IMP

Process View

Mus musculus

27 genes annotated in mouse

activation of cysteine type endopeptidase activity involved in apoptotic process

Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "activation of cysteine type endopeptidase activity involved in apoptotic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "activation of cysteine type endopeptidase activity involved in apoptotic process" (in gray)

Name	Description	Probability	Func Analog Organism
Trp53	transformation related protein 53	0.981	Fly
Tnf	tumor necrosis factor	0.979
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.833	Mouse Fly
Kit	kit oncogene	0.687
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.640	Human
Lepr	leptin receptor	0.487
Pycard	PYD and CARD domain containing	0.397
Casp1	caspase 1	0.365	Mouse Fly
Rb1	retinoblastoma 1	0.318
Stat5a	signal transducer and activator of transcription 5A	0.303	Mouse
Igh	immunoglobulin heavy chain complex	0.289
Ikzf1	IKAROS family zinc finger 1	0.262
Bcl2	B-cell leukemia/lymphoma 2	0.259	Mouse
Skil	SKI-like	0.249
Fas	Fas (TNF receptor superfamily member 6)	0.240
Vhl	von Hippel-Lindau tumor suppressor	0.199
Cd44	CD44 antigen	0.185
Gbp5	guanylate binding protein 5	0.176
Bax	BCL2-associated X protein	0.171
Mcl1	myeloid cell leukemia sequence 1	0.163	Mouse
Lyz2	lysozyme 2	0.163
S100a9	S100 calcium binding protein A9 (calgranulin B)	0.162	Human
Il2rg	interleukin 2 receptor, gamma chain	0.140
Stat5b	signal transducer and activator of transcription 5B	0.127	Mouse
Fadd	Fas (TNFRSF6)-associated via death domain	0.127
Xiap	X-linked inhibitor of apoptosis	0.123
Rara	retinoic acid receptor, alpha	0.120
Ptpn2	protein tyrosine phosphatase, non-receptor type 2	0.119
Pten	phosphatase and tensin homolog	0.119
Irf9	interferon regulatory factor 9	0.103
Cxcr5	chemokine (C-X-C motif) receptor 5	0.103
Il1r1	interleukin 1 receptor, type I	0.103
Elavl1	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	0.100
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.090
Ptgs2	prostaglandin-endoperoxide synthase 2	0.087
Myd88	myeloid differentiation primary response gene 88	0.082
Mdm4	transformed mouse 3T3 cell double minute 4	0.080
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.078
Il2rb	interleukin 2 receptor, beta chain	0.077
Hspe1	heat shock protein 1 (chaperonin 10)	0.075
Ngp	neutrophilic granule protein	0.072
Il2	interleukin 2	0.070
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.070
Rbl1	retinoblastoma-like 1 (p107)	0.069
Trp73	transformation related protein 73	0.068	Fly
Coro1b	coronin, actin binding protein 1B	0.068
Jak2	Janus kinase 2	0.066
Socs1	suppressor of cytokine signaling 1	0.065
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.065
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.064
Il10	interleukin 10	0.060
S100a8	S100 calcium binding protein A8 (calgranulin A)	0.059	Human
Il6st	interleukin 6 signal transducer	0.055
Aim2	absent in melanoma 2	0.055
Tgfb1	transforming growth factor, beta 1	0.055
Ncoa3	nuclear receptor coactivator 3	0.055
Casp3	caspase 3	0.054	Mouse
Pmaip1	phorbol-12-myristate-13-acetate-induced protein 1	0.053
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.053	Human
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.052
Id2	inhibitor of DNA binding 2	0.052
Notch1	Notch gene homolog 1 (Drosophila)	0.052
Ptprc	protein tyrosine phosphatase, receptor type, C	0.052
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.050
Il7	interleukin 7	0.049
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.049
Il4ra	interleukin 4 receptor, alpha	0.049
Mfn2	mitofusin 2	0.047
Trim21	tripartite motif-containing 21	0.047
Wt1	Wilms tumor 1 homolog	0.046
Ilk	integrin linked kinase	0.045
Notch2	Notch gene homolog 2 (Drosophila)	0.044
Daxx	Fas death domain-associated protein	0.043
Stat2	signal transducer and activator of transcription 2	0.043	Mouse
Hif1a	hypoxia inducible factor 1, alpha subunit	0.043
Psen1	presenilin 1	0.042
Wwox	WW domain-containing oxidoreductase	0.042
Bak1	BCL2-antagonist/killer 1	0.041
Huwe1	HECT, UBA and WWE domain containing 1	0.041
Arhgap1	Rho GTPase activating protein 1	0.041
Stat3	signal transducer and activator of transcription 3	0.040	Mouse
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.040	Mouse
Emx1	empty spiracles homolog 1 (Drosophila)	0.040
Lyst	lysosomal trafficking regulator	0.039
Mdm2	transformed mouse 3T3 cell double minute 2	0.039
Wdr1	WD repeat domain 1	0.038
Ppp1cc	protein phosphatase 1, catalytic subunit, gamma isoform	0.038
Ptch2	patched homolog 2	0.038
E2f1	E2F transcription factor 1	0.037
Tlr4	toll-like receptor 4	0.037
Sqstm1	sequestosome 1	0.037
Pold4	polymerase (DNA-directed), delta 4	0.036
Casp7	caspase 7	0.036	Mouse
Ahr	aryl-hydrocarbon receptor	0.036
Bcl2l1	BCL2-like 1	0.035	Mouse
Ar	androgen receptor	0.035
Esr1	estrogen receptor 1 (alpha)	0.035
Ep300	E1A binding protein p300	0.033
Rps3	ribosomal protein S3	0.033
Ltb	lymphotoxin B	0.033
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.033
Wrn	Werner syndrome homolog (human)	0.032
Prf1	perforin 1 (pore forming protein)	0.032
Cyld	cylindromatosis (turban tumor syndrome)	0.032
Sirt1	sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)	0.031
Irf1	interferon regulatory factor 1	0.031
Mcm4	minichromosome maintenance deficient 4 homolog (S. cerevisiae)	0.031
Apaf1	apoptotic peptidase activating factor 1	0.030
Tcrd	T-cell receptor delta chain	0.030
Ifng	interferon gamma	0.030
Slit3	slit homolog 3 (Drosophila)	0.030
Robo2	roundabout homolog 2 (Drosophila)	0.030
Prlr	prolactin receptor	0.030
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.029
Ccrl2	chemokine (C-C motif) receptor-like 2	0.029
Mapk14	mitogen-activated protein kinase 14	0.029
Tcf3	transcription factor 3	0.028
Runx1	runt related transcription factor 1	0.027
Fgfr2	fibroblast growth factor receptor 2	0.027
Apc	adenomatosis polyposis coli	0.027
Cdk4	cyclin-dependent kinase 4	0.027
Cdkn2d	cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)	0.027
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.026
Card11	caspase recruitment domain family, member 11	0.026
Ooep	oocyte expressed protein homolog (dog)	0.026
Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	0.026
Lta	lymphotoxin A	0.025	Mouse
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.025
Cd40	CD40 antigen	0.025
Lif	leukemia inhibitory factor	0.024
0610031J06Rik	RIKEN cDNA 0610031J06 gene	0.024
Il15	interleukin 15	0.024
Timm23	translocase of inner mitochondrial membrane 23 homolog (yeast)	0.024
Nog	noggin	0.024
Bsg	basigin	0.024
Ergic3	ERGIC and golgi 3	0.024
Capn1	calpain 1	0.023
Rttn	rotatin	0.023
Mapk3	mitogen-activated protein kinase 3	0.023
Camp	cathelicidin antimicrobial peptide	0.022
Add1	adducin 1 (alpha)	0.022
Mitf	microphthalmia-associated transcription factor	0.022
Tcra	T-cell receptor alpha chain	0.022
Hhat	hedgehog acyltransferase	0.022
Rpl8	ribosomal protein L8	0.022
Ets1	E26 avian leukemia oncogene 1, 5' domain	0.021
Hoxa10	homeobox A10	0.021
Stat1	signal transducer and activator of transcription 1	0.021
Il18	interleukin 18	0.021
Csf1	colony stimulating factor 1 (macrophage)	0.021
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.020
Tapbp	TAP binding protein	0.020
Cdk6	cyclin-dependent kinase 6	0.020
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.020
Myo1e	myosin IE	0.020
Rxra	retinoid X receptor alpha	0.020
Spna1	spectrin alpha 1	0.020
Nfya	nuclear transcription factor-Y alpha	0.019
Spg21	spastic paraplegia 21 homolog (human)	0.019
Esr2	estrogen receptor 2 (beta)	0.019
Cftr	cystic fibrosis transmembrane conductance regulator homolog	0.019
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.019
Gipc1	GIPC PDZ domain containing family, member 1	0.019
Itga3	integrin alpha 3	0.019
Socs5	suppressor of cytokine signaling 5	0.019
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.019
Vegfa	vascular endothelial growth factor A	0.019
Nphp4	nephronophthisis 4 (juvenile) homolog (human)	0.019
Cycs	cytochrome c, somatic	0.019
Uba7	ubiquitin-like modifier activating enzyme 7	0.019
Tcfcp2l1	transcription factor CP2-like 1	0.019
Ikbkg	inhibitor of kappaB kinase gamma	0.018
Adam17	a disintegrin and metallopeptidase domain 17	0.018
Utf1	undifferentiated embryonic cell transcription factor 1	0.018
Max	Max protein	0.018
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.018
Ywhaq	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.018
Nos2	nitric oxide synthase 2, inducible	0.018
Msh2	mutS homolog 2 (E. coli)	0.018
Adar	adenosine deaminase, RNA-specific	0.018
Trp63	transformation related protein 63	0.018	Fly
Cs	citrate synthase	0.018
Ccnd1	cyclin D1	0.017
Mpv17	MpV17 mitochondrial inner membrane protein	0.017
Itga1	integrin alpha 1	0.017
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.017
Bbc3	BCL2 binding component 3	0.017
Gabarap	gamma-aminobutyric acid receptor associated protein	0.017
Vav2	vav 2 oncogene	0.017
Hes5	hairy and enhancer of split 5 (Drosophila)	0.017
Tgif1	TGFB-induced factor homeobox 1	0.017
Dll1	delta-like 1 (Drosophila)	0.017
Tor3a	torsin family 3, member A	0.017
Ptch1	patched homolog 1	0.016
Emx2	empty spiracles homolog 2 (Drosophila)	0.016
Plxna1	plexin A1	0.016
Pml	promyelocytic leukemia	0.016
Mybl2	myeloblastosis oncogene-like 2	0.016
Atp5g3	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)	0.016
Bid	BH3 interacting domain death agonist	0.016
Ikbkb	inhibitor of kappaB kinase beta	0.016
Siae	sialic acid acetylesterase	0.016
Il1b	interleukin 1 beta	0.016
Gzmb	granzyme B	0.016
Pld3	phospholipase D family, member 3	0.016
Drd4	dopamine receptor D4	0.016
Nucb1	nucleobindin 1	0.016
Txndc17	thioredoxin domain containing 17	0.016
Fuca1	fucosidase, alpha-L- 1, tissue	0.015
Socs3	suppressor of cytokine signaling 3	0.015
Ccl4	chemokine (C-C motif) ligand 4	0.015
Timm8a1	translocase of inner mitochondrial membrane 8 homolog a1 (yeast)	0.015
Mov10	Moloney leukemia virus 10	0.015
Becn1	beclin 1, autophagy related	0.015
Hrh2	histamine receptor H2	0.015
Tgfbr1	transforming growth factor, beta receptor I	0.015
Hdac6	histone deacetylase 6	0.015
Atm	ataxia telangiectasia mutated homolog (human)	0.015
Lgals9	lectin, galactose binding, soluble 9	0.015
Vdr	vitamin D receptor	0.015
Cd8a	CD8 antigen, alpha chain	0.015
Ctnnb1	catenin (cadherin associated protein), beta 1	0.015
Tfrc	transferrin receptor	0.015
Hmgn1	high mobility group nucleosomal binding domain 1	0.015
Hes1	hairy and enhancer of split 1 (Drosophila)	0.015
Pcbp1	poly(rC) binding protein 1	0.015
Mfsd1	major facilitator superfamily domain containing 1	0.015
Nfe2l2	nuclear factor, erythroid derived 2, like 2	0.015
Aip	aryl-hydrocarbon receptor-interacting protein	0.015
2410004A20Rik	RIKEN cDNA 2410004A20 gene	0.014
H2-T24	histocompatibility 2, T region locus 24	0.014
Nos3	nitric oxide synthase 3, endothelial cell	0.014
Stx11	syntaxin 11	0.014
Cd47	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	0.014
Cd4	CD4 antigen	0.014
Ikzf3	IKAROS family zinc finger 3	0.014
Il22	interleukin 22	0.014
Tcrb	T-cell receptor beta chain	0.014
BC017643	cDNA sequence BC017643	0.014
Anxa4	annexin A4	0.014
Gnptab	N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits	0.014
Vdac2	voltage-dependent anion channel 2	0.014
P2rx3	purinergic receptor P2X, ligand-gated ion channel, 3	0.014	Mouse
Ccr1	chemokine (C-C motif) receptor 1	0.014
Crtap	cartilage associated protein	0.014
P2rx2	purinergic receptor P2X, ligand-gated ion channel, 2	0.014	Mouse
Ssrp1	structure specific recognition protein 1	0.014
Cxcr4	chemokine (C-X-C motif) receptor 4	0.014
Rpl7a	ribosomal protein L7A	0.014
Rras	Harvey rat sarcoma oncogene, subgroup R	0.014
Timm22	translocase of inner mitochondrial membrane 22 homolog (yeast)	0.014
Mtor	mechanistic target of rapamycin (serine/threonine kinase)	0.014
Anxa7	annexin A7	0.014
Gcsh	glycine cleavage system protein H (aminomethyl carrier)	0.014
Cd81	CD81 antigen	0.013
Agpat2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	0.013
Xcl1	chemokine (C motif) ligand 1	0.013
Btk	Bruton agammaglobulinemia tyrosine kinase	0.013
Dkc1	dyskeratosis congenita 1, dyskerin homolog (human)	0.013
Fndc7	fibronectin type III domain containing 7	0.013
Ltb4r1	leukotriene B4 receptor 1	0.013
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.013
Tnfsf10	tumor necrosis factor (ligand) superfamily, member 10	0.013	Mouse
Gna15	guanine nucleotide binding protein, alpha 15	0.013
St6galnac3	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	0.013
Csf2rb2	colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)	0.013
Cdx2	caudal type homeobox 2	0.013
Men1	multiple endocrine neoplasia 1	0.013
Wls	wntless homolog (Drosophila)	0.013
Cd28	CD28 antigen	0.013
Gli2	GLI-Kruppel family member GLI2	0.013
Src	Rous sarcoma oncogene	0.012
Foxn1	forkhead box N1	0.012
Gbp7	guanylate binding protein 7	0.012
Rnf115	ring finger protein 115	0.012
Sfpi1	SFFV proviral integration 1	0.012
Foxp1	forkhead box P1	0.012
Hspa9	heat shock protein 9	0.012
Cyb5r3	cytochrome b5 reductase 3	0.012
Foxo3	forkhead box O3	0.012
Terf1	telomeric repeat binding factor 1	0.012
Pou2af1	POU domain, class 2, associating factor 1	0.012
Nf1	neurofibromatosis 1	0.012
Slc6a4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.012
Abcc6	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	0.012
Ercc1	excision repair cross-complementing rodent repair deficiency, complementation group 1	0.012
Adrb3	adrenergic receptor, beta 3	0.012
Nedd9	neural precursor cell expressed, developmentally down-regulated gene 9	0.012
Smad3	MAD homolog 3 (Drosophila)	0.012	Human Rat
Casr	calcium-sensing receptor	0.012
Psap	prosaposin	0.012
Pdgfb	platelet derived growth factor, B polypeptide	0.012
Slfn4	schlafen 4	0.012
Crkl	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	0.012
F2rl2	coagulation factor II (thrombin) receptor-like 2	0.012
Irf8	interferon regulatory factor 8	0.012
Aire	autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)	0.012
Myb	myeloblastosis oncogene	0.012
Tm4sf1	transmembrane 4 superfamily member 1	0.012
Zp3	zona pellucida glycoprotein 3	0.012
Ltf	lactotransferrin	0.012
Irf4	interferon regulatory factor 4	0.011
Polr2a	polymerase (RNA) II (DNA directed) polypeptide A	0.011
Atp6v0d1	ATPase, H+ transporting, lysosomal V0 subunit D1	0.011
Hoxd11	homeobox D11	0.011
Ifngr2	interferon gamma receptor 2	0.011
Chi3l3	chitinase 3-like 3	0.011
Ccndbp1	cyclin D-type binding-protein 1	0.011
Bag1	BCL2-associated athanogene 1	0.011
Nsfl1c	NSFL1 (p97) cofactor (p47)	0.011
Flot2	flotillin 2	0.011
Inpp5d	inositol polyphosphate-5-phosphatase D	0.011
Cxcl13	chemokine (C-X-C motif) ligand 13	0.011
Sat1	spermidine/spermine N1-acetyl transferase 1	0.011
Zeb1	zinc finger E-box binding homeobox 1	0.011
Gar1	GAR1 ribonucleoprotein homolog (yeast)	0.011
Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.011
Nphs2	nephrosis 2 homolog, podocin (human)	0.011
Necap2	NECAP endocytosis associated 2	0.011
Ren1	renin 1 structural	0.011
Smarcd1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.011
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.011
March5	membrane-associated ring finger (C3HC4) 5	0.011
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.011
Klf6	Kruppel-like factor 6	0.011
Hprt	hypoxanthine guanine phosphoribosyl transferase	0.011
Rc3h1	RING CCCH (C3H) domains 1	0.011
Mapk8	mitogen-activated protein kinase 8	0.011
Cdk2	cyclin-dependent kinase 2	0.011
Sfn	stratifin	0.011
Arpc1a	actin related protein 2/3 complex, subunit 1A	0.011
Prss30	protease, serine, 30	0.011
Dppa5a	developmental pluripotency associated 5A	0.011
Gadd45a	growth arrest and DNA-damage-inducible 45 alpha	0.011
S1pr2	sphingosine-1-phosphate receptor 2	0.011
Mrps33	mitochondrial ribosomal protein S33	0.011
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.011
Fgf3	fibroblast growth factor 3	0.011
Exoc6	exocyst complex component 6	0.011
Irgm2	immunity-related GTPase family M member 2	0.011
Trim26	tripartite motif-containing 26	0.011
Htt	huntingtin	0.011
Tnfrsf13c	tumor necrosis factor receptor superfamily, member 13c	0.011
Nhej1	nonhomologous end-joining factor 1	0.011
Ifnar2	interferon (alpha and beta) receptor 2	0.011
Polm	polymerase (DNA directed), mu	0.010
Cd38	CD38 antigen	0.010
Cdh1	cadherin 1	0.010
Robo1	roundabout homolog 1 (Drosophila)	0.010	Human
Lag3	lymphocyte-activation gene 3	0.010
Inpp5k	inositol polyphosphate 5-phosphatase K	0.010
Il12rb2	interleukin 12 receptor, beta 2	0.010
Atp6v0b	ATPase, H+ transporting, lysosomal V0 subunit B	0.010
Ncr1	natural cytotoxicity triggering receptor 1	0.010
Ret	ret proto-oncogene	0.010	Human
Ccl22	chemokine (C-C motif) ligand 22	0.010
AW112010	expressed sequence AW112010	0.010
Helb	helicase (DNA) B	0.010
Foxp3	forkhead box P3	0.010
Serpinb9	serine (or cysteine) peptidase inhibitor, clade B, member 9	0.010
Lgals8	lectin, galactose binding, soluble 8	0.010
Tnfsf8	tumor necrosis factor (ligand) superfamily, member 8	0.010
Cbl	Casitas B-lineage lymphoma	0.010
Slit2	slit homolog 2 (Drosophila)	0.010
Mknk1	MAP kinase-interacting serine/threonine kinase 1	0.010
Jak3	Janus kinase 3	0.010	Mouse
Sod2	superoxide dismutase 2, mitochondrial	0.010
Ufd1l	ubiquitin fusion degradation 1 like	0.010
Pim1	proviral integration site 1	0.010
Tax1bp3	Tax1 (human T-cell leukemia virus type I) binding protein 3	0.010
Sox2	SRY-box containing gene 2	0.010
Herc6	hect domain and RLD 6	0.010