|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
1.000
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
1.000
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
1.000
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
1.000
|
|
|
|
activation of nf kappab inducing kinase activity
|
GO:0007250 |
9 |
1.000
|
|
|
|
positive regulation of i kappab kinase nf kappab signaling
|
GO:0043123 |
132 |
1.000
|
|
|
|
protein polyubiquitination
|
GO:0000209 |
110 |
1.000
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
1.000
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
1.000
|
|
|
|
activation of innate immune response
|
GO:0002218 |
55 |
1.000
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
1.000
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
1.000
|
|
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.999
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.999
|
Human |
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.999
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.999
|
|
|
|
activation of jnkk activity
|
GO:0007256 |
1 |
0.999
|
|
|
|
positive regulation of nik nf kappab signaling
|
GO:1901224 |
10 |
0.999
|
|
|
|
toll like receptor 2 signaling pathway
|
GO:0034134 |
4 |
0.999
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.998
|
|
|
|
immune response regulating signaling pathway
|
GO:0002764 |
97 |
0.998
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.998
|
|
|
|
regulation of nik nf kappab signaling
|
GO:1901222 |
11 |
0.998
|
|
|
|
protein autoubiquitination
|
GO:0051865 |
37 |
0.998
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.997
|
|
|
|
activation of immune response
|
GO:0002253 |
114 |
0.997
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.997
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.997
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.996
|
Human Mouse Rat |
|
|
negative regulation of nf kappab transcription factor activity
|
GO:0032088 |
51 |
0.996
|
Human |
|
|
pattern recognition receptor signaling pathway
|
GO:0002221 |
48 |
0.996
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.996
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.996
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
71 |
0.995
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.995
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.995
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.995
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.994
|
|
|
|
interleukin 6 production
|
GO:0032635 |
37 |
0.993
|
Mouse |
|
|
innate immune response activating signal transduction
|
GO:0002758 |
48 |
0.993
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.993
|
|
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
89 |
0.992
|
Human |
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.991
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.991
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.990
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.990
|
Zebrafish |
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
57 |
0.989
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
87 |
0.989
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.989
|
|
|
|
nik nf kappab signaling
|
GO:0038061 |
12 |
0.988
|
|
|
|
regulation of cytokine mediated signaling pathway
|
GO:0001959 |
41 |
0.987
|
|
|
|
regulation of t cell cytokine production
|
GO:0002724 |
10 |
0.987
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.986
|
Human Mouse Rat |
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.985
|
|
|
|
positive regulation of innate immune response
|
GO:0045089 |
79 |
0.985
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.984
|
|
|
|
regulation of jun kinase activity
|
GO:0043506 |
27 |
0.984
|
|
|
|
regulation of immune effector process
|
GO:0002697 |
91 |
0.984
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
52 |
0.981
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.980
|
Zebrafish |
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.980
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.977
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.976
|
|
|
|
interleukin 2 production
|
GO:0032623 |
20 |
0.974
|
|
|
|
lipopolysaccharide mediated signaling pathway
|
GO:0031663 |
26 |
0.968
|
Mouse |
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.968
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.966
|
|
|
|
regulation of cytokine production involved in immune response
|
GO:0002718 |
22 |
0.966
|
|
|
|
positive regulation of t cell cytokine production
|
GO:0002726 |
4 |
0.966
|
|
|
|
positive regulation of production of molecular mediator of immune response
|
GO:0002702 |
11 |
0.966
|
|
|
|
regulation of adaptive immune response
|
GO:0002819 |
33 |
0.964
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.964
|
Human |
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.963
|
|
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
62 |
0.961
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.959
|
|
|
|
protein k48 linked ubiquitination
|
GO:0070936 |
38 |
0.955
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.953
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
0.950
|
Human |
|
|
mapk cascade
|
GO:0000165 |
288 |
0.949
|
|
|
|
neural tube formation
|
GO:0001841 |
3 |
0.948
|
Mouse |
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.947
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.944
|
|
|
|
cytokine production involved in immune response
|
GO:0002367 |
27 |
0.943
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.942
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.936
|
Human |
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.931
|
|
|
|
regulation of tumor necrosis factor production
|
GO:0032680 |
43 |
0.922
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.918
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.915
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.905
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.890
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.883
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
70 |
0.874
|
|
|
|
negative regulation of protein catabolic process
|
GO:0042177 |
59 |
0.869
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.864
|
|
|
|
negative regulation of cytokine production
|
GO:0001818 |
82 |
0.861
|
|
|
|
t cell cytokine production
|
GO:0002369 |
12 |
0.858
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.855
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.845
|
Human |
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
81 |
0.842
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.841
|
|
|
|
regulation of t cell mediated immunity
|
GO:0002709 |
18 |
0.834
|
|
|
|
negative regulation of cytokine mediated signaling pathway
|
GO:0001960 |
22 |
0.833
|
|
|
|
regulation of production of molecular mediator of immune response
|
GO:0002700 |
25 |
0.830
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.824
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.820
|
|
|
|
negative regulation of tumor necrosis factor production
|
GO:0032720 |
20 |
0.816
|
|
|
|
protein k63 linked ubiquitination
|
GO:0070534 |
31 |
0.800
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.799
|
|
|
|
response to peptidoglycan
|
GO:0032494 |
3 |
0.786
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.783
|
|
|
|
positive regulation of toll like receptor 4 signaling pathway
|
GO:0034145 |
6 |
0.782
|
|
|
|
response to interleukin 1
|
GO:0070555 |
47 |
0.782
|
|
|
|
regulation of interleukin 2 production
|
GO:0032663 |
19 |
0.772
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.766
|
|
|
|
production of molecular mediator of immune response
|
GO:0002440 |
37 |
0.765
|
|
|
|
lymphocyte mediated immunity
|
GO:0002449 |
48 |
0.760
|
|
|
|
positive regulation of adaptive immune response
|
GO:0002821 |
21 |
0.748
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.743
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.743
|
|
|
|
adaptive immune response
|
GO:0002250 |
49 |
0.736
|
|
|
|
positive regulation of jun kinase activity
|
GO:0043507 |
23 |
0.733
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.731
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.731
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.726
|
Human |
|
|
muscle cell proliferation
|
GO:0033002 |
35 |
0.719
|
Rat |
|
|
er associated ubiquitin dependent protein catabolic process
|
GO:0030433 |
31 |
0.717
|
|
|
|
toll like receptor signaling pathway
|
GO:0002224 |
25 |
0.702
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
74 |
0.688
|
Mouse |
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.685
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.668
|
|
|
|
tumor necrosis factor superfamily cytokine production
|
GO:0071706 |
45 |
0.660
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.636
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.636
|
|
|
|
negative regulation of tumor necrosis factor mediated signaling pathway
|
GO:0010804 |
7 |
0.633
|
|
|
|
interleukin 1 mediated signaling pathway
|
GO:0070498 |
12 |
0.616
|
Mouse Rat |
|
|
negative regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903556 |
20 |
0.609
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.607
|
|
|
|
negative regulation of catabolic process
|
GO:0009895 |
104 |
0.594
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.575
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.565
|
|
|
|
t cell receptor signaling pathway
|
GO:0050852 |
21 |
0.564
|
|
|
|
positive regulation of toll like receptor signaling pathway
|
GO:0034123 |
10 |
0.554
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.546
|
|
|
|
regulation of interleukin 1 mediated signaling pathway
|
GO:2000659 |
3 |
0.532
|
|
|
|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002460 |
40 |
0.531
|
|
|
|
regulation of reactive oxygen species biosynthetic process
|
GO:1903426 |
3 |
0.524
|
|
|
|
positive regulation of protein ubiquitination
|
GO:0031398 |
53 |
0.523
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.520
|
Mouse |
|
|
cellular response to interleukin 1
|
GO:0071347 |
35 |
0.517
|
Mouse Rat |
|
|
regulation of tumor necrosis factor mediated signaling pathway
|
GO:0010803 |
12 |
0.502
|
|
|
|
interleukin 17 production
|
GO:0032620 |
12 |
0.467
|
|
|
|
negative regulation of response to cytokine stimulus
|
GO:0060761 |
25 |
0.464
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.462
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.450
|
|
|
|
negative regulation of sterol transport
|
GO:0032372 |
8 |
0.449
|
|
|
|
regulation of interleukin 12 production
|
GO:0032655 |
15 |
0.446
|
Mouse |
|
|
regulation of response to cytokine stimulus
|
GO:0060759 |
46 |
0.445
|
|
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
57 |
0.439
|
|
|
|
protein deubiquitination
|
GO:0016579 |
79 |
0.438
|
|
|
|
cellular component disassembly
|
GO:0022411 |
92 |
0.435
|
|
|
|
dna repair
|
GO:0006281 |
198 |
0.433
|
|
|
|
positive regulation of interleukin 2 production
|
GO:0032743 |
11 |
0.431
|
|
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.424
|
|
|
|
negative regulation of interleukin 6 production
|
GO:0032715 |
13 |
0.409
|
|
|
|
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002822 |
29 |
0.404
|
|
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
104 |
0.401
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.396
|
|
|
|
cellular response to bacterial lipoprotein
|
GO:0071220 |
3 |
0.394
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
56 |
0.393
|
|
|
|
defense response to bacterium
|
GO:0042742 |
63 |
0.391
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.387
|
|
|
|
nucleotide binding oligomerization domain containing signaling pathway
|
GO:0070423 |
4 |
0.385
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
136 |
0.383
|
|
|
|
regulation of cell activation
|
GO:0050865 |
125 |
0.382
|
Mouse |
|
|
immune system development
|
GO:0002520 |
195 |
0.368
|
|
|
|
leukocyte mediated immunity
|
GO:0002443 |
59 |
0.368
|
|
|
|
regulation of leukocyte mediated immunity
|
GO:0002703 |
38 |
0.362
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.352
|
|
|
|
smooth muscle cell proliferation
|
GO:0048659 |
28 |
0.351
|
Rat |
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.347
|
|
|
|
positive regulation of cytokine biosynthetic process
|
GO:0042108 |
25 |
0.346
|
Mouse |
|
|
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002824 |
19 |
0.345
|
|
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
38 |
0.336
|
|
|
|
negative regulation of protein ubiquitination
|
GO:0031397 |
35 |
0.334
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.332
|
Mouse |
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.323
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.320
|
Mouse |
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.319
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.307
|
Mouse |
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.302
|
|
|
|
positive regulation of t cell mediated immunity
|
GO:0002711 |
12 |
0.301
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.296
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.283
|
|
|
|
protein k63 linked deubiquitination
|
GO:0070536 |
21 |
0.278
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.276
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.274
|
|
|
|
regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903555 |
44 |
0.267
|
|
|
|
embryonic epithelial tube formation
|
GO:0001838 |
4 |
0.266
|
Mouse |
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.265
|
|
|
|
regulation of endothelial cell apoptotic process
|
GO:2000351 |
24 |
0.264
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.263
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.251
|
|
|
|
negative regulation of multi organism process
|
GO:0043901 |
92 |
0.250
|
|
|
|
jnk cascade
|
GO:0007254 |
80 |
0.245
|
|
|
|
activation of mapkk activity
|
GO:0000186 |
18 |
0.239
|
|
|
|
toll like receptor 4 signaling pathway
|
GO:0034142 |
12 |
0.238
|
|
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
91 |
0.238
|
|
|
|
neuroblast proliferation
|
GO:0007405 |
4 |
0.237
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.236
|
|
|
|
negative regulation of map kinase activity
|
GO:0043407 |
27 |
0.233
|
|
|
|
negative regulation of cholesterol efflux
|
GO:0090370 |
2 |
0.233
|
|
|
|
positive regulation of mononuclear cell proliferation
|
GO:0032946 |
47 |
0.232
|
Mouse |
|
|
protein monoubiquitination
|
GO:0006513 |
39 |
0.229
|
|
|
|
response to fungus
|
GO:0009620 |
4 |
0.226
|
|
|
|
positive regulation of protein binding
|
GO:0032092 |
24 |
0.224
|
Human |
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.222
|
Human |
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
63 |
0.203
|
Human |
|
|
positive regulation of cell activation
|
GO:0050867 |
81 |
0.202
|
Mouse |
|
|
endodermal cell fate specification
|
GO:0001714 |
4 |
0.200
|
|
|
|
endothelial cell apoptotic process
|
GO:0072577 |
26 |
0.197
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.195
|
|
|
|
negative regulation of cholesterol transport
|
GO:0032375 |
8 |
0.192
|
|
|
|
regulation of mononuclear cell proliferation
|
GO:0032944 |
65 |
0.190
|
Mouse |
|
|
i kappab phosphorylation
|
GO:0007252 |
7 |
0.187
|
|
|
|
positive regulation of leukocyte activation
|
GO:0002696 |
80 |
0.182
|
Mouse |
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.180
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.177
|
|
|
|
positive regulation of lymphocyte activation
|
GO:0051251 |
73 |
0.175
|
Mouse |
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.174
|
|
|
|
regulation of cd40 signaling pathway
|
GO:2000348 |
3 |
0.174
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.171
|
|
|
|
negative regulation of protein modification by small protein conjugation or removal
|
GO:1903321 |
41 |
0.165
|
|
|
|
lymphocyte homeostasis
|
GO:0002260 |
4 |
0.159
|
|
|
|
nucleotide binding oligomerization domain containing 2 signaling pathway
|
GO:0070431 |
4 |
0.156
|
|
|
|
extrinsic apoptotic signaling pathway via death domain receptors
|
GO:0008625 |
42 |
0.155
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.146
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.144
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.142
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.142
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.140
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.140
|
|
|
|
aging
|
GO:0007568 |
66 |
0.132
|
|
|
|
toll like receptor 3 signaling pathway
|
GO:0034138 |
4 |
0.129
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.129
|
|
|
|
positive regulation of toll like receptor 3 signaling pathway
|
GO:0034141 |
1 |
0.128
|
|
|
|
positive regulation of interleukin 23 production
|
GO:0032747 |
4 |
0.127
|
|
|
|
regulation of autophagy
|
GO:0010506 |
52 |
0.126
|
|
|
|
positive regulation of dna metabolic process
|
GO:0051054 |
73 |
0.121
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.121
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.121
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.120
|
Mouse |
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.118
|
|
|
|
regulation of proteasomal protein catabolic process
|
GO:0061136 |
87 |
0.117
|
|
|
|
negative regulation of endopeptidase activity
|
GO:0010951 |
84 |
0.117
|
|
|
|
regulation of interferon beta production
|
GO:0032648 |
22 |
0.116
|
|
|
|
protein k11 linked deubiquitination
|
GO:0035871 |
9 |
0.116
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
|
GO:1902042 |
15 |
0.116
|
|
|
|
protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:0042787 |
37 |
0.115
|
|
|
|
regulation of smooth muscle cell proliferation
|
GO:0048660 |
28 |
0.115
|
Rat |
|
|
regulation of cytokine biosynthetic process
|
GO:0042035 |
35 |
0.113
|
Mouse |
|
|
chemokine production
|
GO:0032602 |
32 |
0.113
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.112
|
|
|
|
tumor necrosis factor mediated signaling pathway
|
GO:0033209 |
27 |
0.110
|
Human |
|
|
b cell activation
|
GO:0042113 |
33 |
0.108
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.106
|
|
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
75 |
0.105
|
|
|
|
response to nitric oxide
|
GO:0071731 |
4 |
0.105
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.105
|
|
|
|
modulation of growth of symbiont involved in interaction with host
|
GO:0044144 |
2 |
0.104
|
|
|
|
positive regulation of smooth muscle cell proliferation
|
GO:0048661 |
14 |
0.104
|
Rat |
|
|
positive regulation of protein modification by small protein conjugation or removal
|
GO:1903322 |
61 |
0.102
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.102
|
Human |
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.101
|
|
|
|
negative regulation of protein complex disassembly
|
GO:0043242 |
20 |
0.098
|
|
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.098
|
|
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
45 |
0.097
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.097
|
|
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
132 |
0.096
|
|
|
|
protein modification by small protein removal
|
GO:0070646 |
92 |
0.095
|
|
|
|
positive regulation of chemokine production
|
GO:0032722 |
22 |
0.095
|
|
|
|
regulation of t cell receptor signaling pathway
|
GO:0050856 |
7 |
0.094
|
|
|
|
sterol transport
|
GO:0015918 |
39 |
0.093
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.093
|
|
|
|
programmed necrotic cell death
|
GO:0097300 |
18 |
0.090
|
|
|
|
negative regulation of interleukin 1 mediated signaling pathway
|
GO:2000660 |
2 |
0.090
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.089
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.089
|
Mouse |
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
96 |
0.089
|
|
|
|
growth
|
GO:0040007 |
202 |
0.088
|
|
|
|
type i interferon production
|
GO:0032606 |
27 |
0.085
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
147 |
0.085
|
|
|
|
nuclear division
|
GO:0000280 |
128 |
0.085
|
|
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.085
|
Mouse |
|
|
response to mechanical stimulus
|
GO:0009612 |
51 |
0.085
|
|
|
|
autophagy
|
GO:0006914 |
88 |
0.083
|
|
|
|
regulation of interleukin 6 production
|
GO:0032675 |
37 |
0.083
|
Mouse |
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.083
|
|
|
|
negative regulation of neurological system process
|
GO:0031645 |
2 |
0.082
|
|
|
|
regulation of protein binding
|
GO:0043393 |
66 |
0.082
|
Human |
|
|
cytoplasmic pattern recognition receptor signaling pathway
|
GO:0002753 |
12 |
0.081
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.081
|
|
|
|
organelle fission
|
GO:0048285 |
149 |
0.080
|
|
|
|
regulation of response to dna damage stimulus
|
GO:2001020 |
94 |
0.079
|
|
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.079
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.079
|
|
|
|
neural nucleus development
|
GO:0048857 |
47 |
0.079
|
|
|
|
growth involved in symbiotic interaction
|
GO:0044110 |
2 |
0.077
|
|
|
|
nitric oxide biosynthetic process
|
GO:0006809 |
20 |
0.076
|
|
|
|
negative regulation of leukocyte activation
|
GO:0002695 |
26 |
0.075
|
|
|
|
heart development
|
GO:0007507 |
95 |
0.075
|
|
|
|
regulation of toll like receptor signaling pathway
|
GO:0034121 |
17 |
0.075
|
|
|
|
spinal cord development
|
GO:0021510 |
4 |
0.075
|
|
|
|
forebrain generation of neurons
|
GO:0021872 |
3 |
0.075
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.074
|
|
|
|
muscle cell fate commitment
|
GO:0042693 |
4 |
0.074
|
|
|
|
regulation of potassium ion transmembrane transport
|
GO:1901379 |
20 |
0.072
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.072
|
|
|
|
negative regulation of toll like receptor 3 signaling pathway
|
GO:0034140 |
2 |
0.071
|
|
|
|
inflammatory response
|
GO:0006954 |
79 |
0.071
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.071
|
|
|
|
protein k48 linked deubiquitination
|
GO:0071108 |
19 |
0.069
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.069
|
|
|
|
negative regulation of type i interferon production
|
GO:0032480 |
5 |
0.069
|
|
|
|
positive regulation of osteoclast differentiation
|
GO:0045672 |
9 |
0.069
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.069
|
|
|
|
response to radiation
|
GO:0009314 |
151 |
0.068
|
|
|
|
positive regulation of toll like receptor 2 signaling pathway
|
GO:0034137 |
2 |
0.068
|
|
|
|
negative regulation of reactive oxygen species metabolic process
|
GO:2000378 |
11 |
0.068
|
|
|
|
negative regulation of proteasomal protein catabolic process
|
GO:1901799 |
32 |
0.067
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.067
|
|
|
|
embryonic morphogenesis
|
GO:0048598 |
85 |
0.067
|
Mouse |
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
67 |
0.066
|
Mouse |
|
|
lipid transport
|
GO:0006869 |
90 |
0.065
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.065
|
|
|
|
protein complex disassembly
|
GO:0043241 |
52 |
0.065
|
|
|
|
stem cell division
|
GO:0017145 |
2 |
0.064
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
51 |
0.064
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.062
|
|
|
|
macromolecular complex disassembly
|
GO:0032984 |
60 |
0.061
|
|
|
|
mrna metabolic process
|
GO:0016071 |
175 |
0.061
|
|
|
|
asymmetric neuroblast division
|
GO:0055059 |
1 |
0.061
|
|
|
|
regulation of protein polyubiquitination
|
GO:1902914 |
8 |
0.060
|
|
|
|
regulation of toll like receptor 2 signaling pathway
|
GO:0034135 |
2 |
0.060
|
|
|
|
regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032434 |
71 |
0.060
|
|
|
|
negative regulation of necroptotic process
|
GO:0060546 |
2 |
0.059
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.059
|
|
|
|
positive regulation of transcription regulatory region dna binding
|
GO:2000679 |
8 |
0.058
|
|
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
26 |
0.058
|
Human |
|
|
regulation of transmembrane transport
|
GO:0034762 |
139 |
0.057
|
|
|
|
tissue morphogenesis
|
GO:0048729 |
96 |
0.057
|
Mouse |
|
|
regulation of response to biotic stimulus
|
GO:0002831 |
55 |
0.057
|
Mouse |
|
|
chemokine metabolic process
|
GO:0050755 |
4 |
0.056
|
|
|
|
b cell homeostasis
|
GO:0001782 |
1 |
0.055
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.055
|
|
|
|
defense response to virus
|
GO:0051607 |
71 |
0.055
|
|
|
|
regulation of protein complex disassembly
|
GO:0043244 |
28 |
0.054
|
|
|
|
male meiosis
|
GO:0007140 |
1 |
0.054
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.053
|
|
|
|
rna catabolic process
|
GO:0006401 |
71 |
0.052
|
|
|
|
compound eye development
|
GO:0048749 |
1 |
0.052
|
|
|
|
reactive nitrogen species metabolic process
|
GO:2001057 |
3 |
0.052
|
|
|
|
cellular response to heat
|
GO:0034605 |
14 |
0.052
|
|
|
|
endodermal cell fate commitment
|
GO:0001711 |
4 |
0.051
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.051
|
Mouse |
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
60 |
0.050
|
|
|
|
negative regulation of toll signaling pathway
|
GO:0045751 |
1 |
0.050
|
|
|
|
response to light stimulus
|
GO:0009416 |
87 |
0.050
|
|
|
|
regulation of lymphocyte apoptotic process
|
GO:0070228 |
15 |
0.050
|
|
|
|
interleukin 8 production
|
GO:0032637 |
51 |
0.050
|
|
|
|
histone ubiquitination
|
GO:0016574 |
31 |
0.049
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.049
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.048
|
|
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.047
|
Mouse |
|
|
regulation of antigen receptor mediated signaling pathway
|
GO:0050854 |
10 |
0.047
|
|
|
|
response to extracellular stimulus
|
GO:0009991 |
85 |
0.047
|
|
|
|
negative regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903051 |
35 |
0.046
|
|
|
|
mature b cell differentiation
|
GO:0002335 |
1 |
0.046
|
|
|
|
negative regulation of i kappab kinase nf kappab signaling
|
GO:0043124 |
32 |
0.046
|
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.045
|
|
|
|
response to starvation
|
GO:0042594 |
59 |
0.045
|
|
|
|
fatty acid metabolic process
|
GO:0006631 |
115 |
0.045
|
|
|
|
regulation of protein stability
|
GO:0031647 |
87 |
0.043
|
|
|
|
positive regulation of t cell activation
|
GO:0050870 |
54 |
0.043
|
Mouse |
|
|
negative regulation of chemokine production
|
GO:0032682 |
9 |
0.042
|
|
|
|
spermatid differentiation
|
GO:0048515 |
4 |
0.042
|
|
|
|
cellular lipid catabolic process
|
GO:0044242 |
65 |
0.042
|
|
|
|
response to endoplasmic reticulum stress
|
GO:0034976 |
49 |
0.042
|
|
|
|
toll signaling pathway
|
GO:0008063 |
2 |
0.042
|
|
|
|
negative regulation of lipopolysaccharide mediated signaling pathway
|
GO:0031665 |
7 |
0.042
|
|
|
|
regulation of cell division
|
GO:0051302 |
116 |
0.042
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
156 |
0.040
|
|
|
|
tube morphogenesis
|
GO:0035239 |
95 |
0.040
|
Mouse |
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.040
|
|
|
|
endodermal cell differentiation
|
GO:0035987 |
31 |
0.040
|
|
|
|
positive regulation of stress activated protein kinase signaling cascade
|
GO:0070304 |
61 |
0.040
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.039
|
|
|
|
negative regulation of jun kinase activity
|
GO:0043508 |
4 |
0.039
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.039
|
|
|
|
regulation of lipid transport
|
GO:0032368 |
44 |
0.039
|
|
|
|
cellular response to starvation
|
GO:0009267 |
58 |
0.038
|
|
|
|
positive regulation of b cell proliferation
|
GO:0030890 |
12 |
0.038
|
|
|
|
regulation of protein localization to plasma membrane
|
GO:1903076 |
40 |
0.038
|
|
|
|
growth of symbiont involved in interaction with host
|
GO:0044116 |
2 |
0.038
|
|
|
|
head development
|
GO:0060322 |
108 |
0.038
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.037
|
|
|
|
negative regulation of interleukin 12 production
|
GO:0032695 |
6 |
0.037
|
|
|
|
regulation of protein linear polyubiquitination
|
GO:1902528 |
2 |
0.036
|
|
|
|
regulation of osteoclast differentiation
|
GO:0045670 |
18 |
0.036
|
|
|
|
response to virus
|
GO:0009615 |
126 |
0.036
|
Zebrafish |
|
|
apoptotic mitochondrial changes
|
GO:0008637 |
57 |
0.036
|
|
|
|
positive regulation of protein linear polyubiquitination
|
GO:1902530 |
2 |
0.035
|
|
|
|
cellular response to uv
|
GO:0034644 |
32 |
0.035
|
|
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.035
|
|
|
|
symbiosis encompassing mutualism through parasitism
|
GO:0044403 |
156 |
0.035
|
|
|
|
regulation of protein localization to nucleus
|
GO:1900180 |
85 |
0.035
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.035
|
|
|
|
regulation of gene expression epigenetic
|
GO:0040029 |
73 |
0.035
|
|
|
|
negative regulation of macrophage cytokine production
|
GO:0010936 |
3 |
0.035
|
|
|
|
cellular response to misfolded protein
|
GO:0071218 |
2 |
0.035
|
|
|
|
lymphocyte apoptotic process
|
GO:0070227 |
20 |
0.034
|
|
|
|
defense response to gram negative bacterium
|
GO:0050829 |
14 |
0.034
|
|
|
|
embryo development
|
GO:0009790 |
123 |
0.034
|
Mouse |
|
|
regulation of lymphocyte activation
|
GO:0051249 |
103 |
0.034
|
Mouse |
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.034
|
Human |
|
|
epithelium development
|
GO:0060429 |
227 |
0.034
|
Mouse |
|
|
jak stat cascade
|
GO:0007259 |
46 |
0.033
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.033
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.033
|
Mouse |
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.032
|
|
|
|
brain development
|
GO:0007420 |
97 |
0.032
|
|
|
|
embryonic heart tube development
|
GO:0035050 |
9 |
0.032
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
176 |
0.032
|
|
|
|
negative regulation of protein transport
|
GO:0051224 |
75 |
0.031
|
|
|
|
positive regulation of dendrite morphogenesis
|
GO:0050775 |
3 |
0.031
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.030
|
|
|
|
formation of primary germ layer
|
GO:0001704 |
42 |
0.029
|
|
|
|
negative regulation of defense response
|
GO:0031348 |
47 |
0.029
|
|
|
|
negative regulation of peptidase activity
|
GO:0010466 |
91 |
0.029
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.029
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.029
|
|
|
|
positive regulation of chemokine biosynthetic process
|
GO:0045080 |
3 |
0.029
|
|
|
|
negative regulation of stress activated protein kinase signaling cascade
|
GO:0070303 |
19 |
0.028
|
|
|
|
regulation of type i interferon production
|
GO:0032479 |
26 |
0.028
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
77 |
0.028
|
Mouse |
|
|
positive regulation of lymphocyte mediated immunity
|
GO:0002708 |
23 |
0.028
|
|
|
|
regulation of cell growth
|
GO:0001558 |
135 |
0.027
|
|
|
|
negative regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:2000059 |
3 |
0.027
|
|
|
|
rna interference
|
GO:0016246 |
4 |
0.027
|
|
|
|
immunoglobulin secretion
|
GO:0048305 |
1 |
0.026
|
Mouse |
|
|
negative regulation of cysteine type endopeptidase activity
|
GO:2000117 |
48 |
0.026
|
|
|
|
chromosome segregation
|
GO:0007059 |
114 |
0.026
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.026
|
|
|
|
eye development
|
GO:0001654 |
42 |
0.026
|
|
|
|
rna processing
|
GO:0006396 |
255 |
0.026
|
|
|
|
negative regulation of striated muscle cell apoptotic process
|
GO:0010664 |
2 |
0.026
|
|
|
|
regulation of neurotransmitter secretion
|
GO:0046928 |
3 |
0.026
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.025
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.025
|
|
|
|
negative regulation of smooth muscle cell proliferation
|
GO:0048662 |
14 |
0.025
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.025
|
|
|
|
er associated misfolded protein catabolic process
|
GO:0071712 |
1 |
0.025
|
|
|
|
protein acetylation
|
GO:0006473 |
116 |
0.025
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.025
|
|
|
|
meiosis i
|
GO:0007127 |
4 |
0.025
|
|
|
|
covalent chromatin modification
|
GO:0016569 |
254 |
0.025
|
|
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.025
|
|
|
|
regulation of nervous system development
|
GO:0051960 |
88 |
0.025
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
85 |
0.024
|
|
|
|
regulation of toll like receptor 3 signaling pathway
|
GO:0034139 |
2 |
0.024
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.024
|
|
|
|
regulation of interleukin 17 production
|
GO:0032660 |
12 |
0.024
|
|
|
|
ripoptosome assembly
|
GO:0097343 |
1 |
0.024
|
|
|
|
cell aging
|
GO:0007569 |
52 |
0.024
|
|
|
|
cdc42 protein signal transduction
|
GO:0032488 |
4 |
0.024
|
|
|
|
response to hypoxia
|
GO:0001666 |
96 |
0.024
|
|
|
|
t cell activation
|
GO:0042110 |
99 |
0.024
|
Mouse |
|
|
neurological system process
|
GO:0050877 |
163 |
0.023
|
|
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.023
|
|
|
|
cholesterol transport
|
GO:0030301 |
39 |
0.023
|
|
|
|
positive regulation of growth
|
GO:0045927 |
58 |
0.023
|
|
|
|
response to uv
|
GO:0009411 |
73 |
0.023
|
|
|
|
positive regulation of interferon beta biosynthetic process
|
GO:0045359 |
4 |
0.023
|
|
