Homo sapiens

83 known processes

IRAK2

interleukin-1 receptor-associated kinase 2

(Aliases: IRAK-2,MGC150550)

IRAK2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
interleukin 6 production GO:0032635 37 1.000
Human
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 44 1.000
Human
cellular response to bacterial lipoprotein GO:0071220 3 1.000
negative regulation of tumor necrosis factor superfamily cytokine production GO:1903556 20 1.000
Human
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.999
negative regulation of tumor necrosis factor production GO:0032720 20 0.999
Human
activation of innate immune response GO:0002218 55 0.999
Human
innate immune response activating signal transduction GO:0002758 48 0.999
Human
toll like receptor 2 signaling pathway GO:0034134 4 0.998
Human
regulation of cytokine production GO:0001817 232 0.996
Human
response to biotic stimulus GO:0009607 276 0.996
Human Mouse
negative regulation of interleukin 6 production GO:0032715 13 0.995
Human
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.995
positive regulation of toll like receptor 4 signaling pathway GO:0034145 6 0.995
activation of protein kinase activity GO:0032147 90 0.995
Human
cytokine production GO:0001816 247 0.994
Human
regulation of tumor necrosis factor production GO:0032680 43 0.994
Human
response to peptidoglycan GO:0032494 3 0.994
cellular response to lipopolysaccharide GO:0071222 57 0.994
Human Mouse
negative regulation of multicellular organismal process GO:0051241 317 0.993
Human
cellular response to biotic stimulus GO:0071216 71 0.993
Human Mouse
cytokine mediated signaling pathway GO:0019221 109 0.993
pattern recognition receptor signaling pathway GO:0002221 48 0.992
Human
positive regulation of lipopolysaccharide mediated signaling pathway GO:0031666 4 0.992
growth of symbiont in host GO:0044117 1 0.992
cellular response to molecule of bacterial origin GO:0071219 62 0.988
Human Mouse
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.986
positive regulation of toll like receptor signaling pathway GO:0034123 10 0.984
tumor necrosis factor superfamily cytokine production GO:0071706 45 0.983
Human
positive regulation of innate immune response GO:0045089 79 0.979
Human
lipopolysaccharide mediated signaling pathway GO:0031663 26 0.978
Human Mouse
negative regulation of reactive oxygen species biosynthetic process GO:1903427 1 0.975
mapk cascade GO:0000165 288 0.974
Human
response to bacterium GO:0009617 144 0.974
Human Mouse
response to molecule of bacterial origin GO:0002237 82 0.973
Human Mouse
response to lipoteichoic acid GO:0070391 3 0.973
positive regulation of defense response GO:0031349 87 0.970
Human
response to lipopolysaccharide GO:0032496 70 0.967
Human Mouse
positive regulation of nik nf kappab signaling GO:1901224 10 0.966
Human
immune response activating signal transduction GO:0002757 90 0.965
Human
i kappab kinase nf kappab signaling GO:0007249 166 0.964
Human
regulation of nik nf kappab signaling GO:1901222 11 0.964
Human
regulation of interleukin 6 production GO:0032675 37 0.962
Human
toll like receptor signaling pathway GO:0002224 25 0.961
Human
response to other organism GO:0051707 261 0.961
Human Mouse
regulation of protein kinase activity GO:0045859 289 0.958
Human
activation of nf kappab inducing kinase activity GO:0007250 9 0.958
Human
positive regulation of phosphorylation GO:0042327 394 0.951
Human
tumor necrosis factor production GO:0032640 43 0.950
Human
positive regulation of interleukin 23 production GO:0032747 4 0.950
regulation of immune response GO:0050776 201 0.949
Human
positive regulation of lipid storage GO:0010884 10 0.944
positive regulation of protein kinase activity GO:0045860 190 0.943
Human
interleukin 1 mediated signaling pathway GO:0070498 12 0.940
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.934
Human
positive regulation of toll like receptor 2 signaling pathway GO:0034137 2 0.922
response to external biotic stimulus GO:0043207 261 0.917
Human Mouse
regulation of mapk cascade GO:0043408 262 0.916
Human
cellular response to oxygen containing compound GO:1901701 276 0.915
Human Mouse
regulation of toll like receptor signaling pathway GO:0034121 17 0.910
cellular response to lipid GO:0071396 127 0.905
Human Mouse
immune response regulating signaling pathway GO:0002764 97 0.904
Human
chemokine biosynthetic process GO:0042033 4 0.903
response to cytokine GO:0034097 232 0.901
modulation of growth of symbiont involved in interaction with host GO:0044144 2 0.900
regulation of interleukin 12 production GO:0032655 15 0.899
Human
growth involved in symbiotic interaction GO:0044110 2 0.897
signal transduction by phosphorylation GO:0023014 297 0.887
Human
positive regulation of toll like receptor 3 signaling pathway GO:0034141 1 0.879
growth of symbiont involved in interaction with host GO:0044116 2 0.876
regulation of transferase activity GO:0051338 355 0.876
Human
activation of immune response GO:0002253 114 0.874
Human
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.873
response to interleukin 1 GO:0070555 47 0.868
regulation of innate immune response GO:0045088 97 0.859
Human
regulation of kinase activity GO:0043549 314 0.849
Human
negative regulation of macrophage cytokine production GO:0010936 3 0.846
chemokine metabolic process GO:0050755 4 0.840
response to lipid GO:0033993 206 0.829
Human Mouse
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.817
Human
reactive nitrogen species metabolic process GO:2001057 3 0.816
negative regulation of protein complex disassembly GO:0043242 20 0.814
Human
response to oxygen containing compound GO:1901700 369 0.813
Human Mouse
positive regulation of protein phosphorylation GO:0001934 313 0.813
Human
antifungal humoral response GO:0019732 2 0.811
regulation of interleukin 17 production GO:0032660 12 0.804
positive regulation of mapk cascade GO:0043410 190 0.802
positive regulation of immune response GO:0050778 159 0.797
Human
defense response GO:0006952 315 0.797
Human
interleukin 17 production GO:0032620 12 0.788
regulation of toll like receptor 2 signaling pathway GO:0034135 2 0.785
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.780
negative regulation of reactive oxygen species metabolic process GO:2000378 11 0.778
regulation of lipopolysaccharide mediated signaling pathway GO:0031664 13 0.777
innate immune response GO:0045087 178 0.774
Human
positive regulation of catabolic process GO:0009896 310 0.764
regulation of chemokine biosynthetic process GO:0045073 4 0.761
regulation of protein serine threonine kinase activity GO:0071900 179 0.752
Human
negative regulation of cytokine production GO:0001818 82 0.740
Human
positive regulation of chemokine production GO:0032722 22 0.723
smooth muscle cell proliferation GO:0048659 28 0.709
positive regulation of stress activated protein kinase signaling cascade GO:0070304 61 0.704
positive regulation of cytokine biosynthetic process GO:0042108 25 0.700
positive regulation of map kinase activity GO:0043406 80 0.700
response to bacterial lipoprotein GO:0032493 3 0.694
positive regulation of chemokine biosynthetic process GO:0045080 3 0.691
toll like receptor 4 signaling pathway GO:0034142 12 0.690
regulation of fat cell differentiation GO:0045598 23 0.689
cellular response to cytokine stimulus GO:0071345 181 0.685
regulation of reactive oxygen species metabolic process GO:2000377 41 0.684
positive regulation of jun kinase activity GO:0043507 23 0.677
positive regulation of kinase activity GO:0033674 204 0.676
Human
regulation of response to cytokine stimulus GO:0060759 46 0.642
positive regulation of transferase activity GO:0051347 227 0.639
Human
negative regulation of cholesterol transport GO:0032375 8 0.638
response to abiotic stimulus GO:0009628 336 0.624
response to diacyl bacterial lipopeptide GO:0071724 2 0.591
negative regulation of interleukin 12 production GO:0032695 6 0.590
Human
immune response GO:0006955 307 0.586
Human
organic hydroxy compound transport GO:0015850 63 0.568
negative regulation of growth GO:0045926 97 0.554
nitric oxide biosynthetic process GO:0006809 20 0.545
reactive oxygen species biosynthetic process GO:1903409 4 0.542
regulation of nitric oxide biosynthetic process GO:0045428 17 0.540
lipid localization GO:0010876 106 0.519
negative regulation of mapk cascade GO:0043409 56 0.511
Human
jnk cascade GO:0007254 80 0.509
cellular response to bacterial lipopeptide GO:0071221 3 0.497
positive regulation of smooth muscle cell proliferation GO:0048661 14 0.495
negative regulation of cholesterol efflux GO:0090370 2 0.494
regulation of cytokine mediated signaling pathway GO:0001959 41 0.492
detection of diacyl bacterial lipopeptide GO:0042496 2 0.476
i kappab phosphorylation GO:0007252 7 0.472
regulation of cytokine production involved in immune response GO:0002718 22 0.462
positive regulation of immune system process GO:0002684 283 0.460
Human
positive regulation of jnk cascade GO:0046330 52 0.458
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.457
cholesterol efflux GO:0033344 28 0.456
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.442
negative regulation of growth of symbiont involved in interaction with host GO:0044146 2 0.440
positive regulation of developmental process GO:0051094 314 0.440
regulation of smooth muscle cell proliferation GO:0048660 28 0.436
macrophage cytokine production GO:0010934 4 0.428
regulation of jun kinase activity GO:0043506 27 0.427
regulation of map kinase activity GO:0043405 108 0.424
Human
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.402
Human
immune effector process GO:0002252 159 0.402
positive regulation of interferon alpha biosynthetic process GO:0045356 4 0.397
interleukin 12 production GO:0032615 15 0.385
Human
regulation of cell cycle GO:0051726 393 0.380
fat cell differentiation GO:0045444 32 0.380
defense response to bacterium GO:0042742 63 0.375
cellular component disassembly GO:0022411 92 0.370
Human
detection of bacterial lipoprotein GO:0042494 3 0.363
regulation of stress activated mapk cascade GO:0032872 84 0.360
macromolecular complex disassembly GO:0032984 60 0.359
Human
reactive oxygen species metabolic process GO:0072593 75 0.358
negative regulation of protein catabolic process GO:0042177 59 0.354
Human
production of molecular mediator of immune response GO:0002440 37 0.352
cellular response to uv GO:0034644 32 0.350
type i interferon biosynthetic process GO:0045351 4 0.350
negative regulation of mitotic cell cycle GO:0045930 102 0.341
negative regulation of protein phosphorylation GO:0001933 140 0.339
Human
negative regulation of nitric oxide biosynthetic process GO:0045019 5 0.332
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.325
positive regulation of cellular catabolic process GO:0031331 284 0.320
positive regulation of stress activated mapk cascade GO:0032874 60 0.319
positive regulation of protein binding GO:0032092 24 0.318
negative regulation of protein metabolic process GO:0051248 391 0.314
Human
regulation of mitotic cell cycle GO:0007346 189 0.310
negative regulation of cytokine production involved in immune response GO:0002719 13 0.305
negative regulation of cytokine mediated signaling pathway GO:0001960 22 0.303
response to triacyl bacterial lipopeptide GO:0071725 2 0.300
regulation of immune effector process GO:0002697 91 0.291
cellular response to abiotic stimulus GO:0071214 117 0.290
regulation of jnk cascade GO:0046328 73 0.290
response to fungus GO:0009620 4 0.286
regulation of autophagy GO:0010506 52 0.279
negative regulation of phosphorus metabolic process GO:0010563 267 0.271
Human
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.269
positive regulation of cell differentiation GO:0045597 211 0.266
regulation of cell cycle process GO:0010564 266 0.266
negative regulation of cellular protein metabolic process GO:0032269 353 0.263
Human
regulation of growth GO:0040008 165 0.262
protein autophosphorylation GO:0046777 123 0.256
Human
mitotic cell cycle GO:0000278 326 0.248
positive regulation of cell proliferation GO:0008284 301 0.244
stress activated protein kinase signaling cascade GO:0031098 94 0.243
stress activated mapk cascade GO:0051403 93 0.242
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 29 0.241
regulation of cellular amino acid metabolic process GO:0006521 6 0.239
negative regulation of cell cycle g1 s phase transition GO:1902807 29 0.239
negative regulation of cell cycle phase transition GO:1901988 89 0.239
response to organonitrogen compound GO:0010243 156 0.236
positive regulation of leukocyte proliferation GO:0070665 48 0.232
lipid transport GO:0006869 90 0.232
negative regulation of cellular component organization GO:0051129 235 0.231
Human
autophagy GO:0006914 88 0.228
positive regulation of interferon beta biosynthetic process GO:0045359 4 0.228
cell growth GO:0016049 160 0.217
negative regulation of cell cycle GO:0045786 193 0.217
positive regulation of cytokine production GO:0001819 167 0.217
regulation of cell motility GO:2000145 299 0.215
type i interferon production GO:0032606 27 0.213
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 22 0.213
rna stabilization GO:0043489 18 0.213
hemopoiesis GO:0030097 180 0.209
positive regulation of interleukin 6 production GO:0032755 21 0.204
positive regulation of interleukin 8 production GO:0032757 36 0.200
nitric oxide metabolic process GO:0046209 22 0.198
positive regulation of lymphocyte activation GO:0051251 73 0.197
protein oligomerization GO:0051259 173 0.187
Human
interferon alpha biosynthetic process GO:0045349 4 0.186
regulation of cell growth GO:0001558 135 0.185
cellular response to diacyl bacterial lipopeptide GO:0071726 2 0.184
positive regulation of autophagy GO:0010508 24 0.182
protein catabolic process GO:0030163 325 0.182
Human
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 4 0.182
positive regulation of mononuclear cell proliferation GO:0032946 47 0.177
immunoglobulin secretion GO:0048305 1 0.175
cellular response to radiation GO:0071478 65 0.173
regulation of cell activation GO:0050865 125 0.173
cytokine production involved in immune response GO:0002367 27 0.170
lymphocyte mediated immunity GO:0002449 48 0.170
primary neural tube formation GO:0014020 3 0.166
defense response to gram positive bacterium GO:0050830 29 0.163
defense response to fungus GO:0050832 4 0.162
regulation of cell cycle phase transition GO:1901987 126 0.162
regulation of protein binding GO:0043393 66 0.160
negative regulation of intracellular signal transduction GO:1902532 183 0.157
Human
lymphocyte activation GO:0046649 133 0.156
response to radiation GO:0009314 151 0.156
response to uv GO:0009411 73 0.152
regulation of cytokine biosynthetic process GO:0042035 35 0.149
lipid storage GO:0019915 28 0.147
negative regulation of phosphorylation GO:0042326 174 0.146
Human
epithelium development GO:0060429 227 0.145
regulation of rna stability GO:0043487 23 0.143
cholesterol transport GO:0030301 39 0.142
regulation of cellular response to stress GO:0080135 244 0.142
regulation of leukocyte activation GO:0002694 115 0.140
immune system development GO:0002520 195 0.139
regulation of cell cycle g1 s phase transition GO:1902806 42 0.139
regulation of protein transport GO:0051223 213 0.132
protein complex disassembly GO:0043241 52 0.131
Human
g1 s transition of mitotic cell cycle GO:0000082 78 0.130
cellular amine metabolic process GO:0044106 41 0.127
positive regulation of interleukin 6 biosynthetic process GO:0045410 1 0.127
cellular response to triacyl bacterial lipopeptide GO:0071727 2 0.127
positive regulation of humoral immune response GO:0002922 3 0.124
growth GO:0040007 202 0.124
chemokine production GO:0032602 32 0.123
myeloid leukocyte cytokine production GO:0061082 5 0.123
negative regulation of catalytic activity GO:0043086 335 0.121
Human
negative regulation of protein modification process GO:0031400 200 0.120
Human
regulation of tolerance induction GO:0002643 4 0.120
leukocyte proliferation GO:0070661 74 0.114
mitotic cell cycle phase transition GO:0044772 162 0.113
negative regulation of multi organism process GO:0043901 92 0.112
regulation of lipid storage GO:0010883 21 0.109
response to heat GO:0009408 21 0.107
response to nitrogen compound GO:1901698 184 0.106
negative regulation of cell growth GO:0030308 83 0.105
response to organic cyclic compound GO:0014070 204 0.105
detection of bacterial lipopeptide GO:0070340 3 0.105
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.103
Human
inflammatory response GO:0006954 79 0.102
regulation of lymphocyte proliferation GO:0050670 64 0.102
negative regulation of catabolic process GO:0009895 104 0.102
Human
positive regulation of interleukin 17 production GO:0032740 8 0.101
regulation of apoptotic signaling pathway GO:2001233 175 0.100
regulation of chemokine c x c motif ligand 2 production GO:2000341 2 0.100
cellular response to oxygen levels GO:0071453 55 0.099
mitotic cell cycle process GO:1903047 286 0.099
negative regulation of immune response GO:0050777 40 0.098
muscle cell proliferation GO:0033002 35 0.097
mrna stabilization GO:0048255 18 0.097
positive regulation of lymphocyte proliferation GO:0050671 46 0.097
positive regulation of apoptotic process GO:0043065 246 0.097
positive regulation of chemotaxis GO:0050921 57 0.097
response to light stimulus GO:0009416 87 0.097
negative regulation of cell cycle process GO:0010948 121 0.096
cell activation GO:0001775 213 0.094
cellular response to heat GO:0034605 14 0.094
morphogenesis of embryonic epithelium GO:0016331 4 0.093
regulation of locomotion GO:0040012 329 0.092
regulation of production of molecular mediator of immune response GO:0002700 25 0.091
cytokine biosynthetic process GO:0042089 37 0.089
negative regulation of map kinase activity GO:0043407 27 0.087
Human
regulation of nucleocytoplasmic transport GO:0046822 98 0.087
extrinsic apoptotic signaling pathway GO:0097191 119 0.087
regulation of macrophage cytokine production GO:0010935 4 0.087
regulation of defense response GO:0031347 154 0.086
Human
negative regulation of immune system process GO:0002683 136 0.085
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.085
cellular response to external stimulus GO:0071496 111 0.084
cell cycle phase transition GO:0044770 173 0.083
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.082
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.082
regulation of interferon alpha biosynthetic process GO:0045354 4 0.082
negative regulation of production of molecular mediator of immune response GO:0002701 13 0.080
nik nf kappab signaling GO:0038061 12 0.077
Human
negative regulation of phosphate metabolic process GO:0045936 267 0.077
Human
response to bacterial lipopeptide GO:0070339 3 0.076
positive regulation of t cell cytokine production GO:0002726 4 0.076
response to hypoxia GO:0001666 96 0.075
toll like receptor 3 signaling pathway GO:0034138 4 0.073
protein ubiquitination GO:0016567 314 0.073
cell cycle g1 s phase transition GO:0044843 80 0.072
sterol transport GO:0015918 39 0.072
cellular response to lipoteichoic acid GO:0071223 3 0.071
regulation of lipid transport GO:0032368 44 0.071
nf kappab import into nucleus GO:0042348 22 0.070
cellular amino acid metabolic process GO:0006520 116 0.070
cytokine metabolic process GO:0042107 38 0.070
regulation of secretion GO:0051046 194 0.070
regulation of toll like receptor 3 signaling pathway GO:0034139 2 0.070
epithelial cell differentiation GO:0030855 141 0.069
positive regulation of interleukin 8 biosynthetic process GO:0045416 8 0.068
ribonucleoside catabolic process GO:0042454 406 0.068
regulation of immunoglobulin production GO:0002637 4 0.068
positive regulation of nf kappab import into nucleus GO:0042346 13 0.067
regulation of protein homodimerization activity GO:0043496 9 0.067
regulation of cellular amine metabolic process GO:0033238 11 0.067
negative regulation of growth of symbiont in host GO:0044130 1 0.066
maintenance of location GO:0051235 112 0.065
neural tube formation GO:0001841 3 0.065
interspecies interaction between organisms GO:0044419 156 0.064
regulation of mrna stability GO:0043488 23 0.064
nucleoside triphosphate metabolic process GO:0009141 422 0.064
cellular response to light stimulus GO:0071482 34 0.064
negative regulation of tumor necrosis factor mediated signaling pathway GO:0010804 7 0.062
negative regulation of defense response GO:0031348 47 0.061
regulation of sterol transport GO:0032371 21 0.060
regulation of cell migration GO:0030334 289 0.059
interleukin 1 production GO:0032612 26 0.058
3 utr mediated mrna stabilization GO:0070935 8 0.058
leukocyte activation GO:0045321 164 0.058
regulation of chemotaxis GO:0050920 74 0.058
negative regulation of toll signaling pathway GO:0045751 1 0.056
negative regulation of transferase activity GO:0051348 124 0.056
Human
negative regulation of protein ubiquitination GO:0031397 35 0.055
regulation of interleukin 2 production GO:0032663 19 0.055
regulation of interleukin 6 biosynthetic process GO:0045408 5 0.055
myeloid leukocyte activation GO:0002274 34 0.054
purine nucleotide catabolic process GO:0006195 405 0.054
detection of triacyl bacterial lipopeptide GO:0042495 2 0.054
positive regulation of granulocyte chemotaxis GO:0071624 9 0.053
positive regulation of b cell proliferation GO:0030890 12 0.053
nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070431 4 0.053
positive regulation of cytokine mediated signaling pathway GO:0001961 12 0.053
positive regulation of interleukin 1 production GO:0032732 14 0.053
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.053
antimicrobial humoral response GO:0019730 26 0.053
hematopoietic or lymphoid organ development GO:0048534 186 0.052
response to oxygen levels GO:0070482 100 0.051
protein import GO:0017038 130 0.051
interleukin 6 biosynthetic process GO:0042226 5 0.051
apoptotic signaling pathway GO:0097190 268 0.050
b cell activation GO:0042113 33 0.049
embryonic epithelial tube formation GO:0001838 4 0.049
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.049
myeloid dendritic cell activation GO:0001773 4 0.049
purine ribonucleoside metabolic process GO:0046128 437 0.048
nitrogen compound transport GO:0071705 191 0.048
myeloid cell differentiation GO:0030099 117 0.047
regulation of mitotic cell cycle phase transition GO:1901990 118 0.046
regulation of response to external stimulus GO:0032101 222 0.046
negative regulation of transport GO:0051051 176 0.046
erk1 and erk2 cascade GO:0070371 104 0.046
regulation of binding GO:0051098 111 0.044
purine nucleoside monophosphate catabolic process GO:0009128 158 0.044
amine metabolic process GO:0009308 44 0.044
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 15 0.044
regulation of interleukin 1 production GO:0032652 21 0.043
regulation of alkaline phosphatase activity GO:0010692 2 0.043
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.042
regulation of chemokine production GO:0032642 31 0.042
myeloid dendritic cell differentiation GO:0043011 3 0.042
regulation of establishment of protein localization GO:0070201 242 0.041
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.041
regulation of tumor necrosis factor mediated signaling pathway GO:0010803 12 0.041
locomotory behavior GO:0007626 1 0.041
cellular response to decreased oxygen levels GO:0036294 51 0.041
regulation of interleukin 1 mediated signaling pathway GO:2000659 3 0.041
positive regulation of antimicrobial humoral response GO:0002760 1 0.040
regulation of mononuclear cell proliferation GO:0032944 65 0.040
establishment of endothelial barrier GO:0061028 16 0.040
negative regulation of apoptotic process GO:0043066 316 0.039
negative regulation of toll like receptor signaling pathway GO:0034122 9 0.039
ribonucleotide catabolic process GO:0009261 405 0.039
response to wounding GO:0009611 168 0.038
tumor necrosis factor mediated signaling pathway GO:0033209 27 0.038
protein modification by small protein conjugation GO:0032446 342 0.038
leukocyte migration GO:0050900 107 0.038
regulation of response to wounding GO:1903034 101 0.037
regulation of multi organism process GO:0043900 157 0.037
t helper 1 type immune response GO:0042088 8 0.037
interleukin 8 production GO:0032637 51 0.036
wnt signaling pathway GO:0016055 156 0.036
multicellular organismal aging GO:0010259 3 0.036
type i interferon signaling pathway GO:0060337 11 0.035
regulation of cell division GO:0051302 116 0.035
regulation of inflammatory response GO:0050727 46 0.034
negative regulation of cell death GO:0060548 345 0.034
negative regulation of toll like receptor 3 signaling pathway GO:0034140 2 0.034
ribonucleoside triphosphate metabolic process GO:0009199 412 0.034
positive regulation of production of molecular mediator of immune response GO:0002702 11 0.032
regulation of intracellular transport GO:0032386 195 0.032
regulation of antimicrobial humoral response GO:0002759 1 0.032
positive regulation of locomotion GO:0040017 186 0.032
response to exogenous dsrna GO:0043330 10 0.031
regulation of interferon beta production GO:0032648 22 0.031
cellular response to hypoxia GO:0071456 51 0.031
positive regulation of neutrophil migration GO:1902624 7 0.030
cellular response to tumor necrosis factor GO:0071356 63 0.030
cellular protein catabolic process GO:0044257 261 0.030
regulation of erk1 and erk2 cascade GO:0070372 99 0.030
purine containing compound catabolic process GO:0072523 411 0.029
purine ribonucleotide catabolic process GO:0009154 404 0.029
adult locomotory behavior GO:0008344 1 0.029
positive regulation of response to external stimulus GO:0032103 88 0.029
cellular homeostasis GO:0019725 196 0.029
neurotransmitter secretion GO:0007269 4 0.029
protein homooligomerization GO:0051260 100 0.029
regulation of nucleotide metabolic process GO:0006140 269 0.028
positive regulation of cell migration GO:0030335 172 0.028
tube closure GO:0060606 3 0.028
regulation of type i interferon mediated signaling pathway GO:0060338 9 0.028
anatomical structure homeostasis GO:0060249 100 0.028
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.027
cellular response to interleukin 1 GO:0071347 35 0.027
positive regulation of cell motility GO:2000147 177 0.027
endothelial cell development GO:0001885 18 0.027
circadian behavior GO:0048512 2 0.026
positive regulation of nucleotide metabolic process GO:0045981 230 0.026
nucleotide catabolic process GO:0009166 408 0.025
protein targeting GO:0006605 187 0.025
nucleoside triphosphate catabolic process GO:0009143 394 0.025
negative regulation of smooth muscle cell proliferation GO:0048662 14 0.025
single organism cellular localization GO:1902580 332 0.025
regulation of b cell activation GO:0050864 24 0.025
regulation of cholesterol efflux GO:0010874 11 0.025
antigen processing and presentation GO:0019882 33 0.024
intracellular receptor signaling pathway GO:0030522 104 0.024
regulation of protein complex disassembly GO:0043244 28 0.024
Human
neuromuscular junction development GO:0007528 3 0.024
atp metabolic process GO:0046034 176 0.024
ribonucleoside triphosphate catabolic process GO:0009203 391 0.024
cellular response to mechanical stimulus GO:0071260 39 0.024
regulation of protein localization GO:0032880 296 0.024
positive regulation of binding GO:0051099 45 0.024
positive regulation of b cell activation GO:0050871 17 0.023
response to temperature stimulus GO:0009266 22 0.023
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.023
organonitrogen compound biosynthetic process GO:1901566 200 0.023
glycosyl compound catabolic process GO:1901658 413 0.022
response to mechanical stimulus GO:0009612 51 0.022
regulation of b cell proliferation GO:0030888 18 0.022
tube morphogenesis GO:0035239 95 0.022
small molecule biosynthetic process GO:0044283 157 0.022
positive regulation of leukocyte activation GO:0002696 80 0.022
positive regulation of type i interferon mediated signaling pathway GO:0060340 4 0.022
negative regulation of programmed cell death GO:0043069 321 0.022
cell cell signaling GO:0007267 155 0.022
ribonucleoside monophosphate catabolic process GO:0009158 158 0.022
regulation of mitosis GO:0007088 63 0.022
nucleoside phosphate catabolic process GO:1901292 412 0.022
female gamete generation GO:0007292 2 0.022
organic anion transport GO:0015711 103 0.021
defense response to virus GO:0051607 71 0.021
positive regulation of protein homodimerization activity GO:0090073 5 0.021
leukocyte chemotaxis GO:0030595 76 0.021
positive regulation of tumor necrosis factor production GO:0032760 21 0.021
anatomical structure formation involved in morphogenesis GO:0048646 284 0.021
vasculature development GO:0001944 181 0.021
regulation of cellular component movement GO:0051270 334 0.021
negative regulation of cell proliferation GO:0008285 228 0.021
positive regulation of leukocyte migration GO:0002687 46 0.021
regulation of interleukin 10 production GO:0032653 16 0.021
positive regulation of intracellular transport GO:0032388 104 0.021
positive regulation of monocyte chemotactic protein 1 production GO:0071639 3 0.020
interleukin 2 production GO:0032623 20 0.020

IRAK2 disease predictions

Disease DO term ID Size Probability Func Analog Org
parasitic infectious disease DOID:1398 16 0.217
disease by infectious agent DOID:0050117 34 0.217
cancer DOID:162 167 0.198
disease of cellular proliferation DOID:14566 174 0.198
organ system cancer DOID:0050686 164 0.136
musculoskeletal system disease DOID:17 223 0.091
disease of metabolism DOID:0014667 295 0.038
inherited metabolic disorder DOID:655 242 0.038
immune system cancer DOID:0060083 36 0.031
skin disease DOID:37 33 0.030
integumentary system disease DOID:16 43 0.030
central nervous system disease DOID:331 186 0.030
nervous system disease DOID:863 431 0.030
hematologic cancer DOID:2531 36 0.028
neurodegenerative disease DOID:1289 102 0.021