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Homo sapiens

27 genes annotated in human

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negative regulation of map kinase activity

GO:0043407

Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of map kinase activity"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of map kinase activity" (in gray)

Name	Description	Probability	Func Analog Organism
MAPK1	mitogen-activated protein kinase 1	1.000
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.999	Human
MAPK14	mitogen-activated protein kinase 14	0.995
MAPK8	mitogen-activated protein kinase 8	0.985	Fly
FYN	FYN oncogene related to SRC, FGR, YES	0.976
SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	0.951
MAP2K4	mitogen-activated protein kinase kinase 4	0.944
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.928
ZNF43	zinc finger protein 43	0.906
SH3KBP1	SH3-domain kinase binding protein 1	0.893
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.855	Yeast
ZNF253	zinc finger protein 253	0.822
MAP3K5	mitogen-activated protein kinase kinase kinase 5	0.806
CRK	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.800
EGFR	epidermal growth factor receptor	0.786
DUSP1	dual specificity phosphatase 1	0.729
PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	0.700
LCK	lymphocyte-specific protein tyrosine kinase	0.680
ARRB1	arrestin, beta 1	0.594
MAP2K1	mitogen-activated protein kinase kinase 1	0.593
A2M	alpha-2-macroglobulin	0.521
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.516
MAPK3	mitogen-activated protein kinase 3	0.503
MET	met proto-oncogene (hepatocyte growth factor receptor)	0.499
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.480	Human
BMPR1A	bone morphogenetic protein receptor, type IA	0.472
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.468
ITCH	itchy E3 ubiquitin protein ligase homolog (mouse)	0.463
ZNF273	zinc finger protein 273	0.442	Human
GHR	growth hormone receptor	0.431
PPP2R5C	protein phosphatase 2, regulatory subunit B', gamma	0.422
SPRY2	sprouty homolog 2 (Drosophila)	0.344	Mouse
JUN	jun proto-oncogene	0.336
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.335
INSIG1	insulin induced gene 1	0.308
NOXA1	NADPH oxidase activator 1	0.294
WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	0.290
ARRB2	arrestin, beta 2	0.289
ZNF91	zinc finger protein 91	0.267
PDCD6IP	programmed cell death 6 interacting protein	0.264
TRAF6	TNF receptor-associated factor 6	0.233
SYK	spleen tyrosine kinase	0.231
EGR2	early growth response 2	0.225
NCF1	neutrophil cytosolic factor 1	0.222
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.219
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.213	Mouse
ATF2	activating transcription factor 2	0.199
IL1R1	interleukin 1 receptor, type I	0.194
MYD88	myeloid differentiation primary response gene (88)	0.189
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.182
PTPRR	protein tyrosine phosphatase, receptor type, R	0.179
VAV1	vav 1 guanine nucleotide exchange factor	0.161
RICTOR	RPTOR independent companion of MTOR, complex 2	0.161
MAP2K7	mitogen-activated protein kinase kinase 7	0.158
HP	haptoglobin	0.157
SHC1	SHC (Src homology 2 domain containing) transforming protein 1	0.155
BCAR1	breast cancer anti-estrogen resistance 1	0.155
ZNF680	zinc finger protein 680	0.143	Human
PTPN11	protein tyrosine phosphatase, non-receptor type 11	0.139
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.131
DUSP7	dual specificity phosphatase 7	0.127
ZFP36L1	zinc finger protein 36, C3H type-like 1	0.123
PRKCZ	protein kinase C, zeta	0.117	Human
ZNF85	zinc finger protein 85	0.116	Human
ZNF675	zinc finger protein 675	0.115
IER2	immediate early response 2	0.113
TFF1	trefoil factor 1	0.113
YWHAB	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.112
GSK3B	glycogen synthase kinase 3 beta	0.110	Rat Fly
LAMP1	lysosomal-associated membrane protein 1	0.100
IRAK1	interleukin-1 receptor-associated kinase 1	0.099	Human
BCL2	B-cell CLL/lymphoma 2	0.096
NCAM1	neural cell adhesion molecule 1	0.094
WWOX	WW domain containing oxidoreductase	0.091
PRKCB	protein kinase C, beta	0.090
IRAK2	interleukin-1 receptor-associated kinase 2	0.087	Human
PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	0.087
RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	0.085
DUSP6	dual specificity phosphatase 6	0.085
BMPR1B	bone morphogenetic protein receptor, type IB	0.084
ZNF93	zinc finger protein 93	0.082
WAS	Wiskott-Aldrich syndrome (eczema-thrombocytopenia)	0.082
MAPT	microtubule-associated protein tau	0.079
RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3	0.079
PTK2	PTK2 protein tyrosine kinase 2	0.077	Fly
AXIN1	axin 1	0.074
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.073
BMPR2	bone morphogenetic protein receptor, type II (serine/threonine kinase)	0.073
LAT	linker for activation of T cells	0.071
FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	0.071
CHUK	conserved helix-loop-helix ubiquitous kinase	0.070
MAP3K1	mitogen-activated protein kinase kinase kinase 1	0.069
SH3BP2	SH3-domain binding protein 2	0.069
PPP2R5A	protein phosphatase 2, regulatory subunit B', alpha	0.068
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	0.067
NOG	noggin	0.066
ZNF254	zinc finger protein 254	0.066	Human
PARD6A	par-6 partitioning defective 6 homolog alpha (C. elegans)	0.065
CTDP1	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1	0.065
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.065
PRKCD	protein kinase C, delta	0.062
ZNF107	zinc finger protein 107	0.061
PELI3	pellino homolog 3 (Drosophila)	0.061
SPRY4	sprouty homolog 4 (Drosophila)	0.061	Mouse
DOCK7	dedicator of cytokinesis 7	0.057
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.056
RANBP3	RAN binding protein 3	0.055
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.053
STK24	serine/threonine kinase 24	0.053	Worm
CTNND1	catenin (cadherin-associated protein), delta 1	0.053
TESK1	testis-specific kinase 1	0.052
APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	0.052
STRN3	striatin, calmodulin binding protein 3	0.051
PAK2	p21 protein (Cdc42/Rac)-activated kinase 2	0.051
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.050
DUSP23	dual specificity phosphatase 23	0.049
GGA2	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	0.048
NR1H2	nuclear receptor subfamily 1, group H, member 2	0.047
PTPN7	protein tyrosine phosphatase, non-receptor type 7	0.047
DUSP3	dual specificity phosphatase 3	0.045
SGK3	serum/glucocorticoid regulated kinase family, member 3	0.045
PLCG1	phospholipase C, gamma 1	0.045
MUC1	mucin 1, cell surface associated	0.044
APP	amyloid beta (A4) precursor protein	0.044
PTK2B	PTK2B protein tyrosine kinase 2 beta	0.043	Fly
TSC1	tuberous sclerosis 1	0.043
RAB6A	RAB6A, member RAS oncogene family	0.043
CDC42	cell division cycle 42 (GTP binding protein, 25kDa)	0.043
ZNF708	zinc finger protein 708	0.042	Human
ARHGAP9	Rho GTPase activating protein 9	0.042
FDFT1	farnesyl-diphosphate farnesyltransferase 1	0.041
ZNF117	zinc finger protein 117	0.041	Human
ZNF92	zinc finger protein 92	0.041	Human
NCK1	NCK adaptor protein 1	0.041
ALB	albumin	0.040
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.039
NCF4	neutrophil cytosolic factor 4, 40kDa	0.038
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.038
PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha	0.038
PHLDA1	pleckstrin homology-like domain, family A, member 1	0.038
APOC1	apolipoprotein C-I	0.036
IL1RAP	interleukin 1 receptor accessory protein	0.035
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.035
GRB2	growth factor receptor-bound protein 2	0.034
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.034
DTX1	deltex homolog 1 (Drosophila)	0.033
SORT1	sortilin 1	0.032
LIMD1	LIM domains containing 1	0.032
MBP	myelin basic protein	0.032
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.032
CYBA	cytochrome b-245, alpha polypeptide	0.032
CCL14	chemokine (C-C motif) ligand 14	0.031
C17orf28	chromosome 17 open reading frame 28	0.031
HDAC6	histone deacetylase 6	0.031
PRKCA	protein kinase C, alpha	0.030	Mouse
FSTL1	follistatin-like 1	0.030
PARD6B	par-6 partitioning defective 6 homolog beta (C. elegans)	0.030
NUP54	nucleoporin 54kDa	0.030
TOLLIP	toll interacting protein	0.030
ATF3	activating transcription factor 3	0.030
PPP5C	protein phosphatase 5, catalytic subunit	0.029
LRRK2	leucine-rich repeat kinase 2	0.029
SH3GL3	SH3-domain GRB2-like 3	0.029
SH3RF1	SH3 domain containing ring finger 1	0.029
TSC22D1	TSC22 domain family, member 1	0.029
PDCD10	programmed cell death 10	0.028
TOX4	TOX high mobility group box family member 4	0.028
MOBKL3	MOB1, Mps One Binder kinase activator-like 3 (yeast)	0.027
CD14	CD14 molecule	0.027
CASP7	caspase 7, apoptosis-related cysteine peptidase	0.027
SQSTM1	sequestosome 1	0.027
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.027
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.027
CASP8	caspase 8, apoptosis-related cysteine peptidase	0.026
CHORDC1	cysteine and histidine-rich domain (CHORD) containing 1	0.025
CLTC	clathrin, heavy chain (Hc)	0.025
CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	0.025
ZNF430	zinc finger protein 430	0.025	Human
WFIKKN1	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	0.025
SH2D1A	SH2 domain containing 1A	0.024
SPRR2A	small proline-rich protein 2A	0.024
FAM40B	family with sequence similarity 40, member B	0.024
PARD3	par-3 partitioning defective 3 homolog (C. elegans)	0.024
PKM2	pyruvate kinase, muscle	0.024
PARD6G	par-6 partitioning defective 6 homolog gamma (C. elegans)	0.024
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.024
APBB2	amyloid beta (A4) precursor protein-binding, family B, member 2	0.023
TAB1	TGF-beta activated kinase 1/MAP3K7 binding protein 1	0.023
NMT2	N-myristoyltransferase 2	0.023
NEDD9	neural precursor cell expressed, developmentally down-regulated 9	0.023
DCTN1	dynactin 1	0.023
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.023
CREB1	cAMP responsive element binding protein 1	0.022
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.022
EPOR	erythropoietin receptor	0.022
UBASH3B	ubiquitin associated and SH3 domain containing B	0.022
STRN4	striatin, calmodulin binding protein 4	0.022
ACSL3	acyl-CoA synthetase long-chain family member 3	0.021
LDLR	low density lipoprotein receptor	0.021
CSK	c-src tyrosine kinase	0.021
CAV2	caveolin 2	0.021
PPP6C	protein phosphatase 6, catalytic subunit	0.021
PPP2R1A	protein phosphatase 2, regulatory subunit A, alpha	0.021
MAPK9	mitogen-activated protein kinase 9	0.020	Fly
SIAH2	seven in absentia homolog 2 (Drosophila)	0.020
SH3GL2	SH3-domain GRB2-like 2	0.020
XPO6	exportin 6	0.020
SC4MOL	sterol-C4-methyl oxidase-like	0.019
OSGEP	O-sialoglycoprotein endopeptidase	0.019
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.019
ABI1	abl-interactor 1	0.019
DUSP5	dual specificity phosphatase 5	0.019	Human Rat
MAPK8IP1	mitogen-activated protein kinase 8 interacting protein 1	0.019	Rat
NCF2	neutrophil cytosolic factor 2	0.019
ADAM15	ADAM metallopeptidase domain 15	0.019
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.019
SAMD4B	sterile alpha motif domain containing 4B	0.019
IRS1	insulin receptor substrate 1	0.018
MAP2K6	mitogen-activated protein kinase kinase 6	0.018
PEA15	phosphoprotein enriched in astrocytes 15	0.018
PDGFRB	platelet-derived growth factor receptor, beta polypeptide	0.018
CD2AP	CD2-associated protein	0.018
MMP14	matrix metallopeptidase 14 (membrane-inserted)	0.018
EIF4E	eukaryotic translation initiation factor 4E	0.018
ANXA7	annexin A7	0.018
CDCP1	CUB domain containing protein 1	0.018
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	0.018
COL2A1	collagen, type II, alpha 1	0.018
MKNK1	MAP kinase interacting serine/threonine kinase 1	0.017
VPS29	vacuolar protein sorting 29 homolog (S. cerevisiae)	0.017
ZNF682	zinc finger protein 682	0.017	Human
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.017
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.017
TRIB1	tribbles homolog 1 (Drosophila)	0.017
IER3	immediate early response 3	0.017
MAP2K3	mitogen-activated protein kinase kinase 3	0.017
RAB21	RAB21, member RAS oncogene family	0.017
ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	0.017
HSPH1	heat shock 105kDa/110kDa protein 1	0.017
CDH5	cadherin 5, type 2 (vascular endothelium)	0.016
RAB1A	RAB1A, member RAS oncogene family	0.016
PIK3R2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.016
SORBS3	sorbin and SH3 domain containing 3	0.016
SC5DL	sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like	0.016
ATP6V1A	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A	0.016
RET	ret proto-oncogene	0.016
PTPN12	protein tyrosine phosphatase, non-receptor type 12	0.016
SNAI1	snail homolog 1 (Drosophila)	0.016
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.016
PTPN3	protein tyrosine phosphatase, non-receptor type 3	0.016
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.016
IQGAP1	IQ motif containing GTPase activating protein 1	0.016
SOCS1	suppressor of cytokine signaling 1	0.016
PXN	paxillin	0.015
SH2B2	SH2B adaptor protein 2	0.015
DCK	deoxycytidine kinase	0.015
MDFI	MyoD family inhibitor	0.015
PRKCI	protein kinase C, iota	0.015	Human
LCAT	lecithin-cholesterol acyltransferase	0.015
EPHA2	EPH receptor A2	0.014
TRIM9	tripartite motif containing 9	0.014
NUMB	numb homolog (Drosophila)	0.014
LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	0.014
RPS6KA1	ribosomal protein S6 kinase, 90kDa, polypeptide 1	0.014
RPS6KA4	ribosomal protein S6 kinase, 90kDa, polypeptide 4	0.014
MBD6	methyl-CpG binding domain protein 6	0.014
RAPGEF1	Rap guanine nucleotide exchange factor (GEF) 1	0.014
IDI1	isopentenyl-diphosphate delta isomerase 1	0.014
HMGCS1	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	0.014
MTPN	myotrophin	0.014
CD247	CD247 molecule	0.014
TMSB4X	thymosin beta 4, X-linked	0.014
COL4A5	collagen, type IV, alpha 5	0.014
TRAF4	TNF receptor-associated factor 4	0.014
MAP3K4	mitogen-activated protein kinase kinase kinase 4	0.014
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.013
LIMK2	LIM domain kinase 2	0.013
TGFA	transforming growth factor, alpha	0.013
NCKAP1	NCK-associated protein 1	0.013
TUBB2B	tubulin, beta 2B	0.013
SH2D2A	SH2 domain containing 2A	0.013
ZNF136	zinc finger protein 136	0.013
TP73	tumor protein p73	0.013	Mouse
DUSP4	dual specificity phosphatase 4	0.013	Human Rat
NR4A3	nuclear receptor subfamily 4, group A, member 3	0.013
VAV2	vav 2 guanine nucleotide exchange factor	0.013
STK25	serine/threonine kinase 25	0.013	Worm
HK3	hexokinase 3 (white cell)	0.013
GNAQ	guanine nucleotide binding protein (G protein), q polypeptide	0.013
APOC3	apolipoprotein C-III	0.013
SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	0.013	Mouse
HSPA8	heat shock 70kDa protein 8	0.012
MATK	megakaryocyte-associated tyrosine kinase	0.012
STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	0.012
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.012
HCK	hemopoietic cell kinase	0.012
ZNF506	zinc finger protein 506	0.012	Human
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.012
MAP3K10	mitogen-activated protein kinase kinase kinase 10	0.012
ZC3H12C	zinc finger CCCH-type containing 12C	0.012
EGF	epidermal growth factor	0.012
PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	0.012
FGR	Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog	0.012
IRAK3	interleukin-1 receptor-associated kinase 3	0.012
PILRA	paired immunoglobin-like type 2 receptor alpha	0.012
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.012
ERBB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.012
ETV5	ets variant 5	0.012
PPP2R5B	protein phosphatase 2, regulatory subunit B', beta	0.012
CMTM6	CKLF-like MARVEL transmembrane domain containing 6	0.012
RAB3A	RAB3A, member RAS oncogene family	0.012
CAV1	caveolin 1, caveolae protein, 22kDa	0.012	Mouse
IL1RN	interleukin 1 receptor antagonist	0.011
ELK1	ELK1, member of ETS oncogene family	0.011
CD2	CD2 molecule	0.011
ZNF100	zinc finger protein 100	0.011	Human
NUMBL	numb homolog (Drosophila)-like	0.011
DPPA4	developmental pluripotency associated 4	0.011
TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	0.011
RAB5A	RAB5A, member RAS oncogene family	0.011
SORBS1	sorbin and SH3 domain containing 1	0.011
SRCIN1	SRC kinase signaling inhibitor 1	0.011
CBLC	Cas-Br-M (murine) ecotropic retroviral transforming sequence c	0.011
DOCK1	dedicator of cytokinesis 1	0.011
PRKCQ	protein kinase C, theta	0.011	Human
ZNF219	zinc finger protein 219	0.011
MARK3	MAP/microtubule affinity-regulating kinase 3	0.010
TUBA1A	tubulin, alpha 1a	0.010
ZNF138	zinc finger protein 138	0.010
PTPRB	protein tyrosine phosphatase, receptor type, B	0.010	Human
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.010
AP2A1	adaptor-related protein complex 2, alpha 1 subunit	0.010
MKNK2	MAP kinase interacting serine/threonine kinase 2	0.010
GRB10	growth factor receptor-bound protein 10	0.010
HDAC4	histone deacetylase 4	0.010
SHC2	SHC (Src homology 2 domain containing) transforming protein 2	0.010
ACTB	actin, beta	0.010
ZNF493	zinc finger protein 493	0.010
FGFR1OP2	FGFR1 oncogene partner 2	0.010