IMP

Process View

Mus musculus

2 genes annotated in mouse

Multi-species View

negative regulation of interleukin 10 secretion

GO:2001180

Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-10 secretion.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of interleukin 10 secretion"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of interleukin 10 secretion" (in gray)

Name	Description	Probability	Func Analog Organism
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.999
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.999
Tnf	tumor necrosis factor	0.998
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.938
Lta	lymphotoxin A	0.898
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.789
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.761
Traf2	TNF receptor-associated factor 2	0.760
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.696
Traf6	TNF receptor-associated factor 6	0.607
Bcl3	B-cell leukemia/lymphoma 3	0.604
Il1r1	interleukin 1 receptor, type I	0.600
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.584
Nos2	nitric oxide synthase 2, inducible	0.529
Ifng	interferon gamma	0.526
Socs1	suppressor of cytokine signaling 1	0.490
Il4	interleukin 4	0.472
Ccl4	chemokine (C-C motif) ligand 4	0.386
Ccl2	chemokine (C-C motif) ligand 2	0.311
Cd40	CD40 antigen	0.273	Mouse
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.250	Mouse
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.242
Ptgs2	prostaglandin-endoperoxide synthase 2	0.233
S1pr2	sphingosine-1-phosphate receptor 2	0.228
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.221
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.217
Sh2d2a	SH2 domain protein 2A	0.212
Pdcd1	programmed cell death 1	0.210
Il4ra	interleukin 4 receptor, alpha	0.167
Prkcd	protein kinase C, delta	0.164
Csf1	colony stimulating factor 1 (macrophage)	0.128
Batf	basic leucine zipper transcription factor, ATF-like	0.115
Tnfrsf4	tumor necrosis factor receptor superfamily, member 4	0.114
Snai1	snail homolog 1 (Drosophila)	0.102
Btk	Bruton agammaglobulinemia tyrosine kinase	0.100
Mvp	major vault protein	0.097
Ltb	lymphotoxin B	0.092
Fas	Fas (TNF receptor superfamily member 6)	0.092
Il1rn	interleukin 1 receptor antagonist	0.089
Il12b	interleukin 12b	0.089
Stat3	signal transducer and activator of transcription 3	0.085
Ltbr	lymphotoxin B receptor	0.085	Mouse
Myd88	myeloid differentiation primary response gene 88	0.083
Itga5	integrin alpha 5 (fibronectin receptor alpha)	0.080
Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105	0.069
Plaur	plasminogen activator, urokinase receptor	0.063
Icos	inducible T-cell co-stimulator	0.062
Csf2	colony stimulating factor 2 (granulocyte-macrophage)	0.061
Vav2	vav 2 oncogene	0.060
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.059
Il10	interleukin 10	0.055
Prss30	protease, serine, 30	0.052
Plod3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3	0.052
Ubtd1	ubiquitin domain containing 1	0.052
Siglece	sialic acid binding Ig-like lectin E	0.051
Bdkrb1	bradykinin receptor, beta 1	0.050
Traf1	TNF receptor-associated factor 1	0.048
Gzmb	granzyme B	0.046
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.044
Il12rb1	interleukin 12 receptor, beta 1	0.042
Cd19	CD19 antigen	0.039
Ccl17	chemokine (C-C motif) ligand 17	0.037
Il10ra	interleukin 10 receptor, alpha	0.035
Ptges	prostaglandin E synthase	0.035
Inpp5d	inositol polyphosphate-5-phosphatase D	0.035
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.034
Lrp10	low-density lipoprotein receptor-related protein 10	0.034
Ccrl2	chemokine (C-C motif) receptor-like 2	0.033
Il6	interleukin 6	0.033
Zbtb7b	zinc finger and BTB domain containing 7B	0.033
Omp	olfactory marker protein	0.032
Irf4	interferon regulatory factor 4	0.031
Gpr132	G protein-coupled receptor 132	0.031
Birc3	baculoviral IAP repeat-containing 3	0.029
Pou2af1	POU domain, class 2, associating factor 1	0.028
Junb	Jun-B oncogene	0.028
Rel	reticuloendotheliosis oncogene	0.027
Mapkapk2	MAP kinase-activated protein kinase 2	0.027
H6pd	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	0.026
Il2rb	interleukin 2 receptor, beta chain	0.026
Tnip1	TNFAIP3 interacting protein 1	0.025
Zc3h12a	zinc finger CCCH type containing 12A	0.025
Mcoln2	mucolipin 2	0.025
Litaf	LPS-induced TN factor	0.025
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.025
Ctsk	cathepsin K	0.024
Il2rg	interleukin 2 receptor, gamma chain	0.024
Bcl6	B-cell leukemia/lymphoma 6	0.024
Mefv	Mediterranean fever	0.024
Cst7	cystatin F (leukocystatin)	0.023
Cd6	CD6 antigen	0.023
Cd300lf	CD300 antigen like family member F	0.023
Rgs9	regulator of G-protein signaling 9	0.022
Atf5	activating transcription factor 5	0.022
Rab20	RAB20, member RAS oncogene family	0.022
Pdcd1lg2	programmed cell death 1 ligand 2	0.022
Lag3	lymphocyte-activation gene 3	0.022
Ikbkg	inhibitor of kappaB kinase gamma	0.022
Furin	furin (paired basic amino acid cleaving enzyme)	0.022
Prf1	perforin 1 (pore forming protein)	0.021
Zfp36	zinc finger protein 36	0.021
Gdf15	growth differentiation factor 15	0.020
Adora2b	adenosine A2b receptor	0.020
Rhod	ras homolog gene family, member D	0.020
Rhog	ras homolog gene family, member G	0.020
Ccr7	chemokine (C-C motif) receptor 7	0.020
Rhoc	ras homolog gene family, member C	0.019
Il1r2	interleukin 1 receptor, type II	0.019
Traf3	TNF receptor-associated factor 3	0.019
Pvrl2	poliovirus receptor-related 2	0.019
Ern1	endoplasmic reticulum (ER) to nucleus signalling 1	0.019
Actn4	actinin alpha 4	0.019
Spp1	secreted phosphoprotein 1	0.019
Irak1	interleukin-1 receptor-associated kinase 1	0.019
Plekho2	pleckstrin homology domain containing, family O member 2	0.019
Ch25h	cholesterol 25-hydroxylase	0.018
Dusp2	dual specificity phosphatase 2	0.018
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.018
Irf5	interferon regulatory factor 5	0.018
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.018
Fgf4	fibroblast growth factor 4	0.018
Creb3l1	cAMP responsive element binding protein 3-like 1	0.018
Trem1	triggering receptor expressed on myeloid cells 1	0.017
Tgm2	transglutaminase 2, C polypeptide	0.017
Ubd	ubiquitin D	0.017
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.017
Elf3	E74-like factor 3	0.017
Hrh2	histamine receptor H2	0.017
Jak3	Janus kinase 3	0.017
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.017	Mouse
Cxcl1	chemokine (C-X-C motif) ligand 1	0.017
Cd40lg	CD40 ligand	0.017
Arrdc1	arrestin domain containing 1	0.017
Bak1	BCL2-antagonist/killer 1	0.017
Gast	gastrin	0.017
Lama5	laminin, alpha 5	0.017
Acvrl1	activin A receptor, type II-like 1	0.016
Lif	leukemia inhibitory factor	0.016
Madcam1	mucosal vascular addressin cell adhesion molecule 1	0.016
Arid3a	AT rich interactive domain 3A (BRIGHT-like)	0.016
Sprr1a	small proline-rich protein 1A	0.016
Nek6	NIMA (never in mitosis gene a)-related expressed kinase 6	0.016
Slc12a4	solute carrier family 12, member 4	0.016
Ccl22	chemokine (C-C motif) ligand 22	0.016
Col6a2	collagen, type VI, alpha 2	0.016
Cxcl13	chemokine (C-X-C motif) ligand 13	0.015
Ciita	class II transactivator	0.015
Muc1	mucin 1, transmembrane	0.015
Mxd1	MAX dimerization protein 1	0.015
Slc7a11	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	0.015
Qsox1	quiescin Q6 sulfhydryl oxidase 1	0.015
Mapk13	mitogen-activated protein kinase 13	0.015
Fasl	Fas ligand (TNF superfamily, member 6)	0.015
Nucb1	nucleobindin 1	0.014
Cacna1f	calcium channel, voltage-dependent, alpha 1F subunit	0.014
Renbp	renin binding protein	0.014
Cabp4	calcium binding protein 4	0.014
Mgat1	mannoside acetylglucosaminyltransferase 1	0.013
Irg1	immunoresponsive gene 1	0.013
Zfp865	zinc finger protein 865	0.013
Icam1	intercellular adhesion molecule 1	0.013
Tlr9	toll-like receptor 9	0.013
Adam8	a disintegrin and metallopeptidase domain 8	0.013
Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.013
Ccl7	chemokine (C-C motif) ligand 7	0.013
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.013
F2rl3	coagulation factor II (thrombin) receptor-like 3	0.013
Ticam1	toll-like receptor adaptor molecule 1	0.013
Igfbp7	insulin-like growth factor binding protein 7	0.013
Lima1	LIM domain and actin binding 1	0.012
Acap1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	0.012
Batf2	basic leucine zipper transcription factor, ATF-like 2	0.012
Cxcl2	chemokine (C-X-C motif) ligand 2	0.012
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.012
Ppard	peroxisome proliferator activator receptor delta	0.012
F7	coagulation factor VII	0.012
Spsb2	splA/ryanodine receptor domain and SOCS box containing 2	0.012
Elf4	E74-like factor 4 (ets domain transcription factor)	0.012
Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.012
Gpr33	G protein-coupled receptor 33	0.012
Mov10	Moloney leukemia virus 10	0.012
Tnfrsf23	tumor necrosis factor receptor superfamily, member 23	0.012
Fes	feline sarcoma oncogene	0.012
Tnfrsf18	tumor necrosis factor receptor superfamily, member 18	0.011	Mouse
Plau	plasminogen activator, urokinase	0.011
Anpep	alanyl (membrane) aminopeptidase	0.011
Kcnn3	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	0.011
Apoe	apolipoprotein E	0.011
Stx11	syntaxin 11	0.011
B4galt1	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	0.011
Fosl2	fos-like antigen 2	0.011
Tagln2	transgelin 2	0.011
Ccr8	chemokine (C-C motif) receptor 8	0.011
Col15a1	collagen, type XV, alpha 1	0.011
Tcirg1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3	0.011
B3gnt3	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	0.011
Tgfb1	transforming growth factor, beta 1	0.011
Itga3	integrin alpha 3	0.011
Hmox1	heme oxygenase (decycling) 1	0.011
Plekhn1	pleckstrin homology domain containing, family N member 1	0.011
Fut7	fucosyltransferase 7	0.011
Emilin1	elastin microfibril interfacer 1	0.011
Pim1	proviral integration site 1	0.010
Cyld	cylindromatosis (turban tumor syndrome)	0.010
Tnfaip2	tumor necrosis factor, alpha-induced protein 2	0.010
Tnfsf18	tumor necrosis factor (ligand) superfamily, member 18	0.010
Tmc8	transmembrane channel-like gene family 8	0.010
Src	Rous sarcoma oncogene	0.010
Itga2	integrin alpha 2	0.010
Cd80	CD80 antigen	0.010
Vdr	vitamin D receptor	0.010