IMP

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Mus musculus

16 genes annotated in mouse

interleukin 1 secretion

The regulated release of interleukin-1 from a cell. Interleukin 1 is produced mainly by activated macrophages; it stimulates thymocyte proliferation by inducing interleukin 2 release and it is involved in the inflammatory response.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "interleukin 1 secretion"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "interleukin 1 secretion" (in gray)

Name	Description	Probability	Func Analog Organism
Casp1	caspase 1	0.994
Ccl2	chemokine (C-C motif) ligand 2	0.975
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.972
Gbp5	guanylate binding protein 5	0.930
Lyz2	lysozyme 2	0.907
Ccr2	chemokine (C-C motif) receptor 2	0.832	Mouse
Ccr1	chemokine (C-C motif) receptor 1	0.821	Mouse
Ccl3	chemokine (C-C motif) ligand 3	0.731
Ccr5	chemokine (C-C motif) receptor 5	0.663	Mouse
Cd44	CD44 antigen	0.596
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.511
Pycard	PYD and CARD domain containing	0.473
Aim2	absent in melanoma 2	0.347
Socs1	suppressor of cytokine signaling 1	0.343
Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	0.321
Ifngr1	interferon gamma receptor 1	0.301
C3ar1	complement component 3a receptor 1	0.295
Cd40	CD40 antigen	0.237
Selp	selectin, platelet	0.234
Il1b	interleukin 1 beta	0.206
Ifng	interferon gamma	0.181
Mndal	myeloid nuclear differentiation antigen like	0.178
Tnf	tumor necrosis factor	0.175
Tlr4	toll-like receptor 4	0.172
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.161
Ccl8	chemokine (C-C motif) ligand 8	0.148
Ccl7	chemokine (C-C motif) ligand 7	0.138	Mouse
Pax2	paired box gene 2	0.134
Wnt4	wingless-related MMTV integration site 4	0.125	Mouse
Wisp2	WNT1 inducible signaling pathway protein 2	0.114
Gzmb	granzyme B	0.114
Ccl12	chemokine (C-C motif) ligand 12	0.110	Mouse
Xcl1	chemokine (C motif) ligand 1	0.108	Mouse
Lta	lymphotoxin A	0.105
Folr2	folate receptor 2 (fetal)	0.103
Cxcl2	chemokine (C-X-C motif) ligand 2	0.097
Cd180	CD180 antigen	0.090
Ccl4	chemokine (C-C motif) ligand 4	0.087	Mouse
Il1r1	interleukin 1 receptor, type I	0.083
Klrb1b	killer cell lectin-like receptor subfamily B member 1B	0.071
Pax8	paired box gene 8	0.071
Ptgir	prostaglandin I receptor (IP)	0.071
Mmp9	matrix metallopeptidase 9	0.068
Fgf8	fibroblast growth factor 8	0.066
Il10ra	interleukin 10 receptor, alpha	0.066
Gzma	granzyme A	0.066
Gpr132	G protein-coupled receptor 132	0.064
Cxcl13	chemokine (C-X-C motif) ligand 13	0.059
Tlr7	toll-like receptor 7	0.059
Lgals7	lectin, galactose binding, soluble 7	0.059
Ccr7	chemokine (C-C motif) receptor 7	0.058
Pax1	paired box gene 1	0.058
Ciita	class II transactivator	0.057
Fcgr1	Fc receptor, IgG, high affinity I	0.056
Itgax	integrin alpha X	0.056
Ctsw	cathepsin W	0.055
Il27ra	interleukin 27 receptor, alpha	0.053
Il18	interleukin 18	0.053
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.052
Il1a	interleukin 1 alpha	0.051
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.051
Gzmk	granzyme K	0.050
Il15	interleukin 15	0.050
Ikzf1	IKAROS family zinc finger 1	0.048
Il18rap	interleukin 18 receptor accessory protein	0.047
Fcer1a	Fc receptor, IgE, high affinity I, alpha polypeptide	0.047
Otx1	orthodenticle homolog 1 (Drosophila)	0.045
Ctla4	cytotoxic T-lymphocyte-associated protein 4	0.044
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.044
Il6	interleukin 6	0.044
Fut7	fucosyltransferase 7	0.043
Has1	hyaluronan synthase1	0.042
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.042
Batf	basic leucine zipper transcription factor, ATF-like	0.042
Il1rn	interleukin 1 receptor antagonist	0.041
Ch25h	cholesterol 25-hydroxylase	0.040
Cd5	CD5 antigen	0.040
3110079O15Rik	RIKEN cDNA 3110079O15 gene	0.040
Mmp12	matrix metallopeptidase 12	0.039
Fcer2a	Fc receptor, IgE, low affinity II, alpha polypeptide	0.039
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.038
Ccl22	chemokine (C-C motif) ligand 22	0.038
Msx3	homeobox, msh-like 3	0.038
Il12rb2	interleukin 12 receptor, beta 2	0.038
Amhr2	anti-Mullerian hormone type 2 receptor	0.037
Il3	interleukin 3	0.036
Cd33	CD33 antigen	0.036
Mnda	myeloid cell nuclear differentiation antigen	0.036
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.036
Mybph	myosin binding protein H	0.036
Irg1	immunoresponsive gene 1	0.035
Ubd	ubiquitin D	0.035
Slamf8	SLAM family member 8	0.035
Prdm1	PR domain containing 1, with ZNF domain	0.035
Lif	leukemia inhibitory factor	0.034
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.034
Krt86	keratin 86	0.034
Apoe	apolipoprotein E	0.033
Nobox	NOBOX oogenesis homeobox	0.033
Csf3r	colony stimulating factor 3 receptor (granulocyte)	0.032
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.031
Bdkrb1	bradykinin receptor, beta 1	0.031
Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	0.031
Tacr1	tachykinin receptor 1	0.031
Lhx1	LIM homeobox protein 1	0.030
Ccl17	chemokine (C-C motif) ligand 17	0.030	Mouse
Flt3	FMS-like tyrosine kinase 3	0.029
Cxcl10	chemokine (C-X-C motif) ligand 10	0.029
Muc5ac	mucin 5, subtypes A and C, tracheobronchial/gastric	0.029
Il1rl1	interleukin 1 receptor-like 1	0.028
Xcr1	chemokine (C motif) receptor 1	0.028	Mouse
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	0.027	Human
Cx3cr1	chemokine (C-X3-C) receptor 1	0.027	Mouse
Nlrp3	NLR family, pyrin domain containing 3	0.027
Il17a	interleukin 17A	0.026
Il12a	interleukin 12a	0.026
Npc1	Niemann Pick type C1	0.026
Klrk1	killer cell lectin-like receptor subfamily K, member 1	0.025
Tbxas1	thromboxane A synthase 1, platelet	0.025
Sfrp1	secreted frizzled-related protein 1	0.025
Irf1	interferon regulatory factor 1	0.025
Mcpt2	mast cell protease 2	0.025
Ptger1	prostaglandin E receptor 1 (subtype EP1)	0.024
Tnfsf10	tumor necrosis factor (ligand) superfamily, member 10	0.024
Bmp15	bone morphogenetic protein 15	0.024
Rab3il1	RAB3A interacting protein (rabin3)-like 1	0.024
P2rx4	purinergic receptor P2X, ligand-gated ion channel 4	0.023	Mouse
Amh	anti-Mullerian hormone	0.023
Madcam1	mucosal vascular addressin cell adhesion molecule 1	0.023
Elk4	ELK4, member of ETS oncogene family	0.023
Cd160	CD160 antigen	0.023
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.023
H2-M3	histocompatibility 2, M region locus 3	0.022
Foxp3	forkhead box P3	0.022
Cdx1	caudal type homeobox 1	0.022
Itgal	integrin alpha L	0.022
S100a1	S100 calcium binding protein A1	0.022
Fadd	Fas (TNFRSF6)-associated via death domain	0.022
Rarb	retinoic acid receptor, beta	0.021
Cdx2	caudal type homeobox 2	0.021
Pou3f3	POU domain, class 3, transcription factor 3	0.021
Wnt10b	wingless related MMTV integration site 10b	0.021	Mouse
Efna1	ephrin A1	0.021
Msr1	macrophage scavenger receptor 1	0.021
Adam17	a disintegrin and metallopeptidase domain 17	0.020
Elane	elastase, neutrophil expressed	0.020
Pdcd1	programmed cell death 1	0.020
Fxyd2	FXYD domain-containing ion transport regulator 2	0.020
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.020
Art2a-ps	ADP-ribosyltransferase 2a, pseudogene	0.020
Tnni1	troponin I, skeletal, slow 1	0.020
Gm12185	predicted gene 12185	0.020
Batf2	basic leucine zipper transcription factor, ATF-like 2	0.019
Il2rg	interleukin 2 receptor, gamma chain	0.019
Cd86	CD86 antigen	0.019
Cma1	chymase 1, mast cell	0.019
Gzmc	granzyme C	0.019
Porcn	porcupine homolog (Drosophila)	0.019
Rel	reticuloendotheliosis oncogene	0.019
Tnfaip8l2	tumor necrosis factor, alpha-induced protein 8-like 2	0.019
Sele	selectin, endothelial cell	0.019
Irf4	interferon regulatory factor 4	0.019
Emid1	EMI domain containing 1	0.018
Wnt10a	wingless related MMTV integration site 10a	0.018
Il18r1	interleukin 18 receptor 1	0.018
Birc3	baculoviral IAP repeat-containing 3	0.018
Clcn1	chloride channel 1	0.018
Muc13	mucin 13, epithelial transmembrane	0.018
Ltc4s	leukotriene C4 synthase	0.018
Ripk3	receptor-interacting serine-threonine kinase 3	0.018
Fzd10	frizzled homolog 10 (Drosophila)	0.018
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.018
Gdnf	glial cell line derived neurotrophic factor	0.018
Msln	mesothelin	0.018
Ccr3	chemokine (C-C motif) receptor 3	0.017	Mouse
Wnt3a	wingless-related MMTV integration site 3A	0.017	Mouse
2210010C04Rik	RIKEN cDNA 2210010C04 gene	0.017
Cxcl1	chemokine (C-X-C motif) ligand 1	0.017
Agxt	alanine-glyoxylate aminotransferase	0.017
Il2rb	interleukin 2 receptor, beta chain	0.017
Btk	Bruton agammaglobulinemia tyrosine kinase	0.017
Abcg1	ATP-binding cassette, sub-family G (WHITE), member 1	0.017
Mmp3	matrix metallopeptidase 3	0.017
Grem1	gremlin 1	0.017
Cd96	CD96 antigen	0.017
Il7r	interleukin 7 receptor	0.016
Anxa4	annexin A4	0.016
Tbx21	T-box 21	0.016
Lag3	lymphocyte-activation gene 3	0.016
Il5	interleukin 5	0.016
Gja3	gap junction protein, alpha 3	0.016
Fasl	Fas ligand (TNF superfamily, member 6)	0.016
Ccr9	chemokine (C-C motif) receptor 9	0.016	Mouse
Gpr3	G-protein coupled receptor 3	0.016
Dhh	desert hedgehog	0.016
Oc90	otoconin 90	0.016
Cd7	CD7 antigen	0.015
Ccl11	chemokine (C-C motif) ligand 11	0.015	Mouse
Ptafr	platelet-activating factor receptor	0.015
Barx1	BarH-like homeobox 1	0.015
Hoxc6	homeobox C6	0.015
Gdf15	growth differentiation factor 15	0.015
Pdcd1lg2	programmed cell death 1 ligand 2	0.015
Slamf6	SLAM family member 6	0.015
Cxcl12	chemokine (C-X-C motif) ligand 12	0.015
Ccr4	chemokine (C-C motif) receptor 4	0.014	Mouse
Ccl20	chemokine (C-C motif) ligand 20	0.014
Sfrp4	secreted frizzled-related protein 4	0.014
Grin2d	glutamate receptor, ionotropic, NMDA2D (epsilon 4)	0.014
S100a4	S100 calcium binding protein A4	0.014
Tpsb2	tryptase beta 2	0.014
Cmklr1	chemokine-like receptor 1	0.014
T	brachyury	0.014
Spp1	secreted phosphoprotein 1	0.014
Ncr1	natural cytotoxicity triggering receptor 1	0.014
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.014
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.014
Srms	src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites	0.013
Apaf1	apoptotic peptidase activating factor 1	0.013
Cd3d	CD3 antigen, delta polypeptide	0.013
Zan	zonadhesin	0.013
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.013
Pou3f2	POU domain, class 3, transcription factor 2	0.013
Havcr2	hepatitis A virus cellular receptor 2	0.013
H2-Ab1	histocompatibility 2, class II antigen A, beta 1	0.013
Cd2	CD2 antigen	0.013
Cxcl9	chemokine (C-X-C motif) ligand 9	0.013
Sct	secretin	0.013
Rem1	rad and gem related GTP binding protein 1	0.013
Tnni2	troponin I, skeletal, fast 2	0.013
Pitx3	paired-like homeodomain transcription factor 3	0.013
A4galt	alpha 1,4-galactosyltransferase	0.013
Il15ra	interleukin 15 receptor, alpha chain	0.013
Fgf3	fibroblast growth factor 3	0.013
Fgf15	fibroblast growth factor 15	0.013
Pnmt	phenylethanolamine-N-methyltransferase	0.013
C1qtnf1	C1q and tumor necrosis factor related protein 1	0.012
5430421N21Rik	RIKEN cDNA 5430421N21 gene	0.012
H2-Oa	histocompatibility 2, O region alpha locus	0.012
Ager	advanced glycosylation end product-specific receptor	0.012
Blk	B lymphoid kinase	0.012
Pik3cg	phosphoinositide-3-kinase, catalytic, gamma polypeptide	0.012
Mefv	Mediterranean fever	0.012
4833422F24Rik	RIKEN cDNA 4833422F24 gene	0.012
Itk	IL2-inducible T-cell kinase	0.012
Wnt6	wingless-related MMTV integration site 6	0.012	Mouse
Pou2f3	POU domain, class 2, transcription factor 3	0.012
Plekha4	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	0.012
Has2	hyaluronan synthase 2	0.012
Olfr70	olfactory receptor 70	0.012
Klrg1	killer cell lectin-like receptor subfamily G, member 1	0.012
Cacna1b	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.012
Hoxc9	homeobox C9	0.012
Gdf9	growth differentiation factor 9	0.012
Inhba	inhibin beta-A	0.012
Pdgfb	platelet derived growth factor, B polypeptide	0.012
Ifitm6	interferon induced transmembrane protein 6	0.012
Fgf18	fibroblast growth factor 18	0.011
F2rl2	coagulation factor II (thrombin) receptor-like 2	0.011
Dnase1l3	deoxyribonuclease 1-like 3	0.011
Ms4a7	membrane-spanning 4-domains, subfamily A, member 7	0.011
Spn	sialophorin	0.011
Chad	chondroadherin	0.011
Osmr	oncostatin M receptor	0.011
Niacr1	niacin receptor 1	0.011
Cxcl5	chemokine (C-X-C motif) ligand 5	0.011
Mmp13	matrix metallopeptidase 13	0.011
Hoxa13	homeobox A13	0.011
Gpr50	G-protein-coupled receptor 50	0.011
Cd70	CD70 antigen	0.011
Fcna	ficolin A	0.011
H2-Ob	histocompatibility 2, O region beta locus	0.011
Ptprc	protein tyrosine phosphatase, receptor type, C	0.011
Tlr2	toll-like receptor 2	0.011
Mx2	myxovirus (influenza virus) resistance 2	0.011
Tas1r1	taste receptor, type 1, member 1	0.011
Slamf7	SLAM family member 7	0.011
Ccl9	chemokine (C-C motif) ligand 9	0.011	Mouse
Itgb2	integrin beta 2	0.011
Tnfrsf18	tumor necrosis factor receptor superfamily, member 18	0.011
Chst3	carbohydrate (chondroitin 6/keratan) sulfotransferase 3	0.011
Sfpi1	SFFV proviral integration 1	0.010
Ctrb1	chymotrypsinogen B1	0.010
Ccl6	chemokine (C-C motif) ligand 6	0.010	Mouse
Clec4d	C-type lectin domain family 4, member d	0.010
Fgf21	fibroblast growth factor 21	0.010
Fgfr4	fibroblast growth factor receptor 4	0.010
Gp9	glycoprotein 9 (platelet)	0.010
Itgam	integrin alpha M	0.010
Casp3	caspase 3	0.010	Mouse
Slamf9	SLAM family member 9	0.010
Slfn3	schlafen 3	0.010