Mus musculus

217 known processes

Cdkn1a

cyclin-dependent kinase inhibitor 1A (P21)

(Aliases: Waf1,CIP1,CDKI,Cdkn1,CAP20,SDI1,P21,p21Cip1,mda6,p21WAF)

Cdkn1a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
signal transduction involved in dna integrity checkpoint GO:0072401 3 0.994
Human
regulation of kinase activity GO:0043549 249 0.991
regulation of transferase activity GO:0051338 263 0.989
activation of mapkkk activity GO:0000185 1 0.987
g1 s transition of mitotic cell cycle GO:0000082 57 0.983
Human Mouse
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.980
cell cycle arrest GO:0007050 37 0.973
negative regulation of protein phosphorylation GO:0001933 126 0.965
regulation of cell cycle GO:0051726 281 0.964
positive regulation of apoptotic process GO:0043065 217 0.961
negative regulation of cellular protein metabolic process GO:0032269 247 0.960
fibroblast proliferation GO:0048144 35 0.952
Human
negative regulation of blood vessel endothelial cell migration GO:0043537 3 0.943
negative regulation of fibroblast proliferation GO:0048147 14 0.940
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.937
response to endoplasmic reticulum stress GO:0034976 53 0.932
positive regulation of cell death GO:0010942 224 0.926
regulation of protein kinase activity GO:0045859 232 0.912
gland development GO:0048732 330 0.912
Mouse
negative regulation of leukocyte differentiation GO:1902106 51 0.908
apoptotic process involved in mammary gland involution GO:0060057 4 0.903
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 3 0.899
reactive oxygen species metabolic process GO:0072593 84 0.895
negative regulation of molecular function GO:0044092 258 0.880
negative regulation of phosphatidylinositol 3 kinase activity GO:0043553 1 0.878
cellular response to radiation GO:0071478 28 0.851
signal transduction involved in cell cycle checkpoint GO:0072395 3 0.848
Human
negative regulation of protein modification process GO:0031400 163 0.847
oocyte axis specification GO:0007309 2 0.846
negative regulation of protein metabolic process GO:0051248 282 0.839
cellular response to dna damage stimulus GO:0006974 207 0.833
regulation of epithelial cell proliferation GO:0050678 141 0.833
Mouse
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 8 0.829
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.825
negative regulation of cell proliferation GO:0008285 296 0.821
response to acid chemical GO:0001101 111 0.812
regulation of cellular amino acid metabolic process GO:0006521 5 0.810
blood vessel morphogenesis GO:0048514 285 0.807
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.807
regulation of mitochondrial membrane permeability GO:0046902 17 0.805
negative regulation of apoptotic signaling pathway GO:2001234 104 0.804
cation transport GO:0006812 399 0.804
Mouse
signal transduction involved in dna damage checkpoint GO:0072422 3 0.803
Human
sphingolipid metabolic process GO:0006665 45 0.802
intracellular signal transduction involved in g1 dna damage checkpoint GO:1902400 3 0.800
Human
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.797
mitotic cell cycle GO:0000278 195 0.790
positive regulation of cardiac muscle cell apoptotic process GO:0010666 3 0.776
regulation of dna templated transcription in response to stress GO:0043620 9 0.773
muscle tissue development GO:0060537 308 0.763
erythrocyte differentiation GO:0030218 88 0.755
angiogenesis GO:0001525 201 0.750
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.737
germ cell development GO:0007281 185 0.737
activation of mapkk activity GO:0000186 15 0.727
response to oxidative stress GO:0006979 123 0.722
mitotic g1 dna damage checkpoint GO:0031571 4 0.716
Human
positive regulation of protein modification process GO:0031401 299 0.712
Human
microtubule based process GO:0007017 236 0.712
Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.710
Human
cellular response to inorganic substance GO:0071241 37 0.703
digestive tract development GO:0048565 190 0.695
release of cytochrome c from mitochondria GO:0001836 23 0.691
cellular response to cytokine stimulus GO:0071345 189 0.683
regionalization GO:0003002 337 0.683
cellular response to gamma radiation GO:0071480 4 0.682
response to radiation GO:0009314 165 0.679
skeletal muscle organ development GO:0060538 163 0.671
metanephric glomerular mesangium development GO:0072223 3 0.666
negative regulation of phosphorylation GO:0042326 166 0.663
negative regulation of cellular amine metabolic process GO:0033239 1 0.657
signal transduction involved in mitotic dna damage checkpoint GO:1902402 3 0.654
Human
positive regulation of neuron apoptotic process GO:0043525 25 0.653
regulation of cell cycle process GO:0010564 160 0.650
Human
regulation of cellular ketone metabolic process GO:0010565 66 0.648
response to vitamin d GO:0033280 3 0.647
single organismal cell cell adhesion GO:0016337 131 0.641
negative regulation of phosphate metabolic process GO:0045936 184 0.641
response to ionizing radiation GO:0010212 42 0.640
cellular response to x ray GO:0071481 2 0.639
cellular ketone metabolic process GO:0042180 84 0.634
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.633
negative regulation of kinase activity GO:0033673 81 0.630
mitochondrial dna repair GO:0043504 3 0.628
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 2 0.626
cellular response to oxidative stress GO:0034599 76 0.620
nitric oxide mediated signal transduction GO:0007263 4 0.614
regulation of mitotic cell cycle GO:0007346 126 0.614
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.612
apoptotic process involved in embryonic digit morphogenesis GO:1902263 3 0.610
positive regulation of glial cell proliferation GO:0060252 4 0.609
endothelial cell apoptotic process GO:0072577 9 0.609
negative regulation of oxidative stress induced cell death GO:1903202 9 0.604
signal transduction involved in mitotic cell cycle checkpoint GO:0072413 3 0.603
Human
regulation of somitogenesis GO:0014807 6 0.600
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 3 0.597
Human
pole plasm assembly GO:0007315 2 0.596
urogenital system development GO:0001655 261 0.595
Mouse
negative regulation of epithelial cell proliferation GO:0050680 64 0.589
Mouse
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.586
positive regulation of mammary gland involution GO:1903521 4 0.585
cellular amine metabolic process GO:0044106 44 0.584
myeloid cell homeostasis GO:0002262 114 0.582
mitotic cell cycle process GO:1903047 159 0.577
Human Mouse
cellular amino acid metabolic process GO:0006520 103 0.576
cellular response to metal ion GO:0071248 31 0.573
placenta blood vessel development GO:0060674 31 0.572
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.571
mapk cascade GO:0000165 281 0.568
response to x ray GO:0010165 11 0.568
regulation of response to oxidative stress GO:1902882 19 0.565
digestive system development GO:0055123 200 0.564
negative regulation of immune system process GO:0002683 209 0.563
regulation of cellular amine metabolic process GO:0033238 20 0.557
positive regulation of programmed cell death GO:0043068 218 0.557
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.554
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.553
positive regulation of striated muscle cell apoptotic process GO:0010663 3 0.547
homeostasis of number of cells GO:0048872 210 0.545
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.544
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 11 0.542
cerebral cortex development GO:0021987 86 0.541
cellular response to external stimulus GO:0071496 88 0.535
Human
regulation of transcription from rna polymerase ii promoter in response to oxidative stress GO:0043619 2 0.534
regulation of fibroblast proliferation GO:0048145 34 0.529
Human
lymphocyte differentiation GO:0030098 242 0.520
response to hyperoxia GO:0055093 2 0.519
myeloid cell differentiation GO:0030099 233 0.516
striated muscle tissue development GO:0014706 293 0.514
regulation of protein maturation GO:1903317 96 0.508
amine metabolic process GO:0009308 45 0.507
regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902108 14 0.499
cellular response to growth factor stimulus GO:0071363 197 0.499
negative regulation of lipid kinase activity GO:0090219 1 0.496
epithelial cell proliferation GO:0050673 174 0.495
Mouse
ectopic germ cell programmed cell death GO:0035234 9 0.495
regulation of cellular component biogenesis GO:0044087 181 0.494
Mouse
kidney development GO:0001822 213 0.493
negative regulation of intracellular signal transduction GO:1902532 167 0.483
protein processing GO:0016485 163 0.481
cell adhesion GO:0007155 329 0.481
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 34 0.480
regulation of p38mapk cascade GO:1900744 3 0.480
regulation of blood coagulation GO:0030193 28 0.479
t cell activation GO:0042110 289 0.475
regulation of protein serine threonine kinase activity GO:0071900 157 0.473
positive regulation of protein kinase activity GO:0045860 144 0.473
Human
negative regulation of lymphocyte apoptotic process GO:0070229 24 0.471
positive regulation of p38mapk cascade GO:1900745 1 0.470
pallium development GO:0021543 120 0.469
protein modification by small protein conjugation GO:0032446 187 0.469
positive regulation of cellular amine metabolic process GO:0033240 5 0.466
positive regulation of cell cycle phase transition GO:1901989 17 0.460
regulation of apoptotic signaling pathway GO:2001233 197 0.460
positive regulation of cell cycle g1 s phase transition GO:1902808 9 0.460
skeletal system development GO:0001501 356 0.459
wound healing GO:0042060 157 0.457
regulation of cell cycle phase transition GO:1901987 77 0.453
Human
response to nutrient levels GO:0031667 109 0.451
response to inorganic substance GO:0010035 96 0.447
response to amino acid GO:0043200 37 0.442
protein modification by small protein conjugation or removal GO:0070647 207 0.442
negative regulation of endothelial cell migration GO:0010596 4 0.442
positive regulation of apoptotic process involved in morphogenesis GO:1902339 4 0.441
intrinsic apoptotic signaling pathway GO:0097193 132 0.439
mammary gland epithelial cell proliferation GO:0033598 24 0.433
labyrinthine layer development GO:0060711 49 0.433
regulation of lymphocyte activation GO:0051249 240 0.432
negative regulation of ubiquitin protein transferase activity GO:0051444 3 0.428
regulation of mapk cascade GO:0043408 248 0.428
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 9 0.427
cell cycle g1 s phase transition GO:0044843 57 0.413
Human Mouse
regulation of leukocyte differentiation GO:1902105 159 0.413
negative regulation of phosphorus metabolic process GO:0010563 184 0.413
regulation of endothelial cell apoptotic process GO:2000351 9 0.401
response to hypoxia GO:0001666 58 0.400
apoptotic mitochondrial changes GO:0008637 48 0.398
positive regulation of leukocyte differentiation GO:1902107 86 0.396
microtubule cytoskeleton organization GO:0000226 157 0.396
Mouse
regulation of peptidase activity GO:0052547 96 0.395
modulation by virus of host morphology or physiology GO:0019048 3 0.394
spermatid differentiation GO:0048515 115 0.394
positive regulation of angiogenesis GO:0045766 46 0.385
positive regulation of lymphocyte apoptotic process GO:0070230 13 0.384
t cell selection GO:0045058 34 0.384
negative regulation of proteolysis GO:0045861 74 0.384
positive regulation of cell cycle GO:0045787 92 0.381
Human
positive regulation of protein oligomerization GO:0032461 4 0.378
negative regulation of map kinase activity GO:0043407 34 0.372
cellular lipid metabolic process GO:0044255 323 0.370
oocyte differentiation GO:0009994 35 0.369
response to vitamin a GO:0033189 1 0.367
embryonic placenta development GO:0001892 98 0.366
mitochondrial membrane organization GO:0007006 26 0.363
keratinocyte migration GO:0051546 3 0.359
cell growth GO:0016049 130 0.358
Human
developmental maturation GO:0021700 193 0.358
protein maturation GO:0051604 176 0.357
positive regulation of cell development GO:0010720 237 0.356
epithelial cell differentiation involved in prostate gland development GO:0060742 13 0.356
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.356
modification dependent macromolecule catabolic process GO:0043632 133 0.356
positive regulation of mitotic cell cycle phase transition GO:1901992 17 0.354
renal system development GO:0072001 225 0.351
regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway GO:1903376 3 0.348
regulation of cell activation GO:0050865 289 0.348
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.346
negative regulation of protein processing GO:0010955 79 0.346
protein ubiquitination GO:0016567 171 0.343
regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061418 2 0.343
positive regulation of mitochondrial membrane permeability GO:0035794 12 0.340
cellular response to decreased oxygen levels GO:0036294 18 0.339
tissue remodeling GO:0048771 102 0.339
negative regulation of syncytium formation by plasma membrane fusion GO:0034242 5 0.336
regulation of endopeptidase activity GO:0052548 89 0.335
negative regulation of hydrolase activity GO:0051346 71 0.333
t cell differentiation GO:0030217 174 0.329
divalent inorganic cation homeostasis GO:0072507 138 0.326
response to uv GO:0009411 44 0.324
sprouting angiogenesis GO:0002040 26 0.324
negative regulation of cellular response to oxidative stress GO:1900408 10 0.324
extrinsic apoptotic signaling pathway GO:0097191 126 0.323
glomerulus development GO:0032835 40 0.323
regulation of blood vessel remodeling GO:0060312 3 0.322
negative regulation of response to oxidative stress GO:1902883 10 0.320
jnk cascade GO:0007254 72 0.315
oocyte construction GO:0007308 2 0.313
centrosome organization GO:0051297 26 0.311
forebrain development GO:0030900 302 0.307
mammary gland epithelium development GO:0061180 65 0.306
hair follicle morphogenesis GO:0031069 29 0.304
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.304
leukocyte differentiation GO:0002521 342 0.304
b cell activation GO:0042113 161 0.303
negative regulation of protein maturation GO:1903318 79 0.301
positive regulation of protein complex assembly GO:0031334 45 0.300
Mouse
negative regulation of cell cycle arrest GO:0071157 1 0.300
negative regulation of photoreceptor cell differentiation GO:0046533 4 0.295
segmentation GO:0035282 93 0.295
response to extracellular stimulus GO:0009991 127 0.294
Human
response to oxygen levels GO:0070482 62 0.289
negative regulation of interferon gamma mediated signaling pathway GO:0060336 1 0.288
zymogen activation GO:0031638 41 0.287
protein catabolic process GO:0030163 221 0.287
response to chromate GO:0046687 1 0.285
lymphocyte homeostasis GO:0002260 64 0.285
glial cell apoptotic process GO:0034349 3 0.282
regulation of cellular response to stress GO:0080135 159 0.282
multi multicellular organism process GO:0044706 109 0.281
female genitalia morphogenesis GO:0048807 3 0.280
negative regulation of cell cycle GO:0045786 123 0.279
negative regulation of transferase activity GO:0051348 85 0.279
odontogenesis GO:0042476 78 0.278
actin filament organization GO:0007015 113 0.278
regulation of b cell activation GO:0050864 81 0.276
ras protein signal transduction GO:0007265 77 0.276
Human
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 1 0.275
positive regulation of mitotic cell cycle GO:0045931 41 0.274
regulation of cellular response to oxidative stress GO:1900407 19 0.274
positive regulation of histone modification GO:0031058 28 0.274
sensory organ morphogenesis GO:0090596 242 0.272
regulation of mitotic cell cycle phase transition GO:1901990 73 0.272
Human
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.272
regulation of neuron differentiation GO:0045664 281 0.272
mitotic cell cycle arrest GO:0071850 4 0.272
response to lithium ion GO:0010226 10 0.271
positive regulation of cell cycle process GO:0090068 61 0.270
Human
response to organophosphorus GO:0046683 22 0.269
plasma membrane long chain fatty acid transport GO:0015911 1 0.262
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.261
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.258
negative regulation of glial cell proliferation GO:0060253 4 0.258
pharynx development GO:0060465 1 0.257
morphogenesis of a branching epithelium GO:0061138 193 0.256
cell chemotaxis GO:0060326 81 0.253
negative regulation of lipid metabolic process GO:0045833 30 0.250
regulation of protein processing GO:0070613 96 0.250
dendrite development GO:0016358 115 0.248
positive regulation of mapk cascade GO:0043410 170 0.248
mitochondrion degradation GO:0000422 3 0.247
appendage morphogenesis GO:0035107 149 0.244
regulation of epidermal cell division GO:0010482 3 0.243
response to growth factor GO:0070848 198 0.240
negative regulation of dendritic spine development GO:0061000 3 0.240
mitotic sister chromatid cohesion GO:0007064 1 0.240
peptidyl amino acid modification GO:0018193 336 0.238
regulation of wound healing GO:0061041 40 0.237
cellular response to abiotic stimulus GO:0071214 56 0.235
microtubule depolymerization GO:0007019 15 0.234
regulation of protein stability GO:0031647 52 0.232
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.230
regulation of tissue remodeling GO:0034103 38 0.229
neuronal action potential GO:0019228 54 0.226
cellular response to extracellular stimulus GO:0031668 81 0.226
Human
negative regulation of cellular protein catabolic process GO:1903363 22 0.225
calcium ion transport GO:0006816 159 0.225
regulation of mammary gland involution GO:1903519 4 0.223
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.223
signal transduction by p53 class mediator GO:0072331 51 0.223
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator GO:1902255 2 0.221
positive regulation of cytokine production GO:0001819 174 0.219
cellular response to prostaglandin stimulus GO:0071379 2 0.218
positive regulation of muscle cell apoptotic process GO:0010661 6 0.218
negative regulation of cell migration GO:0030336 59 0.216
regulation of leukocyte apoptotic process GO:2000106 56 0.216
response to decreased oxygen levels GO:0036293 59 0.215
macrophage differentiation GO:0030225 20 0.215
leukocyte apoptotic process GO:0071887 71 0.210
stem cell maintenance GO:0019827 130 0.210
face morphogenesis GO:0060325 29 0.210
purine ribonucleotide metabolic process GO:0009150 290 0.210
positive regulation of map kinase activity GO:0043406 84 0.210
peptidyl tyrosine phosphorylation GO:0018108 143 0.209
female gamete generation GO:0007292 74 0.208
neuroblast fate determination GO:0007400 1 0.207
dna metabolic process GO:0006259 303 0.206
regulation of proteolysis GO:0030162 164 0.205
cell type specific apoptotic process GO:0097285 268 0.205
negative regulation of transcription from rna polymerase ii promoter in response to stress GO:0097201 1 0.204
response to light stimulus GO:0009416 135 0.204
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.204
notch signaling pathway GO:0007219 71 0.204
regulation of fibrinolysis GO:0051917 1 0.203
regulation of organelle organization GO:0033043 289 0.202
Mouse
engulfment of apoptotic cell GO:0043652 3 0.202
regulation of protein targeting GO:1903533 61 0.202
b cell apoptotic process GO:0001783 19 0.201
positive regulation of protein acetylation GO:1901985 9 0.201
regulation of anoikis GO:2000209 2 0.200
negative regulation of cell motility GO:2000146 61 0.199
regulation of lymphocyte differentiation GO:0045619 107 0.198
axonogenesis GO:0007409 274 0.198
positive regulation of osteoclast differentiation GO:0045672 15 0.196
regulation of hydrolase activity GO:0051336 246 0.194
blood vessel endothelial cell migration GO:0043534 23 0.194
nuclear division GO:0000280 158 0.194
regulation of cellular response to growth factor stimulus GO:0090287 82 0.194
organ growth GO:0035265 117 0.193
cellular response to ionizing radiation GO:0071479 11 0.193
regulation of endothelial cell chemotaxis GO:2001026 1 0.192
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.192
proteasomal protein catabolic process GO:0010498 98 0.191
neuron apoptotic process GO:0051402 142 0.191
apoptotic signaling pathway GO:0097190 306 0.191
peptidyl tyrosine modification GO:0018212 145 0.190
positive regulation of epithelial cell proliferation GO:0050679 68 0.190
posttranscriptional regulation of gene expression GO:0010608 155 0.190
branching morphogenesis of an epithelial tube GO:0048754 159 0.189
regulation of cytoskeleton organization GO:0051493 122 0.188
Mouse
myeloid cell apoptotic process GO:0033028 22 0.188
negative regulation of cell growth GO:0030308 44 0.188
Human
limb development GO:0060173 166 0.185
carbohydrate metabolic process GO:0005975 230 0.185
modification dependent protein catabolic process GO:0019941 133 0.183
regulation of lymphocyte proliferation GO:0050670 117 0.182
fibroblast growth factor receptor signaling pathway GO:0008543 46 0.181
appendage development GO:0048736 166 0.180
regulation of membrane permeability GO:0090559 18 0.180
regulation of t cell differentiation GO:0045580 83 0.180
prostate gland development GO:0030850 48 0.180
Mouse
circulatory system process GO:0003013 197 0.179
platelet derived growth factor receptor alpha signaling pathway GO:0035790 3 0.179
response to peptide GO:1901652 136 0.177
growth involved in heart morphogenesis GO:0003241 4 0.176
regulation of transmembrane transport GO:0034762 128 0.176
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.175
actin filament bundle assembly GO:0051017 40 0.175
myeloid leukocyte activation GO:0002274 83 0.174
positive t cell selection GO:0043368 23 0.174
liposaccharide metabolic process GO:1903509 27 0.174
regulation of cell cycle g1 s phase transition GO:1902806 35 0.173
Human
regulation of vasculature development GO:1901342 88 0.172
response to ischemia GO:0002931 14 0.172
cytokine production GO:0001816 319 0.171
cellular protein catabolic process GO:0044257 155 0.170
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.167
cell death in response to oxidative stress GO:0036473 24 0.166
cellular response to amino acid stimulus GO:0071230 29 0.166
negative regulation of endopeptidase activity GO:0010951 44 0.165
p38mapk cascade GO:0038066 4 0.165
regulation of stress activated mapk cascade GO:0032872 69 0.165
liver development GO:0001889 66 0.164
regulation of hemostasis GO:1900046 28 0.164
negative regulation of keratinocyte differentiation GO:0045617 4 0.163
glycolipid metabolic process GO:0006664 25 0.163
modification by symbiont of host morphology or physiology GO:0044003 4 0.162
glomerular capillary formation GO:0072104 6 0.162
regulation of cellular response to hypoxia GO:1900037 2 0.161
cellular chemical homeostasis GO:0055082 215 0.161
cgmp mediated signaling GO:0019934 3 0.161
negative regulation of cell activation GO:0050866 111 0.160
positive regulation of nervous system development GO:0051962 221 0.159
endothelial cell proliferation GO:0001935 27 0.159
positive regulation of mitochondrion organization GO:0010822 17 0.159
carbohydrate derivative biosynthetic process GO:1901137 183 0.159
response to tumor necrosis factor GO:0034612 26 0.157
negative regulation of cellular component organization GO:0051129 194 0.156
epidermis development GO:0008544 187 0.156
cell migration involved in endocardial cushion formation GO:0003273 3 0.155
membrane organization GO:0061024 245 0.155
stress response to metal ion GO:0097501 3 0.155
regulation of b cell differentiation GO:0045577 23 0.155
telencephalon development GO:0021537 186 0.154
regulation of angiogenesis GO:0045765 81 0.153
hypoxia inducible factor 1alpha signaling pathway GO:0097411 2 0.152
positive regulation of apoptotic signaling pathway GO:2001235 95 0.151
hippocampus development GO:0021766 52 0.151
response to hydrogen peroxide GO:0042542 32 0.151
cellular response to acid chemical GO:0071229 68 0.151
morphogenesis of a branching structure GO:0001763 203 0.151
traversing start control point of mitotic cell cycle GO:0007089 2 0.150
negative regulation of peptidase activity GO:0010466 46 0.150
regulation of myeloid leukocyte differentiation GO:0002761 58 0.149
dephosphorylation GO:0016311 129 0.146
maternal determination of anterior posterior axis embryo GO:0008358 2 0.146
negative regulation of lymphocyte differentiation GO:0045620 32 0.145
dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 2 0.145
response to corticosterone GO:0051412 1 0.145
placenta development GO:0001890 140 0.144
negative regulation of anoikis GO:2000811 2 0.144
renal system vasculature morphogenesis GO:0061438 7 0.144
negative regulation of neuron apoptotic process GO:0043524 92 0.143
response to corticosteroid GO:0031960 20 0.142
regulation of lipid kinase activity GO:0043550 14 0.142
regulation of body fluid levels GO:0050878 162 0.142
positive regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway GO:0035793 1 0.142
response to drug GO:0042493 75 0.141
receptor biosynthetic process GO:0032800 3 0.141
mitochondrial transport GO:0006839 36 0.141
neuroblast differentiation GO:0014016 2 0.140
epithelial tube morphogenesis GO:0060562 303 0.140
positive regulation of cell motility GO:2000147 116 0.140
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.140
Human
embryonic limb morphogenesis GO:0030326 126 0.139
skin development GO:0043588 220 0.139
establishment or maintenance of cell polarity GO:0007163 86 0.138
dna replication GO:0006260 52 0.138
multicellular organismal metabolic process GO:0044236 28 0.138
cellular response to hypoxia GO:0071456 17 0.138
epidermis morphogenesis GO:0048730 33 0.137
positive regulation of keratinocyte differentiation GO:0045618 3 0.136
ubiquitin dependent protein catabolic process GO:0006511 129 0.135
digestive tract morphogenesis GO:0048546 147 0.134
neutrophil apoptotic process GO:0001781 3 0.134
cell cycle checkpoint GO:0000075 47 0.134
Human
carbohydrate homeostasis GO:0033500 128 0.133
dendritic spine maintenance GO:0097062 4 0.133
hematopoietic progenitor cell differentiation GO:0002244 143 0.132
b cell lineage commitment GO:0002326 4 0.132
meiotic cell cycle GO:0051321 122 0.132
lymphocyte proliferation GO:0046651 164 0.131
regulation of ion transport GO:0043269 215 0.131
regulation of developmental pigmentation GO:0048070 14 0.131
tissue migration GO:0090130 68 0.130
leukocyte homeostasis GO:0001776 79 0.129
regulation of ubiquitin protein transferase activity GO:0051438 7 0.128
inflammatory response GO:0006954 244 0.128
actin cytoskeleton organization GO:0030036 220 0.127
signal transduction involved in mitotic g1 dna damage checkpoint GO:0072431 3 0.127
Human
oocyte development GO:0048599 33 0.127
purine nucleotide metabolic process GO:0006163 302 0.127
response to reactive oxygen species GO:0000302 56 0.126
smooth muscle tissue development GO:0048745 22 0.125
microtubule organizing center organization GO:0031023 28 0.125
regulation of coagulation GO:0050818 31 0.124
organelle fission GO:0048285 170 0.124
b cell differentiation GO:0030183 78 0.123
rrna transcription GO:0009303 9 0.123
regulation of notch signaling pathway GO:0008593 35 0.123
positive regulation of organelle organization GO:0010638 128 0.122
Mouse
activation of cysteine type endopeptidase activity GO:0097202 27 0.122
cytokine mediated signaling pathway GO:0019221 115 0.121
regulation of g1 s transition of mitotic cell cycle GO:2000045 35 0.121
Human
cloacal septation GO:0060197 2 0.120
positive regulation of coagulation GO:0050820 13 0.120
response to starvation GO:0042594 65 0.120
response to increased oxygen levels GO:0036296 2 0.120
protein localization to organelle GO:0033365 185 0.120
regulation of epidermal cell differentiation GO:0045604 21 0.120
long chain fatty acid transport GO:0015909 15 0.119
single organism nuclear import GO:1902593 95 0.119
photoreceptor cell differentiation GO:0046530 52 0.119

Cdkn1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.957
cancer DOID:162 0 0.783
organ system cancer DOID:0050686 0 0.665
disease of anatomical entity DOID:7 0 0.277
musculoskeletal system disease DOID:17 0 0.277
connective tissue disease DOID:65 0 0.277
immune system disease DOID:2914 0 0.210
immune system cancer DOID:0060083 0 0.208
gastrointestinal system cancer DOID:3119 0 0.203
urinary system cancer DOID:3996 0 0.197
endocrine gland cancer DOID:170 0 0.195
hematopoietic system disease DOID:74 0 0.146
kidney cancer DOID:263 0 0.119