IMP

Process View

Homo sapiens

15 genes annotated in human

interleukin 12 production

The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "interleukin 12 production"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "interleukin 12 production" (in gray)

Name	Description	Probability	Func Analog Organism
B2M	beta-2-microglobulin	0.932
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.931	Mouse
MYD88	myeloid differentiation primary response gene (88)	0.926
HLA-B	major histocompatibility complex, class I, B	0.872
HLA-G	major histocompatibility complex, class I, G	0.861
HLA-C	major histocompatibility complex, class I, C	0.854	Human
HLA-A	major histocompatibility complex, class I, A	0.780	Human
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.777
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.567
HLA-F	major histocompatibility complex, class I, F	0.506	Human
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.486	Human
IRAK1	interleukin-1 receptor-associated kinase 1	0.473	Human
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.434
HLA-E	major histocompatibility complex, class I, E	0.393	Human
IRAK2	interleukin-1 receptor-associated kinase 2	0.385	Human
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.373	Mouse
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.245	Mouse
BIRC3	baculoviral IAP repeat containing 3	0.244
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.219
TRAF1	TNF receptor-associated factor 1	0.104
CDHR2	cadherin-related family member 2	0.104
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.070
IRAK3	interleukin-1 receptor-associated kinase 3	0.069
PELI3	pellino homolog 3 (Drosophila)	0.068
PILRA	paired immunoglobin-like type 2 receptor alpha	0.065
TAPBP	TAP binding protein (tapasin)	0.059
TKT	transketolase	0.058
STAT2	signal transducer and activator of transcription 2, 113kDa	0.050
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.046
SIGLEC7	sialic acid binding Ig-like lectin 7	0.042
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.041	Human
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.039
IRAK4	interleukin-1 receptor-associated kinase 4	0.039
CD80	CD80 molecule	0.038
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.035
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.035
MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	0.034
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.029
TRAF3	TNF receptor-associated factor 3	0.028
HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1	0.028
CXCL9	chemokine (C-X-C motif) ligand 9	0.026
RAB5C	RAB5C, member RAS oncogene family	0.026
CD40	CD40 molecule, TNF receptor superfamily member 5	0.026	Mouse Rat
PYCARD	PYD and CARD domain containing	0.026
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.026
RIPK2	receptor-interacting serine-threonine kinase 2	0.025
NCF2	neutrophil cytosolic factor 2	0.024
NLRP3	NLR family, pyrin domain containing 3	0.023
CD14	CD14 molecule	0.022
PTAFR	platelet-activating factor receptor	0.022
TNIP2	TNFAIP3 interacting protein 2	0.022
TRAF6	TNF receptor-associated factor 6	0.021	Mouse
IL10	interleukin 10	0.021
TLR4	toll-like receptor 4	0.019
TLR2	toll-like receptor 2	0.018
BTK	Bruton agammaglobulinemia tyrosine kinase	0.018
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.017
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.017
SOCS3	suppressor of cytokine signaling 3	0.017
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.017
CD86	CD86 molecule	0.017
CTSS	cathepsin S	0.016
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.015
TRAF5	TNF receptor-associated factor 5	0.014
NCL	nucleolin	0.014
SLAMF7	SLAM family member 7	0.014
IRF4	interferon regulatory factor 4	0.014
CXCR3	chemokine (C-X-C motif) receptor 3	0.014
CCL22	chemokine (C-C motif) ligand 22	0.013
IRF7	interferon regulatory factor 7	0.013
CD300A	CD300a molecule	0.013
IL1R1	interleukin 1 receptor, type I	0.013
CD28	CD28 molecule	0.012
PLEK	pleckstrin	0.012
CST3	cystatin C	0.012
AIM2	absent in melanoma 2	0.012
HK3	hexokinase 3 (white cell)	0.012
TICAM2	toll-like receptor adaptor molecule 2	0.012
CSK	c-src tyrosine kinase	0.012
IL2RB	interleukin 2 receptor, beta	0.012
CDCP1	CUB domain containing protein 1	0.012
CCR1	chemokine (C-C motif) receptor 1	0.012
FPR3	formyl peptide receptor 3	0.012
CMKLR1	chemokine-like receptor 1	0.012	Mouse
TLR6	toll-like receptor 6	0.011	Human
ARRB1	arrestin, beta 1	0.011
IL18RAP	interleukin 18 receptor accessory protein	0.011
NCF1	neutrophil cytosolic factor 1	0.011
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.011	Human
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.011
CYTH4	cytohesin 4	0.011
IL2RA	interleukin 2 receptor, alpha	0.011
VNN2	vanin 2	0.011
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.010
HCP5	HLA complex P5	0.010
IL21R	interleukin 21 receptor	0.010