IMP

Process View

Mus musculus

29 genes annotated in mouse

antigen processing and presentation of peptide antigen

The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC protein complex on its cell surface, including proteolysis and transport steps for the peptide antigen both prior to and following assembly with the MHC protein complex. The peptide antigen is typically, but not always, processed from an endogenous or exogenous protein.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "antigen processing and presentation of peptide antigen"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "antigen processing and presentation of peptide antigen" (in gray)

Name	Description	Probability	Func Analog Organism
Cd74	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)	0.999
H2-Ab1	histocompatibility 2, class II antigen A, beta 1	0.998
H2-Aa	histocompatibility 2, class II antigen A, alpha	0.996
H2-Eb1	histocompatibility 2, class II antigen E beta	0.986
H2-DMa	histocompatibility 2, class II, locus DMa	0.947
H2-DMb2	histocompatibility 2, class II, locus Mb2	0.936
B2m	beta-2 microglobulin	0.933
Tapbp	TAP binding protein	0.924
H2-K1	histocompatibility 2, K1, K region	0.867
Cd40	CD40 antigen	0.861
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.834
H2-Q7	histocompatibility 2, Q region locus 7	0.826
Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	0.689
Lyz2	lysozyme 2	0.666
Ciita	class II transactivator	0.644
H2-D1	histocompatibility 2, D region locus 1	0.628
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.616
Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.573	Human Mouse
Ptprc	protein tyrosine phosphatase, receptor type, C	0.454
H2-Q6	histocompatibility 2, Q region locus 6	0.417	Mouse
C1qa	complement component 1, q subcomponent, alpha polypeptide	0.308
Slc40a1	solute carrier family 40 (iron-regulated transporter), member 1	0.266
Ctsb	cathepsin B	0.250
Gbp5	guanylate binding protein 5	0.223
Aif1	allograft inflammatory factor 1	0.219
Tcra	T-cell receptor alpha chain	0.212
C1qc	complement component 1, q subcomponent, C chain	0.210
Casp1	caspase 1	0.193
Lat	linker for activation of T cells	0.178
Ccl5	chemokine (C-C motif) ligand 5	0.152
H2-Ob	histocompatibility 2, O region beta locus	0.132	Mouse
Irf8	interferon regulatory factor 8	0.126
H2-Q8	histocompatibility 2, Q region locus 8	0.110
Tyrobp	TYRO protein tyrosine kinase binding protein	0.106
C1qb	complement component 1, q subcomponent, beta polypeptide	0.087
Irf5	interferon regulatory factor 5	0.085
Trim21	tripartite motif-containing 21	0.077
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.075
Lck	lymphocyte protein tyrosine kinase	0.075
Gm2a	GM2 ganglioside activator protein	0.073
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.073
Psap	prosaposin	0.069
Birc3	baculoviral IAP repeat-containing 3	0.066
Unc93b1	unc-93 homolog B1 (C. elegans)	0.061
Cd79b	CD79B antigen	0.057
Emr1	EGF-like module containing, mucin-like, hormone receptor-like sequence 1	0.055
Apobec1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	0.053
Ncf1	neutrophil cytosolic factor 1	0.052
Cxcl9	chemokine (C-X-C motif) ligand 9	0.050
H2-M3	histocompatibility 2, M region locus 3	0.050
Cybb	cytochrome b-245, beta polypeptide	0.049
Ly86	lymphocyte antigen 86	0.045
Il2rg	interleukin 2 receptor, gamma chain	0.043
H2-Bl	histocompatibility 2, blastocyst	0.043
Agtr1a	angiotensin II receptor, type 1a	0.043
Ccr9	chemokine (C-C motif) receptor 9	0.043
Ctsz	cathepsin Z	0.041
Itgal	integrin alpha L	0.040
Lamp1	lysosomal-associated membrane protein 1	0.040
Myd88	myeloid differentiation primary response gene 88	0.040
Sh2d2a	SH2 domain protein 2A	0.038
Apoe	apolipoprotein E	0.038
Pld4	phospholipase D family, member 4	0.036
Psmb10	proteasome (prosome, macropain) subunit, beta type 10	0.036
Blk	B lymphoid kinase	0.035
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.034
H2-DMb1	histocompatibility 2, class II, locus Mb1	0.034
Lyz1	lysozyme 1	0.033
Il7r	interleukin 7 receptor	0.032
Cd22	CD22 antigen	0.032
Aim2	absent in melanoma 2	0.031
Lgals3bp	lectin, galactoside-binding, soluble, 3 binding protein	0.029
Cd19	CD19 antigen	0.029
Plbd1	phospholipase B domain containing 1	0.028
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.028
Slc12a1	solute carrier family 12, member 1	0.028
AW112010	expressed sequence AW112010	0.028
Ctsh	cathepsin H	0.027
Gabarap	gamma-aminobutyric acid receptor associated protein	0.027
Ms4a1	membrane-spanning 4-domains, subfamily A, member 1	0.027
Epb4.1	erythrocyte protein band 4.1	0.027
Inpp5d	inositol polyphosphate-5-phosphatase D	0.026
Uba7	ubiquitin-like modifier activating enzyme 7	0.025
Cd86	CD86 antigen	0.025
Zfp36	zinc finger protein 36	0.025
C3	complement component 3	0.025
Klrd1	killer cell lectin-like receptor, subfamily D, member 1	0.024
Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	0.024
Mavs	mitochondrial antiviral signaling protein	0.024
Elane	elastase, neutrophil expressed	0.024
Dnase1l3	deoxyribonuclease 1-like 3	0.022
C920025E04Rik	RIKEN cDNA C920025E04 gene	0.021
Itk	IL2-inducible T-cell kinase	0.021
Nlrp6	NLR family, pyrin domain containing 6	0.021
Tgfb1	transforming growth factor, beta 1	0.021
Il2rb	interleukin 2 receptor, beta chain	0.020
Ifngr1	interferon gamma receptor 1	0.020
Tbxas1	thromboxane A synthase 1, platelet	0.020
Folr2	folate receptor 2 (fetal)	0.020
Celsr2	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.019
Cd52	CD52 antigen	0.019
Napsa	napsin A aspartic peptidase	0.019	Mouse
Irf7	interferon regulatory factor 7	0.019
Hexa	hexosaminidase A	0.018
Fcna	ficolin A	0.018
Tnip1	TNFAIP3 interacting protein 1	0.018
Ptprcap	protein tyrosine phosphatase, receptor type, C polypeptide-associated protein	0.018
Zap70	zeta-chain (TCR) associated protein kinase	0.018
Ctss	cathepsin S	0.017
Ifi27l2a	interferon, alpha-inducible protein 27 like 2A	0.016
Glis2	GLIS family zinc finger 2	0.016
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.016
Ly6d	lymphocyte antigen 6 complex, locus D	0.016
Tfrc	transferrin receptor	0.016
Rhoh	ras homolog gene family, member H	0.016
Ccr7	chemokine (C-C motif) receptor 7	0.016
Gm14548	predicted gene 14548	0.015
Slfn2	schlafen 2	0.015
Mpeg1	macrophage expressed gene 1	0.015
P2rx4	purinergic receptor P2X, ligand-gated ion channel 4	0.015
Nr3c2	nuclear receptor subfamily 3, group C, member 2	0.015
Ikzf1	IKAROS family zinc finger 1	0.014
Ly6e	lymphocyte antigen 6 complex, locus E	0.014
Acp5	acid phosphatase 5, tartrate resistant	0.014
Il15	interleukin 15	0.014
Lilrb3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.014
Xcr1	chemokine (C motif) receptor 1	0.013
Irf4	interferon regulatory factor 4	0.013
AF251705	cDNA sequence AF251705	0.013
Tor3a	torsin family 3, member A	0.013
Fcer1g	Fc receptor, IgE, high affinity I, gamma polypeptide	0.013
P2rx7	purinergic receptor P2X, ligand-gated ion channel, 7	0.013
Cd83	CD83 antigen	0.013
Psen1	presenilin 1	0.013
Cxcr3	chemokine (C-X-C motif) receptor 3	0.013
S1pr4	sphingosine-1-phosphate receptor 4	0.013
C4b	complement component 4B (Childo blood group)	0.013
Tmem106a	transmembrane protein 106A	0.013
Ptpn18	protein tyrosine phosphatase, non-receptor type 18	0.012
Cd4	CD4 antigen	0.012
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.012
0610031J06Rik	RIKEN cDNA 0610031J06 gene	0.012
Cd3g	CD3 antigen, gamma polypeptide	0.012
Cd2	CD2 antigen	0.012
Il15ra	interleukin 15 receptor, alpha chain	0.012
Tifa	TRAF-interacting protein with forkhead-associated domain	0.012
Ctsw	cathepsin W	0.012
Nfkbie	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.012
H2-Q5	histocompatibility 2, Q region locus 5	0.012
Lat2	linker for activation of T cells family, member 2	0.012
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.012
Irf1	interferon regulatory factor 1	0.012
C2	complement component 2 (within H-2S)	0.012
Trafd1	TRAF type zinc finger domain containing 1	0.012
Selplg	selectin, platelet (p-selectin) ligand	0.011
Cyba	cytochrome b-245, alpha polypeptide	0.011
H2-Oa	histocompatibility 2, O region alpha locus	0.011
Ighg	Immunoglobulin heavy chain (gamma polypeptide)	0.011
Vpreb3	pre-B lymphocyte gene 3	0.011
H2-M1	histocompatibility 2, M region locus 1	0.011	Mouse
Fgd2	FYVE, RhoGEF and PH domain containing 2	0.011
Npc2	Niemann Pick type C2	0.011
Il18	interleukin 18	0.011
Sfpi1	SFFV proviral integration 1	0.011
Dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58	0.011
Gm7592	predicted gene 7592	0.011
Ccl6	chemokine (C-C motif) ligand 6	0.011
Folr4	folate receptor 4 (delta)	0.010
Ifi27l1	interferon, alpha-inducible protein 27 like 1	0.010
Dnajb11	DnaJ (Hsp40) homolog, subfamily B, member 11	0.010
H2-Eb2	histocompatibility 2, class II antigen E beta2	0.010	Mouse
Cd72	CD72 antigen	0.010
Ms4a4c	membrane-spanning 4-domains, subfamily A, member 4C	0.010