Mus musculus

543 known processes

Tnf

tumor necrosis factor

(Aliases: TNFalpha,DIF,Tnfsf1a,Tnfa,TNFSF2,TNF-alpha,MGC151434)

Tnf biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of chronic inflammatory response to antigenic stimulus GO:0002874 3 1.000
antibacterial peptide production GO:0002778 2 1.000
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 1.000
osteoclast proliferation GO:0002158 4 1.000
Mouse
defense response to other organism GO:0098542 197 1.000
positive regulation of myoblast differentiation GO:0045663 8 1.000
Mouse
regulation of fever generation GO:0031620 6 1.000
fever generation GO:0001660 7 1.000
i kappab kinase nf kappab signaling GO:0007249 85 1.000
chronic inflammatory response GO:0002544 9 1.000
antibacterial humoral response GO:0019731 8 1.000
cellular response to cytokine stimulus GO:0071345 189 1.000
positive regulation of antibacterial peptide biosynthetic process GO:0006963 1 1.000
positive regulation of defense response GO:0031349 124 1.000
regulation of inflammatory response to antigenic stimulus GO:0002861 21 1.000
lymphocyte activation involved in immune response GO:0002285 93 1.000
Mouse
regulation of growth of symbiont in host GO:0044126 19 1.000
cellular response to molecule of bacterial origin GO:0071219 83 1.000
positive regulation of isotype switching to igg isotypes GO:0048304 7 1.000
cytokine production involved in immune response GO:0002367 34 1.000
regulation of interleukin 6 production GO:0032675 55 1.000
tumor necrosis factor mediated signaling pathway GO:0033209 13 1.000
positive regulation of adaptive immune response GO:0002821 61 1.000
positive regulation of chronic inflammatory response GO:0002678 4 1.000
cellular response to lipopolysaccharide GO:0071222 77 1.000
negative regulation of inflammatory response to antigenic stimulus GO:0002862 10 1.000
positive regulation of interferon gamma production GO:0032729 39 1.000
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 1.000
Mouse
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 1.000
Mouse
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 1.000
Mouse
interleukin 12 production GO:0032615 32 1.000
adaptive immune response GO:0002250 155 1.000
defense response to bacterium GO:0042742 119 1.000
cellular response to lipid GO:0071396 145 1.000
t helper cell differentiation GO:0042093 28 1.000
programmed necrotic cell death GO:0097300 28 1.000
response to tumor necrosis factor GO:0034612 26 1.000
modulation of growth of symbiont involved in interaction with host GO:0044144 19 1.000
regulation of cell activation GO:0050865 289 1.000
Mouse
interleukin 10 secretion GO:0072608 4 1.000
leukocyte differentiation GO:0002521 342 1.000
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 1.000
interleukin 5 secretion GO:0072603 2 1.000
positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 2 1.000
necroptotic process GO:0070266 21 1.000
production of molecular mediator of immune response GO:0002440 103 1.000
regulation of cytokine production involved in immune response GO:0002718 26 1.000
cytokine production GO:0001816 319 1.000
extrinsic apoptotic signaling pathway GO:0097191 126 1.000
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 6 1.000
regulation of inflammatory response GO:0050727 147 1.000
antibacterial peptide biosynthetic process GO:0002780 2 1.000
defense response to gram negative bacterium GO:0050829 28 1.000
Fly
immunoglobulin mediated immune response GO:0016064 69 1.000
positive regulation of translational initiation by iron GO:0045994 2 1.000
regulation of b cell proliferation GO:0030888 39 1.000
positive regulation of fever generation GO:0031622 6 1.000
necroptotic signaling pathway GO:0097527 3 1.000
somatic diversification of immune receptors GO:0002200 53 1.000
Mouse
regulation of acute inflammatory response GO:0002673 27 0.999
immunoglobulin secretion GO:0048305 17 0.999
humoral immune response GO:0006959 57 0.999
positive regulation of lymphocyte proliferation GO:0050671 70 0.999
response to lipopolysaccharide GO:0032496 128 0.999
regulation of chronic inflammatory response GO:0002676 7 0.999
positive regulation of inflammatory response to antigenic stimulus GO:0002863 11 0.999
regulation of leukocyte proliferation GO:0070663 121 0.999
cellular response to biotic stimulus GO:0071216 92 0.999
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.999
antimicrobial peptide production GO:0002775 2 0.999
positive regulation of interleukin 12 production GO:0032735 21 0.999
leukocyte activation involved in immune response GO:0002366 126 0.999
Mouse
positive regulation of b cell proliferation GO:0030890 24 0.999
regulation of defense response to bacterium GO:1900424 3 0.999
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.999
regulation of response to wounding GO:1903034 189 0.999
cellular response to amino acid stimulus GO:0071230 29 0.999
lymph node development GO:0048535 18 0.999
Mouse
regulation of antibacterial peptide biosynthetic process GO:0002808 1 0.999
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 36 0.999
Mouse
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.999
negative regulation of growth of symbiont in host GO:0044130 19 0.999
reactive oxygen species metabolic process GO:0072593 84 0.999
positive regulation of lymphocyte activation GO:0051251 140 0.999
Mouse
interleukin 6 production GO:0032635 58 0.999
regulation of cytokine biosynthetic process GO:0042035 59 0.999
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.999
Mouse
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.999
regulation of cellular ketone metabolic process GO:0010565 66 0.999
regulation of lymphocyte proliferation GO:0050670 117 0.999
negative regulation of multi organism process GO:0043901 68 0.999
leukocyte mediated immunity GO:0002443 174 0.999
positive regulation of cell death GO:0010942 224 0.999
regulation of antimicrobial humoral response GO:0002759 3 0.998
negative regulation of interleukin 10 secretion GO:2001180 2 0.998
regulation of map kinase activity GO:0043405 120 0.998
Mouse
regulation of antibacterial peptide production GO:0002786 1 0.998
positive regulation of leukocyte mediated immunity GO:0002705 70 0.998
b cell activation involved in immune response GO:0002312 50 0.998
Mouse
peptidyl tyrosine phosphorylation GO:0018108 143 0.998
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.998
Mouse
cellular response to tumor necrosis factor GO:0071356 21 0.998
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.998
regulation of leukocyte mediated immunity GO:0002703 104 0.998
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.998
growth of symbiont involved in interaction with host GO:0044116 23 0.998
chronic inflammatory response to antigenic stimulus GO:0002439 3 0.998
cytokine mediated signaling pathway GO:0019221 115 0.998
icosanoid secretion GO:0032309 12 0.998
Mouse
regulation of fever generation by regulation of prostaglandin secretion GO:0071810 2 0.997
Mouse
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.997
positive regulation of leukocyte proliferation GO:0070665 73 0.997
cd4 positive alpha beta t cell activation GO:0035710 45 0.997
regulation of cd4 positive alpha beta t cell activation GO:2000514 24 0.997
regulation of protein serine threonine kinase activity GO:0071900 157 0.997
Mouse
t cell activation GO:0042110 289 0.997
Mouse
activation of mapk activity GO:0000187 59 0.997
Mouse
positive regulation of translational initiation GO:0045948 4 0.997
cellular response to interleukin 18 GO:0071351 3 0.997
nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070431 6 0.997
antimicrobial peptide biosynthetic process GO:0002777 2 0.997
positive regulation of cellular amine metabolic process GO:0033240 5 0.997
regulation of cellular amino acid metabolic process GO:0006521 5 0.996
positive regulation of endopeptidase activity GO:0010950 43 0.996
regulation of defense response GO:0031347 233 0.996
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.996
regulation of interleukin 12 production GO:0032655 30 0.996
regulation of protein targeting GO:1903533 61 0.996
positive regulation of apoptotic process GO:0043065 217 0.996
growth involved in symbiotic interaction GO:0044110 23 0.996
regulation of lymphocyte differentiation GO:0045619 107 0.996
positive regulation of jun kinase activity GO:0043507 30 0.996
Mouse
positive regulation of cytokine production GO:0001819 174 0.996
regulation of interleukin 13 secretion GO:2000665 2 0.996
positive regulation of protein localization to nucleus GO:1900182 30 0.996
glial cell apoptotic process GO:0034349 3 0.996
t cell differentiation involved in immune response GO:0002292 30 0.995
inflammatory response GO:0006954 244 0.995
positive regulation of programmed cell death GO:0043068 218 0.995
positive regulation of t cell activation GO:0050870 101 0.995
Mouse
cytokine biosynthetic process GO:0042089 68 0.995
defense response to gram positive bacterium GO:0050830 50 0.995
myeloid leukocyte activation GO:0002274 83 0.995
regulation of translational initiation by iron GO:0006447 2 0.995
positive regulation of b cell mediated immunity GO:0002714 26 0.995
lymphocyte differentiation GO:0030098 242 0.995
Mouse
nik nf kappab signaling GO:0038061 14 0.995
interleukin 13 secretion GO:0072611 2 0.995
regulation of tumor necrosis factor production GO:0032680 49 0.995
regulation of fatty acid transport GO:2000191 10 0.995
Mouse
prostaglandin transport GO:0015732 7 0.995
Mouse
positive regulation of mapk cascade GO:0043410 170 0.995
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.995
cytoplasmic pattern recognition receptor signaling pathway GO:0002753 10 0.995
regulation of reactive oxygen species metabolic process GO:2000377 40 0.994
positive regulation of protein kinase b signaling GO:0051897 32 0.994
regulation of t helper 1 cell differentiation GO:0045625 7 0.994
positive regulation of protein modification process GO:0031401 299 0.994
Mouse
chemokine biosynthetic process GO:0042033 8 0.994
cellular amine metabolic process GO:0044106 44 0.993
interleukin 18 mediated signaling pathway GO:0035655 2 0.993
protein import GO:0017038 101 0.993
regulation of transcription factor import into nucleus GO:0042990 24 0.993
positive regulation of map kinase activity GO:0043406 84 0.993
Mouse
positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 2 0.993
Mouse
tyrosine phosphorylation of stat protein GO:0007260 23 0.993
t helper 2 cell differentiation GO:0045064 12 0.993
positive regulation of protein phosphorylation GO:0001934 242 0.993
Mouse
positive regulation of defense response to bacterium GO:1900426 1 0.993
positive regulation of immune effector process GO:0002699 107 0.992
t cell differentiation GO:0030217 174 0.992
regulation of cd4 positive alpha beta t cell differentiation GO:0043370 21 0.992
alpha beta t cell proliferation GO:0046633 21 0.992
regulation of t cell activation GO:0050863 170 0.992
Mouse
regulation of intracellular transport GO:0032386 159 0.992
t cell receptor signaling pathway GO:0050852 46 0.992
chemokine production GO:0032602 34 0.992
regulation of leukocyte differentiation GO:1902105 159 0.992
regulation of immunoglobulin mediated immune response GO:0002889 37 0.992
alpha beta t cell differentiation GO:0046632 69 0.991
regulation of protein localization GO:0032880 231 0.991
positive regulation of osteoclast differentiation GO:0045672 15 0.991
Mouse
activation of innate immune response GO:0002218 56 0.991
regulation of cytokine production GO:0001817 266 0.991
response to molecule of bacterial origin GO:0002237 143 0.991
negative regulation of interleukin 5 production GO:0032714 4 0.991
heat generation GO:0031649 13 0.990
regulation of jnk cascade GO:0046328 62 0.990
apoptotic signaling pathway GO:0097190 306 0.990
regulation of humoral immune response GO:0002920 22 0.990
protein localization to nucleus GO:0034504 121 0.990
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.990
Mouse
somatic diversification of immunoglobulins GO:0016445 43 0.990
Mouse
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.990
positive regulation of lipid transport GO:0032370 22 0.989
Mouse
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.989
b cell activation GO:0042113 161 0.989
Mouse
positive regulation of t cell proliferation GO:0042102 52 0.989
mammary gland lobule development GO:0061377 22 0.989
Mouse
nuclear import GO:0051170 95 0.988
immune response activating signal transduction GO:0002757 116 0.988
regulation of icosanoid secretion GO:0032303 8 0.988
Mouse
positive regulation of chemokine biosynthetic process GO:0045080 6 0.988
regulation of immunoglobulin production GO:0002637 42 0.987
negative regulation of necrotic cell death GO:0060547 11 0.987
growth of symbiont in host GO:0044117 23 0.987
cytoplasmic transport GO:0016482 234 0.986
temperature homeostasis GO:0001659 26 0.986
t helper 2 cell cytokine production GO:0035745 4 0.985
regulation of b cell mediated immunity GO:0002712 37 0.984
somatic cell dna recombination GO:0016444 51 0.984
Mouse
positive regulation of b cell activation GO:0050871 49 0.984
positive regulation of cell activation GO:0050867 158 0.984
Mouse
negative regulation of growth of symbiont involved in interaction with host GO:0044146 19 0.984
amine metabolic process GO:0009308 45 0.983
myeloid leukocyte differentiation GO:0002573 119 0.983
regulation of t helper cell differentiation GO:0045622 14 0.983
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.983
Mouse
negative regulation of cytokine production GO:0001818 84 0.983
dna recombination GO:0006310 92 0.982
Mouse
pattern recognition receptor signaling pathway GO:0002221 47 0.982
circadian rhythm GO:0007623 114 0.982
cellular amino acid metabolic process GO:0006520 103 0.982
isotype switching GO:0045190 36 0.981
Mouse
positive regulation of icosanoid secretion GO:0032305 7 0.981
Mouse
regulation of nucleocytoplasmic transport GO:0046822 73 0.981
regulation of cellular amine metabolic process GO:0033238 20 0.981
lymphocyte migration GO:0072676 26 0.980
Mouse
regulation of stress activated mapk cascade GO:0032872 69 0.980
cellular response to dna damage stimulus GO:0006974 207 0.980
negative regulation of interleukin 13 secretion GO:2000666 1 0.980
positive regulation of antimicrobial peptide production GO:0002225 1 0.979
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 27 0.979
regulation of prostaglandin secretion GO:0032306 5 0.979
Mouse
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.978
negative regulation of odontogenesis of dentin containing tooth GO:0042489 1 0.978
reactive nitrogen species metabolic process GO:2001057 0 0.978
lymphocyte homeostasis GO:0002260 64 0.978
alpha beta t cell activation involved in immune response GO:0002287 31 0.978
positive regulation of acute inflammatory response GO:0002675 16 0.977
regulation of t cell differentiation GO:0045580 83 0.977
regulation of apoptotic signaling pathway GO:2001233 197 0.976
negative regulation of adaptive immune response GO:0002820 25 0.976
gland development GO:0048732 330 0.976
osteoclast differentiation GO:0030316 62 0.976
regulation of interleukin 5 secretion GO:2000662 2 0.976
regulation of protein import into nucleus GO:0042306 52 0.976
regulation of production of molecular mediator of immune response GO:0002700 65 0.976
myeloid cell differentiation GO:0030099 233 0.975
cd4 positive alpha beta t cell cytokine production GO:0035743 4 0.975
b cell mediated immunity GO:0019724 71 0.975
regulation of corticotropin releasing hormone secretion GO:0043397 2 0.975
Mouse
regulation of peptidase activity GO:0052547 96 0.975
negative regulation of hydrolase activity GO:0051346 71 0.974
regulation of adaptive immune response GO:0002819 90 0.974
positive regulation of cytokine biosynthetic process GO:0042108 40 0.972
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.972
response to interleukin 1 GO:0070555 11 0.972
regulation of interferon gamma production GO:0032649 57 0.972
regulation of transferase activity GO:0051338 263 0.972
Mouse
positive regulation of lymphocyte migration GO:2000403 11 0.971
Mouse
positive regulation of antimicrobial humoral response GO:0002760 2 0.971
interferon beta biosynthetic process GO:0045350 4 0.970
positive regulation of interleukin 6 production GO:0032755 37 0.970
regulation of interleukin 10 production GO:0032653 21 0.970
regulation of anion transport GO:0044070 27 0.969
Mouse Rat
b cell proliferation GO:0042100 53 0.969
negative regulation of glucose transport GO:0010829 9 0.969
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.968
negative regulation of interleukin 5 secretion GO:2000663 1 0.968
defense response to virus GO:0051607 68 0.968
t helper 1 cell differentiation GO:0045063 13 0.967
immune effector process GO:0002252 321 0.967
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.965
corticotropin releasing hormone secretion GO:0043396 2 0.965
Mouse
t cell activation involved in immune response GO:0002286 43 0.965
positive regulation of t helper 1 cell differentiation GO:0045627 4 0.965
positive regulation of jnk cascade GO:0046330 46 0.964
dna metabolic process GO:0006259 303 0.964
Mouse
positive regulation of humoral immune response GO:0002922 11 0.964
regulation of toll like receptor 2 signaling pathway GO:0034135 3 0.964
nuclear transport GO:0051169 139 0.964
regulation of alpha beta t cell proliferation GO:0046640 18 0.963
regulation of interleukin 10 secretion GO:2001179 4 0.963
positive regulation of cytokine production involved in immune response GO:0002720 19 0.962
dephosphorylation GO:0016311 129 0.962
negative regulation of growth GO:0045926 99 0.962
positive regulation of apoptotic signaling pathway GO:2001235 95 0.962
regulation of protein kinase activity GO:0045859 232 0.961
Mouse
regulation of lymphocyte mediated immunity GO:0002706 84 0.961
humoral immune response mediated by circulating immunoglobulin GO:0002455 14 0.960
cytokine metabolic process GO:0042107 71 0.960
stress activated mapk cascade GO:0051403 80 0.959
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 26 0.958
intrinsic apoptotic signaling pathway GO:0097193 132 0.958
regulation of b cell activation GO:0050864 81 0.956
positive regulation of interleukin 10 production GO:0032733 12 0.956
positive regulation of t cell migration GO:2000406 10 0.955
Mouse
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.955
Mouse
isotype switching to igg isotypes GO:0048291 10 0.955
regulation of establishment of protein localization GO:0070201 181 0.954
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.954
positive regulation of nf kappab transcription factor activity GO:0051092 30 0.953
negative regulation of inflammatory response GO:0050728 61 0.952
t cell selection GO:0045058 34 0.952
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.951
negative regulation of t helper 2 cell differentiation GO:0045629 4 0.951
regulation of lymphocyte activation GO:0051249 240 0.951
Mouse
positive regulation of transferase activity GO:0051347 167 0.948
Mouse
regulation of innate immune response GO:0045088 91 0.948
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.947
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.947
single organism nuclear import GO:1902593 95 0.947
negative regulation of phosphorus metabolic process GO:0010563 184 0.946
positive regulation of organic acid transport GO:0032892 11 0.945
Mouse
positive regulation of osteoclast development GO:2001206 3 0.945
Mouse
positive regulation of peptidase activity GO:0010952 49 0.944
regulation of multi organism process GO:0043900 111 0.944
protein targeting GO:0006605 143 0.943
t helper 1 type immune response GO:0042088 25 0.942
positive regulation of protein kinase activity GO:0045860 144 0.941
Mouse
lymphocyte proliferation GO:0046651 164 0.940
cell fate commitment GO:0045165 210 0.940
Fly
regulation of cytokine secretion GO:0050707 61 0.939
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.937
regulation of protein transport GO:0051223 163 0.935
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.935
jak stat cascade GO:0007259 42 0.935
positive regulation of immunoglobulin mediated immune response GO:0002891 26 0.935
necrotic cell death GO:0070265 30 0.935
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.934
regulation of protein secretion GO:0050708 82 0.934
protein import into nucleus GO:0006606 95 0.934
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.933
positive regulation of secretion by cell GO:1903532 114 0.933
Mouse
positive regulation of mhc class ii biosynthetic process GO:0045348 4 0.932
zymogen activation GO:0031638 41 0.932
positive regulation of leukocyte differentiation GO:1902107 86 0.932
Mouse
nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070427 5 0.932
regulation of lymphocyte migration GO:2000401 14 0.932
Mouse
response to organic cyclic compound GO:0014070 198 0.931
Zebrafish
t cell chemotaxis GO:0010818 6 0.930
Mouse
interferon gamma production GO:0032609 67 0.930
transcription factor import into nucleus GO:0042991 26 0.930
regulation of mhc class ii biosynthetic process GO:0045346 7 0.930
regulation of ion transport GO:0043269 215 0.928
Mouse Rat
response to organonitrogen compound GO:0010243 246 0.928
positive regulation of innate immune response GO:0045089 80 0.928
dendritic cell differentiation GO:0097028 26 0.925
mapk cascade GO:0000165 281 0.925
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.923
lymphocyte chemotaxis GO:0048247 10 0.923
Mouse
stress activated protein kinase signaling cascade GO:0031098 81 0.922
positive regulation of t cell differentiation GO:0045582 52 0.922
regulation of defense response to virus by host GO:0050691 8 0.919
negative regulation of alpha beta t cell activation GO:0046636 18 0.919
t cell proliferation GO:0042098 120 0.919
positive regulation of stress activated mapk cascade GO:0032874 48 0.916
regulation of secretion GO:0051046 274 0.912
positive regulation of corticotropin releasing hormone secretion GO:0051466 1 0.911
Mouse
positive regulation of protein transport GO:0051222 93 0.910
interleukin 6 biosynthetic process GO:0042226 12 0.910
cellular response to organonitrogen compound GO:0071417 145 0.907
cytokine secretion involved in immune response GO:0002374 6 0.906
regulation of mapk cascade GO:0043408 248 0.905
regulation of kinase activity GO:0043549 249 0.903
Mouse
positive regulation of kinase activity GO:0033674 155 0.901
Mouse
peptidyl tyrosine modification GO:0018212 145 0.900
positive regulation of ion transport GO:0043270 65 0.900
Mouse
negative regulation of alkaline phosphatase activity GO:0010693 3 0.900
nucleocytoplasmic transport GO:0006913 139 0.900
regulation of hydrolase activity GO:0051336 246 0.899
negative regulation of defense response GO:0031348 77 0.898
interspecies interaction between organisms GO:0044419 83 0.898
tyrosine phosphorylation of stat1 protein GO:0042508 3 0.897
regulation of antimicrobial peptide production GO:0002784 1 0.896
regulation of type 2 immune response GO:0002828 18 0.896
regulation of interleukin 6 biosynthetic process GO:0045408 11 0.895
regulation of cytoplasmic transport GO:1903649 112 0.894
negative regulation of b cell proliferation GO:0030889 13 0.893
regulation of t cell proliferation GO:0042129 92 0.889
positive regulation of hair follicle development GO:0051798 6 0.888
innate immune response activating signal transduction GO:0002758 50 0.887
intracellular protein transport GO:0006886 204 0.887
positive regulation of inflammatory response GO:0050729 47 0.887
regulation of jak stat cascade GO:0046425 34 0.884
regulation of translation GO:0006417 71 0.883
metal ion homeostasis GO:0055065 189 0.883
Mouse
activation of jun kinase activity GO:0007257 15 0.883
Mouse
organic acid transport GO:0015849 101 0.881
Mouse Rat
response to interleukin 18 GO:0070673 4 0.881
negative regulation of molecular function GO:0044092 258 0.880
positive regulation of intracellular protein transport GO:0090316 42 0.880
fatty acid transport GO:0015908 28 0.880
Mouse
negative regulation of map kinase activity GO:0043407 34 0.879
b cell differentiation GO:0030183 78 0.878
Mouse
myeloid dendritic cell activation GO:0001773 25 0.878
positive regulation of myeloid cell differentiation GO:0045639 43 0.878
Mouse
jnk cascade GO:0007254 72 0.877
positive regulation of prostaglandin secretion GO:0032308 5 0.877
Mouse
establishment of protein localization to organelle GO:0072594 118 0.877
leukocyte migration GO:0050900 124 0.876
regulation of cytokine secretion involved in immune response GO:0002739 4 0.875
translation GO:0006412 93 0.874
response to amino acid GO:0043200 37 0.873
toll like receptor 4 signaling pathway GO:0034142 9 0.873
negative regulation of chronic inflammatory response GO:0002677 3 0.871
regulation of jun kinase activity GO:0043506 40 0.869
Mouse
tumor necrosis factor production GO:0032640 50 0.868
negative regulation of t helper 1 cell differentiation GO:0045626 3 0.867
epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 7 0.866
inflammatory response to antigenic stimulus GO:0002437 30 0.864
activation of immune response GO:0002253 138 0.862
leukocyte proliferation GO:0070661 172 0.862
Mouse
germinal center formation GO:0002467 16 0.860
regulation of protein localization to nucleus GO:1900180 60 0.859
peptide transport GO:0015833 133 0.859
positive regulation of translation GO:0045727 19 0.859
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.858
t cell migration GO:0072678 19 0.856
Mouse
positive regulation of isotype switching GO:0045830 15 0.855
cdc42 protein signal transduction GO:0032488 0 0.855
negative regulation of interleukin 12 production GO:0032695 10 0.851
exocrine system development GO:0035272 45 0.849
positive regulation of cd8 positive alpha beta t cell extravasation GO:2000451 2 0.848
regulation of osteoclast differentiation GO:0045670 36 0.842
positive regulation of protein import into nucleus GO:0042307 26 0.842
regulation of proteolysis GO:0030162 164 0.840
positive regulation of hydrolase activity GO:0051345 148 0.839
regulation of cell migration GO:0030334 219 0.839
Mouse
prostaglandin secretion GO:0032310 5 0.836
Mouse
positive regulation of muscle cell differentiation GO:0051149 39 0.834
Mouse
glucose transport GO:0015758 56 0.832
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 0.832
positive regulation of cytokine secretion GO:0050715 41 0.830
positive regulation of cytoplasmic transport GO:1903651 40 0.830
positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 6 0.828
response to dsrna GO:0043331 30 0.827
Zebrafish
leukocyte apoptotic process GO:0071887 71 0.825
activation of cysteine type endopeptidase activity GO:0097202 27 0.823
negative regulation of apoptotic signaling pathway GO:2001234 104 0.822
positive regulation of defense response to virus by host GO:0002230 6 0.819
carboxylic acid transport GO:0046942 100 0.819
Mouse Rat
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.817
positive regulation of response to wounding GO:1903036 66 0.817
innate immune response GO:0045087 157 0.817
Fly
regulation of interleukin 2 production GO:0032663 28 0.815
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 15 0.815
defense response to fungus GO:0050832 12 0.814
regulation of isotype switching to igg isotypes GO:0048302 10 0.813
cation homeostasis GO:0055080 212 0.812
Mouse
regulation of tumor necrosis factor biosynthetic process GO:0042534 10 0.811
regulation of intracellular protein transport GO:0033157 82 0.811
positive regulation of cell development GO:0010720 237 0.811
Mouse
regulation of vitamin d biosynthetic process GO:0060556 1 0.810
regulation of endopeptidase activity GO:0052548 89 0.808
negative regulation of protein metabolic process GO:0051248 282 0.807
icosanoid transport GO:0071715 14 0.807
Mouse
osteoclast development GO:0036035 9 0.804
Mouse
positive regulation of monocyte chemotaxis GO:0090026 2 0.803
regulation of isotype switching GO:0045191 22 0.800
positive regulation of interleukin 1 secretion GO:0050716 14 0.800
regulation of cellular response to stress GO:0080135 159 0.794
positive regulation of tyrosine phosphorylation of stat1 protein GO:0042511 1 0.793
regulation of heat generation GO:0031650 8 0.793
inflammatory cell apoptotic process GO:0006925 11 0.787
negative regulation of interleukin 13 production GO:0032696 2 0.784
regulation of chemokine biosynthetic process GO:0045073 8 0.783
monosaccharide transport GO:0015749 58 0.783
acute phase response GO:0006953 10 0.782
myeloid dendritic cell differentiation GO:0043011 16 0.782
eosinophil degranulation GO:0043308 1 0.781
positive regulation of glial cell proliferation GO:0060252 4 0.780
cellular ketone metabolic process GO:0042180 84 0.779
t cell differentiation in thymus GO:0033077 77 0.779
cell chemotaxis GO:0060326 81 0.779
Mouse
negative regulation of immune system process GO:0002683 209 0.776
regulation of immunoglobulin secretion GO:0051023 12 0.775
organ or tissue specific immune response GO:0002251 13 0.774
negative regulation of interleukin 6 production GO:0032715 17 0.771
regulation of lipid transport GO:0032368 36 0.768
Mouse
fatty acid derivative transport GO:1901571 14 0.766
Mouse
t helper 17 cell lineage commitment GO:0072540 4 0.765
mammary gland epithelial cell proliferation GO:0033598 24 0.764
Mouse
toll like receptor signaling pathway GO:0002224 38 0.762
anion transport GO:0006820 177 0.760
Mouse Rat
mammary gland alveolus development GO:0060749 22 0.757
Mouse
translational initiation GO:0006413 24 0.755
negative regulation of cell activation GO:0050866 111 0.754
positive regulation of hair cycle GO:0042635 7 0.753
positive regulation of cytokine secretion involved in immune response GO:0002741 2 0.752
production of molecular mediator involved in inflammatory response GO:0002532 21 0.751
positive regulation of interleukin 6 biosynthetic process GO:0045410 6 0.751
regulation of branching involved in salivary gland morphogenesis GO:0060693 11 0.750
positive regulation of heat generation GO:0031652 7 0.747
signal transduction in absence of ligand GO:0038034 55 0.747
compound eye development GO:0048749 1 0.742
branching involved in salivary gland morphogenesis GO:0060445 26 0.736
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.735
regulation of homeostatic process GO:0032844 182 0.733

Tnf disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org