IMP
Process View
negative regulation of toll like receptor 2 signaling pathway
Any process that stops, prevents, or reduces the frequency, rate, or extent of toll-like receptor 2 signaling pathway.
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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of toll like receptor 2 signaling pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Tcra | T-cell receptor alpha chain | 0.908 | ||
| Ptprc | protein tyrosine phosphatase, receptor type, C | 0.774 | ||
| Cd19 | CD19 antigen | 0.654 | ||
| Ikzf1 | IKAROS family zinc finger 1 | 0.443 | ||
| Plcg2 | phospholipase C, gamma 2 | 0.321 | ||
| Tnf | tumor necrosis factor | 0.299 | ||
| Inpp5d | inositol polyphosphate-5-phosphatase D | 0.279 | ||
| Blnk | B-cell linker | 0.218 | ||
| Mefv | Mediterranean fever | 0.210 | ||
| Was | Wiskott-Aldrich syndrome homolog (human) | 0.209 | ||
| Igh | immunoglobulin heavy chain complex | 0.202 | ||
| Cd247 | CD247 antigen | 0.187 | ||
| Cd40 | CD40 antigen | 0.164 | ||
| Il2rg | interleukin 2 receptor, gamma chain | 0.161 | ||
| Ptk2 | PTK2 protein tyrosine kinase 2 | 0.153 | ||
| Clnk | cytokine-dependent hematopoietic cell linker | 0.147 | ||
| Grb2 | growth factor receptor bound protein 2 | 0.116 | ||
| Fyb | FYN binding protein | 0.114 | ||
| Cd79a | CD79A antigen (immunoglobulin-associated alpha) | 0.111 | ||
| Hcls1 | hematopoietic cell specific Lyn substrate 1 | 0.102 | ||
| Fyn | Fyn proto-oncogene | 0.097 | Mouse | |
| Ptpn6 | protein tyrosine phosphatase, non-receptor type 6 | 0.095 | ||
| Cbl | Casitas B-lineage lymphoma | 0.087 | ||
| Itgb2 | integrin beta 2 | 0.086 | ||
| Cd22 | CD22 antigen | 0.084 | ||
| Il2rb | interleukin 2 receptor, beta chain | 0.081 | ||
| Il1b | interleukin 1 beta | 0.078 | ||
| Fpr1 | formyl peptide receptor 1 | 0.072 | ||
| Lyz2 | lysozyme 2 | 0.072 | ||
| Dok2 | docking protein 2 | 0.069 | ||
| Il4 | interleukin 4 | 0.068 | ||
| Il2 | interleukin 2 | 0.066 | ||
| Icos | inducible T-cell co-stimulator | 0.064 | ||
| Cd44 | CD44 antigen | 0.062 | ||
| Pik3cd | phosphatidylinositol 3-kinase catalytic delta polypeptide | 0.061 | ||
| Il1a | interleukin 1 alpha | 0.060 | ||
| Casp4 | caspase 4, apoptosis-related cysteine peptidase | 0.055 | ||
| Il1rn | interleukin 1 receptor antagonist | 0.053 | ||
| Ptpra | protein tyrosine phosphatase, receptor type, A | 0.053 | ||
| Cd4 | CD4 antigen | 0.050 | ||
| Zap70 | zeta-chain (TCR) associated protein kinase | 0.049 | ||
| Pou2af1 | POU domain, class 2, associating factor 1 | 0.049 | ||
| Slfn4 | schlafen 4 | 0.047 | ||
| Ccl4 | chemokine (C-C motif) ligand 4 | 0.043 | ||
| Prkce | protein kinase C, epsilon | 0.042 | ||
| Ooep | oocyte expressed protein homolog (dog) | 0.042 | ||
| Fcgr2b | Fc receptor, IgG, low affinity IIb | 0.041 | ||
| Trem3 | triggering receptor expressed on myeloid cells 3 | 0.041 | ||
| Pycard | PYD and CARD domain containing | 0.040 | ||
| Emr1 | EGF-like module containing, mucin-like, hormone receptor-like sequence 1 | 0.039 | ||
| Nlrp3 | NLR family, pyrin domain containing 3 | 0.039 | Mouse | |
| Skap2 | src family associated phosphoprotein 2 | 0.039 | ||
| Il10 | interleukin 10 | 0.038 | ||
| Rag1 | recombination activating gene 1 | 0.038 | ||
| Lat | linker for activation of T cells | 0.037 | ||
| Pilrb1 | paired immunoglobin-like type 2 receptor beta 1 | 0.037 | ||
| Il18rap | interleukin 18 receptor accessory protein | 0.037 | ||
| Siglece | sialic acid binding Ig-like lectin E | 0.036 | ||
| Cd300lf | CD300 antigen like family member F | 0.036 | ||
| Sykb | spleen tyrosine kinase | 0.035 | ||
| Ifng | interferon gamma | 0.035 | ||
| Cd8a | CD8 antigen, alpha chain | 0.034 | ||
| Bcar1 | breast cancer anti-estrogen resistance 1 | 0.034 | ||
| Cd72 | CD72 antigen | 0.033 | ||
| Fcgr1 | Fc receptor, IgG, high affinity I | 0.033 | ||
| Acap1 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 | 0.032 | ||
| Foxn1 | forkhead box N1 | 0.031 | ||
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.031 | ||
| Rag2 | recombination activating gene 2 | 0.030 | ||
| Itgal | integrin alpha L | 0.030 | ||
| Ccr6 | chemokine (C-C motif) receptor 6 | 0.030 | ||
| Fas | Fas (TNF receptor superfamily member 6) | 0.029 | ||
| Cd28 | CD28 antigen | 0.029 | ||
| BC013712 | cDNA sequence BC013712 | 0.029 | ||
| Clec4d | C-type lectin domain family 4, member d | 0.027 | ||
| Foxp3 | forkhead box P3 | 0.027 | ||
| Ptk2b | PTK2 protein tyrosine kinase 2 beta | 0.027 | ||
| Lck | lymphocyte protein tyrosine kinase | 0.027 | Mouse | |
| Ncr1 | natural cytotoxicity triggering receptor 1 | 0.027 | ||
| Il1f9 | interleukin 1 family, member 9 | 0.026 | ||
| Prf1 | perforin 1 (pore forming protein) | 0.026 | ||
| Card11 | caspase recruitment domain family, member 11 | 0.026 | ||
| Lcp2 | lymphocyte cytosolic protein 2 | 0.025 | ||
| Csf2rb | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 0.025 | ||
| Ptpre | protein tyrosine phosphatase, receptor type, E | 0.024 | ||
| Fcer1g | Fc receptor, IgE, high affinity I, gamma polypeptide | 0.024 | ||
| 2410004A20Rik | RIKEN cDNA 2410004A20 gene | 0.024 | ||
| Fpr2 | formyl peptide receptor 2 | 0.023 | ||
| Khdrbs1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.023 | ||
| Itgax | integrin alpha X | 0.023 | ||
| Fcgr4 | Fc receptor, IgG, low affinity IV | 0.023 | ||
| Ccr7 | chemokine (C-C motif) receptor 7 | 0.023 | ||
| Cd180 | CD180 antigen | 0.022 | ||
| Csf3r | colony stimulating factor 3 receptor (granulocyte) | 0.022 | ||
| Cd96 | CD96 antigen | 0.021 | ||
| Nfkb1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 | 0.021 | ||
| Cxcl2 | chemokine (C-X-C motif) ligand 2 | 0.021 | ||
| Dok1 | docking protein 1 | 0.021 | ||
| Ubd | ubiquitin D | 0.021 | ||
| Sell | selectin, lymphocyte | 0.021 | ||
| Tnfrsf13c | tumor necrosis factor receptor superfamily, member 13c | 0.021 | ||
| Gpr35 | G protein-coupled receptor 35 | 0.019 | ||
| Pik3r1 | phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) | 0.019 | ||
| Lcp1 | lymphocyte cytosolic protein 1 | 0.019 | ||
| Mcoln2 | mucolipin 2 | 0.019 | ||
| Irg1 | immunoresponsive gene 1 | 0.018 | ||
| Ikzf3 | IKAROS family zinc finger 3 | 0.018 | ||
| Slfn1 | schlafen 1 | 0.018 | ||
| Ptprcap | protein tyrosine phosphatase, receptor type, C polypeptide-associated protein | 0.018 | ||
| Ebi3 | Epstein-Barr virus induced gene 3 | 0.017 | ||
| Msr1 | macrophage scavenger receptor 1 | 0.017 | ||
| Ccr1 | chemokine (C-C motif) receptor 1 | 0.017 | ||
| Rasa1 | RAS p21 protein activator 1 | 0.016 | ||
| Pou2f2 | POU domain, class 2, transcription factor 2 | 0.016 | ||
| Cdcp1 | CUB domain containing protein 1 | 0.016 | ||
| Aoah | acyloxyacyl hydrolase | 0.016 | ||
| Mmp8 | matrix metallopeptidase 8 | 0.016 | ||
| Cd7 | CD7 antigen | 0.016 | ||
| Hcst | hematopoietic cell signal transducer | 0.015 | ||
| Dynlt1b | dynein light chain Tctex-type 1D | 0.015 | ||
| Il15 | interleukin 15 | 0.015 | ||
| Gpr97 | G protein-coupled receptor 97 | 0.014 | ||
| Itk | IL2-inducible T-cell kinase | 0.014 | ||
| Dok3 | docking protein 3 | 0.014 | ||
| Marco | macrophage receptor with collagenous structure | 0.014 | ||
| Mmp9 | matrix metallopeptidase 9 | 0.014 | ||
| Clec4e | C-type lectin domain family 4, member e | 0.014 | ||
| Ms4a1 | membrane-spanning 4-domains, subfamily A, member 1 | 0.014 | ||
| Spib | Spi-B transcription factor (Spi-1/PU.1 related) | 0.014 | ||
| Trem1 | triggering receptor expressed on myeloid cells 1 | 0.014 | ||
| Tlr6 | toll-like receptor 6 | 0.013 | ||
| Pxn | paxillin | 0.013 | ||
| Zfp865 | zinc finger protein 865 | 0.013 | ||
| Ptpn22 | protein tyrosine phosphatase, non-receptor type 22 (lymphoid) | 0.013 | ||
| Jak3 | Janus kinase 3 | 0.013 | ||
| AF251705 | cDNA sequence AF251705 | 0.013 | ||
| Rel | reticuloendotheliosis oncogene | 0.013 | ||
| Selp | selectin, platelet | 0.013 | ||
| Tnfrsf11b | tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) | 0.013 | ||
| Tcirg1 | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 | 0.013 | ||
| Cd86 | CD86 antigen | 0.013 | ||
| Dsg2 | desmoglein 2 | 0.013 | ||
| Nos2 | nitric oxide synthase 2, inducible | 0.012 | ||
| Klra17 | killer cell lectin-like receptor, subfamily A, member 17 | 0.012 | ||
| Ciita | class II transactivator | 0.012 | ||
| Ly9 | lymphocyte antigen 9 | 0.012 | ||
| Gzmb | granzyme B | 0.012 | ||
| Il27ra | interleukin 27 receptor, alpha | 0.012 | ||
| Slamf8 | SLAM family member 8 | 0.012 | ||
| Map4k1 | mitogen-activated protein kinase kinase kinase kinase 1 | 0.012 | ||
| Sele | selectin, endothelial cell | 0.012 | ||
| Il6 | interleukin 6 | 0.012 | ||
| Nfkbia | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.012 | ||
| Cd79b | CD79B antigen | 0.012 | ||
| BC048562 | cDNA sequence BC048562 | 0.012 | ||
| Man2b1 | mannosidase 2, alpha B1 | 0.012 | ||
| Cxcr2 | chemokine (C-X-C motif) receptor 2 | 0.012 | ||
| Slpi | secretory leukocyte peptidase inhibitor | 0.011 | ||
| Pdcd1lg2 | programmed cell death 1 ligand 2 | 0.011 | ||
| Asprv1 | aspartic peptidase, retroviral-like 1 | 0.011 | ||
| Emr4 | EGF-like module containing, mucin-like, hormone receptor-like sequence 4 | 0.011 | ||
| Il10ra | interleukin 10 receptor, alpha | 0.011 | ||
| Casp1 | caspase 1 | 0.011 | ||
| Ctsw | cathepsin W | 0.011 | ||
| Il1r1 | interleukin 1 receptor, type I | 0.011 | ||
| Irf8 | interferon regulatory factor 8 | 0.011 | ||
| Ms4a4c | membrane-spanning 4-domains, subfamily A, member 4C | 0.011 | ||
| S100a8 | S100 calcium binding protein A8 (calgranulin A) | 0.011 | ||
| Klra2 | killer cell lectin-like receptor, subfamily A, member 2 | 0.011 | ||
| Nfam1 | Nfat activating molecule with ITAM motif 1 | 0.011 | ||
| Ifnar1 | interferon (alpha and beta) receptor 1 | 0.011 | ||
| Plekhg6 | pleckstrin homology domain containing, family G (with RhoGef domain) member 6 | 0.011 | ||
| Cd300a | CD300A antigen | 0.010 | ||
| Tbxa2r | thromboxane A2 receptor | 0.010 | ||
| Adam8 | a disintegrin and metallopeptidase domain 8 | 0.010 | ||
| Lif | leukemia inhibitory factor | 0.010 | ||
| Gna15 | guanine nucleotide binding protein, alpha 15 | 0.010 | ||
| Apobr | apolipoprotein B receptor | 0.010 | ||
| Dock8 | dedicator of cytokinesis 8 | 0.010 | ||
| Cd300ld | CD300 molecule-like family member d | 0.010 | ||
| Fgr | Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog | 0.010 | Mouse | |
| Slc15a3 | solute carrier family 15, member 3 | 0.010 |