IMP

Process View

Homo sapiens

11 genes annotated in human

positive regulation of production of molecular mediator of immune response

Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of production of molecular mediator of immune response"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of production of molecular mediator of immune response" (in gray)

Name	Description	Probability	Func Analog Organism
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	1.000	Fly
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.999
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.999
TRAF1	TNF receptor-associated factor 1	0.998	Human
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.998	Fly
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.998	Fly
IL4R	interleukin 4 receptor	0.995	Mouse
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.995	Fly
BIRC3	baculoviral IAP repeat containing 3	0.987
CD40	CD40 molecule, TNF receptor superfamily member 5	0.983	Mouse Rat
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.983	Fly
RIPK2	receptor-interacting serine-threonine kinase 2	0.975
TRAF6	TNF receptor-associated factor 6	0.966
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.961
TRAF3	TNF receptor-associated factor 3	0.941	Human
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.869	Fly
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.853	Fly
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.851	Fly
CCL2	chemokine (C-C motif) ligand 2	0.677	Human
CCL4	chemokine (C-C motif) ligand 4	0.675	Human
CCR5	chemokine (C-C motif) receptor 5	0.653
CHUK	conserved helix-loop-helix ubiquitous kinase	0.627	Fly
TNFRSF13B	tumor necrosis factor receptor superfamily, member 13B	0.553
ICAM1	intercellular adhesion molecule 1	0.519
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.514
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.496
TRAF2	TNF receptor-associated factor 2	0.463
TNFRSF9	tumor necrosis factor receptor superfamily, member 9	0.459
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.444
BCL3	B-cell CLL/lymphoma 3	0.425	Fly
SOX10	SRY (sex determining region Y)-box 10	0.365
MYD88	myeloid differentiation primary response gene (88)	0.347	Fly
IL2RG	interleukin 2 receptor, gamma	0.318
PAX3	paired box 3	0.301
CCL8	chemokine (C-C motif) ligand 8	0.280	Human
CCR7	chemokine (C-C motif) receptor 7	0.260
ANGPT2	angiopoietin 2	0.256
CCL5	chemokine (C-C motif) ligand 5	0.251	Human
GRAP2	GRB2-related adaptor protein 2	0.204
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.202
LY96	lymphocyte antigen 96	0.187
CXCL2	chemokine (C-X-C motif) ligand 2	0.181
TNIP2	TNFAIP3 interacting protein 2	0.165
CCR1	chemokine (C-C motif) receptor 1	0.144
CXCL9	chemokine (C-X-C motif) ligand 9	0.138
CXCL10	chemokine (C-X-C motif) ligand 10	0.138
DPP4	dipeptidyl-peptidase 4	0.133
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.132	Mouse
CXCR4	chemokine (C-X-C motif) receptor 4	0.128
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.117
IL1B	interleukin 1, beta	0.115
TNF	tumor necrosis factor	0.115
CARD11	caspase recruitment domain family, member 11	0.109
CD80	CD80 molecule	0.094
SQSTM1	sequestosome 1	0.093
TICAM2	toll-like receptor adaptor molecule 2	0.091
TLR2	toll-like receptor 2	0.086
NLRC4	NLR family, CARD domain containing 4	0.086
IL4	interleukin 4	0.079	Mouse
OASL	2'-5'-oligoadenylate synthetase-like	0.075
ANGPT1	angiopoietin 1	0.072
CCL13	chemokine (C-C motif) ligand 13	0.066	Human
IRF1	interferon regulatory factor 1	0.064
TTR	transthyretin	0.061
VCAM1	vascular cell adhesion molecule 1	0.055
SMURF1	SMAD specific E3 ubiquitin protein ligase 1	0.054
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.053
CAV1	caveolin 1, caveolae protein, 22kDa	0.050
IDE	insulin-degrading enzyme	0.047
IL6R	interleukin 6 receptor	0.045
CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	0.044	Human
TNFAIP2	tumor necrosis factor, alpha-induced protein 2	0.042
LCP2	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	0.042
HLA-DPA1	major histocompatibility complex, class II, DP alpha 1	0.041
IL7R	interleukin 7 receptor	0.041
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.040
ENG	endoglin	0.040
IL8	interleukin 8	0.040
HLA-DPB1	major histocompatibility complex, class II, DP beta 1	0.039
HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	0.039
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.038
PLEK	pleckstrin	0.038
TRAF5	TNF receptor-associated factor 5	0.038	Human
BCL10	B-cell CLL/lymphoma 10	0.035
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.035
IL10	interleukin 10	0.034
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.034
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	0.033
IRAK2	interleukin-1 receptor-associated kinase 2	0.032
CASP4	caspase 4, apoptosis-related cysteine peptidase	0.032	Fly
IRF4	interferon regulatory factor 4	0.032
CD83	CD83 molecule	0.031
TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b	0.031	Human
CD48	CD48 molecule	0.030
TGFB3	transforming growth factor, beta 3	0.029
ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	0.029
CCR4	chemokine (C-C motif) receptor 4	0.028
TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	0.028
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.028
CXCL11	chemokine (C-X-C motif) ligand 11	0.027
HLA-DRB1	major histocompatibility complex, class II, DR beta 1 and major histocompatibility complex, class II, DR beta 1	0.027
SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.027
IL6	interleukin 6 (interferon, beta 2)	0.027
FZD1	frizzled homolog 1 (Drosophila)	0.026
CCL3	chemokine (C-C motif) ligand 3	0.026	Human
BCL2A1	BCL2-related protein A1	0.025
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	0.024
CD22	CD22 molecule	0.024
IL1RN	interleukin 1 receptor antagonist	0.024
SEMA4D	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	0.022
CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.021
TRAF3IP2	TRAF3 interacting protein 2	0.021
HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	0.020
CCL1	chemokine (C-C motif) ligand 1	0.020	Human
TP53BP1	tumor protein p53 binding protein 1	0.019
CCL7	chemokine (C-C motif) ligand 7	0.018	Human
IFI44L	interferon-induced protein 44-like	0.018
NUMBL	numb homolog (Drosophila)-like	0.018
PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)	0.018
CCL19	chemokine (C-C motif) ligand 19	0.018	Human
MAVS	mitochondrial antiviral signaling protein	0.018
SOD2	superoxide dismutase 2, mitochondrial	0.017
ZNF512B	zinc finger protein 512B	0.016
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	0.016
SLAMF1	signaling lymphocytic activation molecule family member 1	0.016
IL32	interleukin 32	0.016
ELF4	E74-like factor 4 (ets domain transcription factor)	0.015
AKT2	v-akt murine thymoma viral oncogene homolog 2	0.015
TNFRSF17	tumor necrosis factor receptor superfamily, member 17	0.014
ZC3H12A	zinc finger CCCH-type containing 12A	0.014
MX2	myxovirus (influenza virus) resistance 2 (mouse)	0.014
IFNG	interferon, gamma	0.013
SYK	spleen tyrosine kinase	0.013
CXCL13	chemokine (C-X-C motif) ligand 13	0.013
LYN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	0.012
CSF1	colony stimulating factor 1 (macrophage)	0.012
TYMP	thymidine phosphorylase	0.012
TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.012
TRADD	TNFRSF1A-associated via death domain	0.012
IL13	interleukin 13	0.011
FSTL1	follistatin-like 1	0.011
CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha	0.011
NCOA6	nuclear receptor coactivator 6	0.011
SMAD3	SMAD family member 3	0.011
IDO1	indoleamine 2,3-dioxygenase 1	0.010
TNFRSF11A	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	0.010
IL15RA	interleukin 15 receptor, alpha	0.010
IL2RB	interleukin 2 receptor, beta	0.010
IL3	interleukin 3 (colony-stimulating factor, multiple)	0.010