IMP

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Homo sapiens

41 genes annotated in human

physical disorder

DOID:0080015

A disease that has material basis in a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "physical disorder"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "physical disorder" (in gray)

Name	Description	Probability	Func Analog Organism
ARFGEF1	ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)	0.826	Human
LAMC1	laminin, gamma 1 (formerly LAMB2)	0.547	Human
SASS6	spindle assembly 6 homolog (C. elegans)	0.539
STIL	SCL/TAL1 interrupting locus	0.438
CENPJ	centromere protein J	0.417
BUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	0.264
NDEL1	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	0.232	Human
CTBP2	C-terminal binding protein 2	0.194
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.188
STARD9	StAR-related lipid transfer (START) domain containing 9	0.176
CENPE	centromere protein E, 312kDa	0.168
CTBP1	C-terminal binding protein 1	0.162
FLNB	filamin B, beta	0.147	Human
SMO	smoothened homolog (Drosophila)	0.134
LGALS8	lectin, galactoside-binding, soluble, 8	0.127
NUF2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.123
CEP135	centrosomal protein 135kDa	0.113
CENPF	centromere protein F, 350/400kDa (mitosin)	0.102
NDC80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.099
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.094
CYLD	cylindromatosis (turban tumor syndrome)	0.068
TP53	tumor protein p53	0.051
SPC25	SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.050
ZWINT	ZW10 interactor	0.049
PLK4	polo-like kinase 4	0.048
PAX1	paired box 1	0.047
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.046
STK36	serine/threonine kinase 36	0.041
SPC24	SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)	0.040
CLIP1	CAP-GLY domain containing linker protein 1	0.037
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.036
SENP2	SUMO1/sentrin/SMT3 specific peptidase 2	0.032
PML	promyelocytic leukemia	0.031
GEN1	Gen homolog 1, endonuclease (Drosophila)	0.028
SUMO3	SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)	0.028	Human
BUB1B	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	0.028
TTK	TTK protein kinase	0.027
KIF15	kinesin family member 15	0.026
CEP152	centrosomal protein 152kDa	0.026
TOP1	topoisomerase (DNA) I	0.026
TADA2A	transcriptional adaptor 2A	0.024
BICD2	bicaudal D homolog 2 (Drosophila)	0.022
CENPI	centromere protein I	0.022
SUZ12	suppressor of zeste 12 homolog (Drosophila)	0.022
ZFYVE9	zinc finger, FYVE domain containing 9	0.021
POLQ	polymerase (DNA directed), theta	0.021
HDAC6	histone deacetylase 6	0.021
TEX11	testis expressed 11	0.021
KIF14	kinesin family member 14	0.021
KIF18A	kinesin family member 18A	0.021
PRR11	proline rich 11	0.020
ARHGAP11A	Rho GTPase activating protein 11A	0.019
MSX2	msh homeobox 2	0.019	Human
NCOA2	nuclear receptor coactivator 2	0.019
SUMO2	SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)	0.019
ILK	integrin-linked kinase	0.018
KNTC1	kinetochore associated 1	0.018
CIT	citron (rho-interacting, serine/threonine kinase 21)	0.018
KIF20B	kinesin family member 20B	0.018
EED	embryonic ectoderm development	0.017
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.017
C18orf54	chromosome 18 open reading frame 54	0.017
FOXA1	forkhead box A1	0.016
PPP1R9B	protein phosphatase 1, regulatory (inhibitor) subunit 9B	0.016
ATAD5	ATPase family, AAA domain containing 5	0.016
RARA	retinoic acid receptor, alpha	0.016
DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	0.016
BMPR1A	bone morphogenetic protein receptor, type IA	0.016
HIC1	hypermethylated in cancer 1	0.016
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.016
LRRK2	leucine-rich repeat kinase 2	0.016
ASXL1	additional sex combs like 1 (Drosophila)	0.015
VCL	vinculin	0.015
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.015
GFI1B	growth factor independent 1B transcription repressor	0.015
TUBB2A	tubulin, beta 2A	0.015
BAZ2B	bromodomain adjacent to zinc finger domain, 2B	0.015
MAP2K4	mitogen-activated protein kinase kinase 4	0.014
NCOA1	nuclear receptor coactivator 1	0.014
PPP2R4	protein phosphatase 2A activator, regulatory subunit 4	0.014
ORC6	origin recognition complex, subunit 6	0.014
PPP1R10	protein phosphatase 1, regulatory (inhibitor) subunit 10	0.014
TRIM59	tripartite motif containing 59	0.014
ACTN4	actinin, alpha 4	0.014
HDAC4	histone deacetylase 4	0.014
MYB	v-myb myeloblastosis viral oncogene homolog (avian)	0.014
DYNC1H1	dynein, cytoplasmic 1, heavy chain 1	0.014
NAP1L5	nucleosome assembly protein 1-like 5	0.014
GPSM2	G-protein signaling modulator 2	0.013
MYH9	myosin, heavy chain 9, non-muscle	0.013
DAXX	death-domain associated protein	0.013
ACTN1	actinin, alpha 1	0.013
SENP1	SUMO1/sentrin specific peptidase 1	0.013
DSN1	DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.013
FHL2	four and a half LIM domains 2	0.013
NCAPG	non-SMC condensin I complex, subunit G	0.013
C14orf145	chromosome 14 open reading frame 145	0.013
TPM4	tropomyosin 4	0.013
RALGAPB	Ral GTPase activating protein, beta subunit (non-catalytic)	0.013
HIPK1	homeodomain interacting protein kinase 1	0.013
ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)	0.013
PTN	pleiotrophin	0.013
KIF23	kinesin family member 23	0.013
PDIA3	protein disulfide isomerase family A, member 3	0.013
E2F1	E2F transcription factor 1	0.012
DCTN1	dynactin 1	0.012
ZIC1	Zic family member 1 (odd-paired homolog, Drosophila)	0.012	Human
LRP6	low density lipoprotein receptor-related protein 6	0.012
SGOL2	shugoshin-like 2 (S. pombe)	0.012
PAX6	paired box 6	0.012
FMNL2	formin-like 2	0.012
PDCD7	programmed cell death 7	0.012
FOXO1	forkhead box O1	0.012
DUSP23	dual specificity phosphatase 23	0.012
CDK12	cyclin-dependent kinase 12	0.012
SVIL	supervillin	0.012
MASTL	microtubule associated serine/threonine kinase-like	0.012
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.012
MKI67	antigen identified by monoclonal antibody Ki-67	0.012
NKAP	NFKB activating protein	0.012
GLI1	GLI family zinc finger 1	0.012	Human
PDPK1	3-phosphoinositide dependent protein kinase-1	0.012
NSL1	NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)	0.012
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.012
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.011
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.011
BANP	BTG3 associated nuclear protein	0.011
CRMP1	collapsin response mediator protein 1	0.011
BTG3	BTG family, member 3	0.011
DLGAP5	discs, large (Drosophila) homolog-associated protein 5	0.011
SETDB1	SET domain, bifurcated 1	0.011
PPP1R2	protein phosphatase 1, regulatory (inhibitor) subunit 2	0.011
CTDSP2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2	0.011
FSTL1	follistatin-like 1	0.011
MAPT	microtubule-associated protein tau	0.011
ASXL2	additional sex combs like 2 (Drosophila)	0.011
CCDC18	coiled-coil domain containing 18	0.011
STIM2	stromal interaction molecule 2	0.011
C4orf21	chromosome 4 open reading frame 21	0.011
PROX1	prospero homeobox 1	0.011
RUNX1	runt-related transcription factor 1	0.011
LUC7L2	LUC7-like 2 (S. cerevisiae)	0.011
IKZF1	IKAROS family zinc finger 1 (Ikaros)	0.011
SNAPIN	SNAP-associated protein	0.010
CHD3	chromodomain helicase DNA binding protein 3	0.010
MAPK7	mitogen-activated protein kinase 7	0.010
LMNA	lamin A/C	0.010
FN1	fibronectin 1	0.010
NTRK3	neurotrophic tyrosine kinase, receptor, type 3	0.010
STAU1	staufen, RNA binding protein, homolog 1 (Drosophila)	0.010
MIS18BP1	MIS18 binding protein 1	0.010
SALL2	sal-like 2 (Drosophila)	0.010
ZIC2	Zic family member 2 (odd-paired homolog, Drosophila)	0.009
GLI3	GLI family zinc finger 3	0.009
PTCH1	patched 1	0.008
ZIC3	Zic family member 3 (odd-paired homolog, Drosophila)	0.007
MSX1	msh homeobox 1	0.007
ASPM	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	0.007
MEOX1	mesenchyme homeobox 1	0.007
BMP4	bone morphogenetic protein 4	0.007
SIX3	SIX homeobox 3	0.007
ACVR2B	activin A receptor, type IIB	0.007
GLI2	GLI family zinc finger 2	0.007
INSL3	insulin-like 3 (Leydig cell)	0.006
RXFP2	relaxin/insulin-like family peptide receptor 2	0.006
NODAL	nodal homolog (mouse)	0.006
NDE1	nudE nuclear distribution gene E homolog 1 (A. nidulans)	0.006
DCX	doublecortin	0.006
CDK5RAP2	CDK5 regulatory subunit associated protein 2	0.006
MAMLD1	mastermind-like domain containing 1	0.006
ARX	aristaless related homeobox	0.006
RELN	reelin	0.006
SHH	sonic hedgehog	0.006
CCDC11	coiled-coil domain containing 11	0.006
GDF3	growth differentiation factor 3	0.005
MCPH1	microcephalin 1	0.005
IRF6	interferon regulatory factor 6	0.005
CFC1	cripto, FRL-1, cryptic family 1	0.005
GDF6	growth differentiation factor 6	0.004
LAMB1	laminin, beta 1	0.004
TUBA1A	tubulin, alpha 1a	0.004
TGIF1	TGFB-induced factor homeobox 1	0.003
CASC5	cancer susceptibility candidate 5	0.003
ARFGEF2	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	0.003
AR	androgen receptor	0.003
SUMO1	SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)	0.003
LMBR1	limb region 1 homolog (mouse)	0.003
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.002
EZH2	enhancer of zeste homolog 2 (Drosophila)	0.001
FLNA	filamin A, alpha	0.001
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	0.001