IMP
Process View
nitric oxide mediated signal transduction
Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.
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Click on a gene's description to view its network relationships with genes known to be involved in "nitric oxide mediated signal transduction"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Lep | leptin | 0.952 | ||
| Lyz2 | lysozyme 2 | 0.779 | ||
| Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.614 | ||
| Fas | Fas (TNF receptor superfamily member 6) | 0.536 | ||
| Kit | kit oncogene | 0.441 | ||
| Lepr | leptin receptor | 0.410 | ||
| Cav1 | caveolin 1, caveolae protein | 0.367 | ||
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.268 | ||
| Nfe2l2 | nuclear factor, erythroid derived 2, like 2 | 0.226 | ||
| Ccl2 | chemokine (C-C motif) ligand 2 | 0.199 | ||
| Gucy1b3 | guanylate cyclase 1, soluble, beta 3 | 0.176 | Rat | |
| Cebpb | CCAAT/enhancer binding protein (C/EBP), beta | 0.161 | ||
| Il6st | interleukin 6 signal transducer | 0.160 | ||
| Pparg | peroxisome proliferator activated receptor gamma | 0.148 | ||
| Fbn1 | fibrillin 1 | 0.139 | ||
| Stat3 | signal transducer and activator of transcription 3 | 0.132 | ||
| Apoe | apolipoprotein E | 0.122 | Human | |
| Vhl | von Hippel-Lindau tumor suppressor | 0.118 | ||
| Itgb1 | integrin beta 1 (fibronectin receptor beta) | 0.092 | ||
| Nos3 | nitric oxide synthase 3, endothelial cell | 0.085 | ||
| Notch2 | Notch gene homolog 2 (Drosophila) | 0.076 | ||
| Smad3 | MAD homolog 3 (Drosophila) | 0.076 | ||
| Lox | lysyl oxidase | 0.071 | ||
| Ifngr1 | interferon gamma receptor 1 | 0.067 | ||
| Cd44 | CD44 antigen | 0.065 | ||
| Ptf1a | pancreas specific transcription factor, 1a | 0.062 | ||
| Otx2 | orthodenticle homolog 2 (Drosophila) | 0.061 | ||
| Ldlr | low density lipoprotein receptor | 0.060 | ||
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.058 | ||
| Npy2r | neuropeptide Y receptor Y2 | 0.054 | ||
| Nkx2-2 | NK2 transcription factor related, locus 2 (Drosophila) | 0.052 | ||
| Gucy1a3 | guanylate cyclase 1, soluble, alpha 3 | 0.051 | Rat | |
| Il6 | interleukin 6 | 0.049 | ||
| Apoa1 | apolipoprotein A-I | 0.047 | ||
| Lpl | lipoprotein lipase | 0.047 | ||
| Dmd | dystrophin, muscular dystrophy | 0.045 | ||
| Slc4a5 | solute carrier family 4, sodium bicarbonate cotransporter, member 5 | 0.044 | ||
| Mdm2 | transformed mouse 3T3 cell double minute 2 | 0.043 | ||
| Spp1 | secreted phosphoprotein 1 | 0.042 | ||
| Insm1 | insulinoma-associated 1 | 0.042 | ||
| Mmp9 | matrix metallopeptidase 9 | 0.041 | ||
| Rb1 | retinoblastoma 1 | 0.041 | ||
| Apc | adenomatosis polyposis coli | 0.040 | ||
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.039 | ||
| Ins2 | insulin II | 0.038 | ||
| Col1a1 | collagen, type I, alpha 1 | 0.038 | ||
| Ahr | aryl-hydrocarbon receptor | 0.034 | ||
| Nos2 | nitric oxide synthase 2, inducible | 0.033 | ||
| Il1r1 | interleukin 1 receptor, type I | 0.033 | ||
| Abca1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.033 | ||
| Kitl | kit ligand | 0.033 | ||
| Vdr | vitamin D receptor | 0.031 | ||
| Il10 | interleukin 10 | 0.029 | ||
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.029 | ||
| Tlr4 | toll-like receptor 4 | 0.028 | ||
| Nkx6-1 | NK6 homeobox 1 | 0.026 | ||
| Nr3c1 | nuclear receptor subfamily 3, group C, member 1 | 0.026 | ||
| Esr1 | estrogen receptor 1 (alpha) | 0.025 | ||
| C3 | complement component 3 | 0.025 | ||
| Agtr1a | angiotensin II receptor, type 1a | 0.025 | ||
| Hif1a | hypoxia inducible factor 1, alpha subunit | 0.025 | ||
| Actn2 | actinin alpha 2 | 0.024 | ||
| Neurod4 | neurogenic differentiation 4 | 0.024 | ||
| Sycn | syncollin | 0.023 | ||
| Vegfa | vascular endothelial growth factor A | 0.023 | ||
| Slc2a4 | solute carrier family 2 (facilitated glucose transporter), member 4 | 0.021 | ||
| Timp4 | tissue inhibitor of metalloproteinase 4 | 0.021 | ||
| Kras | v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog | 0.019 | ||
| Myo6 | myosin VI | 0.018 | ||
| Mef2c | myocyte enhancer factor 2C | 0.018 | ||
| Trp53 | transformation related protein 53 | 0.018 | ||
| Cftr | cystic fibrosis transmembrane conductance regulator homolog | 0.018 | ||
| Cfh | complement component factor h | 0.017 | ||
| Lgals3 | lectin, galactose binding, soluble 3 | 0.017 | ||
| Cebpa | CCAAT/enhancer binding protein (C/EBP), alpha | 0.016 | ||
| Grm1 | glutamate receptor, metabotropic 1 | 0.016 | ||
| Arntl | aryl hydrocarbon receptor nuclear translocator-like | 0.016 | ||
| Thra | thyroid hormone receptor alpha | 0.016 | ||
| Scd1 | stearoyl-Coenzyme A desaturase 1 | 0.016 | ||
| Neurog2 | neurogenin 2 | 0.015 | ||
| Prnp | prion protein | 0.015 | ||
| Timp3 | tissue inhibitor of metalloproteinase 3 | 0.015 | ||
| Ghr | growth hormone receptor | 0.015 | ||
| Tgfb1 | transforming growth factor, beta 1 | 0.015 | ||
| Fabp4 | fatty acid binding protein 4, adipocyte | 0.015 | ||
| Pten | phosphatase and tensin homolog | 0.014 | ||
| Fos | FBJ osteosarcoma oncogene | 0.014 | ||
| Tnfrsf1a | tumor necrosis factor receptor superfamily, member 1a | 0.014 | ||
| Klf15 | Kruppel-like factor 15 | 0.014 | ||
| Pax6 | paired box gene 6 | 0.014 | ||
| Hmox1 | heme oxygenase (decycling) 1 | 0.013 | ||
| Cdkn1b | cyclin-dependent kinase inhibitor 1B | 0.013 | ||
| Slc26a4 | solute carrier family 26, member 4 | 0.013 | ||
| Fgf13 | fibroblast growth factor 13 | 0.013 | ||
| Npc1 | Niemann Pick type C1 | 0.013 | ||
| Hopx | HOP homeobox | 0.013 | ||
| Pvrl3 | poliovirus receptor-related 3 | 0.013 | ||
| Adipoq | adiponectin, C1Q and collagen domain containing | 0.012 | ||
| Bcl2 | B-cell leukemia/lymphoma 2 | 0.012 | ||
| Stk11 | serine/threonine kinase 11 | 0.012 | ||
| Plau | plasminogen activator, urokinase | 0.012 | ||
| Pnpla2 | patatin-like phospholipase domain containing 2 | 0.012 | ||
| Serpine1 | serine (or cysteine) peptidase inhibitor, clade E, member 1 | 0.011 | ||
| Gadd45g | growth arrest and DNA-damage-inducible 45 gamma | 0.011 | ||
| Gnas | GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus | 0.011 | ||
| Eltd1 | EGF, latrophilin seven transmembrane domain containing 1 | 0.011 | ||
| Sdpr | serum deprivation response | 0.010 | ||
| Cyct | cytochrome c, testis | 0.010 | ||
| Sparcl1 | SPARC-like 1 | 0.010 | ||
| Ascl1 | achaete-scute complex homolog 1 (Drosophila) | 0.010 |