IMP
Process View
chondroitin sulfate metabolic process
The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate.
In addition to gene-name show these genes:
Click on a gene's description to view its network relationships with genes known to be involved in "chondroitin sulfate metabolic process"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| ELN | elastin | 0.669 | ||
| MFAP2 | microfibrillar-associated protein 2 | 0.245 | ||
| COL6A2 | collagen, type VI, alpha 2 | 0.171 | ||
| PCOLCE | procollagen C-endopeptidase enhancer | 0.156 | ||
| LUM | lumican | 0.100 | ||
| COL1A2 | collagen, type I, alpha 2 | 0.082 | ||
| DPT | dermatopontin | 0.068 | ||
| MRC2 | mannose receptor, C type 2 | 0.056 | ||
| SULF1 | sulfatase 1 | 0.042 | ||
| COL14A1 | collagen, type XIV, alpha 1 | 0.042 | ||
| COL3A1 | collagen, type III, alpha 1 | 0.040 | ||
| COL6A1 | collagen, type VI, alpha 1 | 0.038 | ||
| EDNRA | endothelin receptor type A | 0.036 | ||
| ISLR | immunoglobulin superfamily containing leucine-rich repeat | 0.030 | ||
| THY1 | Thy-1 cell surface antigen | 0.029 | ||
| LOX | lysyl oxidase | 0.027 | ||
| C1S | complement component 1, s subcomponent | 0.027 | ||
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.024 | ||
| GPC1 | glypican 1 | 0.023 | ||
| BMP1 | bone morphogenetic protein 1 | 0.022 | ||
| MFAP4 | microfibrillar-associated protein 4 | 0.022 | ||
| CSPG4 | chondroitin sulfate proteoglycan 4 | 0.022 | ||
| COL4A2 | collagen, type IV, alpha 2 | 0.021 | ||
| FBN1 | fibrillin 1 | 0.021 | ||
| FAP | fibroblast activation protein, alpha | 0.021 | ||
| PDGFRB | platelet-derived growth factor receptor, beta polypeptide | 0.021 | ||
| MXRA5 | matrix-remodelling associated 5 | 0.020 | ||
| LAMA2 | laminin, alpha 2 | 0.020 | ||
| COL5A1 | collagen, type V, alpha 1 | 0.019 | ||
| C1R | complement component 1, r subcomponent | 0.019 | ||
| RCN3 | reticulocalbin 3, EF-hand calcium binding domain | 0.019 | ||
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.018 | ||
| SRPX | sushi-repeat containing protein, X-linked | 0.018 | ||
| COL1A1 | collagen, type I, alpha 1 | 0.017 | ||
| LTBP2 | latent transforming growth factor beta binding protein 2 | 0.017 | ||
| ADAMTS2 | ADAM metallopeptidase with thrombospondin type 1 motif, 2 | 0.017 | ||
| LOXL1 | lysyl oxidase-like 1 | 0.017 | ||
| GLT8D2 | glycosyltransferase 8 domain containing 2 | 0.015 | ||
| THBS2 | thrombospondin 2 | 0.015 | ||
| AEBP1 | AE binding protein 1 | 0.015 | ||
| MGP | matrix Gla protein | 0.015 | ||
| ASPN | asporin | 0.014 | ||
| OLFML2B | olfactomedin-like 2B | 0.013 | ||
| ECM2 | extracellular matrix protein 2, female organ and adipocyte specific | 0.013 | ||
| CTSK | cathepsin K | 0.012 | ||
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | 0.012 | ||
| FBLN5 | fibulin 5 | 0.011 | ||
| PDGFRA | platelet-derived growth factor receptor, alpha polypeptide | 0.011 | ||
| PARK2 | parkinson protein 2, E3 ubiquitin protein ligase (parkin) | 0.010 |