IMP
Process View
negative regulation of macrophage derived foam cell differentiation
Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.
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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of macrophage derived foam cell differentiation"
| Name | Description | Probability | Func Analog Organism | |
|---|---|---|---|---|
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.866 | ||
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.835 | ||
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.514 | ||
| RELB | v-rel reticuloendotheliosis viral oncogene homolog B | 0.482 | ||
| C1QA | complement component 1, q subcomponent, A chain | 0.473 | Human | |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 0.433 | Human | |
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 0.397 | ||
| IKBKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 0.258 | ||
| REL | v-rel reticuloendotheliosis viral oncogene homolog (avian) | 0.198 | ||
| RXRA | retinoid X receptor, alpha | 0.133 | ||
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | 0.112 | ||
| PXN | paxillin | 0.093 | ||
| BCL3 | B-cell CLL/lymphoma 3 | 0.082 | Human | |
| NCOR2 | nuclear receptor corepressor 2 | 0.050 | ||
| ITGA2B | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | 0.048 | ||
| FN1 | fibronectin 1 | 0.046 | ||
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.041 | ||
| C1QC | complement component 1, q subcomponent, C chain | 0.037 | Human | |
| FHL2 | four and a half LIM domains 2 | 0.037 | ||
| ENG | endoglin | 0.030 | ||
| TLN1 | talin 1 | 0.017 | ||
| HNF4A | hepatocyte nuclear factor 4, alpha | 0.016 | ||
| NFKBIB | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | 0.013 | Human | |
| FCN2 | ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) | 0.011 |