Mus musculus

162 known processes

Rag1

recombination activating gene 1

(Aliases: Rag-1)

Rag1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
v d j recombination GO:0033151 14 0.999
positive regulation of isotype switching to igg isotypes GO:0048304 7 0.999
negative regulation of inflammatory response to antigenic stimulus GO:0002862 10 0.999
regulation of cellular amine metabolic process GO:0033238 20 0.986
leukocyte differentiation GO:0002521 342 0.985
regulation of cellular ketone metabolic process GO:0010565 66 0.980
cellular amine metabolic process GO:0044106 44 0.969
t cell differentiation GO:0030217 174 0.965
positive regulation of cellular amine metabolic process GO:0033240 5 0.963
positive regulation of regulatory t cell differentiation GO:0045591 4 0.954
somatic diversification of immune receptors GO:0002200 53 0.950
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.946
amine metabolic process GO:0009308 45 0.940
integrin mediated signaling pathway GO:0007229 27 0.939
alpha beta t cell differentiation GO:0046632 69 0.927
regulation of cd4 positive alpha beta t cell activation GO:2000514 24 0.926
cd4 positive cd25 positive alpha beta regulatory t cell differentiation GO:0002361 4 0.921
t cell activation GO:0042110 289 0.899
t cell lineage commitment GO:0002360 13 0.895
positive regulation of gamma delta t cell differentiation GO:0045588 6 0.894
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.877
production of molecular mediator of immune response GO:0002440 103 0.876
regulation of alpha beta t cell differentiation GO:0046637 35 0.875
regulation of cellular amino acid metabolic process GO:0006521 5 0.865
regulation of tolerance induction dependent upon immune response GO:0002652 1 0.856
regulation of b cell differentiation GO:0045577 23 0.856
positive regulation of tyrosine phosphorylation of stat5 protein GO:0042523 6 0.854
cellular amino acid metabolic process GO:0006520 103 0.851
regulation of dna recombination GO:0000018 34 0.822
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 15 0.821
regulation of mast cell activation GO:0033003 21 0.811
lymphocyte differentiation GO:0030098 242 0.786
t helper cell differentiation GO:0042093 28 0.780
dna recombination GO:0006310 92 0.777
b cell homeostatic proliferation GO:0002358 2 0.775
immune response inhibiting signal transduction GO:0002765 4 0.761
cell fate commitment GO:0045165 210 0.736
immunoglobulin secretion GO:0048305 17 0.733
lymphocyte proliferation GO:0046651 164 0.729
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.723
myeloid leukocyte activation GO:0002274 83 0.722
regulation of lymphocyte proliferation GO:0050670 117 0.710
mast cell activation GO:0045576 27 0.708
positive regulation of jak stat cascade GO:0046427 22 0.707
cell activation involved in immune response GO:0002263 126 0.695
regulation of lymphocyte differentiation GO:0045619 107 0.670
serotonin production involved in inflammatory response GO:0002351 4 0.654
isotype switching to igg isotypes GO:0048291 10 0.649
positive regulation of exocytosis GO:0045921 20 0.645
b cell lineage commitment GO:0002326 4 0.640
reactive oxygen species metabolic process GO:0072593 84 0.628
positive regulation of granulocyte macrophage colony stimulating factor biosynthetic process GO:0045425 2 0.628
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.625
positive t cell selection GO:0043368 23 0.611
b cell activation GO:0042113 161 0.594
adaptive immune response GO:0002250 155 0.590
lymphocyte activation involved in immune response GO:0002285 93 0.590
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.590
regulation of toll like receptor 2 signaling pathway GO:0034135 3 0.552
negative regulation of adaptive immune response GO:0002820 25 0.550
pre b cell differentiation GO:0002329 7 0.543
neutrophil activation GO:0042119 9 0.543
negative regulation of chronic inflammatory response GO:0002677 3 0.528
mast cell activation involved in immune response GO:0002279 20 0.527
negative regulation of interleukin 5 production GO:0032714 4 0.523
fc epsilon receptor signaling pathway GO:0038095 3 0.517
neutrophil apoptotic process GO:0001781 3 0.508
tyrosine phosphorylation of stat protein GO:0007260 23 0.499
regulation of cd4 positive alpha beta t cell differentiation GO:0043370 21 0.490
natural killer cell inhibitory signaling pathway GO:0002769 2 0.486
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.476
t cell receptor v d j recombination GO:0033153 5 0.466
regulation of vasculature development GO:1901342 88 0.460
cellular response to interleukin 18 GO:0071351 3 0.449
somatic diversification of immunoglobulins GO:0016445 43 0.443
defense response to other organism GO:0098542 197 0.442
regulation of striated muscle cell differentiation GO:0051153 81 0.442
antibacterial peptide biosynthetic process GO:0002780 2 0.440
immune response activating signal transduction GO:0002757 116 0.432
somatic cell dna recombination GO:0016444 51 0.429
negative regulation of interleukin 2 biosynthetic process GO:0045085 3 0.427
t cell proliferation GO:0042098 120 0.425
immunoglobulin v d j recombination GO:0033152 5 0.424
negative regulation of myeloid leukocyte differentiation GO:0002762 20 0.415
negative regulation of cellular amine metabolic process GO:0033239 1 0.412
t cell differentiation in thymus GO:0033077 77 0.410
regulation of cytokine production involved in immune response GO:0002718 26 0.402
immature b cell differentiation GO:0002327 10 0.397
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.397
lymphocyte mediated immunity GO:0002449 139 0.394
production of molecular mediator involved in inflammatory response GO:0002532 21 0.394
regulation of cytokine biosynthetic process GO:0042035 59 0.389
leukocyte mediated immunity GO:0002443 174 0.389
negative regulation of cell activation GO:0050866 111 0.387
modulation by virus of host process GO:0019054 2 0.382
regulation of t helper 17 cell differentiation GO:2000319 2 0.382
immune response inhibiting cell surface receptor signaling pathway GO:0002767 3 0.374
cellular response to cytokine stimulus GO:0071345 189 0.373
endodermal cell fate specification GO:0001714 4 0.371
regulation of cell activation GO:0050865 289 0.371
peptidyl tyrosine phosphorylation GO:0018108 143 0.359
tyrosine phosphorylation of stat1 protein GO:0042508 3 0.359
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.357
cd4 positive or cd8 positive alpha beta t cell lineage commitment GO:0043369 8 0.357
circadian rhythm GO:0007623 114 0.356
t helper 2 cell differentiation GO:0045064 12 0.353
negative regulation of b cell mediated immunity GO:0002713 7 0.343
endothelial cell migration GO:0043542 44 0.333
negative regulation of t helper 2 cell differentiation GO:0045629 4 0.330
reactive nitrogen species metabolic process GO:2001057 0 0.330
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 0.328
cellular response to lipid GO:0071396 145 0.325
regulation of isotype switching GO:0045191 22 0.324
somatic recombination of t cell receptor gene segments GO:0002681 5 0.322
negative regulation of leukocyte differentiation GO:1902106 51 0.306
protection from non homologous end joining at telomere GO:0031848 4 0.298
learned vocalization behavior or vocal learning GO:0098598 1 0.294
response to inorganic substance GO:0010035 96 0.292
regulation of calcium mediated signaling GO:0050848 19 0.292
positive regulation of translational initiation GO:0045948 4 0.291
t cell differentiation involved in immune response GO:0002292 30 0.291
peptidyl amino acid modification GO:0018193 336 0.289
lysosome localization GO:0032418 20 0.288
positive regulation of b cell mediated immunity GO:0002714 26 0.288
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.283
response to acid chemical GO:0001101 111 0.282
cd4 positive alpha beta t cell activation GO:0035710 45 0.280
neuroblast fate determination GO:0007400 1 0.275
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.270
chromatin organization GO:0006325 206 0.267
positive regulation of isotype switching GO:0045830 15 0.264
positive regulation of b cell activation GO:0050871 49 0.258
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 36 0.258
antibacterial peptide production GO:0002778 2 0.255
positive regulation of t cell proliferation GO:0042102 52 0.252
modification by symbiont of host morphology or physiology GO:0044003 4 0.248
positive regulation of immune effector process GO:0002699 107 0.244
modulation by virus of host morphology or physiology GO:0019048 3 0.240
immunoglobulin mediated immune response GO:0016064 69 0.231
fc receptor signaling pathway GO:0038093 6 0.228
response to lipopolysaccharide GO:0032496 128 0.227
chronic inflammatory response GO:0002544 9 0.225
positive regulation of b cell differentiation GO:0045579 13 0.224
cellular response to biotic stimulus GO:0071216 92 0.223
viral process GO:0016032 41 0.222
b cell receptor signaling pathway GO:0050853 20 0.222
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.221
response to peptide GO:1901652 136 0.217
negative regulation of lymphocyte activation GO:0051250 91 0.213
b cell proliferation GO:0042100 53 0.210
positive regulation of adaptive immune response GO:0002821 61 0.209
lymphocyte homeostasis GO:0002260 64 0.206
regulation of intracellular transport GO:0032386 159 0.205
alpha beta t cell activation GO:0046631 91 0.200
t helper 1 cell lineage commitment GO:0002296 2 0.200
positive regulation of leukocyte mediated immunity GO:0002705 70 0.198
leukocyte proliferation GO:0070661 172 0.196
positive regulation of mhc class ii biosynthetic process GO:0045348 4 0.194
regulation of regulated secretory pathway GO:1903305 20 0.193
regulation of response to wounding GO:1903034 189 0.192
leukocyte activation involved in immune response GO:0002366 126 0.191
negative regulation of histone deacetylation GO:0031064 2 0.187
response to endoplasmic reticulum stress GO:0034976 53 0.187
regulation of jak stat cascade GO:0046425 34 0.186
negative regulation of protein modification process GO:0031400 163 0.185
mhc class ii biosynthetic process GO:0045342 8 0.183
regulation of inflammatory response GO:0050727 147 0.182
regulation of epithelial cell migration GO:0010632 35 0.182
positive regulation of isotype switching to ige isotypes GO:0048295 4 0.179
nitrogen compound transport GO:0071705 271 0.178
response to retinoic acid GO:0032526 56 0.177
defense response to protozoan GO:0042832 25 0.174
positive regulation of chronic inflammatory response GO:0002678 4 0.172
negative regulation of t cell activation GO:0050868 65 0.172
cellular ketone metabolic process GO:0042180 84 0.172
blood vessel endothelial cell migration GO:0043534 23 0.169
interleukin 10 secretion GO:0072608 4 0.168
sprouting angiogenesis GO:0002040 26 0.168
tyrosine phosphorylation of stat5 protein GO:0042506 9 0.166
regulation of ion transport GO:0043269 215 0.164
immune effector process GO:0002252 321 0.161
cytokine production involved in inflammatory response GO:0002534 9 0.161
positive regulation of chemokine biosynthetic process GO:0045080 6 0.159
serotonin secretion by platelet GO:0002554 3 0.159
natural killer cell mediated cytotoxicity GO:0042267 29 0.159
unsaturated fatty acid metabolic process GO:0033559 31 0.157
positive regulation of cell cycle process GO:0090068 61 0.150
isotype switching to ige isotypes GO:0048289 7 0.148
immunoglobulin production GO:0002377 73 0.144
dendrite development GO:0016358 115 0.143
regulation of cytokine production GO:0001817 266 0.142
activation induced cell death of t cells GO:0006924 10 0.140
negative regulation of t helper cell differentiation GO:0045623 9 0.139
negative regulation of immune effector process GO:0002698 55 0.138
mast cell mediated immunity GO:0002448 20 0.135
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.135
response to hydrogen peroxide GO:0042542 32 0.134
b cell mediated immunity GO:0019724 71 0.132
activation of janus kinase activity GO:0042976 2 0.129
regulation of b cell proliferation GO:0030888 39 0.129
dna metabolic process GO:0006259 303 0.127
t helper cell lineage commitment GO:0002295 6 0.127
b cell differentiation GO:0030183 78 0.125
regulation of toll like receptor 4 signaling pathway GO:0034143 4 0.124
regulation of chemokine biosynthetic process GO:0045073 8 0.123
tyrosine phosphorylation of stat3 protein GO:0042503 12 0.120
cation transport GO:0006812 399 0.118
positive regulation of dna recombination GO:0045911 17 0.118
t cell anergy GO:0002870 4 0.117
myeloid dendritic cell differentiation GO:0043011 16 0.115
positive regulation of protein transport GO:0051222 93 0.115
serotonin secretion involved in inflammatory response GO:0002442 4 0.114
regulation of cell cycle GO:0051726 281 0.113
regulation of tyrosine phosphorylation of stat5 protein GO:0042522 8 0.113
cell adhesion GO:0007155 329 0.112
regulation of mhc class ii biosynthetic process GO:0045346 7 0.110
negative regulation of fibroblast proliferation GO:0048147 14 0.110
imitative learning GO:0098596 1 0.109
negative regulation of toll like receptor 4 signaling pathway GO:0034144 3 0.108
chemokine biosynthetic process GO:0042033 8 0.107
regulation of chronic inflammatory response to antigenic stimulus GO:0002874 3 0.107
signal transduction in absence of ligand GO:0038034 55 0.106
regulation of b cell activation GO:0050864 81 0.106
positive regulation of innate immune response GO:0045089 80 0.103
positive regulation of secretion by cell GO:1903532 114 0.101
cytokine biosynthetic process GO:0042089 68 0.100
regulation of mast cell degranulation GO:0043304 16 0.100
positive regulation of b cell proliferation GO:0030890 24 0.100
negative regulation of cell proliferation GO:0008285 296 0.099
positive regulation of t cell activation GO:0050870 101 0.097
response to organic cyclic compound GO:0014070 198 0.097
positive regulation of intracellular transport GO:0032388 70 0.093
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.092
antibacterial peptide secretion GO:0002779 1 0.092
neutrophil differentiation GO:0030223 3 0.092
regulation of protein localization GO:0032880 231 0.090
mast cell degranulation GO:0043303 19 0.090
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.089
positive regulation of homeostatic process GO:0032846 64 0.088
positive regulation of protein modification process GO:0031401 299 0.087
regulation of activation of jak2 kinase activity GO:0010534 1 0.087
regulation of secretion by cell GO:1903530 249 0.087
neuroblast differentiation GO:0014016 2 0.085
skeletal muscle organ development GO:0060538 163 0.085
positive regulation of type iii hypersensitivity GO:0001805 3 0.082
regulation of leukocyte mediated immunity GO:0002703 104 0.081
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.080
regulation of leukocyte proliferation GO:0070663 121 0.080
positive regulation of activation of membrane attack complex GO:0001970 2 0.079
chemokine metabolic process GO:0050755 10 0.079
t cell mediated immunity GO:0002456 50 0.079
negative regulation of protein metabolic process GO:0051248 282 0.079
regulation of growth of symbiont in host GO:0044126 19 0.078
regulation of b cell mediated immunity GO:0002712 37 0.078
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.077
tissue migration GO:0090130 68 0.077
keratinocyte migration GO:0051546 3 0.076
somatic diversification of t cell receptor genes GO:0002568 5 0.076
t helper 17 cell differentiation GO:0072539 7 0.075
posttranscriptional regulation of gene expression GO:0010608 155 0.074
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.074
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 3 0.072
regulation of t cell anergy GO:0002667 4 0.072
extrinsic apoptotic signaling pathway GO:0097191 126 0.071
t helper 2 cell cytokine production GO:0035745 4 0.069
positive regulation of angiogenesis GO:0045766 46 0.068
regulation of cell migration GO:0030334 219 0.067
covalent chromatin modification GO:0016569 163 0.067
negative regulation of creb transcription factor activity GO:0032792 2 0.067
positive regulation of leukocyte proliferation GO:0070665 73 0.065
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.064
regulation of interleukin 13 secretion GO:2000665 2 0.064
positive regulation of phospholipase activity GO:0010518 3 0.062
interspecies interaction between organisms GO:0044419 83 0.062
carboxylic acid transport GO:0046942 100 0.061
positive regulation of translation GO:0045727 19 0.061
humoral immune response mediated by circulating immunoglobulin GO:0002455 14 0.061
phosphatidylinositol mediated signaling GO:0048015 41 0.061
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.060
platelet aggregation GO:0070527 20 0.060
segmentation GO:0035282 93 0.060
epithelium migration GO:0090132 63 0.060
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.059
cellular response to water stimulus GO:0071462 1 0.059
cytokine production involved in immune response GO:0002367 34 0.058
response to molecule of bacterial origin GO:0002237 143 0.058
response to protozoan GO:0001562 28 0.057
positive regulation of mast cell activation involved in immune response GO:0033008 10 0.057
positive regulation of tyrosine phosphorylation of stat3 protein GO:0042517 7 0.057
regulation of isotype switching to igg isotypes GO:0048302 10 0.057
protein acylation GO:0043543 64 0.057
monocarboxylic acid metabolic process GO:0032787 191 0.057
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.056
organic hydroxy compound metabolic process GO:1901615 203 0.055
response to symbiont GO:0009608 2 0.055
chronic inflammatory response to antigenic stimulus GO:0002439 3 0.055
positive regulation of mast cell degranulation GO:0043306 10 0.055
positive regulation of mapk cascade GO:0043410 170 0.055
negative regulation of histone modification GO:0031057 18 0.055
regulation of mitotic cell cycle GO:0007346 126 0.055
neutrophil homeostasis GO:0001780 7 0.054
positive regulation of complement activation GO:0045917 2 0.054
myeloid leukocyte mediated immunity GO:0002444 42 0.054
negative regulation of phosphorus metabolic process GO:0010563 184 0.054
positive regulation of tyrosine phosphorylation of stat1 protein GO:0042511 1 0.053
regulation of neural precursor cell proliferation GO:2000177 70 0.052
negative t cell selection GO:0043383 13 0.052
humoral immune response GO:0006959 57 0.052
epithelial cell migration GO:0010631 63 0.052
thymic t cell selection GO:0045061 22 0.050
negative regulation of immune system process GO:0002683 209 0.050
interaction with host GO:0051701 22 0.050
single organismal cell cell adhesion GO:0016337 131 0.049
dna repair GO:0006281 107 0.049
regulation of regulatory t cell differentiation GO:0045589 7 0.049
regulation of myotube differentiation GO:0010830 62 0.049
positive regulation of cd4 positive alpha beta t cell differentiation GO:0043372 14 0.048
regulation of dendritic cell apoptotic process GO:2000668 3 0.048
vocal learning GO:0042297 1 0.047
regulation of body fluid levels GO:0050878 162 0.047
histone lysine methylation GO:0034968 50 0.046
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.046
regulation of lymphocyte mediated immunity GO:0002706 84 0.046
telomere capping GO:0016233 4 0.046
regulation of protein transport GO:0051223 163 0.046
regulation of blood vessel endothelial cell migration GO:0043535 12 0.046
peptidyl tyrosine modification GO:0018212 145 0.045
positive regulation of immunoglobulin production GO:0002639 28 0.044
negative regulation of t cell mediated cytotoxicity GO:0001915 3 0.044
cellular response to peptide GO:1901653 92 0.044
positive regulation of mitotic cell cycle GO:0045931 41 0.043
regulation of skeletal muscle fiber development GO:0048742 36 0.043
positive regulation of t cell differentiation GO:0045582 52 0.043
positive regulation of cytokine production GO:0001819 174 0.043
osteoclast differentiation GO:0030316 62 0.042
positive regulation of immunoglobulin secretion GO:0051024 7 0.042
fatty acid derivative biosynthetic process GO:1901570 15 0.041
regulation of secretion GO:0051046 274 0.041
regulation of cell division GO:0051302 76 0.041
regulation of chronic inflammatory response GO:0002676 7 0.041
positive regulation of cell cycle GO:0045787 92 0.040
fatty acid biosynthetic process GO:0006633 41 0.040
apoptotic signaling pathway GO:0097190 306 0.040
dendrite regeneration GO:0031104 1 0.039
positive regulation of cardiac muscle cell apoptotic process GO:0010666 3 0.039
response to amino acid GO:0043200 37 0.039
regulation of interleukin 6 biosynthetic process GO:0045408 11 0.039
hematopoietic progenitor cell differentiation GO:0002244 143 0.039
positive regulation of leukocyte degranulation GO:0043302 10 0.039
positive regulation of glial cell proliferation GO:0060252 4 0.038
activation of mapk activity involved in innate immune response GO:0035419 2 0.038
positive regulation of protein oligomerization GO:0032461 4 0.038
regulation of granulocyte macrophage colony stimulating factor biosynthetic process GO:0045423 2 0.038
negative regulation of toll like receptor 2 signaling pathway GO:0034136 3 0.038
regulation of cardiac muscle cell differentiation GO:2000725 9 0.038
cell killing GO:0001906 67 0.038
regulation of t cell differentiation GO:0045580 83 0.038
interleukin 6 biosynthetic process GO:0042226 12 0.038
t cell receptor signaling pathway GO:0050852 46 0.037
protein secretion GO:0009306 111 0.037
cellular response to molecule of fungal origin GO:0071226 2 0.037
protein import into nucleus translocation GO:0000060 12 0.036
response to insulin GO:0032868 100 0.036
negative regulation of response to wounding GO:1903035 77 0.036
nuclear import GO:0051170 95 0.036
cellular response to abiotic stimulus GO:0071214 56 0.036
regulation of inflammatory response to antigenic stimulus GO:0002861 21 0.036
defense response to bacterium GO:0042742 119 0.035
t cell homeostatic proliferation GO:0001777 4 0.035
regionalization GO:0003002 337 0.035
cellular response to retinoic acid GO:0071300 25 0.035
positive regulation of defense response GO:0031349 124 0.035
regulation of t cell activation GO:0050863 170 0.035
regulation of receptor binding GO:1900120 4 0.035
defense response to virus GO:0051607 68 0.035
negative regulation of t cell differentiation GO:0045581 23 0.034
cytokine production GO:0001816 319 0.034
protein autophosphorylation GO:0046777 61 0.034
regulation of platelet activation GO:0010543 17 0.034
positive regulation of protein phosphorylation GO:0001934 242 0.034
nuclear transport GO:0051169 139 0.034
response to water GO:0009415 1 0.034
extracellular matrix organization GO:0030198 147 0.034
myeloid cell activation involved in immune response GO:0002275 34 0.034
negative regulation of alpha beta t cell activation GO:0046636 18 0.033
regulation of histone modification GO:0031056 56 0.033
regulation of homeostatic process GO:0032844 182 0.033
negative regulation of organelle organization GO:0010639 90 0.033
hepaticobiliary system development GO:0061008 67 0.033
regulation of anion transport GO:0044070 27 0.033
pro b cell differentiation GO:0002328 10 0.033
negative regulation of glial cell proliferation GO:0060253 4 0.033
b cell activation involved in immune response GO:0002312 50 0.032
negative regulation of homeostatic process GO:0032845 71 0.032
stem cell development GO:0048864 219 0.032
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.032
positive regulation of mitosis GO:0045840 14 0.032
regulation of angiogenesis GO:0045765 81 0.032
positive regulation of podosome assembly GO:0071803 3 0.032
negative regulation of chromatin modification GO:1903309 19 0.032
regulation of histone h3 k9 methylation GO:0051570 8 0.032
innate immune response activating signal transduction GO:0002758 50 0.032
positive regulation of epithelial cell migration GO:0010634 19 0.032
regulation of protein homooligomerization GO:0032462 3 0.031
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.031
protein kinase b signaling GO:0043491 74 0.031
neutrophil degranulation GO:0043312 6 0.031
stem cell differentiation GO:0048863 268 0.030
regulation of mitosis GO:0007088 29 0.030
regulation of interleukin 6 production GO:0032675 55 0.030
antimicrobial peptide biosynthetic process GO:0002777 2 0.030
positive regulation of cytokine biosynthetic process GO:0042108 40 0.030
reactive oxygen species biosynthetic process GO:1903409 8 0.030
oligodendrocyte development GO:0014003 20 0.030
endoplasmic reticulum unfolded protein response GO:0030968 19 0.030
regulation of antibacterial peptide biosynthetic process GO:0002808 1 0.029
positive regulation of antibacterial peptide biosynthetic process GO:0006963 1 0.029
negative regulation of t helper 1 cell differentiation GO:0045626 3 0.029
hindbrain development GO:0030902 128 0.029
response to peptide hormone GO:0043434 127 0.029
regulation of tyrosine phosphorylation of stat protein GO:0042509 20 0.029
interleukin 3 production GO:0032632 3 0.029
stem cell maintenance GO:0019827 130 0.028
negative regulation of synapse assembly GO:0051964 3 0.028
regulation of peptidase activity GO:0052547 96 0.028
carboxylic acid biosynthetic process GO:0046394 86 0.028
positive regulation of proteolysis GO:0045862 85 0.028
myotube differentiation GO:0014902 105 0.028
antigen receptor mediated signaling pathway GO:0050851 64 0.028
natural killer cell activation GO:0030101 44 0.028
regulation of chemokine production GO:0032642 30 0.028
regulation of translational initiation GO:0006446 15 0.028
negative regulation of alpha beta t cell differentiation GO:0046639 12 0.028
regulation of t helper 2 cell differentiation GO:0045628 8 0.028
negative regulation of interferon gamma biosynthetic process GO:0045077 2 0.028
myeloid cell differentiation GO:0030099 233 0.027
regulation of isotype switching to ige isotypes GO:0048293 7 0.027
response to organonitrogen compound GO:0010243 246 0.027
negative regulation of humoral immune response mediated by circulating immunoglobulin GO:0002924 3 0.027
positive regulation of myotube differentiation GO:0010831 24 0.027
regulation of odontogenesis GO:0042481 18 0.027
positive regulation of cd4 positive cd25 positive alpha beta regulatory t cell differentiation GO:0032831 2 0.027
negative regulation of isotype switching GO:0045829 4 0.027
gamma delta t cell activation GO:0046629 13 0.026
innate immune response in mucosa GO:0002227 3 0.026
single organism cell adhesion GO:0098602 156 0.026
actin filament bundle assembly GO:0051017 40 0.026
cellularization GO:0007349 1 0.026
response to hyperoxia GO:0055093 2 0.026
organ growth GO:0035265 117 0.026
regulation of binding GO:0051098 111 0.026
monocarboxylic acid transport GO:0015718 44 0.026
immune response regulating signaling pathway GO:0002764 125 0.026
lipid transport GO:0006869 98 0.026
positive regulation of protein homooligomerization GO:0032464 3 0.025
cellular response to organonitrogen compound GO:0071417 145 0.025
calcium mediated signaling GO:0019722 46 0.025
positive regulation of immunoglobulin mediated immune response GO:0002891 26 0.025
negative regulation of blood vessel endothelial cell migration GO:0043537 3 0.025
activation of membrane attack complex GO:0001905 4 0.025
epithelial cell cell adhesion GO:0090136 6 0.025
regulation of chromosome organization GO:0033044 83 0.025
regulation of lymphocyte activation GO:0051249 240 0.025
skin development GO:0043588 220 0.024
insulin receptor signaling pathway GO:0008286 49 0.024
necroptotic signaling pathway GO:0097527 3 0.024
rhythmic process GO:0048511 174 0.024
coagulation GO:0050817 78 0.024
pattern recognition receptor signaling pathway GO:0002221 47 0.024
response to oxidative stress GO:0006979 123 0.024
regulation of immunoglobulin mediated immune response GO:0002889 37 0.024
protein localization to nucleus GO:0034504 121 0.024
regulation of cell migration involved in sprouting angiogenesis GO:0090049 4 0.024

Rag1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system cancer DOID:0060083 0 0.677
hematologic cancer DOID:2531 0 0.677
cancer DOID:162 0 0.677
disease of cellular proliferation DOID:14566 0 0.677
organ system cancer DOID:0050686 0 0.677
immune system disease DOID:2914 0 0.165
disease of anatomical entity DOID:7 0 0.165
primary immunodeficiency disease DOID:612 0 0.100
blood protein disease DOID:620 0 0.100
agammaglobulinemia DOID:2583 0 0.100
common variable immunodeficiency DOID:12177 0 0.100
b cell deficiency DOID:2115 0 0.100
hematopoietic system disease DOID:74 0 0.100
diabetes mellitus DOID:9351 0 0.077
disease of metabolism DOID:0014667 0 0.077
carbohydrate metabolism disease DOID:0050013 0 0.077
glucose metabolism disease DOID:4194 0 0.077
acquired metabolic disease DOID:0060158 0 0.077
type 1 diabetes mellitus DOID:9744 0 0.038
leukemia DOID:1240 0 0.036
bone remodeling disease DOID:0080005 0 0.036
bone disease DOID:0080001 0 0.036
musculoskeletal system disease DOID:17 0 0.036
connective tissue disease DOID:65 0 0.036
myeloid leukemia DOID:8692 0 0.024
lymphatic system disease DOID:75 0 0.024