IMP

Process View

Homo sapiens

32 genes annotated in human

dna geometric change

The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "dna geometric change"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "dna geometric change" (in gray)

Name	Description	Probability	Func Analog Organism
RPA2	replication protein A2, 32kDa	0.999	Yeast
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.994
MCM2	minichromosome maintenance complex component 2	0.992	Yeast Mouse
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.985
H2AFX	H2A histone family, member X	0.983
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.976
MCM7	minichromosome maintenance complex component 7	0.926
RPA1	replication protein A1, 70kDa	0.924	Yeast
BRCA1	breast cancer 1, early onset	0.923
BLM	Bloom syndrome, RecQ helicase-like	0.905
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.874
NBN	nibrin	0.854
GINS2	GINS complex subunit 2 (Psf2 homolog)	0.853
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.836
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.812
RAD50	RAD50 homolog (S. cerevisiae)	0.807
RUVBL1	RuvB-like 1 (E. coli)	0.731
MDC1	mediator of DNA-damage checkpoint 1	0.716
YY1	YY1 transcription factor	0.676
CHEK2	CHK2 checkpoint homolog (S. pombe)	0.637
MCM6	minichromosome maintenance complex component 6	0.585
PARP1	poly (ADP-ribose) polymerase 1	0.548
CHD8	chromodomain helicase DNA binding protein 8	0.545
MCM3	minichromosome maintenance complex component 3	0.537	Yeast Fly
ATR	ataxia telangiectasia and Rad3 related	0.516
FANCD2	Fanconi anemia, complementation group D2	0.507
CDC45	cell division cycle 45 homolog (S. cerevisiae)	0.496	Fly
GINS4	GINS complex subunit 4 (Sld5 homolog)	0.444
MCM5	minichromosome maintenance complex component 5	0.359	Yeast Fly
CHD7	chromodomain helicase DNA binding protein 7	0.346	Human
ACD	adrenocortical dysplasia homolog (mouse)	0.315
ORC6	origin recognition complex, subunit 6	0.296
ARID2	AT rich interactive domain 2 (ARID, RFX-like)	0.286
RAD52	RAD52 homolog (S. cerevisiae)	0.266
BRCA2	breast cancer 2, early onset	0.255
INO80	INO80 homolog (S. cerevisiae)	0.243
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.241
MCM10	minichromosome maintenance complex component 10	0.238
UNG	uracil-DNA glycosylase	0.224
CUX1	cut-like homeobox 1	0.221
PPARA	peroxisome proliferator-activated receptor alpha	0.169
FANCE	Fanconi anemia, complementation group E	0.162
ACTR5	ARP5 actin-related protein 5 homolog (yeast)	0.158	Yeast
EXO1	exonuclease 1	0.140
MNAT1	menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)	0.134
CDCA7	cell division cycle associated 7	0.124
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.123
CDC7	cell division cycle 7 homolog (S. cerevisiae)	0.113
TERF2	telomeric repeat binding factor 2	0.105
INO80E	INO80 complex subunit E	0.093
MSH6	mutS homolog 6 (E. coli)	0.092
E2F1	E2F transcription factor 1	0.090
MCM8	minichromosome maintenance complex component 8	0.088
KPNA4	karyopherin alpha 4 (importin alpha 3)	0.087
MCM4	minichromosome maintenance complex component 4	0.082
GTSE1	G-2 and S-phase expressed 1	0.080
RPA3	replication protein A3, 14kDa	0.077
MCMBP	minichromosome maintenance complex binding protein	0.077
ORC1	origin recognition complex, subunit 1	0.076
POLE	polymerase (DNA directed), epsilon	0.075
ERCC6L	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	0.067
XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 3	0.063
RAD54L	RAD54-like (S. cerevisiae)	0.054	Yeast
POLA1	polymerase (DNA directed), alpha 1, catalytic subunit	0.052
XPC	xeroderma pigmentosum, complementation group C	0.051
C16orf59	chromosome 16 open reading frame 59	0.051
TOP3A	topoisomerase (DNA) III alpha	0.048
ACTR8	ARP8 actin-related protein 8 homolog (yeast)	0.046	Yeast
C15orf42	chromosome 15 open reading frame 42	0.044
CDC5L	CDC5 cell division cycle 5-like (S. pombe)	0.044
CLSPN	claspin	0.043
POLD1	polymerase (DNA directed), delta 1, catalytic subunit 125kDa	0.042
CENPM	centromere protein M	0.042
SSRP1	structure specific recognition protein 1	0.042
GTF2H1	general transcription factor IIH, polypeptide 1, 62kDa	0.042
POC1A	POC1 centriolar protein homolog A (Chlamydomonas)	0.041
ATM	ataxia telangiectasia mutated	0.040
ESPL1	extra spindle pole bodies homolog 1 (S. cerevisiae)	0.040
DDX23	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	0.040
RMI1	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae)	0.038
OTUD6B	OTU domain containing 6B	0.037
SGOL1	shugoshin-like 1 (S. pombe)	0.037
ORC3	origin recognition complex, subunit 3	0.037
NCOR1	nuclear receptor corepressor 1	0.036
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.036
CTCF	CCCTC-binding factor (zinc finger protein)	0.036
XPA	xeroderma pigmentosum, complementation group A	0.036
KIFC1	kinesin family member C1	0.034
PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	0.033
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.033
TTI1	Tel2 interacting protein 1 homolog (S. pombe)	0.033
RUVBL2	RuvB-like 2 (E. coli)	0.033
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	0.032
CHTF18	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	0.031
RECQL4	RecQ protein-like 4	0.031
BMS1	BMS1 homolog, ribosome assembly protein (yeast)	0.031
MYBL2	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	0.030
SRBD1	S1 RNA binding domain 1	0.029
RIF1	RAP1 interacting factor homolog (yeast)	0.029
RANBP2	RAN binding protein 2	0.029
FANCA	Fanconi anemia, complementation group A	0.029
SUPT16H	suppressor of Ty 16 homolog (S. cerevisiae)	0.028
TOP1	topoisomerase (DNA) I	0.028
NCAPD2	non-SMC condensin I complex, subunit D2	0.028
POLE2	polymerase (DNA directed), epsilon 2 (p59 subunit)	0.027
WRN	Werner syndrome, RecQ helicase-like	0.026
DYRK2	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	0.026
BNIPL	BCL2/adenovirus E1B 19kD interacting protein like	0.026
PSMA3	proteasome (prosome, macropain) subunit, alpha type, 3	0.025
POLQ	polymerase (DNA directed), theta	0.025
ASF1B	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.024
RPAP3	RNA polymerase II associated protein 3	0.024
FANCB	Fanconi anemia, complementation group B	0.024
INO80D	INO80 complex subunit D	0.023
NFRKB	nuclear factor related to kappaB binding protein	0.023
EFTUD2	elongation factor Tu GTP binding domain containing 2	0.023
TTF2	transcription termination factor, RNA polymerase II	0.023
SEPT7	septin 7	0.023
PAQR4	progestin and adipoQ receptor family member IV	0.023
ORC2	origin recognition complex, subunit 2	0.022
DTL	denticleless homolog (Drosophila)	0.022
TONSL	tonsoku-like, DNA repair protein	0.021
RNF8	ring finger protein 8	0.021
GINS1	GINS complex subunit 1 (Psf1 homolog)	0.021
DPCD	deleted in primary ciliary dyskinesia homolog (mouse)	0.021
MMS22L	MMS22-like, DNA repair protein	0.020
FANCI	Fanconi anemia, complementation group I	0.020
DSCC1	defective in sister chromatid cohesion 1 homolog (S. cerevisiae)	0.020
DDB1	damage-specific DNA binding protein 1, 127kDa	0.019
GTF2H2	general transcription factor IIH, polypeptide 2, 44kDa	0.019
NME7	non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)	0.018
TOP2A	topoisomerase (DNA) II alpha 170kDa	0.018	Yeast
FANCM	Fanconi anemia, complementation group M	0.018
UBA2	ubiquitin-like modifier activating enzyme 2	0.018
XRN2	5'-3' exoribonuclease 2	0.018
FAM64A	family with sequence similarity 64, member A	0.017
CEP72	centrosomal protein 72kDa	0.017
GSG2	germ cell associated 2 (haspin)	0.017
CDC25A	cell division cycle 25 homolog A (S. pombe)	0.017
TELO2	TEL2, telomere maintenance 2, homolog (S. cerevisiae)	0.017
TRAIP	TRAF interacting protein	0.017
BRD2	bromodomain containing 2	0.016
ESCO2	establishment of cohesion 1 homolog 2 (S. cerevisiae)	0.016
YAF2	YY1 associated factor 2	0.016
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.016
DERA	deoxyribose-phosphate aldolase (putative)	0.016
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.016
INO80B	INO80 complex subunit B	0.015
TROAP	trophinin associated protein (tastin)	0.015
WDHD1	WD repeat and HMG-box DNA binding protein 1	0.015
RIBC2	RIB43A domain with coiled-coils 2	0.015
PLK1	polo-like kinase 1	0.015
C2orf44	chromosome 2 open reading frame 44	0.015
NCAPH2	non-SMC condensin II complex, subunit H2	0.015
C17orf53	chromosome 17 open reading frame 53	0.015
TDP1	tyrosyl-DNA phosphodiesterase 1	0.015
SLC4A1AP	solute carrier family 4 (anion exchanger), member 1, adaptor protein	0.015
INO80C	INO80 complex subunit C	0.015
PRMT2	protein arginine methyltransferase 2	0.015
PSMC3IP	PSMC3 interacting protein	0.014
NEK1	NIMA (never in mitosis gene a)-related kinase 1	0.014
USP9Y	ubiquitin specific peptidase 9, Y-linked	0.014
PALB2	partner and localizer of BRCA2	0.014
BAZ1A	bromodomain adjacent to zinc finger domain, 1A	0.013
RFC2	replication factor C (activator 1) 2, 40kDa	0.013
ETAA1	Ewing tumor-associated antigen 1	0.013
WRAP53	WD repeat containing, antisense to TP53	0.013
TCOF1	Treacher Collins-Franceschetti syndrome 1	0.013
FANCG	Fanconi anemia, complementation group G	0.013
KDM5D	lysine (K)-specific demethylase 5D	0.013
WDR70	WD repeat domain 70	0.013
TOP3B	topoisomerase (DNA) III beta	0.013
C2orf74	chromosome 2 open reading frame 74	0.013
CCDC150	coiled-coil domain containing 150	0.013
C1orf135	chromosome 1 open reading frame 135	0.012
RINT1	RAD50 interactor 1	0.012
TRRAP	transformation/transcription domain-associated protein	0.012
EIF2B1	eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa	0.012
FBXO33	F-box protein 33	0.012
DHX9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	0.012
DNAJC9	DnaJ (Hsp40) homolog, subfamily C, member 9	0.012
UTY	ubiquitously transcribed tetratricopeptide repeat gene, Y-linked	0.012
C22orf28	chromosome 22 open reading frame 28	0.012
CENPI	centromere protein I	0.012
C9orf140	chromosome 9 open reading frame 140	0.012
SLC25A10	solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10	0.012
TNRC6B	trinucleotide repeat containing 6B	0.012
E2F2	E2F transcription factor 2	0.012
DMC1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.012
DNAJC21	DnaJ (Hsp40) homolog, subfamily C, member 21	0.012
EME1	essential meiotic endonuclease 1 homolog 1 (S. pombe)	0.011
CHRNA5	cholinergic receptor, nicotinic, alpha 5	0.011
RARS	arginyl-tRNA synthetase	0.011
RB1	retinoblastoma 1	0.011
NCOR2	nuclear receptor corepressor 2	0.011
ILF2	interleukin enhancer binding factor 2, 45kDa	0.011
FAM98B	family with sequence similarity 98, member B	0.011
NUP93	nucleoporin 93kDa	0.011
CUL2	cullin 2	0.011
C14orf43	chromosome 14 open reading frame 43	0.011
MKI67	antigen identified by monoclonal antibody Ki-67	0.011
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.011
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.011
TARDBP	TAR DNA binding protein	0.010
WDR62	WD repeat domain 62	0.010
SUV420H1	suppressor of variegation 4-20 homolog 1 (Drosophila)	0.010
FKBP5	FK506 binding protein 5	0.010
APLF	aprataxin and PNKP like factor	0.010
PCM1	pericentriolar material 1	0.010
TP53BP1	tumor protein p53 binding protein 1	0.010
RBBP5	retinoblastoma binding protein 5	0.010
GPN1	GPN-loop GTPase 1	0.010
SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	0.010
PAAF1	proteasomal ATPase-associated factor 1	0.010