IMP

Process View

Homo sapiens

3 genes annotated in human

somatic diversification of immunoglobulins involved in immune response

The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "somatic diversification of immunoglobulins involved in immune response"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "somatic diversification of immunoglobulins involved in immune response" (in gray)

Name	Description	Probability	Func Analog Organism
BRCA1	breast cancer 1, early onset	0.996
MDC1	mediator of DNA-damage checkpoint 1	0.942
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.921
IL4R	interleukin 4 receptor	0.910
MSH6	mutS homolog 6 (E. coli)	0.856	Mouse
MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	0.851	Mouse
H2AFX	H2A histone family, member X	0.843
APLF	aprataxin and PNKP like factor	0.839
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.723
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.713
PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	0.705
GRAP2	GRB2-related adaptor protein 2	0.650
MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	0.642	Mouse
FANCD2	Fanconi anemia, complementation group D2	0.608
NBN	nibrin	0.573	Mouse
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.560
TP53BP1	tumor protein p53 binding protein 1	0.422
XRCC4	X-ray repair complementing defective repair in Chinese hamster cells 4	0.358	Mouse
PARP1	poly (ADP-ribose) polymerase 1	0.291
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.283
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.255
BLM	Bloom syndrome, RecQ helicase-like	0.252
PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	0.221
RAD50	RAD50 homolog (S. cerevisiae)	0.175
WRN	Werner syndrome, RecQ helicase-like	0.174
LIG4	ligase IV, DNA, ATP-dependent	0.171	Mouse
TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B	0.169
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.138
MSH3	mutS homolog 3 (E. coli)	0.137
SMC1A	structural maintenance of chromosomes 1A	0.129
TRAF3	TNF receptor-associated factor 3	0.123
DDX39B	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	0.121
IL2RG	interleukin 2 receptor, gamma	0.117
ATR	ataxia telangiectasia and Rad3 related	0.105
TMSB4X	thymosin beta 4, X-linked	0.103
ENG	endoglin	0.079
RBBP8	retinoblastoma binding protein 8	0.076
ATM	ataxia telangiectasia mutated	0.068
BARD1	BRCA1 associated RING domain 1	0.063
NCOR2	nuclear receptor corepressor 2	0.057
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.057
HDAC9	histone deacetylase 9	0.053
TRAF5	TNF receptor-associated factor 5	0.052
NHEJ1	nonhomologous end-joining factor 1	0.051
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.051
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.048
ZNF830	zinc finger protein 830	0.047
APTX	aprataxin	0.046
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.045
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.043
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.043	Mouse
FHL2	four and a half LIM domains 2	0.039
SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	0.038
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.038
RFC1	replication factor C (activator 1) 1, 145kDa	0.036
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.034
SUPT5H	suppressor of Ty 5 homolog (S. cerevisiae)	0.033
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.033
BRCA2	breast cancer 2, early onset	0.033
PPM1D	protein phosphatase, Mg2+/Mn2+ dependent, 1D	0.033
NCOA6	nuclear receptor coactivator 6	0.031
AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1	0.031
PCDH9	protocadherin 9	0.031
RNF8	ring finger protein 8	0.031
CTLA4	cytotoxic T-lymphocyte-associated protein 4	0.030
TNFRSF17	tumor necrosis factor receptor superfamily, member 17	0.030
XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	0.029
DHX9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	0.029
TGFBR1	transforming growth factor, beta receptor 1	0.027
FSTL1	follistatin-like 1	0.027
RBBP4	retinoblastoma binding protein 4	0.027
PPAP2B	phosphatidic acid phosphatase type 2B	0.027
RPA1	replication protein A1, 70kDa	0.026
TGFB3	transforming growth factor, beta 3	0.026
HNRNPA2B1	heterogeneous nuclear ribonucleoprotein A2/B1	0.026
TMEM173	transmembrane protein 173	0.024
DTL	denticleless homolog (Drosophila)	0.024
IL4	interleukin 4	0.024	Mouse
SLC39A7	solute carrier family 39 (zinc transporter), member 7	0.023
POLD3	polymerase (DNA-directed), delta 3, accessory subunit	0.023
LAPTM5	lysosomal protein transmembrane 5	0.022
ASH2L	ash2 (absent, small, or homeotic)-like (Drosophila)	0.022
SUPT16H	suppressor of Ty 16 homolog (S. cerevisiae)	0.021
POLR2A	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	0.020
TDP1	tyrosyl-DNA phosphodiesterase 1	0.020
TERF2	telomeric repeat binding factor 2	0.020
BAZ1B	bromodomain adjacent to zinc finger domain, 1B	0.019
ACACA	acetyl-CoA carboxylase alpha	0.019
KHSRP	KH-type splicing regulatory protein	0.018
RAD18	RAD18 homolog (S. cerevisiae)	0.018
IRF4	interferon regulatory factor 4	0.017
CTDP1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1	0.017
PRKCQ	protein kinase C, theta	0.017
THBS1	thrombospondin 1	0.017
HCFC1	host cell factor C1 (VP16-accessory protein)	0.016
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.016
AP2B1	adaptor-related protein complex 2, beta 1 subunit	0.016
NASP	nuclear autoantigenic sperm protein (histone-binding)	0.016
KDM1A	lysine (K)-specific demethylase 1A	0.016
HDAC5	histone deacetylase 5	0.016
HDAC7	histone deacetylase 7	0.016
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.015
FANCA	Fanconi anemia, complementation group A	0.015
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.015
GBF1	golgi brefeldin A resistant guanine nucleotide exchange factor 1	0.015
SAP30	Sin3A-associated protein, 30kDa	0.015
TRIM28	tripartite motif containing 28	0.015
SH2D2A	SH2 domain containing 2A	0.014
JAK1	Janus kinase 1	0.014
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.014
BRAP	BRCA1 associated protein	0.014
CD247	CD247 molecule	0.014
HNRNPF	heterogeneous nuclear ribonucleoprotein F	0.014
SPTAN1	spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)	0.014
RBBP7	retinoblastoma binding protein 7	0.013
HSPH1	heat shock 105kDa/110kDa protein 1	0.013
CTBP1	C-terminal binding protein 1	0.013
TRAF3IP1	TNF receptor-associated factor 3 interacting protein 1	0.013
DDIT3	DNA-damage-inducible transcript 3	0.013
ODC1	ornithine decarboxylase 1	0.013
FRA10AC1	fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1	0.013
IKZF4	IKAROS family zinc finger 4 (Eos)	0.013
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.013
DCTN1	dynactin 1	0.012
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.012
SFPQ	splicing factor proline/glutamine-rich	0.012
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.012
ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)	0.012
FRMD6	FERM domain containing 6	0.012
FANCE	Fanconi anemia, complementation group E	0.012
PPARA	peroxisome proliferator-activated receptor alpha	0.012
EVI2A	ecotropic viral integration site 2A	0.012
CD2	CD2 molecule	0.012
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.012
ANXA2	annexin A2	0.012
UBB	ubiquitin B	0.012
UBA1	ubiquitin-like modifier activating enzyme 1	0.012
FANCI	Fanconi anemia, complementation group I	0.012
RIPK2	receptor-interacting serine-threonine kinase 2	0.012
NCL	nucleolin	0.012
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.011
PHF12	PHD finger protein 12	0.011
CHD8	chromodomain helicase DNA binding protein 8	0.011
LDHB	lactate dehydrogenase B	0.011
DCLRE1A	DNA cross-link repair 1A	0.011
TOPBP1	topoisomerase (DNA) II binding protein 1	0.011
XAB2	XPA binding protein 2	0.011
HDAC2	histone deacetylase 2	0.011
RPP14	ribonuclease P/MRP 14kDa subunit	0.011
STRN4	striatin, calmodulin binding protein 4	0.011
SYK	spleen tyrosine kinase	0.011
MEF2C	myocyte enhancer factor 2C	0.011
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.011
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.011
NONO	non-POU domain containing, octamer-binding	0.011
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.011
TTI1	Tel2 interacting protein 1 homolog (S. pombe)	0.011
MED12	mediator complex subunit 12	0.011
LARP1	La ribonucleoprotein domain family, member 1	0.011
MUS81	MUS81 endonuclease homolog (S. cerevisiae)	0.011
RAD54L	RAD54-like (S. cerevisiae)	0.011
TRAF1	TNF receptor-associated factor 1	0.011
TAF5L	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	0.011
KAT5	K(lysine) acetyltransferase 5	0.010
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.010
NOM1	nucleolar protein with MIF4G domain 1	0.010
TNFRSF14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.010
HOXB7	homeobox B7	0.010
CLSPN	claspin	0.010
MYO9B	myosin IXB	0.010
MAVS	mitochondrial antiviral signaling protein	0.010
LRMP	lymphoid-restricted membrane protein	0.010
NRP1	neuropilin 1	0.010
PALB2	partner and localizer of BRCA2	0.010
RUNX1	runt-related transcription factor 1	0.010