IMP
Process View
positive regulation of cytosolic calcium ion concentration involved in phospholipase c activating g protein coupled signaling pathway
Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G-protein coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol.
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Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of cytosolic calcium ion concentration involved in phospholipase c activating g protein coupled signaling pathway"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| MPDZ | multiple PDZ domain protein | 0.986 | ||
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.963 | ||
| PPP1R9B | protein phosphatase 1, regulatory (inhibitor) subunit 9B | 0.961 | ||
| ADORA2A | adenosine A2a receptor | 0.927 | ||
| SLC6A3 | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | 0.926 | ||
| ATP2B2 | ATPase, Ca++ transporting, plasma membrane 2 | 0.766 | ||
| TRPC4 | transient receptor potential cation channel, subfamily C, member 4 | 0.741 | ||
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.678 | ||
| RLN3 | relaxin 3 | 0.532 | ||
| PTEN | phosphatase and tensin homolog | 0.380 | ||
| SLC9A3R1 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 | 0.256 | ||
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.236 | ||
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.215 | ||
| SSTR3 | somatostatin receptor 3 | 0.123 | ||
| CAV2 | caveolin 2 | 0.122 | ||
| FN1 | fibronectin 1 | 0.094 | ||
| THBS1 | thrombospondin 1 | 0.068 | ||
| C3 | complement component 3 | 0.062 | ||
| ARRDC3 | arrestin domain containing 3 | 0.062 | ||
| KCNJ9 | potassium inwardly-rectifying channel, subfamily J, member 9 | 0.057 | ||
| GRIN1 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | 0.053 | ||
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.051 | ||
| DLGAP2 | discs, large (Drosophila) homolog-associated protein 2 | 0.047 | ||
| ARRB1 | arrestin, beta 1 | 0.044 | ||
| TBC1D10A | TBC1 domain family, member 10A | 0.040 | ||
| GPR6 | G protein-coupled receptor 6 | 0.039 | ||
| CALCRL | calcitonin receptor-like | 0.037 | ||
| TRPC3 | transient receptor potential cation channel, subfamily C, member 3 | 0.036 | ||
| RHO | rhodopsin | 0.034 | ||
| SLC9A3 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 | 0.033 | ||
| GAD2 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) | 0.031 | ||
| ADORA1 | adenosine A1 receptor | 0.031 | ||
| CCKBR | cholecystokinin B receptor | 0.030 | ||
| HTR2C | 5-hydroxytryptamine (serotonin) receptor 2C | 0.028 | Human Mouse | |
| CALCA | calcitonin-related polypeptide alpha | 0.028 | ||
| AFF2 | AF4/FMR2 family, member 2 | 0.023 | ||
| KCNJ5 | potassium inwardly-rectifying channel, subfamily J, member 5 | 0.022 | ||
| FEZF2 | FEZ family zinc finger 2 | 0.021 | ||
| DRD2 | dopamine receptor D2 | 0.020 | ||
| GFRA4 | GDNF family receptor alpha 4 | 0.020 | ||
| HTR1A | 5-hydroxytryptamine (serotonin) receptor 1A | 0.019 | Human | |
| OR2AG1 | olfactory receptor, family 2, subfamily AG, member 1 | 0.018 | ||
| CTGF | connective tissue growth factor | 0.018 | ||
| CRHR2 | corticotropin releasing hormone receptor 2 | 0.018 | ||
| CACNG3 | calcium channel, voltage-dependent, gamma subunit 3 | 0.017 | ||
| FOXN1 | forkhead box N1 | 0.017 | ||
| MAG | myelin associated glycoprotein | 0.017 | ||
| GHRHR | growth hormone releasing hormone receptor | 0.016 | ||
| PLCD1 | phospholipase C, delta 1 | 0.016 | Rat | |
| TGM2 | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) | 0.016 | Rat | |
| ODF1 | outer dense fiber of sperm tails 1 | 0.014 | ||
| OR2H1 | olfactory receptor, family 2, subfamily H, member 1 | 0.014 | ||
| GRIA1 | glutamate receptor, ionotropic, AMPA 1 | 0.014 | ||
| HTR4 | 5-hydroxytryptamine (serotonin) receptor 4 | 0.013 | Human | |
| SLC30A3 | solute carrier family 30 (zinc transporter), member 3 | 0.012 | ||
| EMX1 | empty spiracles homeobox 1 | 0.012 | ||
| NALCN | sodium leak channel, non-selective | 0.012 | ||
| TSHR | thyroid stimulating hormone receptor | 0.012 | ||
| OPRK1 | opioid receptor, kappa 1 | 0.011 | ||
| SSTR4 | somatostatin receptor 4 | 0.011 | ||
| SIX6 | SIX homeobox 6 | 0.011 | ||
| GLRA1 | glycine receptor, alpha 1 | 0.011 | ||
| FSTL4 | follistatin-like 4 | 0.011 | ||
| OPRM1 | opioid receptor, mu 1 | 0.011 | ||
| NCR2 | natural cytotoxicity triggering receptor 2 | 0.011 | ||
| NGB | neuroglobin | 0.011 | ||
| GABRA1 | gamma-aminobutyric acid (GABA) A receptor, alpha 1 | 0.011 | ||
| SMR3A | submaxillary gland androgen regulated protein 3A | 0.010 | ||
| CALCB | calcitonin-related polypeptide beta | 0.010 | Human | |
| EDNRB | endothelin receptor type B | 0.010 | ||
| NPY2R | neuropeptide Y receptor Y2 | 0.010 |