Homo sapiens

77 known processes

TRAF3

TNF receptor-associated factor 3

(Aliases: LAP1,CAP-1,CD40bp,CRAF1)

TRAF3 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 1.000
Human
i kappab kinase nf kappab signaling GO:0007249 166 1.000
Human
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.999
Human
peptidyl serine autophosphorylation GO:0036289 2 0.997
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.996
Human
extrinsic apoptotic signaling pathway GO:0097191 119 0.994
Human
regulation of cytokine production GO:0001817 232 0.994
Human Mouse
positive regulation of jnk cascade GO:0046330 52 0.992
Human
nik nf kappab signaling GO:0038061 12 0.992
Human
positive regulation of cytokine production GO:0001819 167 0.988
Human
activation of immune response GO:0002253 114 0.988
Human Mouse
protein modification by small protein conjugation GO:0032446 342 0.984
Human
protein ubiquitination GO:0016567 314 0.982
Human
protein autoubiquitination GO:0051865 37 0.978
Human
cellular response to muramyl dipeptide GO:0071225 3 0.973
positive regulation of stress activated mapk cascade GO:0032874 60 0.968
Human
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 22 0.959
positive regulation of developmental process GO:0051094 314 0.953
Human
regulation of adaptive immune response GO:0002819 33 0.953
Human
toll like receptor 2 signaling pathway GO:0034134 4 0.950
protein polyubiquitination GO:0000209 110 0.941
Human
positive regulation of production of molecular mediator of immune response GO:0002702 11 0.941
Human
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 26 0.938
Human
regulation of lymphocyte mediated immunity GO:0002706 33 0.938
Human
mapk cascade GO:0000165 288 0.937
Human
interleukin 2 production GO:0032623 20 0.933
Human
positive regulation of apoptotic signaling pathway GO:2001235 70 0.930
Human
positive regulation of apoptotic process GO:0043065 246 0.926
Human
positive regulation of stress activated protein kinase signaling cascade GO:0070304 61 0.925
Human
carbohydrate derivative transport GO:1901264 20 0.923
regulation of t cell cytokine production GO:0002724 10 0.918
Human
activation of nf kappab inducing kinase activity GO:0007250 9 0.908
Human
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.907
Human
protein k63 linked ubiquitination GO:0070534 31 0.905
Human
regulation of mapk cascade GO:0043408 262 0.904
Human
positive regulation of protein phosphorylation GO:0001934 313 0.901
Human
activation of protein kinase activity GO:0032147 90 0.898
Human
cellular ketone metabolic process GO:0042180 80 0.896
positive regulation of programmed cell death GO:0043068 249 0.895
Human
cellular response to tumor necrosis factor GO:0071356 63 0.885
positive regulation of immunoglobulin mediated immune response GO:0002891 4 0.878
regulation of apoptotic signaling pathway GO:2001233 175 0.874
Human
immune response activating signal transduction GO:0002757 90 0.868
Human Mouse
positive regulation of osteoclast differentiation GO:0045672 9 0.856
Human
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.850
positive regulation of leukocyte mediated immunity GO:0002705 24 0.847
Human
response to virus GO:0009615 126 0.844
Mouse
positive regulation of protein kinase activity GO:0045860 190 0.839
Human
response to lipopolysaccharide GO:0032496 70 0.832
Human
lymphocyte mediated immunity GO:0002449 48 0.826
Human
positive regulation of interleukin 2 production GO:0032743 11 0.810
Human
positive regulation of adaptive immune response GO:0002821 21 0.798
Human
adaptive immune response GO:0002250 49 0.796
Human
response to interleukin 1 GO:0070555 47 0.791
Human
purine ribonucleoside catabolic process GO:0046130 398 0.788
cellular amino acid metabolic process GO:0006520 116 0.777
activation of innate immune response GO:0002218 55 0.771
Mouse
osteoclast differentiation GO:0030316 21 0.765
Human
positive regulation of myeloid leukocyte differentiation GO:0002763 24 0.762
Human
regulation of cell differentiation GO:0045595 393 0.758
Human
nucleoside catabolic process GO:0009164 408 0.757
positive regulation of myeloid cell differentiation GO:0045639 39 0.753
Human
immune response regulating signaling pathway GO:0002764 97 0.749
Human Mouse
regulation of myeloid cell differentiation GO:0045637 81 0.748
Human
cdc42 protein signal transduction GO:0032488 4 0.737
regulation of stress activated mapk cascade GO:0032872 84 0.732
Human
cytokine mediated signaling pathway GO:0019221 109 0.732
regulation of cytokine production involved in immune response GO:0002718 22 0.726
Human
negative regulation of neurological system process GO:0031645 2 0.724
response to oxygen containing compound GO:1901700 369 0.718
Human
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.717
Human
immunoglobulin secretion GO:0048305 1 0.704
immune response activating cell surface receptor signaling pathway GO:0002429 45 0.697
Human
antigen receptor mediated signaling pathway GO:0050851 38 0.689
Human
amine metabolic process GO:0009308 44 0.679
positive regulation of lymphocyte mediated immunity GO:0002708 23 0.678
Human
cd4 positive alpha beta t cell differentiation GO:0043367 4 0.677
response to molecule of bacterial origin GO:0002237 82 0.675
Human
negative regulation of apoptotic signaling pathway GO:2001234 97 0.670
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.661
Human
positive regulation of transcription regulatory region dna binding GO:2000679 8 0.656
Human
nucleotide catabolic process GO:0009166 408 0.648
regulation of dna binding GO:0051101 37 0.627
Human
response to tumor necrosis factor GO:0034612 76 0.608
t cell receptor signaling pathway GO:0050852 21 0.604
Human
cellular response to external stimulus GO:0071496 111 0.603
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.597
regulation of ion transmembrane transport GO:0034765 132 0.590
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.590
Human
regulation of nik nf kappab signaling GO:1901222 11 0.585
Human
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.585
jnk cascade GO:0007254 80 0.584
Human
regulation of protein serine threonine kinase activity GO:0071900 179 0.584
Human
cell type specific apoptotic process GO:0097285 125 0.583
cytokine production GO:0001816 247 0.582
Human Mouse
guanosine containing compound catabolic process GO:1901069 239 0.581
positive regulation of nik nf kappab signaling GO:1901224 10 0.581
Human
cellular response to biotic stimulus GO:0071216 71 0.577
Human
response to biotic stimulus GO:0009607 276 0.575
Human Zebrafish Mouse
positive regulation of jun kinase activity GO:0043507 23 0.564
Human
positive regulation of map kinase activity GO:0043406 80 0.561
Human
regulation of proteolysis GO:0030162 293 0.561
small gtpase mediated signal transduction GO:0007264 78 0.551
regulation of map kinase activity GO:0043405 108 0.542
Human
positive regulation of immune system process GO:0002684 283 0.539
Human Mouse
apoptotic signaling pathway GO:0097190 268 0.533
Human
nucleoside triphosphate metabolic process GO:0009141 422 0.529
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.526
transmission of nerve impulse GO:0019226 11 0.516
purine nucleotide catabolic process GO:0006195 405 0.515
response to other organism GO:0051707 261 0.512
Human Zebrafish Mouse
positive regulation of defense response GO:0031349 87 0.486
Mouse
negative regulation of apoptotic process GO:0043066 316 0.479
response to external biotic stimulus GO:0043207 261 0.478
Human Zebrafish Mouse
regulation of immunoglobulin secretion GO:0051023 1 0.477
positive regulation of protein homodimerization activity GO:0090073 5 0.465
Human
positive regulation of cdc42 gtpase activity GO:0043089 6 0.451
signal transduction by phosphorylation GO:0023014 297 0.448
Human
ion transmembrane transport GO:0034220 338 0.443
positive regulation of cell death GO:0010942 263 0.437
Human
purine ribonucleoside metabolic process GO:0046128 437 0.432
protein homooligomerization GO:0051260 100 0.432
Human
cellular amine metabolic process GO:0044106 41 0.429
positive regulation of immune effector process GO:0002699 40 0.424
Human
ribonucleoside triphosphate catabolic process GO:0009203 391 0.420
immune system development GO:0002520 195 0.410
Human
purine nucleoside catabolic process GO:0006152 398 0.405
response to cytokine GO:0034097 232 0.404
regulation of reactive oxygen species metabolic process GO:2000377 41 0.399
positive regulation of cell proliferation GO:0008284 301 0.398
regulation of leukocyte mediated immunity GO:0002703 38 0.396
Human
regulation of cellular ketone metabolic process GO:0010565 50 0.395
regulation of cdc42 protein signal transduction GO:0032489 14 0.392
regulation of osteoclast differentiation GO:0045670 18 0.388
Human
positive regulation of t cell cytokine production GO:0002726 4 0.388
Human
cellular response to lipopolysaccharide GO:0071222 57 0.386
Human
glycosyl compound catabolic process GO:1901658 413 0.384
positive regulation of immune response GO:0050778 159 0.384
Human Mouse
regulation of mononuclear cell proliferation GO:0032944 65 0.375
nitrogen compound transport GO:0071705 191 0.372
protein secretion GO:0009306 98 0.368
fibril organization GO:0097435 10 0.359
positive regulation of catabolic process GO:0009896 310 0.344
positive regulation of binding GO:0051099 45 0.340
Human
regulation of protein ubiquitination GO:0031396 95 0.338
positive regulation of phosphorylation GO:0042327 394 0.337
Human
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.329
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.329
regulation of protein catabolic process GO:0042176 155 0.323
hematopoietic or lymphoid organ development GO:0048534 186 0.321
Human
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.318
defense response to bacterium GO:0042742 63 0.318
positive regulation of mapk cascade GO:0043410 190 0.316
Human
regulation of anion transport GO:0044070 25 0.312
stress activated mapk cascade GO:0051403 93 0.312
Human
cellular response to oxygen containing compound GO:1901701 276 0.308
Human
production of molecular mediator of immune response GO:0002440 37 0.308
Human
positive regulation of dna binding GO:0043388 17 0.306
Human
positive regulation of cellular amine metabolic process GO:0033240 7 0.305
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.305
Human
immune effector process GO:0002252 159 0.302
Human Mouse
positive regulation of protein kinase c signaling GO:0090037 5 0.302
regulation of immune response GO:0050776 201 0.300
Human Mouse
positive regulation of endothelial cell apoptotic process GO:2000353 8 0.298
detection of muramyl dipeptide GO:0032498 1 0.297
positive regulation of transferase activity GO:0051347 227 0.297
Human
innate immune response activating signal transduction GO:0002758 48 0.297
Mouse
positive regulation of interleukin 8 production GO:0032757 36 0.294
programmed necrotic cell death GO:0097300 18 0.292
regulation of cellular amino acid metabolic process GO:0006521 6 0.289
ubiquitin dependent protein catabolic process GO:0006511 206 0.289
cellular response to lipid GO:0071396 127 0.288
Human
purine nucleoside triphosphate catabolic process GO:0009146 392 0.280
regulation of kinase activity GO:0043549 314 0.273
Human
response to lipid GO:0033993 206 0.271
Human
response to nitrogen compound GO:1901698 184 0.268
regulation of jnk cascade GO:0046328 73 0.267
Human
stress activated protein kinase signaling cascade GO:0031098 94 0.263
Human
regulation of immune effector process GO:0002697 91 0.263
Human Mouse
positive regulation of protein polyubiquitination GO:1902916 3 0.262
ribonucleoside triphosphate metabolic process GO:0009199 412 0.258
membrane protein ectodomain proteolysis GO:0006509 33 0.258
regulation of protein transport GO:0051223 213 0.255
protein oligomerization GO:0051259 173 0.255
Human
regulation of leukocyte proliferation GO:0070663 67 0.251
regulation of cd4 positive alpha beta t cell differentiation GO:0043370 3 0.248
peptidyl tyrosine phosphorylation GO:0018108 170 0.247
regulation of protein homodimerization activity GO:0043496 9 0.246
Human
regulation of tyrosine phosphorylation of stat protein GO:0042509 30 0.246
glutathione metabolic process GO:0006749 20 0.242
protein homotrimerization GO:0070207 9 0.240
Human
organophosphate catabolic process GO:0046434 430 0.239
regulation of cellular response to stress GO:0080135 244 0.238
Human
lipopolysaccharide mediated signaling pathway GO:0031663 26 0.238
anion transport GO:0006820 161 0.236
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.231
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.231
nucleoside triphosphate catabolic process GO:0009143 394 0.230
regulation of cytokine biosynthetic process GO:0042035 35 0.230
regulation of protein binding GO:0043393 66 0.229
Human
positive regulation of kinase activity GO:0033674 204 0.228
Human
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.228
cadmium ion transport GO:0015691 2 0.219
cell development GO:0048468 328 0.218
purine ribonucleotide catabolic process GO:0009154 404 0.215
regulation of ras protein signal transduction GO:0046578 155 0.214
regulation of transmembrane transporter activity GO:0022898 74 0.211
positive regulation of dna metabolic process GO:0051054 73 0.210
guanosine containing compound metabolic process GO:1901068 244 0.208
protein monoubiquitination GO:0006513 39 0.208
positive regulation of lymphocyte proliferation GO:0050671 46 0.207
leukocyte mediated immunity GO:0002443 59 0.207
Human
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.206
myeloid cell differentiation GO:0030099 117 0.194
Human
mononuclear cell proliferation GO:0032943 71 0.187
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.187
Human
regulation of nucleoside transport GO:0032242 1 0.186
regulation of transferase activity GO:0051338 355 0.183
Human
pattern recognition receptor signaling pathway GO:0002221 48 0.183
Mouse
endothelial cell apoptotic process GO:0072577 26 0.183
reactive oxygen species metabolic process GO:0072593 75 0.181
response to mechanical stimulus GO:0009612 51 0.180
positive regulation of rac gtpase activity GO:0032855 31 0.178
negative regulation of myelination GO:0031642 1 0.177
lymphocyte apoptotic process GO:0070227 20 0.177
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.177
myeloid leukocyte differentiation GO:0002573 60 0.173
Human
positive regulation of immunoglobulin production GO:0002639 4 0.170
neuronal action potential GO:0019228 9 0.168
negative regulation of phosphate metabolic process GO:0045936 267 0.168
interferon beta production GO:0032608 23 0.164
Mouse
positive regulation of protein catabolic process GO:0045732 75 0.163
nucleobase containing compound transport GO:0015931 51 0.162
divalent inorganic cation homeostasis GO:0072507 136 0.161
positive regulation of cell activation GO:0050867 81 0.161
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.160
regulation of jun kinase activity GO:0043506 27 0.158
Human
regulation of isotype switching GO:0045191 2 0.152
positive regulation of protein linear polyubiquitination GO:1902530 2 0.151
positive regulation of cellular component movement GO:0051272 181 0.151
transmembrane transport GO:0055085 399 0.148
positive regulation of cellular catabolic process GO:0031331 284 0.146
regulation of myeloid leukocyte differentiation GO:0002761 39 0.144
Human
positive regulation of ras gtpase activity GO:0032320 117 0.144
immune response GO:0006955 307 0.140
Human Mouse
leukocyte proliferation GO:0070661 74 0.137
system process GO:0003008 349 0.137
regulation of interferon beta biosynthetic process GO:0045357 4 0.137
positive regulation of necroptotic process GO:0060545 2 0.137
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.136
Human
negative regulation of phosphorus metabolic process GO:0010563 267 0.135
cellular homeostasis GO:0019725 196 0.135
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 4 0.134
purine nucleoside triphosphate metabolic process GO:0009144 412 0.133
cytokine production involved in immune response GO:0002367 27 0.133
Human
negative regulation of cellular protein metabolic process GO:0032269 353 0.132
regulation of protein monoubiquitination GO:1902525 1 0.132
response to lipoteichoic acid GO:0070391 3 0.132
positive regulation of canonical wnt signaling pathway GO:0090263 33 0.129
ribonucleotide catabolic process GO:0009261 405 0.129
positive regulation of gtp catabolic process GO:0033126 166 0.128
positive regulation of peptidyl serine phosphorylation GO:0033138 42 0.128
t cell cytokine production GO:0002369 12 0.126
Human
positive regulation of interferon alpha production GO:0032727 11 0.125
regulation of cellular amine metabolic process GO:0033238 11 0.124
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 3 0.124
positive regulation of t helper cell differentiation GO:0045624 2 0.124
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.123
positive regulation of mhc class i biosynthetic process GO:0045345 4 0.120
regulation of lymphocyte activation GO:0051249 103 0.120
positive regulation of cell differentiation GO:0045597 211 0.118
Human
ripoptosome assembly GO:0097343 1 0.117
negative regulation of protein metabolic process GO:0051248 391 0.117
regulation of endothelial cell apoptotic process GO:2000351 24 0.116
t helper 1 cell differentiation GO:0045063 1 0.115
regulation of interleukin 2 production GO:0032663 19 0.115
Human
positive regulation of cd4 positive alpha beta t cell activation GO:2000516 3 0.114
positive regulation of cytokine biosynthetic process GO:0042108 25 0.113
positive regulation of protein ubiquitination GO:0031398 53 0.113
negative regulation of protein processing GO:0010955 142 0.113
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.113
ribonucleoside monophosphate catabolic process GO:0009158 158 0.112
regulation of nucleoside metabolic process GO:0009118 209 0.111
tumor necrosis factor mediated signaling pathway GO:0033209 27 0.111
cell activation involved in immune response GO:0002263 30 0.110
cellular modified amino acid metabolic process GO:0006575 64 0.110
defense response to gram positive bacterium GO:0050830 29 0.109
regulation of lymphocyte proliferation GO:0050670 64 0.108
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 19 0.108
Human
leukocyte differentiation GO:0002521 98 0.107
Human
regulation of production of molecular mediator of immune response GO:0002700 25 0.106
Human
negative regulation of developmental process GO:0051093 247 0.106
serine phosphorylation of stat protein GO:0042501 4 0.105
positive regulation of innate immune response GO:0045089 79 0.104
Mouse
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.104
negative regulation of proteolysis GO:0045861 132 0.102
positive regulation of jak stat cascade GO:0046427 35 0.102
regulation of leukocyte activation GO:0002694 115 0.101
regulation of wnt signaling pathway GO:0030111 123 0.101
regulation of purine nucleotide metabolic process GO:1900542 264 0.100
regulation of b cell mediated immunity GO:0002712 7 0.099
interleukin 6 production GO:0032635 37 0.099
purine containing compound catabolic process GO:0072523 411 0.098
positive regulation of necrotic cell death GO:0010940 4 0.098
peptidyl serine phosphorylation GO:0018105 101 0.097
hemopoiesis GO:0030097 180 0.096
Human
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.095
innate immune response GO:0045087 178 0.095
Mouse
regulation of interferon beta production GO:0032648 22 0.093
Mouse
positive regulation of nucleotide catabolic process GO:0030813 185 0.091
regulation of protein linear polyubiquitination GO:1902528 2 0.090
peptidyl threonine modification GO:0018210 45 0.089
nucleoside monophosphate metabolic process GO:0009123 191 0.089
positive regulation of interleukin 6 production GO:0032755 21 0.088
regulation of tumor necrosis factor production GO:0032680 43 0.088
gtp metabolic process GO:0046039 239 0.087
multicellular organismal aging GO:0010259 3 0.087
regulation of canonical wnt signaling pathway GO:0060828 88 0.086
positive regulation of t cell proliferation GO:0042102 33 0.086
positive regulation of t helper 1 type immune response GO:0002827 4 0.086
regulation of defense response to virus GO:0050688 33 0.086
Mouse
regulation of protein kinase activity GO:0045859 289 0.085
Human
protein processing GO:0016485 226 0.084
negative regulation of programmed cell death GO:0043069 321 0.083
regulation of protein processing GO:0070613 150 0.083
regulation of leukocyte apoptotic process GO:2000106 25 0.082
regulation of peptidase activity GO:0052547 180 0.082
regulation of transcription regulatory region dna binding GO:2000677 15 0.082
Human
positive regulation of leukocyte proliferation GO:0070665 48 0.082
canonical wnt signaling pathway GO:0060070 116 0.082
positive regulation of rho gtpase activity GO:0032321 56 0.081
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.080
regulation of multi organism process GO:0043900 157 0.080
Mouse
membrane protein proteolysis GO:0033619 38 0.080
regulation of lymphocyte apoptotic process GO:0070228 15 0.080
positive regulation of membrane protein ectodomain proteolysis GO:0051044 13 0.079
peptide metabolic process GO:0006518 51 0.079
regulation of gtpase activity GO:0043087 180 0.078
multicellular organismal signaling GO:0035637 34 0.077
negative regulation of multicellular organismal process GO:0051241 317 0.077
cellular chemical homeostasis GO:0055082 180 0.077
modified amino acid transport GO:0072337 11 0.077
post embryonic development GO:0009791 2 0.076
negative regulation of endopeptidase activity GO:0010951 84 0.074
negative regulation of cell death GO:0060548 345 0.074
amyloid fibril formation GO:1990000 3 0.073
positive regulation of transport GO:0051050 336 0.072
regulation of immunoglobulin production GO:0002637 4 0.072
positive regulation of erk1 and erk2 cascade via tnfsf11 mediated signaling GO:0071848 2 0.071
cellular response to mechanical stimulus GO:0071260 39 0.071
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.070
neurological system process GO:0050877 163 0.070
peptidyl threonine phosphorylation GO:0018107 41 0.070
positive regulation of proteolysis GO:0045862 142 0.070
nucleoside monophosphate catabolic process GO:0009125 159 0.069
interferon alpha production GO:0032607 11 0.068
immature t cell proliferation GO:0033079 1 0.068
cellular cation homeostasis GO:0030003 163 0.068
nucleoside transport GO:0015858 8 0.067
regulation of cell cycle GO:0051726 393 0.067
nervous system development GO:0007399 293 0.067
necrotic cell death GO:0070265 21 0.066
negative regulation of hydrolase activity GO:0051346 182 0.066
skeletal muscle satellite cell proliferation GO:0014841 1 0.066
dephosphorylation GO:0016311 209 0.065
negative regulation of phosphorylation GO:0042326 174 0.065
regulation of macrophage differentiation GO:0045649 9 0.065
positive regulation of wnt signaling pathway GO:0030177 54 0.065
negative regulation of protein maturation GO:1903318 142 0.064
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.063
protein trimerization GO:0070206 20 0.063
Human
tyrosine phosphorylation of stat protein GO:0007260 33 0.063
jak stat cascade GO:0007259 46 0.063
trail activated apoptotic signaling pathway GO:0036462 4 0.062
cellular response to abiotic stimulus GO:0071214 117 0.061
regulation of rho gtpase activity GO:0032319 66 0.061
regulation of gtp catabolic process GO:0033124 180 0.060
negative regulation of reactive oxygen species metabolic process GO:2000378 11 0.060
regeneration GO:0031099 4 0.059
response to bacterium GO:0009617 144 0.058
Human
regulation of myelination GO:0031641 1 0.058
atp metabolic process GO:0046034 176 0.058
positive regulation of cytokine production involved in immune response GO:0002720 6 0.057
Human
leukocyte apoptotic process GO:0071887 31 0.057
neurogenesis GO:0022008 169 0.057
defense response to other organism GO:0098542 129 0.056
Mouse
necroptotic process GO:0070266 16 0.056
positive regulation of cytokine mediated signaling pathway GO:0001961 12 0.055
erk1 and erk2 cascade GO:0070371 104 0.055
regulation of cysteine type endopeptidase activity GO:2000116 127 0.055
nucleoside phosphate catabolic process GO:1901292 412 0.055
regulation of leukocyte differentiation GO:1902105 61 0.054
Human
protein kinase c signaling GO:0070528 17 0.054
organic anion transport GO:0015711 103 0.054
positive regulation of protein binding GO:0032092 24 0.054
Human
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.053
ribonucleoside monophosphate metabolic process GO:0009161 187 0.053
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.052
nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070431 4 0.052
t cell differentiation GO:0030217 29 0.052
t helper 1 type immune response GO:0042088 8 0.052
cellular response to molecule of bacterial origin GO:0071219 62 0.052
Human
regulation of ras gtpase activity GO:0032318 128 0.051
modification dependent protein catabolic process GO:0019941 209 0.051
drug transmembrane transport GO:0006855 7 0.050
positive regulation of t cell mediated immunity GO:0002711 12 0.050
Human
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.050
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.049
purine nucleoside monophosphate metabolic process GO:0009126 186 0.049
atp catabolic process GO:0006200 157 0.049
negative regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000059 3 0.049
purine nucleoside monophosphate catabolic process GO:0009128 158 0.048
regulation of nervous system development GO:0051960 88 0.048
protein catabolic process GO:0030163 325 0.048
cellular response to nitrogen compound GO:1901699 144 0.048
regulation of nucleotide catabolic process GO:0030811 205 0.048
cellular response to interferon gamma GO:0071346 24 0.048
tumor necrosis factor superfamily cytokine production GO:0071706 45 0.048
wnt signaling pathway GO:0016055 156 0.047
positive regulation of lymphocyte differentiation GO:0045621 13 0.047
regulation of interleukin 8 production GO:0032677 49 0.047
ras protein signal transduction GO:0007265 73 0.047
regulation of t cell proliferation GO:0042129 42 0.046
peptidyl serine modification GO:0018209 106 0.046
b cell mediated immunity GO:0019724 10 0.046
ribonucleoside catabolic process GO:0042454 406 0.046
response to inorganic substance GO:0010035 127 0.046
regulation of purine nucleotide catabolic process GO:0033121 205 0.046
negative regulation of catalytic activity GO:0043086 335 0.046
regulation of transporter activity GO:0032409 82 0.045
amino acid transmembrane transport GO:0003333 20 0.045
response to muramyl dipeptide GO:0032495 4 0.045
proteasomal protein catabolic process GO:0010498 176 0.045
positive regulation of isotype switching GO:0045830 2 0.045
syncytium formation by plasma membrane fusion GO:0000768 2 0.044
nucleotide binding domain leucine rich repeat containing receptor signaling pathway GO:0035872 5 0.043
t cell differentiation involved in immune response GO:0002292 7 0.043
protein maturation GO:0051604 233 0.043
natural killer cell apoptotic process GO:0070246 1 0.043
reactive nitrogen species metabolic process GO:2001057 3 0.042
dna recombination GO:0006310 77 0.042
response to oxidative stress GO:0006979 121 0.042
negative regulation of i kappab kinase nf kappab signaling GO:0043124 32 0.042
regulation of phosphatase activity GO:0010921 81 0.042
cation homeostasis GO:0055080 189 0.041
regulation of innate immune response GO:0045088 97 0.041
Mouse
protein autophosphorylation GO:0046777 123 0.040
positive regulation of protein k48 linked ubiquitination GO:1902524 1 0.040
positive regulation of t cell activation GO:0050870 54 0.039
positive regulation of type i interferon production GO:0032481 20 0.039
cellular macromolecular complex assembly GO:0034622 324 0.039
myeloid dendritic cell differentiation GO:0043011 3 0.039
regulation of peptidyl serine phosphorylation GO:0033135 50 0.039
response to peptidoglycan GO:0032494 3 0.039
negative regulation of cell cycle process GO:0010948 121 0.038
regulation of t helper 1 type immune response GO:0002825 5 0.038
positive regulation of alpha beta t cell activation GO:0046635 10 0.037
response to abiotic stimulus GO:0009628 336 0.037
negative regulation of cellular component organization GO:0051129 235 0.037
regulation of membrane protein ectodomain proteolysis GO:0051043 17 0.037
somatic recombination of immunoglobulin gene segments GO:0016447 4 0.037
epithelium development GO:0060429 227 0.037
neuroblast proliferation GO:0007405 4 0.037
cellular protein catabolic process GO:0044257 261 0.037
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.036
microtubule based process GO:0007017 210 0.036
defense response to virus GO:0051607 71 0.034
Mouse
protein k48 linked ubiquitination GO:0070936 38 0.034
regulation of immunoglobulin mediated immune response GO:0002889 7 0.034
regulation of cellular component movement GO:0051270 334 0.034
regulation of secretion GO:0051046 194 0.034
positive regulation of mononuclear cell proliferation GO:0032946 47 0.034
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.034
regulation of mitotic cell cycle GO:0007346 189 0.034
cell activation GO:0001775 213 0.033
cation transport GO:0006812 331 0.033
mitotic cell cycle GO:0000278 326 0.033
leukocyte activation GO:0045321 164 0.033
negative regulation of cell cycle GO:0045786 193 0.033
regulation of neurological system process GO:0031644 6 0.033
monocarboxylic acid transport GO:0015718 32 0.033
lipid transport GO:0006869 90 0.032
type i interferon production GO:0032606 27 0.032
Mouse
myelination GO:0042552 6 0.032
negative regulation of peptidase activity GO:0010466 91 0.032
regulation of dna metabolic process GO:0051052 153 0.032
interferon gamma production GO:0032609 39 0.031
regulation of jak stat cascade GO:0046425 44 0.031
ion homeostasis GO:0050801 230 0.031
regulation of t helper cell differentiation GO:0045622 3 0.031
positive regulation of macrophage differentiation GO:0045651 7 0.031
regulation of small gtpase mediated signal transduction GO:0051056 156 0.030
regulation of ion transmembrane transporter activity GO:0032412 72 0.030
regulation of secretion by cell GO:1903530 177 0.030

TRAF3 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.087
cancer DOID:162 167 0.064
organ system cancer DOID:0050686 164 0.064