IMP

Process View

Homo sapiens

1 genes annotated in human

renal tubular secretion

Secretion of substances from peritubular capillaries into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "renal tubular secretion"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "renal tubular secretion" (in gray)

Name	Description	Probability	Func Analog Organism
NCR2	natural cytotoxicity triggering receptor 2	0.630
SLC28A1	solute carrier family 28 (sodium-coupled nucleoside transporter), member 1	0.627
SLC34A1	solute carrier family 34 (sodium phosphate), member 1	0.553
PRODH2	proline dehydrogenase (oxidase) 2	0.464
SLC6A13	solute carrier family 6 (neurotransmitter transporter, GABA), member 13	0.335
SLC12A3	solute carrier family 12 (sodium/chloride transporters), member 3	0.289
CST9L	cystatin 9-like	0.271
SLC22A8	solute carrier family 22 (organic anion transporter), member 8	0.185	Human
SLC17A1	solute carrier family 17 (sodium phosphate), member 1	0.144
SLC13A3	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3	0.133
CRYBB3	crystallin, beta B3	0.106
PKLR	pyruvate kinase, liver and RBC	0.088
GLYAT	glycine-N-acyltransferase	0.077
SLC6A12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12	0.068
MASP2	mannan-binding lectin serine peptidase 2	0.063
AIRE	autoimmune regulator	0.063
CRYAA	crystallin, alpha A	0.063
SLC17A3	solute carrier family 17 (sodium phosphate), member 3	0.060
C8A	complement component 8, alpha polypeptide	0.055
AGXT	alanine-glyoxylate aminotransferase	0.055
CCIN	calicin	0.051
SLC22A6	solute carrier family 22 (organic anion transporter), member 6	0.050
TREH	trehalase (brush-border membrane glycoprotein)	0.049
SHBG	sex hormone-binding globulin	0.048
RTP3	receptor (chemosensory) transporter protein 3	0.047
GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	0.046
CCL1	chemokine (C-C motif) ligand 1	0.044
FTCD	formiminotransferase cyclodeaminase	0.044
RDH16	retinol dehydrogenase 16 (all-trans)	0.044
C8B	complement component 8, beta polypeptide	0.044
DBH	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	0.043
GBA3	glucosidase, beta, acid 3 (cytosolic)	0.041
SLC1A7	solute carrier family 1 (glutamate transporter), member 7	0.040
FUT6	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)	0.040
SLC22A7	solute carrier family 22 (organic anion transporter), member 7	0.039	Human
HPX	hemopexin	0.038
NR5A1	nuclear receptor subfamily 5, group A, member 1	0.038
SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.037
UPB1	ureidopropionase, beta	0.035
C21orf62	chromosome 21 open reading frame 62	0.035
GCGR	glucagon receptor	0.035
OR2F1	olfactory receptor, family 2, subfamily F, member 1	0.035
CYP8B1	cytochrome P450, family 8, subfamily B, polypeptide 1	0.035
FOXN1	forkhead box N1	0.034
DPYS	dihydropyrimidinase	0.032
BAAT	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	0.031
HNF1B	HNF1 homeobox B	0.031
HNF4A	hepatocyte nuclear factor 4, alpha	0.030
BTNL3	butyrophilin-like 3	0.030
ALPI	alkaline phosphatase, intestinal	0.029
HPD	4-hydroxyphenylpyruvate dioxygenase	0.029
GPR31	G protein-coupled receptor 31	0.029
PROZ	protein Z, vitamin K-dependent plasma glycoprotein	0.027
FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)	0.027
HABP2	hyaluronan binding protein 2	0.026
FUT5	fucosyltransferase 5 (alpha (1,3) fucosyltransferase)	0.026
SYT11	synaptotagmin XI	0.025
DDC	dopa decarboxylase (aromatic L-amino acid decarboxylase)	0.025
CYP11B2	cytochrome P450, family 11, subfamily B, polypeptide 2	0.025
DRD2	dopamine receptor D2	0.025
XDH	xanthine dehydrogenase	0.024
KCNJ1	potassium inwardly-rectifying channel, subfamily J, member 1	0.024
RHBG	Rh family, B glycoprotein (gene/pseudogene)	0.024
ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.024
LPA	lipoprotein, Lp(a)	0.024
TEX13A	testis expressed 13A	0.023
SPATA21	spermatogenesis associated 21	0.023
ESRRB	estrogen-related receptor beta	0.023
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.023
TM4SF5	transmembrane 4 L six family member 5	0.022
HOXC8	homeobox C8	0.022
BPI	bactericidal/permeability-increasing protein	0.022
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.022
VIL1	villin 1	0.022
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	0.022
XPNPEP2	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound	0.022
IFNA6	interferon, alpha 6	0.022
C9	complement component 9	0.022
CHRND	cholinergic receptor, nicotinic, delta	0.022
RTDR1	rhabdoid tumor deletion region gene 1	0.021
GUCA2B	guanylate cyclase activator 2B (uroguanylin)	0.021
CLCNKB	chloride channel Kb	0.021
SLC13A2	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	0.021
GGTLC1	gamma-glutamyltransferase light chain 1	0.021
PROC	protein C (inactivator of coagulation factors Va and VIIIa)	0.021
LASS2	LAG1 homolog, ceramide synthase 2	0.021
AFM	afamin	0.020
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.020
CYP4F11	cytochrome P450, family 4, subfamily F, polypeptide 11	0.020
HAO2	hydroxyacid oxidase 2 (long chain)	0.020
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.020
FETUB	fetuin B	0.020
CPN2	carboxypeptidase N, polypeptide 2	0.019
ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	0.019
G6PC	glucose-6-phosphatase, catalytic subunit	0.019
NAT8B	N-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene)	0.019
FXYD2	FXYD domain containing ion transport regulator 2	0.019
UNC93A	unc-93 homolog A (C. elegans)	0.018
SLC22A2	solute carrier family 22 (organic cation transporter), member 2	0.018	Human
AQP7	aquaporin 7	0.018
CRP	C-reactive protein, pentraxin-related	0.018
GFRA4	GDNF family receptor alpha 4	0.018
ALPPL2	alkaline phosphatase, placental-like 2	0.018
CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	0.017
EPO	erythropoietin	0.017
TNNI1	troponin I type 1 (skeletal, slow)	0.017
PDZK1	PDZ domain containing 1	0.017
GRK1	G protein-coupled receptor kinase 1	0.017
SLC2A9	solute carrier family 2 (facilitated glucose transporter), member 9	0.017
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.017
UMOD	uromodulin	0.017
OTOF	otoferlin	0.017
ERN2	endoplasmic reticulum to nucleus signaling 2	0.017
ASGR2	asialoglycoprotein receptor 2	0.017
UGT1A3	UDP glucuronosyltransferase 1 family, polypeptide A3	0.016
KRT33A	keratin 33A	0.016
GIP	gastric inhibitory polypeptide	0.016
PLG	plasminogen	0.016
AGXT2	alanine--glyoxylate aminotransferase 2	0.016
WISP3	WNT1 inducible signaling pathway protein 3	0.015
CDHR5	cadherin-related family member 5	0.015
TGM5	transglutaminase 5	0.015
CST5	cystatin D	0.015
CA5A	carbonic anhydrase VA, mitochondrial	0.015
IL27	interleukin 27	0.015
FBXO40	F-box protein 40	0.015
IL1RL2	interleukin 1 receptor-like 2	0.015
HIST1H1T	histone cluster 1, H1t	0.015
DUSP13	dual specificity phosphatase 13	0.015
PRLH	prolactin releasing hormone	0.015
CCL24	chemokine (C-C motif) ligand 24	0.015
CXCR1	chemokine (C-X-C motif) receptor 1	0.014
NMUR1	neuromedin U receptor 1	0.014
NPFFR1	neuropeptide FF receptor 1	0.014
APOB	apolipoprotein B (including Ag(x) antigen)	0.014
TRPM8	transient receptor potential cation channel, subfamily M, member 8	0.014
OR10S1	olfactory receptor, family 10, subfamily S, member 1	0.014
HAAO	3-hydroxyanthranilate 3,4-dioxygenase	0.014
ABP1	amiloride binding protein 1 (amine oxidase (copper-containing))	0.014
KIF25	kinesin family member 25	0.014
SAA4	serum amyloid A4, constitutive	0.013
SLC12A1	solute carrier family 12 (sodium/potassium/chloride transporters), member 1	0.013
DSPP	dentin sialophosphoprotein	0.013
IGFALS	insulin-like growth factor binding protein, acid labile subunit	0.013
KRTAP5-8	keratin associated protein 5-8	0.013
ABO	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)	0.013
SLC38A3	solute carrier family 38, member 3	0.013
HYAL3	hyaluronoglucosaminidase 3	0.013
ASB4	ankyrin repeat and SOCS box containing 4	0.013
FSHB	follicle stimulating hormone, beta polypeptide	0.013
KCNE1	potassium voltage-gated channel, Isk-related family, member 1	0.013
GP2	glycoprotein 2 (zymogen granule membrane)	0.013
F11	coagulation factor XI	0.013
OXER1	oxoeicosanoid (OXE) receptor 1	0.013
CHRM5	cholinergic receptor, muscarinic 5	0.013
SLC22A13	solute carrier family 22 (organic anion transporter), member 13	0.013	Human
LRTM1	leucine-rich repeats and transmembrane domains 1	0.013
APOF	apolipoprotein F	0.013
FITM1	fat storage-inducing transmembrane protein 1	0.013
HCRTR1	hypocretin (orexin) receptor 1	0.013
IBSP	integrin-binding sialoprotein	0.013
SARDH	sarcosine dehydrogenase	0.013
IL1F7	interleukin 1 family, member 7 (zeta)	0.013
ABCA4	ATP-binding cassette, sub-family A (ABC1), member 4	0.013
TAC4	tachykinin 4 (hemokinin)	0.013
TBX10	T-box 10	0.013
HAMP	hepcidin antimicrobial peptide	0.012
SERPINF2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	0.012
UCP3	uncoupling protein 3 (mitochondrial, proton carrier)	0.012
AQPEP	laeverin	0.012
SPP2	secreted phosphoprotein 2, 24kDa	0.012
SEC14L2	SEC14-like 2 (S. cerevisiae)	0.012
KLK15	kallikrein-related peptidase 15	0.012
FOXI1	forkhead box I1	0.012
MYH8	myosin, heavy chain 8, skeletal muscle, perinatal	0.012
NPPA	natriuretic peptide A	0.012
HSD17B2	hydroxysteroid (17-beta) dehydrogenase 2	0.012
MLXIPL	MLX interacting protein-like	0.012
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.012
MOGAT2	monoacylglycerol O-acyltransferase 2	0.012
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.012
IL1F10	interleukin 1 family, member 10 (theta)	0.012
CALCA	calcitonin-related polypeptide alpha	0.012
ADRA1A	adrenergic, alpha-1A-, receptor	0.012
KRT76	keratin 76	0.012
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.012
CSRP3	cysteine and glycine-rich protein 3 (cardiac LIM protein)	0.012
LRRC3	leucine rich repeat containing 3	0.012
AMELY	amelogenin, Y-linked	0.012
FBP2	fructose-1,6-bisphosphatase 2	0.012
C1orf129	chromosome 1 open reading frame 129	0.012
SULT1B1	sulfotransferase family, cytosolic, 1B, member 1	0.011
LIPC	lipase, hepatic	0.011
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.011
EPB42	erythrocyte membrane protein band 4.2	0.011
NEU3	sialidase 3 (membrane sialidase)	0.011
PBOV1	prostate and breast cancer overexpressed 1	0.011
SLC6A7	solute carrier family 6 (neurotransmitter transporter, L-proline), member 7	0.011
CDKL1	cyclin-dependent kinase-like 1 (CDC2-related kinase)	0.011
TRPV5	transient receptor potential cation channel, subfamily V, member 5	0.011
TRPC7	transient receptor potential cation channel, subfamily C, member 7	0.011
LELP1	late cornified envelope-like proline-rich 1	0.011
AQP6	aquaporin 6, kidney specific	0.011
CLEC1B	C-type lectin domain family 1, member B	0.011
RAPSN	receptor-associated protein of the synapse	0.011
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.011
LDHC	lactate dehydrogenase C	0.011
RDH5	retinol dehydrogenase 5 (11-cis/9-cis)	0.011
AMN	amnionless homolog (mouse)	0.011
BDKRB1	bradykinin receptor B1	0.011
SLCO1B3	solute carrier organic anion transporter family, member 1B3	0.011
OR10A4	olfactory receptor, family 10, subfamily A, member 4	0.011
DIO1	deiodinase, iodothyronine, type I	0.011
MGAM	maltase-glucoamylase (alpha-glucosidase)	0.011
CPN1	carboxypeptidase N, polypeptide 1	0.011
DAO	D-amino-acid oxidase	0.011
GRPR	gastrin-releasing peptide receptor	0.011
CLPS	colipase, pancreatic	0.010
CDH16	cadherin 16, KSP-cadherin	0.010
CRX	cone-rod homeobox	0.010
F13B	coagulation factor XIII, B polypeptide	0.010
PTH1R	parathyroid hormone 1 receptor	0.010
MYH7	myosin, heavy chain 7, cardiac muscle, beta	0.010
TMSB4Y	thymosin beta 4, Y-linked	0.010
AGXT2L1	alanine-glyoxylate aminotransferase 2-like 1	0.010
P2RX2	purinergic receptor P2X, ligand-gated ion channel, 2	0.010
LRRC6	leucine rich repeat containing 6	0.010
C2orf83	chromosome 2 open reading frame 83	0.010
FAM92A1	family with sequence similarity 92, member A1	0.010
CLCN1	chloride channel 1, skeletal muscle	0.010
NXF3	nuclear RNA export factor 3	0.010
CLCN5	chloride channel 5	0.010
SERPINA4	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	0.010
UGT2B4	UDP glucuronosyltransferase 2 family, polypeptide B4	0.010