IMP

Process View

Homo sapiens

4 genes annotated in human

alkaloid metabolic process

The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases).

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Known genes in the process in human Include functional analogs

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Gene Predictions

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Name	Description	Probability	Func Analog Organism
CYP2C9	cytochrome P450, family 2, subfamily C, polypeptide 9	1.000	Human
CYP2A6	cytochrome P450, family 2, subfamily A, polypeptide 6	1.000
CYP4A11	cytochrome P450, family 4, subfamily A, polypeptide 11	0.982
CYP3A7	cytochrome P450, family 3, subfamily A, polypeptide 7	0.976	Human
CYP3A43	cytochrome P450, family 3, subfamily A, polypeptide 43	0.963	Human
CYP2B6	cytochrome P450, family 2, subfamily B, polypeptide 6	0.899	Human Rat
CYP3A5	cytochrome P450, family 3, subfamily A, polypeptide 5	0.864
CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	0.804
CYP2C19	cytochrome P450, family 2, subfamily C, polypeptide 19	0.609	Human
C8B	complement component 8, beta polypeptide	0.584
CYP4F12	cytochrome P450, family 4, subfamily F, polypeptide 12	0.452
CYP4F2	cytochrome P450, family 4, subfamily F, polypeptide 2	0.444
C8A	complement component 8, alpha polypeptide	0.432
C6	complement component 6	0.415
HRG	histidine-rich glycoprotein	0.408
ADH6	alcohol dehydrogenase 6 (class V)	0.390
MASP2	mannan-binding lectin serine peptidase 2	0.341
F9	coagulation factor IX	0.248
CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2	0.225
CYP2C18	cytochrome P450, family 2, subfamily C, polypeptide 18	0.217	Human
MAT1A	methionine adenosyltransferase I, alpha	0.216
GLYAT	glycine-N-acyltransferase	0.216
DAO	D-amino-acid oxidase	0.212
ALDOB	aldolase B, fructose-bisphosphate	0.203
OTC	ornithine carbamoyltransferase	0.163
FMO4	flavin containing monooxygenase 4	0.153
NAT2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	0.142
CFHR4	complement factor H-related 4	0.136
SULT1B1	sulfotransferase family, cytosolic, 1B, member 1	0.129
APCS	amyloid P component, serum	0.125
SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	0.122
SLC10A1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.104
NR1I2	nuclear receptor subfamily 1, group I, member 2	0.103
SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	0.103
LAMC3	laminin, gamma 3	0.100
PON1	paraoxonase 1	0.100
GBA3	glucosidase, beta, acid 3 (cytosolic)	0.089
GSTA3	glutathione S-transferase alpha 3	0.077
ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	0.075
UGT2B15	UDP glucuronosyltransferase 2 family, polypeptide B15	0.075
ITIH4	inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)	0.073
HMGCS2	3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)	0.073
PLG	plasminogen	0.072
FETUB	fetuin B	0.072
G6PC	glucose-6-phosphatase, catalytic subunit	0.069
SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	0.068
CCL16	chemokine (C-C motif) ligand 16	0.067
NR1H4	nuclear receptor subfamily 1, group H, member 4	0.061
HABP2	hyaluronan binding protein 2	0.059
C4BPB	complement component 4 binding protein, beta	0.058
AGXT2	alanine--glyoxylate aminotransferase 2	0.057
CYP4F3	cytochrome P450, family 4, subfamily F, polypeptide 3	0.056
CRP	C-reactive protein, pentraxin-related	0.055
F11	coagulation factor XI	0.055
GPLD1	glycosylphosphatidylinositol specific phospholipase D1	0.051
AADAC	arylacetamide deacetylase (esterase)	0.050
DPYS	dihydropyrimidinase	0.050
LGALS4	lectin, galactoside-binding, soluble, 4	0.050
PFKFB1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.048
ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	0.048
C4BPA	complement component 4 binding protein, alpha	0.048
F13B	coagulation factor XIII, B polypeptide	0.047
BHMT	betaine--homocysteine S-methyltransferase	0.047
MTTP	microsomal triglyceride transfer protein	0.047
SLC22A1	solute carrier family 22 (organic cation transporter), member 1	0.047
XDH	xanthine dehydrogenase	0.046
APOC3	apolipoprotein C-III	0.046
HAL	histidine ammonia-lyase	0.046
C9	complement component 9	0.045
A2M	alpha-2-macroglobulin	0.042
MEP1B	meprin A, beta	0.042
APOC4	apolipoprotein C-IV	0.041
CYP4F11	cytochrome P450, family 4, subfamily F, polypeptide 11	0.040
PAH	phenylalanine hydroxylase	0.040
KNG1	kininogen 1	0.039
ANXA10	annexin A10	0.039
HPX	hemopexin	0.039
DNASE1L3	deoxyribonuclease I-like 3	0.037
LECT2	leukocyte cell-derived chemotaxin 2	0.036
A1CF	APOBEC1 complementation factor	0.036
PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	0.036
GYS2	glycogen synthase 2 (liver)	0.035
CYP7A1	cytochrome P450, family 7, subfamily A, polypeptide 1	0.034
CYP2A7	cytochrome P450, family 2, subfamily A, polypeptide 7	0.034	Human
LPA	lipoprotein, Lp(a)	0.034
CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	0.033	Human
HPD	4-hydroxyphenylpyruvate dioxygenase	0.032
PGRMC1	progesterone receptor membrane component 1	0.032
PIK3C2G	phosphoinositide-3-kinase, class 2, gamma polypeptide	0.032
TM4SF4	transmembrane 4 L six family member 4	0.030
CNGA1	cyclic nucleotide gated channel alpha 1	0.029
HGD	homogentisate 1,2-dioxygenase	0.029
CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	0.029	Human
FUT6	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)	0.028
GATM	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	0.028
AKR1C4	aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)	0.028
ACRV1	acrosomal vesicle protein 1	0.028
ENTPD5	ectonucleoside triphosphate diphosphohydrolase 5	0.028
TM4SF5	transmembrane 4 L six family member 5	0.028
UGT2B17	UDP glucuronosyltransferase 2 family, polypeptide B17	0.028
SGK2	serum/glucocorticoid regulated kinase 2	0.027
COLEC10	collectin sub-family member 10 (C-type lectin)	0.027
HNF4G	hepatocyte nuclear factor 4, gamma	0.026
MAST1	microtubule associated serine/threonine kinase 1	0.026
RNF32	ring finger protein 32	0.026
UGT2B28	UDP glucuronosyltransferase 2 family, polypeptide B28	0.025
TTPA	tocopherol (alpha) transfer protein	0.025
ITIH2	inter-alpha (globulin) inhibitor H2	0.024
UGT1A3	UDP glucuronosyltransferase 1 family, polypeptide A3	0.024
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.024
TAT	tyrosine aminotransferase	0.023
GC	group-specific component (vitamin D binding protein)	0.023
SERPINA6	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	0.023
AKR1D1	aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)	0.022
CYP2D6	cytochrome P450, family 2, subfamily D, polypeptide 6	0.022
CDH17	cadherin 17, LI cadherin (liver-intestine)	0.022
LRRC31	leucine rich repeat containing 31	0.022
ADH1A	alcohol dehydrogenase 1A (class I), alpha polypeptide	0.022
TMPRSS6	transmembrane protease, serine 6	0.022
BAAT	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)	0.021
SLC28A1	solute carrier family 28 (sodium-coupled nucleoside transporter), member 1	0.021
MUC3A	mucin 3A, cell surface associated	0.021
SAA4	serum amyloid A4, constitutive	0.021
PON3	paraoxonase 3	0.020
PNLIPRP1	pancreatic lipase-related protein 1	0.020
AFM	afamin	0.020
FABP1	fatty acid binding protein 1, liver	0.020
RDH13	retinol dehydrogenase 13 (all-trans/9-cis)	0.020
REG1A	regenerating islet-derived 1 alpha	0.020
CDHR5	cadherin-related family member 5	0.019
HNF1B	HNF1 homeobox B	0.019
CPB2	carboxypeptidase B2 (plasma)	0.019
ATP10B	ATPase, class V, type 10B	0.019
GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	0.019
UPB1	ureidopropionase, beta	0.019
ATOH8	atonal homolog 8 (Drosophila)	0.019
HAO1	hydroxyacid oxidase (glycolate oxidase) 1	0.019
ENPP3	ectonucleotide pyrophosphatase/phosphodiesterase 3	0.018
GCKR	glucokinase (hexokinase 4) regulator	0.018
RAB3D	RAB3D, member RAS oncogene family	0.018
ALDH1L1	aldehyde dehydrogenase 1 family, member L1	0.018
FGL1	fibrinogen-like 1	0.018
APOH	apolipoprotein H (beta-2-glycoprotein I)	0.018
HGFAC	HGF activator	0.018
PIPOX	pipecolic acid oxidase	0.018
NR1I3	nuclear receptor subfamily 1, group I, member 3	0.018
ZG16	zymogen granule protein 16 homolog (rat)	0.017
SPP2	secreted phosphoprotein 2, 24kDa	0.017
SLC7A9	solute carrier family 7 (cationic amino acid transporter, y+ system), member 9	0.017
APOB	apolipoprotein B (including Ag(x) antigen)	0.017
KLKB1	kallikrein B, plasma (Fletcher factor) 1	0.017
AZGP1	alpha-2-glycoprotein 1, zinc-binding	0.017
PLA2G10	phospholipase A2, group X	0.017
HAO2	hydroxyacid oxidase 2 (long chain)	0.017
ADH4	alcohol dehydrogenase 4 (class II), pi polypeptide	0.017
CA5A	carbonic anhydrase VA, mitochondrial	0.017
PLA2G1B	phospholipase A2, group IB (pancreas)	0.016
SERPINA10	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	0.016
PZP	pregnancy-zone protein	0.016
MBL2	mannose-binding lectin (protein C) 2, soluble	0.016
SLC17A4	solute carrier family 17 (sodium phosphate), member 4	0.016
HAAO	3-hydroxyanthranilate 3,4-dioxygenase	0.016
C9orf68	chromosome 9 open reading frame 68	0.015
ERN2	endoplasmic reticulum to nucleus signaling 2	0.015
TMPRSS2	transmembrane protease, serine 2	0.015
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.015
CYP4A22	cytochrome P450, family 4, subfamily A, polypeptide 22	0.015
SPINK1	serine peptidase inhibitor, Kazal type 1	0.015
MIA2	melanoma inhibitory activity 2	0.015
CHAD	chondroadherin	0.015
UGT1A9	UDP glucuronosyltransferase 1 family, polypeptide A9	0.015
CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8	0.015	Human
AGXT	alanine-glyoxylate aminotransferase	0.015
RORC	RAR-related orphan receptor C	0.014
SULT1E1	sulfotransferase family 1E, estrogen-preferring, member 1	0.014
ACE2	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	0.014
BARX1	BARX homeobox 1	0.014
ZKSCAN3	zinc finger with KRAB and SCAN domains 3	0.014
ASB4	ankyrin repeat and SOCS box containing 4	0.014
CAPN5	calpain 5	0.014
SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	0.014
CIDEB	cell death-inducing DFFA-like effector b	0.014
S100G	S100 calcium binding protein G	0.014
RPAIN	RPA interacting protein	0.014
CPN1	carboxypeptidase N, polypeptide 1	0.014
ADRA1A	adrenergic, alpha-1A-, receptor	0.014
CFHR5	complement factor H-related 5	0.013
SLCO1B3	solute carrier organic anion transporter family, member 1B3	0.013
SLC6A12	solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12	0.013
RDH16	retinol dehydrogenase 16 (all-trans)	0.013
AOC2	amine oxidase, copper containing 2 (retina-specific)	0.013
SLC19A3	solute carrier family 19, member 3	0.013
BBOX1	butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1	0.013
GK	glycerol kinase	0.013
ARG1	arginase, liver	0.013
FMO5	flavin containing monooxygenase 5	0.013
APOF	apolipoprotein F	0.013
SERPIND1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	0.013
CD163	CD163 molecule	0.013
SCNN1G	sodium channel, nonvoltage-gated 1, gamma	0.013
SLC13A2	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	0.013
ABCG5	ATP-binding cassette, sub-family G (WHITE), member 5	0.013
C8G	complement component 8, gamma polypeptide	0.013
UGT1A7	UDP glucuronosyltransferase 1 family, polypeptide A7	0.013
DEFB1	defensin, beta 1	0.012
ANXA13	annexin A13	0.012
ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	0.012
SLC30A10	solute carrier family 30, member 10	0.012
HNF4A	hepatocyte nuclear factor 4, alpha	0.012
CLCA4	chloride channel accessory 4	0.012
SPRR1A	small proline-rich protein 1A	0.012
HRASLS2	HRAS-like suppressor 2	0.012
GCM1	glial cells missing homolog 1 (Drosophila)	0.012
STAB2	stabilin 2	0.012
AQP8	aquaporin 8	0.012
TTR	transthyretin	0.012
CES3	carboxylesterase 3	0.012
HHLA2	HERV-H LTR-associating 2	0.012
CD5L	CD5 molecule-like	0.012
MOGAT2	monoacylglycerol O-acyltransferase 2	0.012
CYP4B1	cytochrome P450, family 4, subfamily B, polypeptide 1	0.012
RDH5	retinol dehydrogenase 5 (11-cis/9-cis)	0.012
FCN3	ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)	0.012
GPX2	glutathione peroxidase 2 (gastrointestinal)	0.011
KRT20	keratin 20	0.011
LRRC19	leucine rich repeat containing 19	0.011
HSD3B2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	0.011
HSD17B3	hydroxysteroid (17-beta) dehydrogenase 3	0.011
BCMO1	beta-carotene 15,15'-monooxygenase 1	0.011
CYP2J2	cytochrome P450, family 2, subfamily J, polypeptide 2	0.011	Human
PTPRH	protein tyrosine phosphatase, receptor type, H	0.011
TEC	tec protein tyrosine kinase	0.011
PROC	protein C (inactivator of coagulation factors Va and VIIIa)	0.011
KRT12	keratin 12	0.011
MADCAM1	mucosal vascular addressin cell adhesion molecule 1	0.011
THRB	thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)	0.011
NAT8	N-acetyltransferase 8 (GCN5-related, putative)	0.011
FAM164C	family with sequence similarity 164, member C	0.011
USH1C	Usher syndrome 1C (autosomal recessive, severe)	0.011
CRHBP	corticotropin releasing hormone binding protein	0.010
GPD1	glycerol-3-phosphate dehydrogenase 1 (soluble)	0.010
AKR1B10	aldo-keto reductase family 1, member B10 (aldose reductase)	0.010
TGFBI	transforming growth factor, beta-induced, 68kDa	0.010
SLC17A3	solute carrier family 17 (sodium phosphate), member 3	0.010
PROZ	protein Z, vitamin K-dependent plasma glycoprotein	0.010
LIPF	lipase, gastric	0.010
KRT13	keratin 13	0.010
XPNPEP2	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound	0.010
LRTOMT	leucine rich transmembrane and 0-methyltransferase domain containing	0.010
TRIM15	tripartite motif containing 15	0.010