IMP
Process View
neuron intrinsic apoptotic signaling pathway in response to oxidative stress
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered.
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Click on a gene's description to view its network relationships with genes known to be involved in "neuron intrinsic apoptotic signaling pathway in response to oxidative stress"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| BCL2 | B-cell CLL/lymphoma 2 | 1.000 | Human | |
| BCL2L1 | BCL2-like 1 | 1.000 | Human | |
| MCL1 | myeloid cell leukemia sequence 1 (BCL2-related) | 0.992 | ||
| BCL2L11 | BCL2-like 11 (apoptosis facilitator) | 0.954 | ||
| SFPQ | splicing factor proline/glutamine-rich | 0.871 | Human | |
| BAX | BCL2-associated X protein | 0.849 | Human | |
| BID | BH3 interacting domain death agonist | 0.731 | ||
| BAK1 | BCL2-antagonist/killer 1 | 0.238 | Human | |
| BAD | BCL2-associated agonist of cell death | 0.169 | ||
| FBXO7 | F-box protein 7 | 0.145 | ||
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.138 | ||
| EGLN1 | egl nine homolog 1 (C. elegans) | 0.136 | ||
| VHL | von Hippel-Lindau tumor suppressor | 0.119 | ||
| NONO | non-POU domain containing, octamer-binding | 0.090 | ||
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.085 | ||
| FUS | fused in sarcoma | 0.065 | ||
| WBP4 | WW domain binding protein 4 (formin binding protein 21) | 0.059 | ||
| HDAC1 | histone deacetylase 1 | 0.054 | ||
| ARNT | aryl hydrocarbon receptor nuclear translocator | 0.053 | ||
| ZNF746 | zinc finger protein 746 | 0.049 | ||
| RNF144B | ring finger protein 144B | 0.048 | ||
| EGLN3 | egl nine homolog 3 (C. elegans) | 0.046 | ||
| PARK2 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | 0.036 | ||
| SIN3A | SIN3 homolog A, transcription regulator (yeast) | 0.029 | ||
| TOP1 | topoisomerase (DNA) I | 0.023 | ||
| SP1 | Sp1 transcription factor | 0.020 | ||
| SOD1 | superoxide dismutase 1, soluble | 0.015 | ||
| CCDC6 | coiled-coil domain containing 6 | 0.014 | ||
| PINK1 | PTEN induced putative kinase 1 | 0.013 | ||
| TP53BP2 | tumor protein p53 binding protein, 2 | 0.013 | ||
| BIK | BCL2-interacting killer (apoptosis-inducing) | 0.012 | ||
| EWSR1 | Ewing sarcoma breakpoint region 1 | 0.011 |