007274 5 0.020
tripartite regional subdivision GO:0007351 2 0.019
positive regulation of cellular response to oxidative stress GO:1900409 7 0.019
regulation of dephosphorylation GO:0035303 96 0.019
posttranscriptional gene silencing by rna GO:0035194 25 0.019
regulation of viral process GO:0050792 103 0.019
cellular response to interferon gamma GO:0071346 24 0.019
regulation of leukocyte mediated immunity GO:0002703 38 0.019
hemopoiesis GO:0030097 180 0.019
response to virus GO:0009615 126 0.019
regulation of cytoplasmic transport GO:1903649 149 0.019
cell projection organization GO:0030030 252 0.019
positive regulation of intracellular transport GO:0032388 104 0.019
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.019
positive regulation of defense response GO:0031349 87 0.019
mapk cascade GO:0000165 288 0.019
osteoblast differentiation GO:0001649 92 0.019
response to reactive oxygen species GO:0000302 61 0.019
positive regulation of leukocyte activation GO:0002696 80 0.019
negative regulation of protein modification process GO:0031400 200 0.019
heart looping GO:0001947 7 0.019
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.018
ion transmembrane transport GO:0034220 338 0.018
negative regulation of phosphate metabolic process GO:0045936 267 0.018
viral genome replication GO:0019079 50 0.018
striated muscle adaptation GO:0014888 4 0.018
positive regulation of protein kinase activity GO:0045860 190 0.018
positive regulation of intracellular protein transport GO:0090316 76 0.018
limbic system development GO:0021761 3 0.018
cell cell signaling GO:0007267 155 0.018
stem cell development GO:0048864 69 0.018
regionalization GO:0003002 29 0.018
cell activation GO:0001775 213 0.018
amino acid transport GO:0006865 28 0.018
negative regulation of multi organism process GO:0043901 92 0.018
lipid localization GO:0010876 106 0.018
response to oxygen levels GO:0070482 100 0.018
positive regulation of response to external stimulus GO:0032103 88 0.018
meiotic chromosome segregation GO:0045132 4 0.018
Worm
developmental maturation GO:0021700 28 0.018
modification dependent macromolecule catabolic process GO:0043632 212 0.017
translational initiation GO:0006413 48 0.017
negative regulation of binding GO:0051100 57 0.017
mesenchymal cell development GO:0014031 50 0.017
reciprocal dna recombination GO:0035825 4 0.017
regulation of cell maturation GO:1903429 3 0.017
ribonucleoside triphosphate catabolic process GO:0009203 391 0.017
female sex differentiation GO:0046660 12 0.017
response to lipopolysaccharide GO:0032496 70 0.017
negative regulation of cell differentiation GO:0045596 171 0.017
negative regulation of intracellular signal transduction GO:1902532 183 0.017
response to biotic stimulus GO:0009607 276 0.016
multicellular organism reproduction GO:0032504 42 0.016
Worm Fly
cartilage development GO:0051216 31 0.016
regulation of microtubule based process GO:0032886 74 0.016
ribonucleoside catabolic process GO:0042454 406 0.016
nuclear export GO:0051168 69 0.016
regulation of vasculature development GO:1901342 97 0.016
histone h3 deacetylation GO:0070932 9 0.016
centrosome organization GO:0051297 58 0.016
secretion GO:0046903 254 0.016
embryonic morphogenesis GO:0048598 85 0.016
nucleosome assembly GO:0006334 50 0.016
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.016
rna localization GO:0006403 41 0.016
stem cell proliferation GO:0072089 25 0.016
regulation of signal transduction by p53 class mediator GO:1901796 26 0.016
regulation of cell shape GO:0008360 48 0.015
cellular protein complex assembly GO:0043623 188 0.015
regulation of muscle tissue development GO:1901861 26 0.015
response to external biotic stimulus GO:0043207 261 0.015
intracellular protein transport GO:0006886 270 0.015
regulation of muscle system process GO:0090257 53 0.015
branching morphogenesis of an epithelial tube GO:0048754 19 0.015
negative regulation of catabolic process GO:0009895 104 0.015
cellular response to oxidative stress GO:0034599 85 0.015
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.015
dna ligation GO:0006266 10 0.015
regulation of dna replication GO:0006275 68 0.015
response to nutrient levels GO:0031667 81 0.015
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.015
response to starvation GO:0042594 59 0.015
protein methylation GO:0006479 74 0.015
microtubule based process GO:0007017 210 0.015
neuron development GO:0048666 113 0.015
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.015
oxidation reduction process GO:0055114 396 0.015
negative regulation of nucleocytoplasmic transport GO:0046823 37 0.015
regulation of intracellular transport GO:0032386 195 0.014
lipid metabolic process GO:0006629 381 0.014
protein modification by small protein conjugation GO:0032446 342 0.014
axon extension GO:0048675 13 0.014
embryonic heart tube morphogenesis GO:0003143 8 0.014
cellular response to hypoxia GO:0071456 51 0.014
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.014
positive regulation of mitosis GO:0045840 25 0.014
cell junction organization GO:0034330 79 0.014
mismatch repair GO:0006298 15 0.014
negative regulation of cytoplasmic transport GO:1903650 46 0.014
negative regulation of catalytic activity GO:0043086 335 0.014
positive regulation of developmental process GO:0051094 314 0.014
multi organism metabolic process GO:0044033 41 0.013
response to exogenous dsrna GO:0043330 10 0.013
multi organism behavior GO:0051705 14 0.013
positive regulation of protein localization to nucleus GO:1900182 48 0.013
positive regulation of ion transmembrane transport GO:0034767 40 0.013
regulation of circadian rhythm GO:0042752 11 0.013
glycosyl compound catabolic process GO:1901658 413 0.013
lymphocyte proliferation GO:0046651 70 0.013
regulation of mapk cascade GO:0043408 262 0.013
purine nucleoside monophosphate metabolic process GO:0009126 186 0.013

TOP1 disease predictions

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 104 0.067
muscular disease DOID:0080000 114 0.067
musculoskeletal system disease DOID:17 223 0.067
muscle tissue disease DOID:66 113 0.067
sensory system disease DOID:0050155 203 0.035
eye and adnexa disease DOID:1492 150 0.035
nervous system disease DOID:863 431 0.035
central nervous system disease DOID:331 186 0.031
neurodegenerative disease DOID:1289 102 0.031
physical disorder DOID:0080015 41 0.026
retinal disease DOID:5679 118 0.023
retinal degeneration DOID:8466 89 0.023
eye disease DOID:5614 149 0.023