IMP

Process View

Homo sapiens

4 genes annotated in human

somatic recombination of immunoglobulin gene segments

The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "somatic recombination of immunoglobulin gene segments"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "somatic recombination of immunoglobulin gene segments" (in gray)

Name	Description	Probability	Func Analog Organism
MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	0.985	Mouse
BRCA1	breast cancer 1, early onset	0.985
MSH6	mutS homolog 6 (E. coli)	0.982	Mouse
MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	0.848	Mouse
IL4R	interleukin 4 receptor	0.778
MDC1	mediator of DNA-damage checkpoint 1	0.770
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.751
RAD50	RAD50 homolog (S. cerevisiae)	0.714
APLF	aprataxin and PNKP like factor	0.629
NBN	nibrin	0.503	Mouse
BRIP1	BRCA1 interacting protein C-terminal helicase 1	0.423
H2AFX	H2A histone family, member X	0.399
SMC1A	structural maintenance of chromosomes 1A	0.390
MSH3	mutS homolog 3 (E. coli)	0.342	Mouse
RPA2	replication protein A2, 32kDa	0.224
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.218
GRAP2	GRB2-related adaptor protein 2	0.192
FANCD2	Fanconi anemia, complementation group D2	0.171
PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	0.171
TAL1	T-cell acute lymphocytic leukemia 1	0.170
TP53BP1	tumor protein p53 binding protein 1	0.153
TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B	0.148
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.145
THOC5	THO complex 5	0.136
ZNF830	zinc finger protein 830	0.128
IL2RG	interleukin 2 receptor, gamma	0.093
RUNX1	runt-related transcription factor 1	0.093
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.083
RAD1	RAD1 homolog (S. pombe)	0.082
PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	0.069	Mouse
BAZ1B	bromodomain adjacent to zinc finger domain, 1B	0.067
NCOR2	nuclear receptor corepressor 2	0.062
ENG	endoglin	0.060
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.057
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.056
IKZF3	IKAROS family zinc finger 3 (Aiolos)	0.052
HDAC9	histone deacetylase 9	0.049
RBBP8	retinoblastoma binding protein 8	0.044
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.043
ATM	ataxia telangiectasia mutated	0.042
NHEJ1	nonhomologous end-joining factor 1	0.040
THOC4	THO complex 4	0.040
CD22	CD22 molecule	0.040
SLX4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)	0.039
ATR	ataxia telangiectasia and Rad3 related	0.039
SSB	Sjogren syndrome antigen B (autoantigen La)	0.038
ID3	inhibitor of DNA binding 3, dominant negative helix-loop-helix protein	0.038
TRAF3	TNF receptor-associated factor 3	0.037
RFC1	replication factor C (activator 1) 1, 145kDa	0.036
XRCC4	X-ray repair complementing defective repair in Chinese hamster cells 4	0.035	Mouse
TGFBR1	transforming growth factor, beta receptor 1	0.034
TCF12	transcription factor 12	0.034	Human
CD80	CD80 molecule	0.033
TRIM33	tripartite motif containing 33	0.033
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.033	Mouse
MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	0.032
DDX39B	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	0.032
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	0.031
POLR2A	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	0.031
ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	0.031
PCDH9	protocadherin 9	0.030
AR	androgen receptor	0.030
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.027
FRA10AC1	fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1	0.026
BARD1	BRCA1 associated RING domain 1	0.025
RIPK2	receptor-interacting serine-threonine kinase 2	0.025
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.023
MEF2C	myocyte enhancer factor 2C	0.023
LIG4	ligase IV, DNA, ATP-dependent	0.023	Mouse
TRAF2	TNF receptor-associated factor 2	0.023
HSPH1	heat shock 105kDa/110kDa protein 1	0.023
RNF8	ring finger protein 8	0.022
FSTL1	follistatin-like 1	0.022
HDAC4	histone deacetylase 4	0.022
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	0.021
TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	0.020
ASH2L	ash2 (absent, small, or homeotic)-like (Drosophila)	0.020
ANAPC1	anaphase promoting complex subunit 1	0.020
RPP14	ribonuclease P/MRP 14kDa subunit	0.020
RBBP4	retinoblastoma binding protein 4	0.019
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.019
NMI	N-myc (and STAT) interactor	0.019
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.019
SUPT5H	suppressor of Ty 5 homolog (S. cerevisiae)	0.018
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.018
GATA2	GATA binding protein 2	0.018
ASCL1	achaete-scute complex homolog 1 (Drosophila)	0.018
SH2D2A	SH2 domain containing 2A	0.018
EXO1	exonuclease 1	0.018	Mouse
PPARA	peroxisome proliferator-activated receptor alpha	0.018
PRKCQ	protein kinase C, theta	0.017
TNFRSF17	tumor necrosis factor receptor superfamily, member 17	0.017
POLK	polymerase (DNA directed) kappa	0.017
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.017
SUPT16H	suppressor of Ty 16 homolog (S. cerevisiae)	0.016
THOC2	THO complex 2	0.016
METAP1	methionyl aminopeptidase 1	0.016
BACH2	BTB and CNC homology 1, basic leucine zipper transcription factor 2	0.016
DIP2A	DIP2 disco-interacting protein 2 homolog A (Drosophila)	0.015
KAT2A	K(lysine) acetyltransferase 2A	0.015
CWC27	CWC27 spliceosome-associated protein homolog (S. cerevisiae)	0.015
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.015
NCOA6	nuclear receptor coactivator 6	0.015
STAG1	stromal antigen 1	0.015
TRRAP	transformation/transcription domain-associated protein	0.015
PARP1	poly (ADP-ribose) polymerase 1	0.015
SH2D1A	SH2 domain containing 1A	0.015
SIN3A	SIN3 homolog A, transcription regulator (yeast)	0.015
GBF1	golgi brefeldin A resistant guanine nucleotide exchange factor 1	0.015
RPIA	ribose 5-phosphate isomerase A	0.015
PRPF3	PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)	0.014
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.014
MAX	MYC associated factor X	0.014
HDAC5	histone deacetylase 5	0.014
MS4A1	membrane-spanning 4-domains, subfamily A, member 1	0.014
IRF4	interferon regulatory factor 4	0.014
TMSB4X	thymosin beta 4, X-linked	0.014
CEBPD	CCAAT/enhancer binding protein (C/EBP), delta	0.014
SLC39A7	solute carrier family 39 (zinc transporter), member 7	0.014
DHFR	dihydrofolate reductase	0.013
RAD21	RAD21 homolog (S. pombe)	0.013
RPA1	replication protein A1, 70kDa	0.013
GATAD2B	GATA zinc finger domain containing 2B	0.013
USP13	ubiquitin specific peptidase 13 (isopeptidase T-3)	0.013
HDAC7	histone deacetylase 7	0.013
H2AFV	H2A histone family, member V	0.013
ZBTB20	zinc finger and BTB domain containing 20	0.013
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.013
BMP2	bone morphogenetic protein 2	0.013
HUS1	HUS1 checkpoint homolog (S. pombe)	0.012
TCF4	transcription factor 4	0.012	Human
ACACA	acetyl-CoA carboxylase alpha	0.012
SYK	spleen tyrosine kinase	0.012
GAB1	GRB2-associated binding protein 1	0.012
EBF1	early B-cell factor 1	0.012
PPAP2B	phosphatidic acid phosphatase type 2B	0.012
THBS1	thrombospondin 1	0.012
TMEM173	transmembrane protein 173	0.012
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.012
ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	0.012
ANAPC4	anaphase promoting complex subunit 4	0.012
NONO	non-POU domain containing, octamer-binding	0.012
CITED2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.012
STRN4	striatin, calmodulin binding protein 4	0.012
CHD8	chromodomain helicase DNA binding protein 8	0.012
GRB7	growth factor receptor-bound protein 7	0.011
C12orf11	chromosome 12 open reading frame 11	0.011
ACVR2B	activin A receptor, type IIB	0.011
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.011
PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.011
SSBP2	single-stranded DNA binding protein 2	0.011
BCOR	BCL6 corepressor	0.011
PHF12	PHD finger protein 12	0.011
IL4	interleukin 4	0.011	Mouse
TOPBP1	topoisomerase (DNA) II binding protein 1	0.011
RAD54L2	RAD54-like 2 (S. cerevisiae)	0.011
TRAF3IP1	TNF receptor-associated factor 3 interacting protein 1	0.011
BIN1	bridging integrator 1	0.011
SKAP1	src kinase associated phosphoprotein 1	0.011
PELO	pelota homolog (Drosophila)	0.011
BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	0.011
ZBTB8A	zinc finger and BTB domain containing 8A	0.011
IRF8	interferon regulatory factor 8	0.011
FOXP1	forkhead box P1	0.011	Mouse
SAP30BP	SAP30 binding protein	0.011
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.011
CD247	CD247 molecule	0.011
TRAT1	T cell receptor associated transmembrane adaptor 1	0.011
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.011
ACYP1	acylphosphatase 1, erythrocyte (common) type	0.011
FHL2	four and a half LIM domains 2	0.010
CELF2	CUGBP, Elav-like family member 2	0.010
CD7	CD7 molecule	0.010
LARS2	leucyl-tRNA synthetase 2, mitochondrial	0.010
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.010
IRS1	insulin receptor substrate 1	0.010
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.010
BRAP	BRCA1 associated protein	0.010
ARHGAP15	Rho GTPase activating protein 15	0.010