IMP
Process View
negative regulation of alkaline phosphatase activity
Any process that decreases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.
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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of alkaline phosphatase activity"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| Map3k14 | mitogen-activated protein kinase kinase kinase 14 | 0.962 | ||
| Tnf | tumor necrosis factor | 0.900 | ||
| Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.568 | ||
| Lta | lymphotoxin A | 0.378 | Mouse | |
| Ifng | interferon gamma | 0.180 | ||
| Pik3cd | phosphatidylinositol 3-kinase catalytic delta polypeptide | 0.138 | ||
| Ltb | lymphotoxin B | 0.097 | ||
| Il7 | interleukin 7 | 0.088 | ||
| Cxcr5 | chemokine (C-X-C motif) receptor 5 | 0.086 | ||
| Tox | thymocyte selection-associated high mobility group box | 0.070 | ||
| Il10 | interleukin 10 | 0.070 | ||
| Srrm4 | serine/arginine repetitive matrix 4 | 0.065 | ||
| Cxcl13 | chemokine (C-X-C motif) ligand 13 | 0.065 | ||
| Tnfsf14 | tumor necrosis factor (ligand) superfamily, member 14 | 0.052 | Mouse | |
| Dlg4 | discs, large homolog 4 (Drosophila) | 0.046 | ||
| Ikzf1 | IKAROS family zinc finger 1 | 0.036 | ||
| Cd19 | CD19 antigen | 0.034 | ||
| Il4 | interleukin 4 | 0.032 | ||
| Icos | inducible T-cell co-stimulator | 0.031 | ||
| Kcnq1 | potassium voltage-gated channel, subfamily Q, member 1 | 0.029 | ||
| Pou2af1 | POU domain, class 2, associating factor 1 | 0.029 | ||
| Ptgs2 | prostaglandin-endoperoxide synthase 2 | 0.026 | ||
| Tnfsf11 | tumor necrosis factor (ligand) superfamily, member 11 | 0.025 | Mouse | |
| Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 0.024 | ||
| Plxna4 | plexin A4 | 0.023 | ||
| Prrx1 | paired related homeobox 1 | 0.022 | ||
| Cd28 | CD28 antigen | 0.022 | ||
| Atp1b2 | ATPase, Na+/K+ transporting, beta 2 polypeptide | 0.021 | ||
| Cdh23 | cadherin 23 (otocadherin) | 0.020 | ||
| Grxcr1 | glutaredoxin, cysteine rich 1 | 0.019 | ||
| Tgfa | transforming growth factor alpha | 0.019 | ||
| Igh | immunoglobulin heavy chain complex | 0.018 | ||
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.018 | ||
| Dtna | dystrobrevin alpha | 0.017 | ||
| Il15 | interleukin 15 | 0.017 | ||
| Il2 | interleukin 2 | 0.016 | ||
| Tcf3 | transcription factor 3 | 0.016 | ||
| Vdr | vitamin D receptor | 0.016 | ||
| Ikbkg | inhibitor of kappaB kinase gamma | 0.016 | ||
| Pxdn | peroxidasin homolog (Drosophila) | 0.015 | ||
| Mmp15 | matrix metallopeptidase 15 | 0.015 | ||
| Pstpip1 | proline-serine-threonine phosphatase-interacting protein 1 | 0.015 | ||
| Cd40 | CD40 antigen | 0.015 | ||
| Cd40lg | CD40 ligand | 0.014 | Mouse | |
| Zfpm2 | zinc finger protein, multitype 2 | 0.014 | ||
| Utf1 | undifferentiated embryonic cell transcription factor 1 | 0.014 | ||
| Epha4 | Eph receptor A4 | 0.014 | ||
| Etl4 | enhancer trap locus 4 | 0.014 | ||
| Batf2 | basic leucine zipper transcription factor, ATF-like 2 | 0.014 | ||
| Pou4f3 | POU domain, class 4, transcription factor 3 | 0.014 | ||
| Foxc1 | forkhead box C1 | 0.013 | ||
| Lgr4 | leucine-rich repeat-containing G protein-coupled receptor 4 | 0.013 | ||
| Bmp5 | bone morphogenetic protein 5 | 0.013 | ||
| Rab25 | RAB25, member RAS oncogene family | 0.013 | ||
| Epha3 | Eph receptor A3 | 0.013 | ||
| Sema3c | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.013 | ||
| Tnfrsf11a | tumor necrosis factor receptor superfamily, member 11a | 0.012 | ||
| Il22 | interleukin 22 | 0.012 | ||
| Jag1 | jagged 1 | 0.012 | ||
| Trhr2 | thyrotropin releasing hormone receptor 2 | 0.012 | ||
| Ednrb | endothelin receptor type B | 0.012 | ||
| Aicda | activation-induced cytidine deaminase | 0.012 | ||
| Id2 | inhibitor of DNA binding 2 | 0.012 | ||
| Rag1 | recombination activating gene 1 | 0.012 | ||
| Slc28a3 | solute carrier family 28 (sodium-coupled nucleoside transporter), member 3 | 0.012 | ||
| Nos2 | nitric oxide synthase 2, inducible | 0.011 | ||
| Mid2 | midline 2 | 0.011 | ||
| Slc12a8 | solute carrier family 12 (potassium/chloride transporters), member 8 | 0.011 | ||
| 2210407C18Rik | RIKEN cDNA 2210407C18 gene | 0.011 | ||
| Xcr1 | chemokine (C motif) receptor 1 | 0.011 | ||
| Efna1 | ephrin A1 | 0.011 | ||
| Sh2d2a | SH2 domain protein 2A | 0.011 | ||
| Plxna1 | plexin A1 | 0.011 | ||
| Slc23a3 | solute carrier family 23 (nucleobase transporters), member 3 | 0.011 | ||
| Prf1 | perforin 1 (pore forming protein) | 0.011 | ||
| D730039F16Rik | RIKEN cDNA D730039F16 gene | 0.011 | ||
| Klk7 | kallikrein related-peptidase 7 (chymotryptic, stratum corneum) | 0.011 | ||
| Clip2 | CAP-GLY domain containing linker protein 2 | 0.011 | ||
| Psp | parotid secretory protein | 0.011 | ||
| Sprr2a2 | small proline-rich protein 2A2 | 0.011 | ||
| Plcg1 | phospholipase C, gamma 1 | 0.011 | ||
| Fas | Fas (TNF receptor superfamily member 6) | 0.011 | ||
| Tll1 | tolloid-like | 0.011 | ||
| Angpt1 | angiopoietin 1 | 0.011 | ||
| Adam19 | a disintegrin and metallopeptidase domain 19 (meltrin beta) | 0.011 | ||
| Gnaq | guanine nucleotide binding protein, alpha q polypeptide | 0.011 | ||
| Zbp1 | Z-DNA binding protein 1 | 0.010 | ||
| Il2rg | interleukin 2 receptor, gamma chain | 0.010 | ||
| Casp4 | caspase 4, apoptosis-related cysteine peptidase | 0.010 | ||
| Itk | IL2-inducible T-cell kinase | 0.010 | ||
| Fgf7 | fibroblast growth factor 7 | 0.010 | ||
| Tlr4 | toll-like receptor 4 | 0.010 | ||
| Muc1 | mucin 1, transmembrane | 0.010 | ||
| Ror1 | receptor tyrosine kinase-like orphan receptor 1 | 0.010 | ||
| Kcna6 | potassium voltage-gated channel, shaker-related, subfamily, member 6 | 0.010 | ||
| Il6 | interleukin 6 | 0.010 | ||
| Tubb4 | tubulin, beta 4 | 0.010 |