Mus musculus

149 known processes

Casp1

caspase 1

(Aliases: Il1bc,ICE)

Casp1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of interleukin 1 secretion GO:0050716 14 1.000
i kappab kinase nf kappab signaling GO:0007249 85 0.999
positive regulation of interleukin 1 beta production GO:0032731 16 0.998
defense response to other organism GO:0098542 197 0.998
Fly
regulation of defense response GO:0031347 233 0.997
interleukin 1 secretion GO:0050701 16 0.994
cellular response to molecule of bacterial origin GO:0071219 83 0.994
cytokine production GO:0001816 319 0.994
cellular response to interferon beta GO:0035458 21 0.993
regulation of cytokine production GO:0001817 266 0.993
regulation of interleukin 8 production GO:0032677 3 0.991
interleukin 1 beta production GO:0032611 30 0.991
positive regulation of defense response GO:0031349 124 0.991
Fly
negative regulation of necroptotic process GO:0060546 9 0.991
Mouse
cellular response to biotic stimulus GO:0071216 92 0.989
defense response to virus GO:0051607 68 0.989
Fly
positive regulation of innate immune response GO:0045089 80 0.986
Fly
release of cytochrome c from mitochondria GO:0001836 23 0.984
Mouse
interleukin 1 production GO:0032612 31 0.984
cellular response to cytokine stimulus GO:0071345 189 0.983
response to molecule of bacterial origin GO:0002237 143 0.983
regulation of protein transport GO:0051223 163 0.982
response to lipopolysaccharide GO:0032496 128 0.981
regulation of protein targeting GO:1903533 61 0.981
regulation of response to biotic stimulus GO:0002831 38 0.978
Fly
cellular response to lipid GO:0071396 145 0.978
Mouse
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.976
Mouse Fly
pyroptosis GO:0070269 8 0.975
protein import into nucleus GO:0006606 95 0.968
cellular response to lipopolysaccharide GO:0071222 77 0.965
regulation of establishment of protein localization GO:0070201 181 0.964
negative regulation of cytokine production GO:0001818 84 0.963
regulation of chemokine production GO:0032642 30 0.963
regulation of interleukin 1 production GO:0032652 26 0.961
activation of immune response GO:0002253 138 0.961
activation of innate immune response GO:0002218 56 0.960
positive regulation of interleukin 1 beta secretion GO:0050718 14 0.959
regulation of apoptotic dna fragmentation GO:1902510 5 0.957
Mouse
regulation of cytoplasmic transport GO:1903649 112 0.953
regulation of intracellular protein transport GO:0033157 82 0.951
interleukin 1 alpha secretion GO:0050703 3 0.951
protein import GO:0017038 101 0.950
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.949
Mouse
defense response to bacterium GO:0042742 119 0.947
Fly
defense response to gram positive bacterium GO:0050830 50 0.943
negative regulation of phosphorus metabolic process GO:0010563 184 0.937
Mouse
glial cell apoptotic process GO:0034349 3 0.935
Mouse
interleukin 8 production GO:0032637 4 0.935
positive regulation of cytokine production GO:0001819 174 0.930
establishment of protein localization to organelle GO:0072594 118 0.918
positive regulation of interleukin 1 alpha production GO:0032730 4 0.917
positive regulation of secretion GO:0051047 130 0.916
nuclear transport GO:0051169 139 0.915
interleukin 1 beta secretion GO:0050702 16 0.910
positive regulation of interleukin 1 alpha secretion GO:0050717 3 0.909
t cell proliferation GO:0042098 120 0.906
Mouse
cytokine secretion GO:0050663 72 0.902
regulation of protein localization GO:0032880 231 0.898
regulation of defense response to virus by host GO:0050691 8 0.896
Fly
cytoplasmic pattern recognition receptor signaling pathway GO:0002753 10 0.891
regulation of type i interferon production GO:0032479 22 0.889
regulation of peptidase activity GO:0052547 96 0.886
Mouse Fly
single organism nuclear import GO:1902593 95 0.885
positive regulation of secretion by cell GO:1903532 114 0.885
apoptotic dna fragmentation GO:0006309 7 0.884
Mouse
positive regulation of endopeptidase activity GO:0010950 43 0.880
Mouse Fly
protein autoprocessing GO:0016540 2 0.880
Worm Fly
regulation of lymphocyte activation GO:0051249 240 0.878
Mouse
positive regulation of interleukin 8 secretion GO:2000484 1 0.877
positive regulation of interleukin 6 secretion GO:2000778 1 0.873
membrane hyperpolarization GO:0060081 21 0.872
interspecies interaction between organisms GO:0044419 83 0.872
positive regulation of interleukin 1 production GO:0032732 17 0.863
negative regulation of transferase activity GO:0051348 85 0.863
Mouse
positive regulation of cytokine secretion GO:0050715 41 0.861
regulation of intracellular transport GO:0032386 159 0.852
regulation of endopeptidase activity GO:0052548 89 0.849
Mouse Fly
positive regulation of protein secretion GO:0050714 52 0.846
regulation of nucleocytoplasmic transport GO:0046822 73 0.842
negative regulation of protein modification process GO:0031400 163 0.832
Mouse
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.831
Mouse Fly
regulation of interleukin 18 production GO:0032661 3 0.826
cytoplasmic transport GO:0016482 234 0.826
positive regulation of programmed cell death GO:0043068 218 0.821
Mouse Rat Fly
positive regulation of peptidase activity GO:0010952 49 0.821
Mouse Fly
regulation of interferon alpha production GO:0032647 5 0.817
cytokine biosynthetic process GO:0042089 68 0.813
regulation of execution phase of apoptosis GO:1900117 9 0.812
Mouse
leukocyte activation involved in immune response GO:0002366 126 0.811
regulation of interleukin 1 alpha production GO:0032650 4 0.802
protein secretion GO:0009306 111 0.801
regulation of antibacterial peptide production GO:0002786 1 0.800
Fly
nucleocytoplasmic transport GO:0006913 139 0.796
secondary metabolic process GO:0019748 18 0.792
Fly
regulation of interleukin 6 production GO:0032675 55 0.789
negative regulation of phosphate metabolic process GO:0045936 184 0.787
Mouse
jnk cascade GO:0007254 72 0.786
mitochondrion organization GO:0007005 134 0.784
Mouse
negative regulation of cellular protein metabolic process GO:0032269 247 0.782
Mouse
regulation of interleukin 1 beta production GO:0032651 25 0.782
antibacterial peptide production GO:0002778 2 0.778
Fly
adaptive immune response GO:0002250 155 0.777
regulation of lymphocyte proliferation GO:0050670 117 0.773
Mouse
activation of cysteine type endopeptidase activity GO:0097202 27 0.772
Mouse Fly
apoptotic mitochondrial changes GO:0008637 48 0.769
Mouse
positive regulation of jnk cascade GO:0046330 46 0.767
regulation of cysteine type endopeptidase activity GO:2000116 65 0.766
Mouse Fly
apoptotic signaling pathway GO:0097190 306 0.765
Mouse Fly
innate immune response GO:0045087 157 0.763
Fly
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.752
Mouse Fly
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.745
leukocyte proliferation GO:0070661 172 0.744
Mouse
defense response to gram negative bacterium GO:0050829 28 0.743
Fly
negative regulation of phosphorylation GO:0042326 166 0.740
Mouse
intracellular protein transport GO:0006886 204 0.740
regulation of interleukin 8 secretion GO:2000482 2 0.739
inflammatory response GO:0006954 244 0.736
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.730
Mouse
b cell proliferation GO:0042100 53 0.726
Mouse
toxin transport GO:1901998 38 0.726
response to endoplasmic reticulum stress GO:0034976 53 0.724
Mouse
organic cyclic compound catabolic process GO:1901361 295 0.723
Mouse
positive regulation of proteolysis GO:0045862 85 0.714
Mouse Fly
zymogen activation GO:0031638 41 0.714
Mouse Fly
dna catabolic process endonucleolytic GO:0000737 15 0.705
Mouse
negative regulation of protein transport GO:0051224 46 0.703
b cell activation GO:0042113 161 0.690
Mouse
positive regulation of protein transport GO:0051222 93 0.684
regulation of autophagy GO:0010506 30 0.677
regulation of stress activated mapk cascade GO:0032872 69 0.673
defense response to protozoan GO:0042832 25 0.670
purine nucleoside metabolic process GO:0042278 241 0.667
protein modification by small protein conjugation GO:0032446 187 0.663
regulation of antimicrobial peptide biosynthetic process GO:0002805 1 0.657
Fly
positive regulation of chemokine biosynthetic process GO:0045080 6 0.654
negative regulation of protein phosphorylation GO:0001933 126 0.652
Mouse
regulation of proteolysis GO:0030162 164 0.649
Mouse Fly
regulation of secretion by cell GO:1903530 249 0.643
cellular response to interferon gamma GO:0071346 25 0.640
dna metabolic process GO:0006259 303 0.636
Mouse
antimicrobial peptide biosynthetic process GO:0002777 2 0.636
Fly
pigment metabolic process GO:0042440 32 0.636
Fly
morphogenesis of embryonic epithelium GO:0016331 159 0.634
Mouse
regulation of interferon beta production GO:0032648 13 0.633
regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001267 4 0.629
Fly
amide transport GO:0042886 138 0.629
negative regulation of inflammatory response to antigenic stimulus GO:0002862 10 0.628
positive regulation of lymphocyte activation GO:0051251 140 0.623
regulation of defense response to bacterium GO:1900424 3 0.621
Fly
rac protein signal transduction GO:0016601 13 0.613
regulation of apoptotic signaling pathway GO:2001233 197 0.606
Mouse Fly
cellular nitrogen compound catabolic process GO:0044270 280 0.606
Mouse
peptide transport GO:0015833 133 0.600
positive regulation of interleukin 10 secretion GO:2001181 1 0.598
type i interferon production GO:0032606 29 0.595
heterocycle catabolic process GO:0046700 280 0.588
Mouse
membrane depolarization GO:0051899 64 0.587
mitochondrial depolarization GO:0051882 6 0.587
phagocytosis GO:0006909 66 0.586
Worm
cellular response to peptidoglycan GO:0071224 4 0.575
engulfment of apoptotic cell GO:0043652 3 0.569
Worm
negative regulation of nik nf kappab signaling GO:1901223 2 0.568
regulation of response to wounding GO:1903034 189 0.566
aromatic compound catabolic process GO:0019439 286 0.565
Mouse
tube formation GO:0035148 140 0.564
Mouse
regulation of interleukin 10 secretion GO:2001179 4 0.563
cellular response to dna damage stimulus GO:0006974 207 0.562
Mouse
protein maturation GO:0051604 176 0.561
pattern recognition receptor signaling pathway GO:0002221 47 0.553
regulation of interleukin 1 beta secretion GO:0050706 15 0.550
extrinsic apoptotic signaling pathway GO:0097191 126 0.547
Mouse
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001269 3 0.545
Fly
sperm individualization GO:0007291 1 0.544
Fly
regulation of protein serine threonine kinase activity GO:0071900 157 0.544
Mouse
regulation of leukocyte proliferation GO:0070663 121 0.539
Mouse
protein localization to nucleus GO:0034504 121 0.535
detection of molecule of bacterial origin GO:0032490 2 0.532
negative regulation of lymphocyte proliferation GO:0050672 45 0.530
Mouse
regulation of multi organism process GO:0043900 111 0.529
Fly
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.518
lymphocyte homeostasis GO:0002260 64 0.517
Mouse
response to atp GO:0033198 8 0.517
organonitrogen compound catabolic process GO:1901565 264 0.516
interleukin 18 production GO:0032621 4 0.515
regulation of transferase activity GO:0051338 263 0.514
Mouse
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.513
regulation of necroptotic process GO:0060544 10 0.510
Mouse
protein localization to organelle GO:0033365 185 0.509
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.508
Fly
positive regulation of stress activated mapk cascade GO:0032874 48 0.503
protein processing GO:0016485 163 0.499
positive regulation of apoptotic process GO:0043065 217 0.492
Mouse Rat Fly
myeloid cell differentiation GO:0030099 233 0.488
Mouse
b cell mediated immunity GO:0019724 71 0.486
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 6 0.482
autophagy GO:0006914 45 0.481
positive regulation of release of cytochrome c from mitochondria GO:0090200 5 0.480
positive regulation of protein localization to nucleus GO:1900182 30 0.478
natural killer cell activation GO:0030101 44 0.472
actin filament polymerization GO:0030041 44 0.471
immunoglobulin mediated immune response GO:0016064 69 0.468
regulation of prostaglandin endoperoxide synthase activity GO:0060584 2 0.467
response to organic cyclic compound GO:0014070 198 0.467
positive regulation of nf kappab transcription factor activity GO:0051092 30 0.463
compound eye development GO:0048749 1 0.460
Fly
positive regulation of interleukin 8 production GO:0032757 2 0.459
keratinocyte differentiation GO:0030216 48 0.458
Mouse
regulation of cellular catabolic process GO:0031329 242 0.456
regulation of adaptive immune response GO:0002819 90 0.454
lymphocyte proliferation GO:0046651 164 0.453
Mouse
regulation of kinase activity GO:0043549 249 0.449
Mouse
necroptotic process GO:0070266 21 0.448
Mouse
regulation of interleukin 10 production GO:0032653 21 0.448
protein modification by small protein conjugation or removal GO:0070647 207 0.445
positive regulation of antibacterial peptide biosynthetic process GO:0006963 1 0.444
Fly
positive regulation of interleukin 6 production GO:0032755 37 0.444
regulation of t cell activation GO:0050863 170 0.443
Mouse
regulation of interleukin 1 secretion GO:0050704 15 0.432
regulation of production of molecular mediator of immune response GO:0002700 65 0.432
Fly
regulation of protein kinase activity GO:0045859 232 0.431
Mouse
positive regulation of t cell proliferation GO:0042102 52 0.430
hepatocyte apoptotic process GO:0097284 11 0.429
Mouse
regulation of neuron death GO:1901214 134 0.429
Mouse
interferon beta production GO:0032608 16 0.426
positive regulation of antimicrobial peptide production GO:0002225 1 0.422
Fly
positive regulation of transcription factor import into nucleus GO:0042993 8 0.420
negative regulation of intracellular protein transport GO:0090317 27 0.403
glycosyl compound catabolic process GO:1901658 206 0.402
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.401
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.395
Mouse
tumor necrosis factor production GO:0032640 50 0.394
nuclear import GO:0051170 95 0.394
blood vessel morphogenesis GO:0048514 285 0.392
Mouse
positive regulation of hydrolase activity GO:0051345 148 0.390
Mouse Fly
epidermis development GO:0008544 187 0.389
Mouse
regulation of protein import into nucleus GO:0042306 52 0.388
rho protein signal transduction GO:0007266 32 0.387
interferon beta biosynthetic process GO:0045350 4 0.387
neural tube development GO:0021915 160 0.386
Mouse
negative regulation of immune system process GO:0002683 209 0.383
Mouse
positive regulation of interferon gamma production GO:0032729 39 0.381
interleukin 6 secretion GO:0072604 3 0.378
negative regulation of protein localization to nucleus GO:1900181 23 0.372
positive regulation of interleukin 18 production GO:0032741 2 0.370
interferon gamma production GO:0032609 67 0.367
cellular amino acid metabolic process GO:0006520 103 0.365
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 27 0.365
Mouse Fly
negative regulation of t cell proliferation GO:0042130 38 0.364
Mouse
response to interferon beta GO:0035456 22 0.364
response to organophosphorus GO:0046683 22 0.364
negative regulation of cell cycle GO:0045786 123 0.363
Mouse
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.359
positive regulation of leukocyte proliferation GO:0070665 73 0.357
regulation of cell cycle GO:0051726 281 0.357
Mouse
myeloid leukocyte differentiation GO:0002573 119 0.356
Mouse
regulation of mitochondrial membrane potential GO:0051881 17 0.355
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.352
inflammatory response to wounding GO:0090594 4 0.350
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.345
Fly
regulation of transcription factor import into nucleus GO:0042990 24 0.341
regulation of cell activation GO:0050865 289 0.340
Mouse
b cell homeostasis GO:0001782 34 0.337
Mouse
positive regulation of mapk cascade GO:0043410 170 0.336
regulation of leukocyte apoptotic process GO:2000106 56 0.335
Mouse
regulation of inflammatory response to antigenic stimulus GO:0002861 21 0.330
positive regulation of nitric oxide synthase biosynthetic process GO:0051770 6 0.329
positive regulation of neuron death GO:1901216 28 0.327
Mouse
intrinsic apoptotic signaling pathway GO:0097193 132 0.326
Mouse
cytokine metabolic process GO:0042107 71 0.324
regulation of hydrolase activity GO:0051336 246 0.318
Mouse Fly
regulation of b cell activation GO:0050864 81 0.314
Mouse
interleukin 10 secretion GO:0072608 4 0.307
cell fate commitment GO:0045165 210 0.304
Mouse
protein complex localization GO:0031503 19 0.304
macromolecule catabolic process GO:0009057 281 0.295
Mouse Worm
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.291
neuron death GO:0070997 154 0.289
Mouse
positive regulation by symbiont of defense related host nitric oxide production GO:0052347 1 0.287
regulation of t cell proliferation GO:0042129 92 0.287
Mouse
response to dexamethasone GO:0071548 8 0.286
Mouse
response to dsrna GO:0043331 30 0.286
regulation of acute inflammatory response GO:0002673 27 0.282
chemokine production GO:0032602 34 0.276
positive regulation of cell death GO:0010942 224 0.274
Mouse Rat Fly
cell type specific apoptotic process GO:0097285 268 0.274
Mouse Fly
regulation of tumor necrosis factor production GO:0032680 49 0.272
negative regulation of protein import into nucleus GO:0042308 21 0.270
cytokine mediated signaling pathway GO:0019221 115 0.269
epithelial tube morphogenesis GO:0060562 303 0.268
Mouse
phenol containing compound metabolic process GO:0018958 60 0.268
Fly
regulation of cytokine secretion GO:0050707 61 0.265
negative regulation of interleukin 6 production GO:0032715 17 0.265
spermatogenesis GO:0007283 284 0.263
Fly
purine containing compound metabolic process GO:0072521 311 0.262
t cell homeostasis GO:0043029 35 0.262
Mouse
er nucleus signaling pathway GO:0006984 27 0.262
Mouse
ribonucleoside catabolic process GO:0042454 206 0.262
immunoglobulin production GO:0002377 73 0.259
protein targeting GO:0006605 143 0.259
protein catabolic process GO:0030163 221 0.258
Worm
positive regulation of chemokine production GO:0032722 22 0.258
cellular response to dexamethasone stimulus GO:0071549 8 0.257
Mouse
reactive nitrogen species metabolic process GO:2001057 0 0.252
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.249
Mouse
cellular amine metabolic process GO:0044106 44 0.248
cellular response to hormone stimulus GO:0032870 150 0.248
Mouse
antibacterial humoral response GO:0019731 8 0.246
Fly
regulation of necrotic cell death GO:0010939 13 0.246
Mouse
immune effector process GO:0002252 321 0.245
Fly
cellular response to oxidative stress GO:0034599 76 0.243
Mouse
leukocyte apoptotic process GO:0071887 71 0.243
Mouse
carbohydrate derivative catabolic process GO:1901136 231 0.243
regulation of actin cytoskeleton organization GO:0032956 84 0.242
antibacterial peptide biosynthetic process GO:0002780 2 0.239
Fly
positive regulation of interleukin 10 production GO:0032733 12 0.239
wound healing involved in inflammatory response GO:0002246 4 0.239
positive regulation of chemokine secretion GO:0090197 4 0.239
positive regulation of t cell activation GO:0050870 101 0.235
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.233
regulation of inflammatory response GO:0050727 147 0.231
positive regulation of intracellular protein transport GO:0090316 42 0.230
negative regulation of cytoplasmic transport GO:1903650 29 0.230
nitrogen compound transport GO:0071705 271 0.228
skin development GO:0043588 220 0.226
Mouse
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.225
Mouse
nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070431 6 0.225
positive regulation of cytoplasmic transport GO:1903651 40 0.220
activation of mapk activity involved in innate immune response GO:0035419 2 0.220
cellularization GO:0007349 1 0.220
Fly
regulation of cytokine biosynthetic process GO:0042035 59 0.218
t cell activation GO:0042110 289 0.214
Mouse
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.213
Mouse
leukocyte differentiation GO:0002521 342 0.213
Mouse
multicellular organismal homeostasis GO:0048871 164 0.211
negative regulation of activated t cell proliferation GO:0046007 7 0.210
Mouse
helper t cell enhancement of adaptive immune response GO:0035397 1 0.207
myeloid dendritic cell activation involved in immune response GO:0002277 2 0.207
innate immune response activating cell surface receptor signaling pathway GO:0002220 4 0.207
negative regulation of molecular function GO:0044092 258 0.207
Mouse
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.207
Mouse
mapk cascade GO:0000165 281 0.201
positive regulation of apoptotic signaling pathway GO:2001235 95 0.200
Mouse Fly
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.199
developmental maturation GO:0021700 193 0.193
Fly
antigen processing and presentation of peptide antigen GO:0048002 29 0.193
negative regulation of hydrolase activity GO:0051346 71 0.192
negative regulation of erk1 and erk2 cascade GO:0070373 21 0.192
thymocyte apoptotic process GO:0070242 19 0.191
Mouse
regulation of body fluid levels GO:0050878 162 0.191
positive regulation of lymphocyte proliferation GO:0050671 70 0.191
protein oligomerization GO:0051259 67 0.189
Fly
stress activated protein kinase signaling cascade GO:0031098 81 0.189
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.188
antimicrobial peptide production GO:0002775 2 0.187
Fly
regulation of release of cytochrome c from mitochondria GO:0090199 11 0.186
induction by organism of immune response of other organism involved in symbiotic interaction GO:0052558 1 0.186
regulation of protein secretion GO:0050708 82 0.182
response to tumor necrosis factor GO:0034612 26 0.182
homeostasis of number of cells GO:0048872 210 0.180
Mouse
growth of symbiont in host GO:0044117 23 0.180
positive regulation of immune effector process GO:0002699 107 0.179
Fly
regulation of nucleoside metabolic process GO:0009118 130 0.179
carboxylic acid transport GO:0046942 100 0.179
epithelial tube formation GO:0072175 130 0.179
Mouse
regulation of protein localization to nucleus GO:1900180 60 0.176
regulation of toll like receptor 2 signaling pathway GO:0034135 3 0.175
negative regulation of intracellular signal transduction GO:1902532 167 0.172
organic acid transport GO:0015849 101 0.171
nucleoside triphosphate metabolic process GO:0009141 230 0.169
pinocytosis GO:0006907 6 0.168
cell surface pattern recognition receptor signaling pathway GO:0002752 2 0.168
response to defense related host nitric oxide production GO:0052565 2 0.167
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.167
regulation of peptide transport GO:0090087 91 0.167
dna catabolic process GO:0006308 19 0.166
Mouse
toll like receptor signaling pathway GO:0002224 38 0.166
regulation of nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070428 3 0.164
myoblast differentiation GO:0045445 52 0.163
interferon alpha production GO:0032607 7 0.163
reactive oxygen species metabolic process GO:0072593 84 0.163
regulation of defense response to virus GO:0050688 18 0.163
Fly
b cell activation involved in immune response GO:0002312 50 0.162
response to radiation GO:0009314 165 0.160
Mouse
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.159
regulation of antibacterial peptide biosynthetic process GO:0002808 1 0.157
Fly
regulation of b cell proliferation GO:0030888 39 0.157
Mouse
t cell migration GO:0072678 19 0.155
gtp catabolic process GO:0006184 143 0.154
lymphocyte activation involved in immune response GO:0002285 93 0.154
regulation of antimicrobial humoral response GO:0002759 3 0.153
Fly
actin polymerization or depolymerization GO:0008154 54 0.153
cellular response to topologically incorrect protein GO:0035967 25 0.151
Mouse
response to peptide GO:1901652 136 0.149
regulation of thymocyte apoptotic process GO:0070243 14 0.148
Mouse
negative regulation of macrophage apoptotic process GO:2000110 3 0.148
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.146
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.146
purine containing compound catabolic process GO:0072523 213 0.145
interleukin 1 alpha production GO:0032610 5 0.145
reactive oxygen species biosynthetic process GO:1903409 8 0.145
response to defense related nitric oxide production by other organism involved in symbiotic interaction GO:0052551 2 0.145
cellular response to organonitrogen compound GO:0071417 145 0.144
negative regulation of leukocyte proliferation GO:0070664 46 0.144
Mouse
negative regulation of toll like receptor signaling pathway GO:0034122 14 0.141
transcription factor import into nucleus GO:0042991 26 0.140
regulation of secretion GO:0051046 274 0.138
regulation of cellular response to stress GO:0080135 159 0.138
purine nucleoside catabolic process GO:0006152 205 0.136
positive regulation of kinase activity GO:0033674 155 0.136
regulation of jnk cascade GO:0046328 62 0.135
positive regulation of defense response to bacterium GO:1900426 1 0.133
Fly
sensory perception of sound GO:0007605 97 0.133
Mouse
amine metabolic process GO:0009308 45 0.132
cellular response to glucocorticoid stimulus GO:0071385 13 0.132
Mouse
cellular response to alcohol GO:0097306 23 0.131
Mouse
cellular response to corticosteroid stimulus GO:0071384 13 0.130
Mouse
regulation of interferon gamma production GO:0032649 57 0.128
ribonucleotide catabolic process GO:0009261 208 0.128
response to bacterial lipoprotein GO:0032493 4 0.127
angiogenesis GO:0001525 201 0.127
Mouse
regulation of mapk cascade GO:0043408 248 0.126
positive regulation of actin filament polymerization GO:0030838 26 0.125
regulation of growth of symbiont in host GO:0044126 19 0.125
negative regulation of t cell activation GO:0050868 65 0.125
Mouse
positive regulation of interferon beta biosynthetic process GO:0045359 3 0.125
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.124
interleukin 10 production GO:0032613 23 0.124
nucleotide metabolic process GO:0009117 332 0.122
regulation of antigen processing and presentation GO:0002577 10 0.121
response to host immune response GO:0052572 3 0.121
positive regulation of lipopolysaccharide mediated signaling pathway GO:0031666 5 0.120
positive regulation of antimicrobial humoral response GO:0002760 2 0.119
Fly
negative regulation of interferon gamma production GO:0032689 18 0.118
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.118
nucleoside triphosphate catabolic process GO:0009143 205 0.118
positive regulation of cytoskeleton organization GO:0051495 49 0.117
production of molecular mediator of immune response GO:0002440 103 0.115
Fly
regulation of nucleotide metabolic process GO:0006140 169 0.114
connective tissue replacement involved in inflammatory response wound healing GO:0002248 3 0.113
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.113
positive regulation of protein kinase activity GO:0045860 144 0.113
cation transport GO:0006812 399 0.113
regulation of ion transport GO:0043269 215 0.111
interleukin 8 secretion GO:0072606 3 0.110
cellular component disassembly involved in execution phase of apoptosis GO:0006921 9 0.109
Mouse
regulation of ras protein signal transduction GO:0046578 114 0.109
purine nucleoside triphosphate metabolic process GO:0009144 226 0.108
muscle system process GO:0003012 141 0.106
myotube differentiation GO:0014902 105 0.105
Rat
inflammatory cell apoptotic process GO:0006925 11 0.105
modulation by symbiont of host immune response GO:0052553 1 0.104
protein ubiquitination GO:0016567 171 0.103
nucleobase containing small molecule metabolic process GO:0055086 352 0.103
positive regulation of cellular amine metabolic process GO:0033240 5 0.103
negative regulation of protein metabolic process GO:0051248 282 0.103
Mouse
response to organonitrogen compound GO:0010243 246 0.103
myotube cell development GO:0014904 60 0.102
organonitrogen compound biosynthetic process GO:1901566 192 0.101
Fly
acute inflammatory response GO:0002526 41 0.101
purine ribonucleotide catabolic process GO:0009154 208 0.099
regulation of response to cytokine stimulus GO:0060759 23 0.098
stress activated mapk cascade GO:0051403 80 0.098
glycosyl compound metabolic process GO:1901657 246 0.097
cellular ketone metabolic process GO:0042180 84 0.097
negative regulation of cell proliferation GO:0008285 296 0.097
Mouse Fly
adhesion of symbiont to host GO:0044406 8 0.095
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.095
regulation of neutrophil chemotaxis GO:0090022 14 0.095
purine ribonucleoside catabolic process GO:0046130 205 0.094
negative regulation of mapk cascade GO:0043409 65 0.094
interleukin 17 production GO:0032620 11 0.094
lymphocyte apoptotic process GO:0070227 54 0.093
Mouse
response to peptidoglycan GO:0032494 9 0.092
positive regulation of mitotic cell cycle GO:0045931 41 0.092
modulation of growth of symbiont involved in interaction with host GO:0044144 19 0.091
modulation by organism of defense response of other organism involved in symbiotic interaction GO:0052255 1 0.091
cellular chemical homeostasis GO:0055082 215 0.091
body fluid secretion GO:0007589 53 0.091
positive regulation of cellular component biogenesis GO:0044089 94 0.090
anion transport GO:0006820 177 0.090
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.089
organ or tissue specific immune response GO:0002251 13 0.088
positive regulation of interferon alpha production GO:0032727 4 0.088
endocytosis GO:0006897 168 0.087
Worm
interleukin 6 production GO:0032635 58 0.087
regulation of protein processing GO:0070613 96 0.087
positive regulation of homeostatic process GO:0032846 64 0.087
regulation of cytoskeleton organization GO:0051493 122 0.086
actin cytoskeleton organization GO:0030036 220 0.086
regulation of t cell mediated immunity GO:0002709 34 0.085
macropinocytosis GO:0044351 4 0.085
response to interleukin 1 GO:0070555 11 0.084
regulation of organelle organization GO:0033043 289 0.084
negative regulation of growth GO:0045926 99 0.083
myeloid dendritic cell activation GO:0001773 25 0.083
response to alcohol GO:0097305 48 0.083
Mouse

Casp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.164
disease of cellular proliferation DOID:14566 0 0.164
organ system cancer DOID:0050686 0 0.139